Professor Derk-Jan Dijk
Professor of Sleep and Physiology, Director Surrey Sleep Research Centre
Qualifications: BSc, MSc, PhD, FSB
Email: d.j.dijk@surrey.ac.uk
Phone: Work: 01483 68 9341
Room no: 16 MA 00
Further information
Biography
Please see my profile
Research Interests
Please go to the Surrey Sleep Research Centre.
Human sleep and biological rhythms
Quantitative EEG analysis
Circadian rhythm disorders
Effects of light on sleep, performance and circadian rhythms
Aging
Sleep disorders
Hypnotics
Actigraphy
Performance
Publications
Highlights
- . (2013) 'Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.'. Proc Natl Acad Sci U S A,
- . (2013) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men'. Metabolism: Clinical and Experimental, 62 (2), pp. 204-211.
- .
(2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res, doi: 10.1111/jsr.12001
- . (2012) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans'. Journal of Pineal Research, 53 (1), pp. 47-59.
- .
(2012) 'Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep.'. J Psychopharmacol, United States: 26 (8), pp. 1047-1057.Full text is available at: http://epubs.surrey.ac.uk/7385/
Abstract
AMPA receptor modulation is a potential novel approach to enhance cognitive performance. CX717 is a positive allosteric modulator of the AMPA receptor that has shown efficacy in rodent and primate cognition models. CX717 (100 mg, 300 mg and 1000 mg) and placebo were studied in 16 healthy male volunteers (18-45 years) in a randomized, crossover study. Cognitive function, arousal and recovery sleep (by polysomnography) were assessed during the extended wakefulness protocol. Placebo condition was associated with significant decrements in cognition, particularly at the circadian nadir (between 03:00 and 05:00). Pre-specified primary and secondary analyses (general linear mixed modelling, GLMM) at each separate time point did not reveal consistent improvements in performance or objective alertness with any dose of CX717. Exploratory repeated measures analysis, a method used to take into account the influence of individual differences, demonstrated an improvement in attention-based task performance following the 1000 mg dose. Analysis of the recovery sleep showed that CX717 1000 mg significantly reduced stage 4 and slow-wave sleep (p ≤ 0.05) with evidence of reduced electroencephalogram (EEG) slow-wave and spindle activity. The study suggests that CX717 only at the 1000 mg dose may counteract effects of sleep deprivation on attention-based tasks and that it may interfere with subsequent recovery sleep.
- . (2012) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiology of aging, 33 (5)
- .
(2012) 'Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia.'. Nature Neuropsychopharmacology, England: 37 (5), pp. 1224-1233.doi: 10.1038/npp.2011.310Full text is available at: http://epubs.surrey.ac.uk/286648/
Abstract
Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABA(A) receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy male volunteers in a traffic noise model of situational insomnia. Compared with placebo, SB-649868 10 and 30 mg increased total sleep time (TST) by 17 and 31 min (p<0.001), whereas after zolpidem TST was increased by 11.0 min (p=0.012). Wake after sleep onset was reduced significantly by 14.7 min for the SB-6489698 30 mg dose (p<0.001). Latency to persistent sleep was significantly reduced after both doses of SB-6489698 (p=0.003), but not after zolpidem. Slow wave sleep (SWS) and electroencephalogram (EEG) power spectra in non-REM sleep were not affected by either dose of SB-640868, whereas SWS (p< 0.001) and low delta activity (<=1.0 Hz) were increased, and 2.25-11.0 Hz activity decreased after zolpidem. REM sleep duration was increased after SB-649868 30 mg (p=0.002) and reduced after zolpidem (p=0.049). Latency to REM sleep was reduced by 20.1 (p=0.034) and 34.0 min (p<0.001) after 10 and 30 mg of SB-649868. Sleep-onset REM episodes were observed. SB-649868 was well tolerated. This dual orexin receptor antagonist exerts hypnotic activity, with effects on sleep structure and the EEG that are different from those of zolpidem.
- . (2012) 'Sleep and circadian rhythm disruption in schizophrenia.'. Br J Psychiatry, England: 200 (4), pp. 308-316.
- . (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
- .
(2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J, doi: 10.1096/fj.11-201699
- . (2012) 'Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans.'. PLoS One, United States: 7 (2)
- . (2010) 'Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 88 (6), pp. 831-839.
- . (2010) 'Spectral quality of light modulates emotional brain responses in humans'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (45), pp. 19549-19554.
- . (2010) 'Age-related Reduction in Daytime Sleep Propensity and Nocturnal Slow Wave Sleep'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (2), pp. 211-223.
- .
(2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.Full text is available at: http://epubs.surrey.ac.uk/289609/
- . (2008) 'Age-related reduction in the maximal capacity for sleep - Implications for insomnia'. CELL PRESS CURRENT BIOLOGY, 18 (15), pp. 1118-1123.
- . (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
Journal articles
- . (2013) 'Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.'. Proc Natl Acad Sci U S A,
- .
(2013) 'Sleep fragmentation, metabolism, and sleepiness'. Journal of Sleep Research, 22 (1), pp. 1-2.doi: 10.1111/jsr.12031
- . (2013) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men'. Metabolism: Clinical and Experimental, 62 (2), pp. 204-211.
- . (2013) 'Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep'. Neurobiology of Aging, 34 (1), pp. 309-318.
- .
(2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res, doi: 10.1111/jsr.12001
- .
(2012) 'Sleep spindles, mobile phones, lucid dreaming and sleep in Parkinson's disease and autism spectrum disorders.'. J Sleep Res, England: 21 (6), pp. 601-602.doi: 10.1111/jsr.12022
- . (2012) 'A method to assess the dissipation of residual hypnotics: eszopiclone versus zopiclone.'. Lippincott, Williams & Wilkins J Clin Psychopharmacol, United States: 32 (5), pp. 704-709.
- . (2012) 'Imaging and monitoring sleep and its disorders: local sleep, circadian rhythms and variability.'. J Sleep Res, England: 21 (5), pp. 485-486.
- . (2012) 'A method to assess the dissipation of residual hypnotics: Eszopiclone versus zopiclone'. Journal of Clinical Psychopharmacology, 32 (5), pp. 704-709.
- . (2012) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men.'. Metabolism,
- . (2012) 'Sleep and health: beyond sleep duration and sleepiness?'. J Sleep Res, England: 21 (4), pp. 355-356.
- .
(2012) 'Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep.'. J Psychopharmacol, United States: 26 (8), pp. 1047-1057.Full text is available at: http://epubs.surrey.ac.uk/7385/
Abstract
AMPA receptor modulation is a potential novel approach to enhance cognitive performance. CX717 is a positive allosteric modulator of the AMPA receptor that has shown efficacy in rodent and primate cognition models. CX717 (100 mg, 300 mg and 1000 mg) and placebo were studied in 16 healthy male volunteers (18-45 years) in a randomized, crossover study. Cognitive function, arousal and recovery sleep (by polysomnography) were assessed during the extended wakefulness protocol. Placebo condition was associated with significant decrements in cognition, particularly at the circadian nadir (between 03:00 and 05:00). Pre-specified primary and secondary analyses (general linear mixed modelling, GLMM) at each separate time point did not reveal consistent improvements in performance or objective alertness with any dose of CX717. Exploratory repeated measures analysis, a method used to take into account the influence of individual differences, demonstrated an improvement in attention-based task performance following the 1000 mg dose. Analysis of the recovery sleep showed that CX717 1000 mg significantly reduced stage 4 and slow-wave sleep (p ≤ 0.05) with evidence of reduced electroencephalogram (EEG) slow-wave and spindle activity. The study suggests that CX717 only at the 1000 mg dose may counteract effects of sleep deprivation on attention-based tasks and that it may interfere with subsequent recovery sleep.
- . (2012) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans'. Journal of Pineal Research, 53 (1), pp. 47-59.
- . (2012) 'Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep.'. Neurobiol Aging,
- . (2012) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiology of aging, 33 (5)
- . (2012) 'From apnea and insomnia in Iceland to season and slow wave sleep.'. J Sleep Res, England: 21 (2), pp. 129-130.
- .
(2012) 'Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia.'. Nature Neuropsychopharmacology, England: 37 (5), pp. 1224-1233.doi: 10.1038/npp.2011.310Full text is available at: http://epubs.surrey.ac.uk/286648/
Abstract
Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABA(A) receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy male volunteers in a traffic noise model of situational insomnia. Compared with placebo, SB-649868 10 and 30 mg increased total sleep time (TST) by 17 and 31 min (p<0.001), whereas after zolpidem TST was increased by 11.0 min (p=0.012). Wake after sleep onset was reduced significantly by 14.7 min for the SB-6489698 30 mg dose (p<0.001). Latency to persistent sleep was significantly reduced after both doses of SB-6489698 (p=0.003), but not after zolpidem. Slow wave sleep (SWS) and electroencephalogram (EEG) power spectra in non-REM sleep were not affected by either dose of SB-640868, whereas SWS (p< 0.001) and low delta activity (<=1.0 Hz) were increased, and 2.25-11.0 Hz activity decreased after zolpidem. REM sleep duration was increased after SB-649868 30 mg (p=0.002) and reduced after zolpidem (p=0.049). Latency to REM sleep was reduced by 20.1 (p=0.034) and 34.0 min (p<0.001) after 10 and 30 mg of SB-649868. Sleep-onset REM episodes were observed. SB-649868 was well tolerated. This dual orexin receptor antagonist exerts hypnotic activity, with effects on sleep structure and the EEG that are different from those of zolpidem.
- . (2012) 'Sleep and circadian rhythm disruption in schizophrenia.'. Br J Psychiatry, England: 200 (4), pp. 308-316.
- . (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
- .
(2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J, doi: 10.1096/fj.11-201699
- . (2012) 'Sleep research: observing dreams and inducing hypnagogic images.'. J Sleep Res, England: 21 (1), pp. 1-2.
- . (2012) 'Sleep: Moving to a 24/7 society'. New Scientist, 213 (2850)
- . (2012) 'Sleep restriction and emotion, electroencephalography (EEG) and dream recall, and insomnia and punctuality'. Journal of Sleep Research, 21 (3), pp. 233-234.
- .
(2012) 'Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia'. Neuropsychopharmacology, 37 (5), pp. 1224-1233.doi: 10.1038/npp.2011.310
- . (2012) 'Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans.'. PLoS One, United States: 7 (2)
- . (2012) 'Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase.'. PLoS One, United States: 7 (9)
- . (2012) 'Sleep: What it is and what it's for'. New Scientist, 213 (2850), pp. ii-iii.
- . (2012) 'Sleep: How much we need and what keeps us awake'. New Scientist, 213 (2850), pp. iv-v.
- . (2012) 'Sleep: The way we snooze now'. New Scientist, 213 (2850), pp. vi-vii.
- . (2011) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiol Aging,
- . (2011) 'Phenotyping sleep.'. J Sleep Res, England: 20 (4)
- .
(2011) 'EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.'. J Clin Sleep Med, United States: 7 (5), pp. 493-501A.doi: 10.5664/JCSM.1316
- . (2011) 'Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomnia.'. J Psychopharmacol,
- . (2011) 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol,
- . (2011) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.'. J Pineal Res,
- . (2011) 'Risk-taking and other effects of sleep loss on brain function and behaviour'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 20 (3), pp. 375-376.
- . (2011) 'Reciprocal Interactions between Wakefulness and Sleep Influence Global and Regional Brain Activity.'. Curr Top Med Chem,
- . (2011) 'Sleep highlights'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 20 (2), pp. 257-258.
- .
(2011) 'Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.'. Sage J Biol Rhythms, United States: 26 (3), pp. 249-259.Full text is available at: http://epubs.surrey.ac.uk/289613/
Abstract
Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct effects on brain function as identified by neuroimaging. How the direct impact of light on brain function varies with wavelength of light, circadian phase, and sleep homeostasis, and how this differs between individuals, is a largely unexplored area. Using functional MRI, we compared the effects of 1 minute of low-intensity blue (473 nm) and green light (527 nm) exposures on brain responses to an auditory working memory task while varying circadian phase and status of the sleep homeostat. Data were collected in 27 subjects genotyped for the PER3 VNTR (12 PER3(5/5) and 15 PER3(4/4) ) in whom it was previously shown that the brain responses to this task, when conducted in darkness, depend on circadian phase, sleep homeostasis, and genotype. In the morning after sleep, blue light, relative to green light, increased brain responses primarily in the ventrolateral and dorsolateral prefrontal cortex and in the intraparietal sulcus, but only in PER3(4/4) individuals. By contrast, in the morning after sleep loss, blue light increased brain responses in a left thalamofrontoparietal circuit to a larger extent than green light, and only so in PER3(5/5) individuals. In the evening wake maintenance zone following a normal waking day, no differential effect of 1 minute of blue versus green light was observed in either genotype. Comparison of the current results with the findings observed in darkness indicates that light acts as an activating agent particularly under those circumstances in which and in those individuals in whom brain function is jeopardized by an adverse circadian phase and high homeostatic sleep pressure.
- .
(2011) 'Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers.'. Springer Psychopharmacology (Berl), Germany: 215 (4), pp. 643-653.Full text is available at: http://epubs.surrey.ac.uk/289611/
Abstract
Rationale Histamine and dopamine contribute to the maintenance of wakefulness. Objective This study aims to conduct an exploratory analysis of the effects of 10 and 50 mg of MK-0249, a novel histamine subtype-3 receptor inverse agonist, and 200 mg of modafinil, a presumed dopaminergic compound, on EEG power spectra during sleep deprivation and subsequent recovery sleep. Methods A total of 25 healthy men were recruited to a double-blind, placebo-controlled cross-over design. EEG power spectra, an electrophysiological marker of changes in sleepiness and vigilance, were obtained at the beginning of wake maintenance tests at two-hourly intervals throughout a night and day of sleep deprivation, which is an established model of excessive sleepiness. Results After placebo, sleep deprivation was associated with enhancements in delta and theta and reductions in alpha and beta activity. Following dosing at 02:00 h, MK-0249 and modafinil reduced delta and theta activity and enhanced alpha and beta activity, compared to placebo. During recovery sleep initiated at 21:00 h, latency to sleep onset and number of awakenings were not different from placebo for any of the active treatments. Wake after sleep onset and stage 1% was increased and total sleep time, SWS% and REM% were reduced after both doses of MK-0249. Compared to placebo, MK-0249, the 50-mg dose in particular, reduced activity in some delta and theta/alpha frequencies and enhanced beta activity during NREM sleep and REM sleep. After modafinil, no changes were observed for power spectra during sleep. Conclusion Both MK-0249 and modafinil exert effects on the EEG which are consistent with wake promotion.
- . (2011) 'Quantification of Behavior Sackler Colloquium: Sex difference in the near-24-hour intrinsic period of the human circadian timing system.'. Proc Natl Acad Sci U S A,
- .
(2011) 'Effects of Sleep Inertia After Daytime Naps Vary With Executive Load and Time of Day'. AMER PSYCHOLOGICAL ASSOC BEHAVIORAL NEUROSCIENCE, 125 (2), pp. 252-260.doi: 10.1037/a0022692Full text is available at: http://epubs.surrey.ac.uk/289610/
- .
(2011) 'Slow wave sleep in patients with respiratory failure'. ELSEVIER SCIENCE BV SLEEP MEDICINE, 12 (4), pp. 378-383.Full text is available at: http://epubs.surrey.ac.uk/289612/
- . (2011) 'Sleep for all ages: at home or in the laboratory?'. J Sleep Res, England: 20 (1 Pt 1), pp. 1-2.
- . (2010) 'Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 88 (6), pp. 831-839.
- . (2010) 'Spectral quality of light modulates emotional brain responses in humans'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (45), pp. 19549-19554.
- . (2010) 'British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.'. J Psychopharmacol,
- . (2010) 'Sleep variety: physiology, psychology and epidemiology'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 19 (3), pp. 381-383.
- . (2010) 'Slow-wave sleep deficiency and enhancement: Implications for insomnia and its management'. TAYLOR & FRANCIS LTD WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 11, pp. 22-28.
- . (2010) 'PERIOD3, circadian phenotypes, and sleep homeostasis'. W B SAUNDERS CO LTD SLEEP MED REV, 14 (3), pp. 151-160.
- . (2010) 'Journal of Sleep Research: present and future'. WILEY-BLACKWELL PUBLISHING, INC J SLEEP RES, 19 (2), pp. 259-259.
- . (2010) 'Age-related Reduction in Daytime Sleep Propensity and Nocturnal Slow Wave Sleep'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (2), pp. 211-223.
- . (2010) 'Uncovering Residual Effects of Chronic Sleep Loss on Human Performance'. AMER ASSOC ADVANCEMENT SCIENCE SCIENCE TRANSLATIONAL MEDICINE, 2 (14) Article number ARTN 14ra3
- . (2010) 'A sleep-centric view'. Journal of Sleep Research, 19 (4), pp. 505-507.
- . (2009) 'Light as a modulator of cognitive brain function'. ELSEVIER SCIENCE LONDON TRENDS IN COGNITIVE SCIENCES, 13 (10), pp. 429-438.
- . (2009) 'Use of Transdermal Melatonin Delivery to Improve Sleep Maintenance During Daytime'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 86 (4), pp. 378-382.
- .
(2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.Full text is available at: http://epubs.surrey.ac.uk/289609/
- .
(2009) 'Light, Sleep, and Circadian Rhythms: Together Again'. PUBLIC LIBRARY SCIENCE PLOS BIOL, 7 (6) Article number e1000145 Full text is available at: http://epubs.surrey.ac.uk/2608/
- . (2009) 'Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep'. SAGE PUBLICATIONS LTD JOURNAL OF PSYCHOPHARMACOLOGY, 24 (11), pp. 1613-1618.
- . (2009) 'Circadian clock genes and sleep homeostasis'. WILEY-BLACKWELL PUBLISHING, INC EUROPEAN JOURNAL OF NEUROSCIENCE, 29 (9), pp. 1820-1829.
- . (2009) 'Sleep function: current questions and new approaches'. WILEY-BLACKWELL PUBLISHING, INC EUROPEAN JOURNAL OF NEUROSCIENCE, 29 (9), pp. 1830-1841.
- . (2009) 'Regulation and functional correlates of slow wave sleep'. Journal of Clinical Sleep Medicine, 5 (2 SUPPL.)
- . (2009) 'Can Per3 Length Polymorphism Predict Sleep Duration in Older Individuals?'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 255-255.
- .
(2009) 'Daily and Seasonal Variation in the Spectral Composition of Light Exposure in Humans'. Informa Healthcare CHRONOBIOL INT, 26 (5), pp. 854-866.Full text is available at: http://epubs.surrey.ac.uk/289608/
Abstract
Light is considered the most potent synchronizer of the human circadian system and exerts many other non-image-forming effects, including those that affect brain function. These effects are mediated in part by intrinsically photosensitive retinal ganglion cells that express the photopigment melanopsin. The spectral sensitivity of melanopsin is greatest for blue light at approximately 480 nm. At present, there is little information on how the spectral composition of light to which people are exposed varies over the 24 h period and across seasons. Twenty-two subjects, aged 22±4 yrs (mean±SD) participated during the winter months (November–February), and 12 subjects aged 25±3 yrs participated during the summer months (April–August). Subjects wore Actiwatch-RGB monitors, as well as Actiwatch-L monitors, for seven consecutive days while living in England. These monitors measured activity and light exposure in the red, green, and blue spectral regions, in addition to broad-spectrum white light, with a 2 min resolution. Light exposure during the day was analyzed for the interval between 09:00 and 21:00 h. The time course of white-light exposure differed significantly between seasons (p = 0.0022), with light exposure increasing in the morning hours and declining in the afternoon hours, and with a more prominent decline in the winter. Overall light exposure was significantly higher in summer than winter (p = 0.0002). Seasonal differences in the relative contribution of blue-light exposure to overall light exposure were also observed (p = 0.0006), in particular during the evening hours. During the summer evenings (17:00–21:00 h), the relative contribution of blue light was significantly higher (p < 0.0001) (40.2±1.1%) than during winter evenings (26.6±0.9%). The present data show that in addition to overall light exposure, the spectral composition of light exposure varies over the day and with season.
- . (2009) 'Circadian and Homeostatic Regulation of Human Sleep and Cognitive Performance and Its Modulation by PERIOD3'. Sleep Medicine Clinics, 4 (2), pp. 111-125.
- . (2008) 'PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 295 (5), pp. H2156-H2163.
- . (2008) 'Age-related reduction in the maximal capacity for sleep - Implications for insomnia'. CELL PRESS CURRENT BIOLOGY, 18 (15), pp. 1118-1123.
- . (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
- .
(2008) 'Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality'. SCAND J WORK ENV HEALTH SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 34 (4), pp. 297-306.doi: 10.5271/sjweh.1268
- . (2008) 'Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 17 (2), pp. 207-216.
- . (2008) 'Slow-wave sleep, diabetes, and the sympathetic nervous system'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 (4), pp. 1107-1108.
- . (2008) 'Sleep correlates of motor recovery in chronic stroke: a pilot study using sleep diaries and actigraphy.'. Journal of Sleep Research, 17, pp. 103-103.
- .
(2008) 'Time to wake-up: Sleep problems and daytime sleepiness in long-term stroke survivors'. TAYLOR & FRANCIS LTD BRAIN INJURY, 22 (7-8), pp. 575-579.Full text is available at: http://epubs.surrey.ac.uk/188332/
- .
(2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.Full text is available at: http://epubs.surrey.ac.uk/285505/
- . (2008) 'The Menstrual Cycle Effects on Sleep'. Sleep Medicine Clinics, 3 (1), pp. 1-11.
- . (2008) 'Sleep actigraphy in brain injured patients with chronic low functioning upper limb hemiparesis'. Journal of Sleep Research, 17, pp. 102-102.
- . (2007) 'Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure'. OXFORD UNIV PRESS INC CEREBRAL CORTEX, 17 (12), pp. 2788-2795.
- . (2007) 'Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake'. AMER ACAD SLEEP MEDICINE SLEEP, 30 (11), pp. 1437-1443.
- . (2007) 'Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (2), pp. 148-155.
- . (2007) 'The selective extrasynaptic GABA(A) agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia'. AMER ACADEMY SLEEP MEDICINE SLEEP, 30 (5), pp. 593-602.
- . (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURRENT BIOLOGY, 17 (7), pp. 613-618.
- . (2007) 'Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (1), pp. 12-16.
- .
(2007) 'Brain Responses to Violet, Blue, and Green Monochromatic Light Exposures in Humans: Prominent Role of Blue Light and the Brainstem'. PUBLIC LIBRARY SCIENCE PLOS ONE, 2 (11) Article number ARTN e1247 Full text is available at: http://epubs.surrey.ac.uk/2609/
- . (2006) 'Daytime light exposure dynamically enhances brain responses'. CELL PRESS CURRENT BIOLOGY, 16 (16), pp. 1616-1621.
- . (2006) 'Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent'. AMER ACADEMY SLEEP MEDICINE SLEEP, 29 (5), pp. 609-618.
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Conference papers
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- . (2012) 'Individual differences in sleep revisited: stability across sleep restriction, extension and total sleep loss'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 207-208.
- . (2012) 'Influence of sleep homeostasis and circadian rhythm on executive discriminative ability during a constant routine'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 328-328.
- . (2012) ''Trait-like' susceptibility to sleep loss varies with circadian phase and the task used to index vulnerable-resilient sleep-deprived performance'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 36-37.
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- . (2012) 'Difference in neural correlates of discrimination during sleep deprivation in PER3 homozygous'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
- . (2012) 'Effects of circadian phase and prior partial sleep deprivation on executive functions during total sleep deprivation are modulated by PER3 polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 41-41.
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- . (2008) 'Dissociable effects of recent and enduring sleep quality on reported everyday affect and function: a structural equation modeling approach'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 236-236.
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- . (2008) 'Blue-enriched light improves self-reported alertness and performance in the workplace'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 117-117.
- . (2008) 'Sleep and rest/activity cycle disturbances in schizophrenia patients in comparison to unemployed healthy controls'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 76-77.
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- . (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 1-1.
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