Professor Costas Ioannides

Research Interests

• Anticarcinogenic potential of phytochemicals, with emphasis on tea.
• Pharmacokinetics of phytochemicals in animals and humans
• Interactions between melatonin and cytochrome P450
  Bioactivation of chemical carcinogens
• Cytochrome P450 expression in domesticated animals

My current work is funded by the European Union and the Association for International Cancer Research

Publications

Barnett CR and Ioannides C (2000) Xenobiotic metabolizing enzyme systems and aging. In: Aging Methods and Protocols. Barnett Y.A. and Barnett C.R. (eds), Humana Press, Totowa USA, pp. 119-130.

Catterall F, Souquet J-M, Cheynier V, Clifford MN and Ioannides C (2000) Modulation of the mutagenicity of food carcinogens by oligomeric and polymeric procyanidins isolated form grape seeds: synergistic genotoxicity with N-nitrosopyrrolidine. J. Sci. Fd. Agri., 80, 91-101.

Ioannides C (2000) Xenobiotic metabolism and bioactivation by cytochromes P450. In: Biomolecular Injury: Causes and prevention of toxicity. Wiseman H, Goldfarb P, Ridgway T and Wiseman A (eds), John Wiley & Sons, pp. 103-144.

Catterall F, Souqet J-M, Cheynier V, de Pascual-Teresa S, Santos-Buelga C, Clifford MN and Ioannides C (2000) Differential modulation of the genotoxicity of food carcinogens by naturally occurring monomeric and dimeric polyphenolics. Environ. Molec. Mutagen., 35, 86-98.

Walton K, Coombs MM, King LJ, Walker R and Ioannides C (2000) The fate of the mushroom hydrazine, agaritine, in the rat and mouse. Nutrition and Cancer, 37, 55-64.

Catterall F, Coombs MM, Ioannides C and Walton K (2000) Bioactivation of the carcinogen 11-methoxy-16,17-dihydro-15H-cyclopenta[a]phenanthrene. Mutat. Res., 465, 85-90.

Hashemi E, Till C and Ioannides C (2000) Stability of cytochrome P450 in cultured precision-cut rat liver slices. Toxicology, 149, 51-61.

Lewis DFV, Ioannides C, Schulte-Hermann R and Parke DV (2000) Quantitative structure-activity relationships in a series of endogenous and synthetic steroids exhibiting induction of CYP3A activity and hepatomegaly associated with increased DNA synthesis. J. Steroid Biochem. Molec. Biol., 74, 179-185.

Anderson D, Dhawan A, Yardley-Jones A, Ioannides C and J. Webb J (2001) Effect of antioxidant flavonoids and a food mutagen on lymphocytes of a thalassaemia patient without chelation therapy in the Comet assay. Teratogenesis, Carcinogenesis and Mutagenesis, 21, 165-174.

Walton K, Coombs MM, Walker R and Ioannides C (2001) The metabolism and bioactivation of agaritine and other mushroom hydrazines by whole mushroom homogenate and by mushroom tyrosinase. Toxicology, 161, 165-177.

Catterall F, Coombs MM, Ioannides C, Sepiol JJ and Wilson J (2001) Mutagenicity of bay-region amino-substituted cyclopenta[a]phenanthrenes and 2- and 5-aminochrysene. Mutation Res., 492, 7-11.

Sivapathasundaram S, Magnisali P, Coldham NG, Howells LC, Sauer MJ and Ioannides C (2001) A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver. Biochem. Pharmacol., 62, 635-645.

Skene DJ, Papapagiannidou E, Hashemi E, Snelling J, Lewis DFV, Fernandez M and Ioannides C (2001) Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices. J. Pineal Res., 31, 333-342.

Dhawan A, Anderson D, de Pascual-Teresa S, Santos-Buelga C, Clifford MN and Ioannides C (2002) Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. Mutation Research, 515, 39-56.

Ioannides C (2002) Xenobiotic metabolism: an overview. In: Enzyme Systems that Metabolise Drugs and Other Xenobiotics, Ioannides C (Ed), John Wiley & Sons, Chichester, pp. 1-32.

Ioannides C (2002) Pharmacokinetic interactions between herbal remedies and medicinal drugs. Xenobiotica, 32, 451-478. (1.856).

Teaching

Most of my teaching is to the MSc Tox students, the topics being: Mechanisms of chemical toxicity, Chemical Carcinogenesis, Cytochromes P450.

To the final year students I teach Pharmacokinetics, and Mutagenicity tests.