Biography

1995-1999      Biochemistry (Medical) (1^st class Honours); University of Surrey Guildford, UK

1997-1998      Research assistant at Bayer Pharmaceuticals, Stoke Poges, UK

1999-2002      PhD. Neuropharmacology; University of Surrey, Guildford, UK

                     Thesis: Interactions between opioid and adenosine systems in the CNS               

2003-2005      Smart Foundation Post Doctoral Fellow at The Laboratory of the Biology of  Addictive Diseases, Rockefeller University, New York, USA

2005-2008   Post Doctoral Fellow; FP6 EC funded grant on genetics of addiction (GENADDICT)

                     University of Surrey, Guildford, UK

2008-present  RCUK Academic Fellow in Drug Safety, University of Surrey, Guildford, UK

Research Interests

Research Themes (links)

•  Pharmacology & Toxicology

-         Cardiovascular

My current research focuses on how specific genes influence the behavioural and neurochemical effects of chronic drug abuse with the use of in vivo and neurochemical studies.  I have set up, in collaboration with Prof. Ian Kitchen, behavioural pharmacology techniques at Surrey University including actimotor system for measuring locomotion, conditioned place preference, stereotypy, elevated plus maze, rotorod and forced swim test.  These techniques are currently being used in order to measure behavioural effects of drugs of abuse in gene knockout mice as well as in different strains of mice.  In addition, I have been developing novel paradigms of cocaine and opioid administration in rodents which better mimic human drug abuse after spending 2 years of post doctoral research training (2003-2005) at The Laboratory of the Biology of Addictive Diseases at Rockefeller University, New York.  Moreover, we are characterizing the neurobiological changes that occur in response to drugs of abuse and trying to correlate them with behavioural effects of the drugs.  The neurochemical techniques used include freely moving microdialysis to measure release of neurotransmitter and receptor autoradiography.  Other aspects of my research include the investigation of the interactions between opioids and adenosine in pain and addiction. 

Publications

2009
Fan, L.M., Sawbridge, D., George, V., Teng, L., Bailey, A., Kitchen I., Li .J.M. (2009) Chronic cocaine-induced cardiac oxidative stress and MAPK activation: The role of Nox2 oxidase The Journal of Pharmacology and Experimental Therapeutics 328:99–106

2008
Bailey, A., Metaxas, A., Yoo, YH., McGee, T., Kitchen. I. (2008) Decrease of D2 receptor binding but increase in D2 stimulated G protein activation, dopamine transporter binding and behavioural sensitisation in brains of mice treated with a chronic escalating dose "binge" cocaine administration paradigm European Journal Neuroscience 28 (4): 759-770

2007
Cabello, J., Bailey, A., Kitchen, I., Prydderch, M., Clark, A., Turchetta, R., Wells, K. (2007) Digital autoradiography using room temperature CCD and CMOS imaging technology Phys. Med. Biol. 52 (16): 4993-5022

Bailey, A., Yoo, J.H., Racz, I., Zimmer, A., Kitchen, I. (2007) Preprodynorphin mediates locomotion and D2 dopamine and - opioid receptor changes induced by chronic “binge” cocaine administration Journal of Neurochemistry 102 (6): 1817-30

Bailey, A., Gianotti, R., Ho, A., Kreek. M.J. (2007) Downregulation of - opioid receptors in the basolateral amygdala and septum of rats withdrawn for 14 days from an escalating dose “binge” cocaine administration paradigm Synapse 61 (10):820-6

2005
Bailey, A., Gianotti, R., Kreek, M.J. (2005) Persistent upregulation of - opioid but not adenosine receptors in brains of long term withdrawn escalating dose “binge” cocaine treated rats. Synapse 57: 160-166

Schlussman, S.D., Zhou, Y., Bailey, A., Ho, A., Kreek, M.J. (2005) Steady-dose and escalating dose “binge” administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats. Brain Research Bulletin 67: 169-175

Bailey, A., Yuferov, V., Bendor, J., Schlussman, S.D., Zhou, Y., Ho, A., Kreek, M.J. (2005) Acute withdrawal from chronic “binge” cocaine administration increases -opioid receptor mRNA levels in rat frontal cortex. Molecular Brain Research 137: 258-262

2004
Kelly, M., Bailey, A., Kitchen, I., Hourani, S.M.O. (2004) Characterization of [3H]ZM 24385 binding in wild-type and adenosine A2A receptor knockout mice European Journal of Pharmacology, 504: 55-59

Bailey, A., Weber, D., Zimmer, A., Zimmer, A.M., Hourani, S.M. & Kitchen, I.
(2004) Quantitative autoradiography of adenosine receptors and NBTI-sensitive
adenosine transporters in the brains of mice deficient in the preproenkephalin gene
Brain Research, 1025, 1-9

Bailey, A., Lesscher, H.M.B., Kelly, M., Ledent, C., Davis, L., Hourani, S.M.O.,
Kitchen, I. (2004) Enhanced morphine withdrawal and -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice. Journal of Neurochemistry 88 (4): 827-834

2003
Bailey, A., Hawkins, R.M., Hourani, S.M.O., Kitchen, I., (2003) Quantitative autoradiography of adenosine receptors in brains of chronic naltrexone-treated mice.
British Journal of Pharmacology 139 (6): 1187-1195

Lesscher, H.M.B., Bailey, A., Burbach, J.P.H., van Ree, J.M., Kitchen, I., Gerrits, M.A.F.M., (2003) Receptor-selective changes in -, - and -opioid receptors after chronic naltrexone treatment in mice. European Journal of Neuroscience 17: 1006-1012

Kokkinou, E., Wells, K., Petrou, M., Bailey, A. (2003) Digital autoroadiography imaging using direct irradiation of a CCD between 278-309 K IEE Transactions on Nuclear Science 50 (5): 1702-1707

2002
Bailey, A., Kelly, M., Hourani, S.M.O., Ledent, C., Kitchen, I., (2002)
Changes in spinal  and  opioid systems in mice deficient in the A2A receptor gene. Journal of Neuroscience 22 (21): 9210-9220

Bailey, A., Matthes, H., Kieffer, B., Slowe, S., Hourani, S.M.O., Kitchen,
I. (2002) Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains and spinal cords of mice deficient in the -opioid receptor gene. Brain Research 943 (1): 68-79

2001
Bailey, A., Kelland, E.E., Thomas, A., Biggs, J., Crawford, D., Kitchen, I., Toms, N.J. (2001) Regional mapping of low-affinity kainate receptors in mouse brain using [3H](2S,4R)-4-methylglutamate autoradiography. European Journal of Pharmacology 431, 305-310

Teaching

Level 1

• BMS1003 Practical Biochemistry and Chemistry 1

Level 2

• BMS2006 Pharmacology
• BM2025 Neuroscience

Level 3

• BMS3036 Neuropharmacology (module organizer)
• BMS3049 Practical Neuropharmacology
• BMS3037 Peripheral Pharmacology
• BMS3002 Receptors
• BMS3042 Neuroscience: From molecules to mind

MSc Toxicology

• TOX M002 Principles of Toxicology
• TOX M007 Techniques in Toxicology
• TOX M008 Practical Toxicity Testing Study