Dr Derek Stevenson

Biography

After leaving school I worked as an analytical chemist in the Agrochemical industry (Fisons as it then was) and Shell Research for 6 years. This was followed by 2 years at Westminster Medical School undertaking research in drug pharmacokinetics. Concurrently I did ONC, HNC and Grad RSC on day release. I did a PhD at the University of Surrey in the Wolfson Bioanalytical Centre (later incorporated into the Robens Institute) as an SRC Case studentship with ICI pharmaceuticals. I eventually became Head of the Analytical Unit and Lecturer then Senior Lecturer in Analytical Chemistry.
As Head of Robens Analytical Unit/Centre over 40 major reports were written for sponsors. These included, Health and Safety Executive, Environment Agency, Department of Health, WHO, Pfizer, ICI Pharmaceuticals, ICI Agrochemicals, Glaxo, Pharmachemie BV, Monsanto, Du Pont, British Agrochemical Association, British Telecom. Since 1997 these analytical activities have been part of the School of Biomedical and Molecular Sciences.

Research Interests

Development of analytical methods (HPLC, GC) to measure drugs, metabolites and endogenous compounds in biological fluids.
Simplified methods for occupational and environmental monitoring of trace organics.
Miniaturisation of separation science.
Selectivity in sample preparation using immobilised antibodies and molecular imprinted polymers.
Development and validation of immuno sensors.

Publications

Determination of morphine in urine by solid-phase immunoextraction and electrochemical detection. B.A. Rashid, G.W. Aherne, M.F. Katmeh, P. Kwasowski and D. Stevenson, J. Chromatogr. A, 797 (1998) 245-250

Highly selective antibody-mediated extraction of isoproturon from complex matrices, J S Shahtaheri, P. Kwazowski, and D Stevenson, Chromatographia. 47 (1998) 453-456

Selective extraction via immunoaffinity sorbents and Molecular Imprinted Polymers, D. Stevenson, J. Pharm. Belg. 53 (1998) 122

Illustrative Immunoaffinity approaches, Stevenson, D., Rashid, B.A., Katmeh, M.F., Kwasowski, P. in Methodological Surveys in biochemistry, (eds E Reid, H. Hill and I D Wilson), 1998, Royal Society of Chemistry, pp 52-54

Molecular imprinted polymer for solid phase extraction of tamoxifen, Stevenson, D., Briggs, R.J., Hay, J., Rashid, B.A. in Methodological Surveys in biochemistry, (eds E Reid, H. Hill and I D Wilson), 1998, Royal Society of Chemistry, pp 49-51

Serum and urine levels of tamoxifen and its metabolites in patients with advanced breast cancer after a loading dose and at steady state levels. de Vos D., Slee, H.Th.J., Briggs, R.J., Stevenson, D. Cancer Chemother. Pharmacol. 42 (1998) 512-514

Evaluation of a mixed immunosorbent for selective trace enrichment of phenylurea herbicides in plant material. Herrera, S., Martin-Esteban, A., Fernandez, P., Stevenson, D., Camara, C. Fresenius J Anal Chem 362 (1998) 547-551

Application to Biological Samples, Stevenson, D., Miller, S. Wilson, I.D. Extraction Methods in Organic Analysis (A. Handley ed.) Sheffield Academic Press, Sheffield 1999, pp 194-220

Molecular imprinted polymers for solid phase extraction, Stevenson, D. TrAC 18 (1999) 154-158

Solid phase extraction of Clenbuterol from plasma using immunoaffinity followed by HPLC. Rashid, B.A., Kwasowski, P., Stevenson, D. J. Pharm. Biomed. Anal.21, (1999) 635-639

Immunoaffinity Solid Phase Extraction, D. Stevenson. J. Chromatgr. B 745 (2000) 39-48

Immuno-affinity extraction, D. Stevenson, B.A. Rashid, S.J. Shahtaheri, in Solid Phase Extraction: Principles, Techniques, and Applications (ed N. Simpson) Marcel Dekker, New York (2000) pp349-360

Immunoaffinity Extraction, Stevenson, D. in Encyclopaedia of Separation Science (Wilson ID., Adlard, ER., Poole, C. and Cooke, M., eds) Academic Press, London, 2000 pp 3060-3064

Immunoaffinity Chromatography, I.D. Wilson and D. Stevenson in Encyclopaedia of Separation Science (Wilson Id., Adlard, ER., Poole, C. and Cooke, M., eds) Academic Press, London, 2000 pp 283-288

Fast prototyping of microfluidic devices for separation science, Hoettges, KF, Gwilliam, RM, Homewood, KP, and Stevenson, D. Chromatographia, 53, (2001) 424-426

Effect of Template Size on the Selectivity of Molecularly Imprinted Polymers for Phenylurea Herbicides, A. Martín-Esteban, E. Turiel, D. Stevenson, Chromatographia, 53 (2001) 434-437

Editorship of Books

Chiral Separation by D.Stevenson and I.D.Wilson, Plenum 1988. 0ISBN 0-306-43252-8.

Recent Advances in Chiral Separation by D.Stevenson and I.D.Wilson, Plenum 1990 ISBN 0-306
43836-4.

Sample preparation for Biomedical and Environmental Analysis, D. Stevenson and I.D.Wilson, Plenum 1994 - ISBN0-306-44663-4.

Patent

Development of a chip-based liquid-liquid separator.
See http://www.unisdirect.com/whatwedo/ip/opportunities/liquid.html

Teaching

BS 105: Introduction to spectrophotometry
BS 225: HPLC, GC and analytical quality assurance in food analysis
BS 237: Chromatography and quality assurance in analytical biochemistry
BS 301: HPLC and GC in biomedical analysis

CH 180:Quality assurance in analytical chemistry
CH 230: Analysis of pesticides, PCBs and PAHs in the environment.
CH 307: Chiral separations, advances in GC and HPLC
CH330: Immunoassays, miniaturisation, regulatory aspects of analytical quality assurance

MSc Clinical: Biochemistry HPLC and GC in biomedical analysis
MSc Toxicology: HPLC and GC in analytical toxicology
MSc Applied Toxicology
MSc Water and Environmental Engineering: Analytical quality assurance

Affiliations

Fellow of the Royal Society of Chemistry

Member of Analytical Division Council, member of South East Region Analytical division Committee

Fellow of the Chromatographic Society

Winner of the Royal Society of Chemistry Separations medal 2007