Dr Changhao Wu

Biography

1995-2000:         Lecturer, Department of Medicine and Institute of Urology, University College London.

2001-2008 (Feb): Senior Lecturer, Department of Medicine and Institute of Urology, University College London.

2008 (March) to date: Senior Lecturer, PGMS, Faculty of Health and Medical Sciences, University of Surrey

Research Interests

Cellular physiology and pathophysiology; environmental medicine and toxicology

1. Excitable tissue: smooth muscle and cardiac muscle

2. Non-excitable tissue: epithelial/endothelial cells, fibroblasts/myofibroblasts/interstitial cells, hepatocytes.

Research strength: Ca²⁺ imaging, electrophysiology, cell signaling, purinergic function, cell to cell interaction and sensory mechanisms. 

Recent grants (as PI):

2003-2004 An investigation of the cellular physiology of suburothelium myofibroblasts. St Peter's Trust for Kidney, Bladder & Prostate Research. £48,409. C Wu, G Sui, C Fry

2004-2008 The cellular basis of spontaneous activity in the unstable urinary bladder. The WellcomeTrust, £224,816. C Wu, C Fry, G Sui.

2009-2012 Mode of action of sensory transmitters in bladder urothelium and the effect of ageing. BBSRC. £491,735. C Wu, C Fry, G Sui

2012-2016 Surrey and Shanghai Jiao Tong partnership on visceral organ sensory research during ageing. BBSRC £26,144. 

Research Collaborations

University of Sheffield, sensory mechanisms

University College London, system biology; urinary incontinence and infection

Royal Veterinary College, epithelial cell physiology

Anhui Medical University, Environmental Medicine and Dermatotoxicology

Shanghai Jiaotong University, visceral organ cell physiology and sensory mechanism

Publications

1. Wu C, Sui G and Fry CH (2011).  Intracellular Ca²⁺ regulation and electrophysiolgical properties of bladder urothelium subjected to stretch and exogenous agonists. Cell Calcium 49:395-9.
2. Zhang J, Pan L, Xu Y, Wu C, Wang C, Cheng Z, Zhao R (2011).  Total cholesterol content of erythrocyte membranes in acute coronary syndrome: correlation with apolipoprotein A-I nd lipoprotein (a). Coron Artery Dis 2011; 22: 145-152.
3. Sui G, Fry CH, Malone-Lee J and Wu C (2009). Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders. Cell Calcium 45: 456-464
4. Roosen, A, Sui GP, Fry CH and Wu, C. (2009). Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and independent mechanisms. Cell Calcium 45: 11-17.
5. Roosen A, Wu C, Sui G, Chowdhury RA, Patel PM, Fry CH (2009). Characteristics of Spontaneous Activity in the Bladder Trigone. Eur Urol 56: 237-406
6. Fry CH, Roosen A, Wu C, Sui GP, AJ Kanai AJ. The pathophysiology of the overactive bladder (OAB): recent developments in the understanding of aetiology and mechanisms. A book chapter in Key Advances in Medicine (in press).
7. Sui G, Wu C, Roosen A, Ikeda Y, Kanai KJ, Fry CH (2008). Modulation of bladder myofibroblast activity: implications for bladder function. Am J Physiol (Renal Physiol) 295: F688-97.
8. Shen T, Zhu QX, Yang S, Wu CH, Zhang HF, Zhou CF, Zhang XJ (2008). Trichloroethylene induced cutaneous irritation in BALB/c hairless mice: histopathological changes and oxidative damage. Toxicology. 248:113-20.
9. Roosen, A, Wu, C, Sui GP, and Fry CH. (2008). Synergistic effects in  neuromuscular activation and calcium sensitization in the bladder trigone. BJU International 101(5):610-4.
10. Fry CH, Sui G.-P , Kanai  AJ, Wu C. (2007). The function of suburothelial myofibroblasts in the bladder. Neurourol and Urodyn 26 (S6): 914-919.
11. Wu, C, Thiruchelvam, N, Sui, G., Woolf, AS, et al (2007). Ca²⁺ regulation in detrusor smooth muscle from ovine fetal bladder after in utero bladder outflow obstruction. J Urol 177(2): 776-780.
12. Sui, G, Wu, C., Severs, N, Newgreen D., and Fry, CH. (2007). The association between T-type Ca²⁺ current and outward current in isolated human detru sor cells from stable and overactive bladders. BJU International. 99(2), 436-441.
13. Wu, C, Sui, G, Thiruchelvam, N, Cuckow, P, Fry, CH. (2006). Ca²⁺ regulation in detrusor smooth muscle from developing fetal sheep bladders. Cell Calcium 39(4), 367-374.
14. Sui GP, Wu C, Fry CH. (2006). Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts. BJU International 97(6), 1327-1331.
15. Fry CH, Sui G, Wu C. (2006). T-type Ca²⁺ channels in non-vascular smooth muscles. Cell Calcium 40(2), 231-239.
16. Besarani, D, Wu, C, Fry, CH. (2006). The influence of changes in extracellular and intracellular sodium concentration on detrusor contractility. BJU International 97(5), 1083-1086.
17. Wu, C, Fry, PM, Sui, G, Fry, CH. (2005). Intracellular Ca²⁺ regulation in a human prostate stromal cell culture. Neurourol Urodyn 24(1), 81-88.
18. Sui, GP, Wu, C, Fry, CH. (2004). Ca²⁺ currents in smooth muscle cells isolated from human prostate. Prostate 59: 275-281.
19. Wu, C, Sui, GP, Fry, CH. (2004). Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol 559, 231-243.
20. Sui, GP, Wu, C, Fry, CH. (2004). Electrical characteristics of suburothelial cells isolated from the human bladder. J Urol 171: 938-943.
21. Fry, CH, Hussain, M, McCarthy, C, Ikeda, Y, Sui, GP, Wu, C. (2004). Recent advances in detrusor muscle function. Scand J Urol and Nephrol. Suppl 215, 20-25.
22. Fry, CH, Ikeda, Y, Harvey, R, Wu, C, Sui, GP. (2004). Control of bladder function by peripheral nerves: avenues for novel drug targets. Urology 63(3 Suppl 1), 24-31.
23.  Fry, CH, Sui, GP, Severs, NJ, Wu, C. (2004). Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity? Urology 63: 3-10.
24. Sui G, Wu C and Fry CH (2003). A description Ca²⁺ channels in human detrusor smooth muscle. BJU Int 92:  476-482.
25. Fry, CH, Wu, C, Sui, GP. (2003). Cellular properties of human sub-urothelial myofibroblasts - their role in bladder sensation. Neurourology and Urodynamics 22, 374-375.
26. Chow K-Y, Wu C, Sui GP, Fry CH (2003). The role of the T-type Ca²⁺ current on the contractile performance of guinea-pig detrusor smooth muscle.  Neurourol Urodyn 22: 77-82.
27. Thiruchelvam N, Wu C, David A, Woolf AS, Cuckow PM and Fry CH (2003). Neurotransmission and visco-elasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol 284:R1296-1305. 
28. Fry CH, Skennerton D, Wood DN and Wu C (2002). The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders. Urology 59, Supplement 5A: 3-12.
29. Wu C, Sui G, Mundy AR and Fry CH (2002). The role of the L-type Ca²⁺ channel in refilling functional intracellular Ca2+ stores in detrusor smooth muscle cells. J Physiol, 538: 357-369.
30. Wu C and Fry CH (2001). Evidence for Na⁺/Ca²⁺ exchange and its role in intracellular Ca2+ regulation in guinea-pig detrusor smooth muscle cells. Am J Physiol (Cell Physiology), 280: C1090-1096.
31. Sui G, Wu C and Fry CH (2001). The electrophysiological properties of cultured and freshly isolated detrusor smooth muscle cells. J Urol, 165: 627-632.
32. Sui G, Wu C and Fry CH (2001). Inward Ca²⁺ currents in cultured and freshly isolated detrusor muscle cells – evidence of a T-type Ca²⁺ current. J Urol, 165: 621-626.

Teaching

Pathology and Medicine - Module BMS2046

Physiology Practicals - Module BMS1032

Affiliations

The Physiological Society, full member

International Continence Society, full member

Visiting Professor in Occupational Medicine and Environmental Health, Anhui Medical University, China