Professor Derk-Jan Dijk

Professor of Sleep and Physiology, Director Surrey Sleep Research Centre

Qualifications: BSc, MSc, PhD, FSB

Email:
Phone: Work: 01483 68 9341
Room no: 16 MA 00

Further information

Biography

Please see my profile

Research Interests

Please go to the Surrey Sleep Research Centre.

Human sleep and biological rhythms
Quantitative EEG analysis
Circadian rhythm disorders
Effects of light on sleep, performance and circadian rhythms
Aging
Sleep disorders
Hypnotics
Actigraphy
Performance

Publications

Highlights

  • Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ. (2013) 'Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.'. Proc Natl Acad Sci U S A,
    doi: 10.1073/pnas.1217154110
  • Robertson MD, Russell-Jones D, Umpleby AM, Dijk D-J. (2013) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men'. Metabolism: Clinical and Experimental, 62 (2), pp. 204-211.
    doi: 10.1016/j.metabol.2012.07.016
  • Lazar AS, Santhi N, Hasan S, Lo JC, Johnston JD, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res,
    doi: 10.1111/jsr.12001
  • Santhi N, Thorne HC, Van Der Veen DR, Archer SN, Dijk D-J, Johnsen S, Mills SL, Hommes V, Schlangen LJM. (2012) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans'. Journal of Pineal Research, 53 (1), pp. 47-59.
    doi: 10.1111/j.1600-079X.2011.00970.x
  • Boyle J, Stanley N, James LM, Wright N, Johnsen S, Arbon EL, Dijk DJ. (2012) 'Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep.'. J Psychopharmacol, United States: 26 (8), pp. 1047-1057.
    doi: 10.1177/0269881111405353
    Full text is available at: http://epubs.surrey.ac.uk/7385/

    Abstract

    AMPA receptor modulation is a potential novel approach to enhance cognitive performance. CX717 is a positive allosteric modulator of the AMPA receptor that has shown efficacy in rodent and primate cognition models. CX717 (100 mg, 300 mg and 1000 mg) and placebo were studied in 16 healthy male volunteers (18-45 years) in a randomized, crossover study. Cognitive function, arousal and recovery sleep (by polysomnography) were assessed during the extended wakefulness protocol. Placebo condition was associated with significant decrements in cognition, particularly at the circadian nadir (between 03:00 and 05:00). Pre-specified primary and secondary analyses (general linear mixed modelling, GLMM) at each separate time point did not reveal consistent improvements in performance or objective alertness with any dose of CX717. Exploratory repeated measures analysis, a method used to take into account the influence of individual differences, demonstrated an improvement in attention-based task performance following the 1000 mg dose. Analysis of the recovery sleep showed that CX717 1000 mg significantly reduced stage 4 and slow-wave sleep (p ≤ 0.05) with evidence of reduced electroencephalogram (EEG) slow-wave and spindle activity. The study suggests that CX717 only at the 1000 mg dose may counteract effects of sleep deprivation on attention-based tasks and that it may interfere with subsequent recovery sleep.

  • Viola AU, Chellappa SL, Archer SN, Pugin F, Götz T, Dijk DJ, Cajochen C. (2012) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiology of aging, 33 (5)
  • Bettica P, Squassante L, Groeger JA, Gennery B, Winsky-Sommerer R, Dijk DJ. (2012) 'Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia.'. Nature Neuropsychopharmacology, England: 37 (5), pp. 1224-1233.
    doi: 10.1038/npp.2011.310
    Full text is available at: http://epubs.surrey.ac.uk/286648/

    Abstract

    Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABA(A) receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy male volunteers in a traffic noise model of situational insomnia. Compared with placebo, SB-649868 10 and 30 mg increased total sleep time (TST) by 17 and 31 min (p<0.001), whereas after zolpidem TST was increased by 11.0 min (p=0.012). Wake after sleep onset was reduced significantly by 14.7 min for the SB-6489698 30 mg dose (p<0.001). Latency to persistent sleep was significantly reduced after both doses of SB-6489698 (p=0.003), but not after zolpidem. Slow wave sleep (SWS) and electroencephalogram (EEG) power spectra in non-REM sleep were not affected by either dose of SB-640868, whereas SWS (p< 0.001) and low delta activity (<=1.0 Hz) were increased, and 2.25-11.0 Hz activity decreased after zolpidem. REM sleep duration was increased after SB-649868 30 mg (p=0.002) and reduced after zolpidem (p=0.049). Latency to REM sleep was reduced by 20.1 (p=0.034) and 34.0 min (p<0.001) after 10 and 30 mg of SB-649868. Sleep-onset REM episodes were observed. SB-649868 was well tolerated. This dual orexin receptor antagonist exerts hypnotic activity, with effects on sleep structure and the EEG that are different from those of zolpidem.

  • Wulff K, Dijk DJ, Middleton B, Foster RG, Joyce EM. (2012) 'Sleep and circadian rhythm disruption in schizophrenia.'. Br J Psychiatry, England: 200 (4), pp. 308-316.
    doi: 10.1192/bjp.bp.111.096321
  • Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ. (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
    doi: 10.3109/07420528.2011.641193
  • Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ. (2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J,
    doi: 10.1096/fj.11-201699
  • Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA. (2012) 'Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans.'. PLoS One, United States: 7 (2)
    doi: 10.1371/journal.pone.0030037
  • Iannone R, Palcza J, Renger JJ, Calder N, Cerchio K, Gottesdiener K, Hargreaves R, Dijk DJ, Boyle J, Murphy MG. (2010) 'Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 88 (6), pp. 831-839.
    doi: 10.1038/clpt.2010.205
  • Vandewalle G, Schwartz S, Grandjean D, Wuillaume C, Balteau E, Degueldre C, Schabus M, Phillips C, Luxen A, Dijk DJ, Maquet P. (2010) 'Spectral quality of light modulates emotional brain responses in humans'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (45), pp. 19549-19554.
    doi: 10.1073/pnas.1010180107
  • Dijk D-J, Groeger JA, Stanley N, Deacon S. (2010) 'Age-related Reduction in Daytime Sleep Propensity and Nocturnal Slow Wave Sleep'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (2), pp. 211-223.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D-J. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.
    doi: 10.1523/JNEUROSCI.0229-09.2009
    Full text is available at: http://epubs.surrey.ac.uk/289609/
  • Klerman EB, Dijk D-J. (2008) 'Age-related reduction in the maximal capacity for sleep - Implications for insomnia'. CELL PRESS CURRENT BIOLOGY, 18 (15), pp. 1118-1123.
    doi: 10.1016/j.cub.2008.06.047
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk D-J. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.

Journal articles

  • Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ. (2013) 'Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.'. Proc Natl Acad Sci U S A,
    doi: 10.1073/pnas.1217154110
  • Dijk D-J. (2013) 'Sleep fragmentation, metabolism, and sleepiness'. Journal of Sleep Research, 22 (1), pp. 1-2.
    doi: 10.1111/jsr.12031
  • Robertson MD, Russell-Jones D, Umpleby AM, Dijk D-J. (2013) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men'. Metabolism: Clinical and Experimental, 62 (2), pp. 204-211.
    doi: 10.1016/j.metabol.2012.07.016
  • Klerman EB, Wang W, Duffy JF, Dijk D-J, Czeisler CA, Kronauer RE. (2013) 'Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep'. Neurobiology of Aging, 34 (1), pp. 309-318.
    doi: 10.1016/j.neurobiolaging.2012.05.018
  • Lazar AS, Santhi N, Hasan S, Lo JC, Johnston JD, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res,
    doi: 10.1111/jsr.12001
  • Dijk DJ. (2012) 'Sleep spindles, mobile phones, lucid dreaming and sleep in Parkinson's disease and autism spectrum disorders.'. J Sleep Res, England: 21 (6), pp. 601-602.
    doi: 10.1111/jsr.12022
  • Boyle J, Groeger JA, Paska W, Cooper JA, Rockett C, Jones S, Gandhi P, Scott J, Atzori G, Dijk DJ. (2012) 'A method to assess the dissipation of residual hypnotics: eszopiclone versus zopiclone.'. Lippincott, Williams & Wilkins J Clin Psychopharmacol, United States: 32 (5), pp. 704-709.
    doi: 10.1097/JCP.0b013e3182664eec
  • Dijk DJ. (2012) 'Imaging and monitoring sleep and its disorders: local sleep, circadian rhythms and variability.'. J Sleep Res, England: 21 (5), pp. 485-486.
    doi: 10.1111/j.1365-2869.2012.01057.x
  • Boyle J, Atzori G, Dijk D-J, Groeger JA, Paska W, Jones S, Scott J, Cooper JA, Gandhi P, Rockett C. (2012) 'A method to assess the dissipation of residual hypnotics: Eszopiclone versus zopiclone'. Journal of Clinical Psychopharmacology, 32 (5), pp. 704-709.
    doi: 10.1097/JCP.0b013e3182664eec
  • Robertson MD, Russell-Jones D, Umpleby AM, Dijk DJ. (2012) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men.'. Metabolism,
    doi: 10.1016/j.metabol.2012.07.016
  • Dijk DJ. (2012) 'Sleep and health: beyond sleep duration and sleepiness?'. J Sleep Res, England: 21 (4), pp. 355-356.
    doi: 10.1111/j.1365-2869.2012.01036.x
  • Boyle J, Stanley N, James LM, Wright N, Johnsen S, Arbon EL, Dijk DJ. (2012) 'Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep.'. J Psychopharmacol, United States: 26 (8), pp. 1047-1057.
    doi: 10.1177/0269881111405353
    Full text is available at: http://epubs.surrey.ac.uk/7385/

    Abstract

    AMPA receptor modulation is a potential novel approach to enhance cognitive performance. CX717 is a positive allosteric modulator of the AMPA receptor that has shown efficacy in rodent and primate cognition models. CX717 (100 mg, 300 mg and 1000 mg) and placebo were studied in 16 healthy male volunteers (18-45 years) in a randomized, crossover study. Cognitive function, arousal and recovery sleep (by polysomnography) were assessed during the extended wakefulness protocol. Placebo condition was associated with significant decrements in cognition, particularly at the circadian nadir (between 03:00 and 05:00). Pre-specified primary and secondary analyses (general linear mixed modelling, GLMM) at each separate time point did not reveal consistent improvements in performance or objective alertness with any dose of CX717. Exploratory repeated measures analysis, a method used to take into account the influence of individual differences, demonstrated an improvement in attention-based task performance following the 1000 mg dose. Analysis of the recovery sleep showed that CX717 1000 mg significantly reduced stage 4 and slow-wave sleep (p ≤ 0.05) with evidence of reduced electroencephalogram (EEG) slow-wave and spindle activity. The study suggests that CX717 only at the 1000 mg dose may counteract effects of sleep deprivation on attention-based tasks and that it may interfere with subsequent recovery sleep.

  • Santhi N, Thorne HC, Van Der Veen DR, Archer SN, Dijk D-J, Johnsen S, Mills SL, Hommes V, Schlangen LJM. (2012) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans'. Journal of Pineal Research, 53 (1), pp. 47-59.
    doi: 10.1111/j.1600-079X.2011.00970.x
  • Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. (2012) 'Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep.'. Neurobiol Aging,
    doi: 10.1016/j.neurobiolaging.2012.05.018
  • Viola AU, Chellappa SL, Archer SN, Pugin F, Götz T, Dijk DJ, Cajochen C. (2012) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiology of aging, 33 (5)
  • Dijk DJ. (2012) 'From apnea and insomnia in Iceland to season and slow wave sleep.'. J Sleep Res, England: 21 (2), pp. 129-130.
    doi: 10.1111/j.1365-2869.2012.01014.x
  • Bettica P, Squassante L, Groeger JA, Gennery B, Winsky-Sommerer R, Dijk DJ. (2012) 'Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia.'. Nature Neuropsychopharmacology, England: 37 (5), pp. 1224-1233.
    doi: 10.1038/npp.2011.310
    Full text is available at: http://epubs.surrey.ac.uk/286648/

    Abstract

    Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-649868 (10 or 30 mg) and a positive control zolpidem (10 mg), an allosteric modulator of GABA(A) receptors. Objective and subjective sleep parameters and next-day performance were assessed in 51 healthy male volunteers in a traffic noise model of situational insomnia. Compared with placebo, SB-649868 10 and 30 mg increased total sleep time (TST) by 17 and 31 min (p<0.001), whereas after zolpidem TST was increased by 11.0 min (p=0.012). Wake after sleep onset was reduced significantly by 14.7 min for the SB-6489698 30 mg dose (p<0.001). Latency to persistent sleep was significantly reduced after both doses of SB-6489698 (p=0.003), but not after zolpidem. Slow wave sleep (SWS) and electroencephalogram (EEG) power spectra in non-REM sleep were not affected by either dose of SB-640868, whereas SWS (p< 0.001) and low delta activity (<=1.0 Hz) were increased, and 2.25-11.0 Hz activity decreased after zolpidem. REM sleep duration was increased after SB-649868 30 mg (p=0.002) and reduced after zolpidem (p=0.049). Latency to REM sleep was reduced by 20.1 (p=0.034) and 34.0 min (p<0.001) after 10 and 30 mg of SB-649868. Sleep-onset REM episodes were observed. SB-649868 was well tolerated. This dual orexin receptor antagonist exerts hypnotic activity, with effects on sleep structure and the EEG that are different from those of zolpidem.

  • Wulff K, Dijk DJ, Middleton B, Foster RG, Joyce EM. (2012) 'Sleep and circadian rhythm disruption in schizophrenia.'. Br J Psychiatry, England: 200 (4), pp. 308-316.
    doi: 10.1192/bjp.bp.111.096321
  • Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ. (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
    doi: 10.3109/07420528.2011.641193
  • Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ. (2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J,
    doi: 10.1096/fj.11-201699
  • Dijk DJ. (2012) 'Sleep research: observing dreams and inducing hypnagogic images.'. J Sleep Res, England: 21 (1), pp. 1-2.
    doi: 10.1111/j.1365-2869.2011.00995.x
  • Dijk D-J, Winsky-Sommerer R. (2012) 'Sleep: Moving to a 24/7 society'. New Scientist, 213 (2850)
    doi: 10.1016/S0262-4079(12)60261-9
  • Dijk D-J. (2012) 'Sleep restriction and emotion, electroencephalography (EEG) and dream recall, and insomnia and punctuality'. Journal of Sleep Research, 21 (3), pp. 233-234.
    doi: 10.1111/j.1365-2869.2012.01024.x
  • Bettica P, Squassante L, Gennery B, Dijk D-J, Groeger JA, Winsky-Sommerer R. (2012) 'Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia'. Neuropsychopharmacology, 37 (5), pp. 1224-1233.
    doi: 10.1038/npp.2011.310
  • Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA. (2012) 'Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans.'. PLoS One, United States: 7 (2)
    doi: 10.1371/journal.pone.0030037
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase.'. PLoS One, United States: 7 (9)
    doi: 10.1371/journal.pone.0045987
  • Dijk D-J, Winsky-Sommerer R. (2012) 'Sleep: What it is and what it's for'. New Scientist, 213 (2850), pp. ii-iii.
    doi: 10.1016/S0262-4079(12)60258-9
  • Dijk D-J, Winsky-Sommerer R. (2012) 'Sleep: How much we need and what keeps us awake'. New Scientist, 213 (2850), pp. iv-v.
    doi: 10.1016/S0262-4079(12)60259-0
  • Dijk D-J, Winsky-Sommerer R. (2012) 'Sleep: The way we snooze now'. New Scientist, 213 (2850), pp. vi-vii.
    doi: 10.1016/S0262-4079(12)60260-7
  • Viola AU, Chellappa SL, Archer SN, Pugin F, Götz T, Dijk DJ, Cajochen C. (2011) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiol Aging,
    doi: 10.1016/j.neurobiolaging.2011.10.024
  • Dijk DJ. (2011) 'Phenotyping sleep.'. J Sleep Res, England: 20 (4)
    doi: 10.1111/j.1365-2869.2011.00980.x
  • Ma J, Dijk DJ, Svetnik V, Tymofyeyev Y, Ray S, Walsh JK, Deacon S. (2011) 'EEG power spectra response to a 4-h phase advance and gaboxadol treatment in 822 men and women.'. J Clin Sleep Med, United States: 7 (5), pp. 493-501A.
    doi: 10.5664/JCSM.1316
  • Dijk DJ, Stanley N, Lundahl J, Groeger JA, Legters A, Trap Huusom AK, Deacon S. (2011) 'Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomnia.'. J Psychopharmacol,
    doi: 10.1177/0269881111421971
  • Hasan S, van der Veen DR, Winsky-Sommerer R, Dijk DJ, Archer SN. (2011) 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol,
    doi: 10.1152/ajpregu.00260.2011
  • Santhi N, Thorne HC, van der Veen DR, Johnsen S, Mills SL, Hommes V, Schlangen LJ, Archer SN, Dijk DJ. (2011) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.'. J Pineal Res,
    doi: 10.1111/j.1600-079X.2011.00970.x
  • Dijk D-J. (2011) 'Risk-taking and other effects of sleep loss on brain function and behaviour'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 20 (3), pp. 375-376.
    doi: 10.1111/j.1365-2869.2011.00941.x
  • Muto V, Mascetti L, Matarazzo L, Kussé C, Foret A, Shaffii-Le Bourdiec A, Vandewalle G, Dijk DJ, Maquet P. (2011) 'Reciprocal Interactions between Wakefulness and Sleep Influence Global and Regional Brain Activity.'. Curr Top Med Chem,
    doi: 10.2174/156802611797470358
  • Dijk D-J. (2011) 'Sleep highlights'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 20 (2), pp. 257-258.
    doi: 10.1111/j.1365-2869.2011.00920.x
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P. (2011) 'Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.'. Sage J Biol Rhythms, United States: 26 (3), pp. 249-259.
    doi: 10.1177/0748730411401736
    Full text is available at: http://epubs.surrey.ac.uk/289613/

    Abstract

    Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct effects on brain function as identified by neuroimaging. How the direct impact of light on brain function varies with wavelength of light, circadian phase, and sleep homeostasis, and how this differs between individuals, is a largely unexplored area. Using functional MRI, we compared the effects of 1 minute of low-intensity blue (473 nm) and green light (527 nm) exposures on brain responses to an auditory working memory task while varying circadian phase and status of the sleep homeostat. Data were collected in 27 subjects genotyped for the PER3 VNTR (12 PER3(5/5) and 15 PER3(4/4) ) in whom it was previously shown that the brain responses to this task, when conducted in darkness, depend on circadian phase, sleep homeostasis, and genotype. In the morning after sleep, blue light, relative to green light, increased brain responses primarily in the ventrolateral and dorsolateral prefrontal cortex and in the intraparietal sulcus, but only in PER3(4/4) individuals. By contrast, in the morning after sleep loss, blue light increased brain responses in a left thalamofrontoparietal circuit to a larger extent than green light, and only so in PER3(5/5) individuals. In the evening wake maintenance zone following a normal waking day, no differential effect of 1 minute of blue versus green light was observed in either genotype. Comparison of the current results with the findings observed in darkness indicates that light acts as an activating agent particularly under those circumstances in which and in those individuals in whom brain function is jeopardized by an adverse circadian phase and high homeostatic sleep pressure.

  • James LM, Iannone R, Palcza J, Renger JJ, Calder N, Cerchio K, Gottesdiener K, Hargreaves R, Murphy MG, Boyle J, Dijk DJ. (2011) 'Effect of a novel histamine subtype-3 receptor inverse agonist and modafinil on EEG power spectra during sleep deprivation and recovery sleep in male volunteers.'. Springer Psychopharmacology (Berl), Germany: 215 (4), pp. 643-653.
    doi: 10.1007/s00213-010-2158-3
    Full text is available at: http://epubs.surrey.ac.uk/289611/

    Abstract

    Rationale Histamine and dopamine contribute to the maintenance of wakefulness. Objective This study aims to conduct an exploratory analysis of the effects of 10 and 50 mg of MK-0249, a novel histamine subtype-3 receptor inverse agonist, and 200 mg of modafinil, a presumed dopaminergic compound, on EEG power spectra during sleep deprivation and subsequent recovery sleep. Methods A total of 25 healthy men were recruited to a double-blind, placebo-controlled cross-over design. EEG power spectra, an electrophysiological marker of changes in sleepiness and vigilance, were obtained at the beginning of wake maintenance tests at two-hourly intervals throughout a night and day of sleep deprivation, which is an established model of excessive sleepiness. Results After placebo, sleep deprivation was associated with enhancements in delta and theta and reductions in alpha and beta activity. Following dosing at 02:00 h, MK-0249 and modafinil reduced delta and theta activity and enhanced alpha and beta activity, compared to placebo. During recovery sleep initiated at 21:00 h, latency to sleep onset and number of awakenings were not different from placebo for any of the active treatments. Wake after sleep onset and stage 1% was increased and total sleep time, SWS% and REM% were reduced after both doses of MK-0249. Compared to placebo, MK-0249, the 50-mg dose in particular, reduced activity in some delta and theta/alpha frequencies and enhanced beta activity during NREM sleep and REM sleep. After modafinil, no changes were observed for power spectra during sleep. Conclusion Both MK-0249 and modafinil exert effects on the EEG which are consistent with wake promotion.

  • Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP, Czeisler CA. (2011) 'Quantification of Behavior Sackler Colloquium: Sex difference in the near-24-hour intrinsic period of the human circadian timing system.'. Proc Natl Acad Sci U S A,
    doi: 10.1073/pnas.1010666108
  • Groeger JA, Lo JCY, Burns CG, Dijk D-J. (2011) 'Effects of Sleep Inertia After Daytime Naps Vary With Executive Load and Time of Day'. AMER PSYCHOLOGICAL ASSOC BEHAVIORAL NEUROSCIENCE, 125 (2), pp. 252-260.
    doi: 10.1037/a0022692
    Full text is available at: http://epubs.surrey.ac.uk/289610/
  • Wang D, Piper AJ, Wong KK, Yee BJ, Marshall NS, Dijk D-J, Grunstein RR. (2011) 'Slow wave sleep in patients with respiratory failure'. ELSEVIER SCIENCE BV SLEEP MEDICINE, 12 (4), pp. 378-383.
    doi: 10.1016/j.sleep.2011.01.007
    Full text is available at: http://epubs.surrey.ac.uk/289612/
  • Dijk DJ. (2011) 'Sleep for all ages: at home or in the laboratory?'. J Sleep Res, England: 20 (1 Pt 1), pp. 1-2.
    doi: 10.1111/j.1365-2869.2011.00908.x
  • Iannone R, Palcza J, Renger JJ, Calder N, Cerchio K, Gottesdiener K, Hargreaves R, Dijk DJ, Boyle J, Murphy MG. (2010) 'Acute Alertness-Promoting Effects of a Novel Histamine Subtype-3 Receptor Inverse Agonist in Healthy Sleep-Deprived Male Volunteers'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 88 (6), pp. 831-839.
    doi: 10.1038/clpt.2010.205
  • Vandewalle G, Schwartz S, Grandjean D, Wuillaume C, Balteau E, Degueldre C, Schabus M, Phillips C, Luxen A, Dijk DJ, Maquet P. (2010) 'Spectral quality of light modulates emotional brain responses in humans'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 (45), pp. 19549-19554.
    doi: 10.1073/pnas.1010180107
  • Wilson SJ, Nutt DJ, Alford C, Argyropoulos SV, Baldwin DS, Bateson A, Britton T, Crowe C, Dijk DJ, Espie C, Gringras P, Hajak G, Idzikowski C, Krystal A, Nash JR, Selsick H, Sharpley AL, Wade AG. (2010) 'British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.'. J Psychopharmacol,
    doi: 10.1177/0269881110379307
  • Dijk D-J. (2010) 'Sleep variety: physiology, psychology and epidemiology'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 19 (3), pp. 381-383.
    doi: 10.1111/j.1365-2869.2010.00879.x
  • Dijk D-J. (2010) 'Slow-wave sleep deficiency and enhancement: Implications for insomnia and its management'. TAYLOR & FRANCIS LTD WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 11, pp. 22-28.
    doi: 10.3109/15622971003637645
  • Dijk DJ, Archer SN. (2010) 'PERIOD3, circadian phenotypes, and sleep homeostasis'. W B SAUNDERS CO LTD SLEEP MED REV, 14 (3), pp. 151-160.
    doi: 10.1016/j.smrv.2009.07.002
  • Dijk DJ. (2010) 'Journal of Sleep Research: present and future'. WILEY-BLACKWELL PUBLISHING, INC J SLEEP RES, 19 (2), pp. 259-259.
    doi: 10.1111/j.1365-2869.2010.00855.x
  • Dijk D-J, Groeger JA, Stanley N, Deacon S. (2010) 'Age-related Reduction in Daytime Sleep Propensity and Nocturnal Slow Wave Sleep'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (2), pp. 211-223.
  • Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk D-J, Czeisler CA, Klerman EB. (2010) 'Uncovering Residual Effects of Chronic Sleep Loss on Human Performance'. AMER ASSOC ADVANCEMENT SCIENCE SCIENCE TRANSLATIONAL MEDICINE, 2 (14) Article number ARTN 14ra3
    doi: 10.1126/scitranslmed.3000458
  • Dijk D-J. (2010) 'A sleep-centric view'. Journal of Sleep Research, 19 (4), pp. 505-507.
    doi: 10.1111/j.1365-2869.2010.00896.x
  • Vandewalle G, Maquet P, Dijk D-J. (2009) 'Light as a modulator of cognitive brain function'. ELSEVIER SCIENCE LONDON TRENDS IN COGNITIVE SCIENCES, 13 (10), pp. 429-438.
    doi: 10.1016/j.tics.2009.07.004
  • Aeschbach D, Lockyer BJ, Dijk D-J, Lockley SW, Nuwayser ES, Nichols LD, Czeisler CA. (2009) 'Use of Transdermal Melatonin Delivery to Improve Sleep Maintenance During Daytime'. NATURE PUBLISHING GROUP CLINICAL PHARMACOLOGY & THERAPEUTICS, 86 (4), pp. 378-382.
    doi: 10.1038/clpt.2009.109
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D-J. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.
    doi: 10.1523/JNEUROSCI.0229-09.2009
    Full text is available at: http://epubs.surrey.ac.uk/289609/
  • Dijk DJ, Archer SN. (2009) 'Light, Sleep, and Circadian Rhythms: Together Again'. PUBLIC LIBRARY SCIENCE PLOS BIOL, 7 (6) Article number e1000145
    doi: 10.1371/journal.pbio.1000145
    Full text is available at: http://epubs.surrey.ac.uk/2608/
  • Dijk DJ, James LM, Peters S, Walsh JK, Deacon S. (2009) 'Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep'. SAGE PUBLICATIONS LTD JOURNAL OF PSYCHOPHARMACOLOGY, 24 (11), pp. 1613-1618.
    doi: 10.1177/0269881109105788
  • Franken P, Dijk D-J. (2009) 'Circadian clock genes and sleep homeostasis'. WILEY-BLACKWELL PUBLISHING, INC EUROPEAN JOURNAL OF NEUROSCIENCE, 29 (9), pp. 1820-1829.
    doi: 10.1111/j.1460-9568.2009.06723.x
  • Vassalli A, Dijk D-J. (2009) 'Sleep function: current questions and new approaches'. WILEY-BLACKWELL PUBLISHING, INC EUROPEAN JOURNAL OF NEUROSCIENCE, 29 (9), pp. 1830-1841.
    doi: 10.1111/j.1460-9568.2009.06767.x
  • Dijk D-J. (2009) 'Regulation and functional correlates of slow wave sleep'. Journal of Clinical Sleep Medicine, 5 (2 SUPPL.)
  • Pugin F, Viola AU, Chellappa SL, Archer S, Dijk DJ, Cajochen C. (2009) 'Can Per3 Length Polymorphism Predict Sleep Duration in Older Individuals?'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 255-255.
  • Thorne HC, Jones KH, Peters SP, Archer SN, Dijk DJ. (2009) 'Daily and Seasonal Variation in the Spectral Composition of Light Exposure in Humans'. Informa Healthcare CHRONOBIOL INT, 26 (5), pp. 854-866.
    doi: 10.1080/07420520903044315
    Full text is available at: http://epubs.surrey.ac.uk/289608/

    Abstract

    Light is considered the most potent synchronizer of the human circadian system and exerts many other non-image-forming effects, including those that affect brain function. These effects are mediated in part by intrinsically photosensitive retinal ganglion cells that express the photopigment melanopsin. The spectral sensitivity of melanopsin is greatest for blue light at approximately 480 nm. At present, there is little information on how the spectral composition of light to which people are exposed varies over the 24 h period and across seasons. Twenty-two subjects, aged 22±4 yrs (mean±SD) participated during the winter months (November–February), and 12 subjects aged 25±3 yrs participated during the summer months (April–August). Subjects wore Actiwatch-RGB monitors, as well as Actiwatch-L monitors, for seven consecutive days while living in England. These monitors measured activity and light exposure in the red, green, and blue spectral regions, in addition to broad-spectrum white light, with a 2 min resolution. Light exposure during the day was analyzed for the interval between 09:00 and 21:00 h. The time course of white-light exposure differed significantly between seasons (p = 0.0022), with light exposure increasing in the morning hours and declining in the afternoon hours, and with a more prominent decline in the winter. Overall light exposure was significantly higher in summer than winter (p = 0.0002). Seasonal differences in the relative contribution of blue-light exposure to overall light exposure were also observed (p = 0.0006), in particular during the evening hours. During the summer evenings (17:00–21:00 h), the relative contribution of blue light was significantly higher (p < 0.0001) (40.2±1.1%) than during winter evenings (26.6±0.9%). The present data show that in addition to overall light exposure, the spectral composition of light exposure varies over the day and with season.

  • Dijk D-J, Archer SN. (2009) 'Circadian and Homeostatic Regulation of Human Sleep and Cognitive Performance and Its Modulation by PERIOD3'. Sleep Medicine Clinics, 4 (2), pp. 111-125.
    doi: 10.1016/j.jsmc.2009.02.001
  • Viola AU, James LM, Archer SN, Dijk D-J. (2008) 'PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 295 (5), pp. H2156-H2163.
    doi: 10.1152/ajpheart.00662.2008
  • Klerman EB, Dijk D-J. (2008) 'Age-related reduction in the maximal capacity for sleep - Implications for insomnia'. CELL PRESS CURRENT BIOLOGY, 18 (15), pp. 1118-1123.
    doi: 10.1016/j.cub.2008.06.047
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk D-J. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Viola AU, James LM, Schlangen LJM, Dijk D-J. (2008) 'Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality'. SCAND J WORK ENV HEALTH SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 34 (4), pp. 297-306.
    doi: 10.5271/sjweh.1268
  • Lockley SW, Dijk D-J, Kosti O, Skene DJ, Arendt J. (2008) 'Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, 17 (2), pp. 207-216.
    doi: 10.1111/j.1365-2869.2008.00656.x
  • Dijk D-J. (2008) 'Slow-wave sleep, diabetes, and the sympathetic nervous system'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 (4), pp. 1107-1108.
    doi: 10.1073/pnas.0711635105
  • Herron K, Dijk D, Ellis J, Sanders J, Sterr AM. (2008) 'Sleep correlates of motor recovery in chronic stroke: a pilot study using sleep diaries and actigraphy.'. Journal of Sleep Research, 17, pp. 103-103.
    doi: 10.1111/j.1365-2869.2008.00690.x
  • Sterr A, Herron K, Dijk D-J, Ellis J. (2008) 'Time to wake-up: Sleep problems and daytime sleepiness in long-term stroke survivors'. TAYLOR & FRANCIS LTD BRAIN INJURY, 22 (7-8), pp. 575-579.
    doi: 10.1080/02699050802189727
    Full text is available at: http://epubs.surrey.ac.uk/188332/
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk D-J. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.
    Full text is available at: http://epubs.surrey.ac.uk/285505/
  • Driver HS, Werth E, Dijk D-J, Borbély AA. (2008) 'The Menstrual Cycle Effects on Sleep'. Sleep Medicine Clinics, 3 (1), pp. 1-11.
    doi: 10.1016/j.jsmc.2007.10.003
  • Herron K, Dijk D, Ellis J, Sanders J, Sterr AM. (2008) 'Sleep actigraphy in brain injured patients with chronic low functioning upper limb hemiparesis'. Journal of Sleep Research, 17, pp. 102-102.
    doi: 10.1111/j.1365-2869.2008.00690.x
  • Vandewalle G, Gais S, Schabus M, Balteau E, Carrier J, Darsaud A, Sterpenich V, Albouy G, Dijk DJ, Maquet P. (2007) 'Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure'. OXFORD UNIV PRESS INC CEREBRAL CORTEX, 17 (12), pp. 2788-2795.
    doi: 10.1093/cercor/bhm007
  • Zeitzer JM, Duffy JF, Lockley SW, Dijk D-J, Czeisler CA. (2007) 'Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake'. AMER ACAD SLEEP MEDICINE SLEEP, 30 (11), pp. 1437-1443.
  • Vandewalle G, Middleton B, Rajaratnam SMW, Stone BM, Thorleifsdottir B, Arendt J, Dijk D-J. (2007) 'Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (2), pp. 148-155.
    doi: 10.1111/j.1365-2869.2007.00581.x
  • Walsh JK, Deacon S, Dijk D-J, Lundahl J. (2007) 'The selective extrasynaptic GABA(A) agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia'. AMER ACADEMY SLEEP MEDICINE SLEEP, 30 (5), pp. 593-602.
  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk D-J. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURRENT BIOLOGY, 17 (7), pp. 613-618.
    doi: 10.1016/j.cub.2007.01.073
  • Jones KHS, Ellis J, Von Schantz M, Skene DJ, Dijk D-J, Archer SN. (2007) 'Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (1), pp. 12-16.
    doi: 10.1111/j.1365-2869.2007.00561.x
  • Vandewalle G, Schmidt C, Albouy G, Sterpenich V, Darsaud A, Rauchs G, Berken P-Y, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D-J. (2007) 'Brain Responses to Violet, Blue, and Green Monochromatic Light Exposures in Humans: Prominent Role of Blue Light and the Brainstem'. PUBLIC LIBRARY SCIENCE PLOS ONE, 2 (11) Article number ARTN e1247
    doi: 10.1371/journal.pone.0001247
    Full text is available at: http://epubs.surrey.ac.uk/2609/
  • Vandewalle G, Balteau E, Phillips C, Degueldre C, Moreau V, Sterpenich V, Albouy G, Darsaud A, Desseilles M, Dang-Vu TT, Peigneux P, Luxen A, Dijk D-J, Maquet P. (2006) 'Daytime light exposure dynamically enhances brain responses'. CELL PRESS CURRENT BIOLOGY, 16 (16), pp. 1616-1621.
    doi: 10.1016/j.cub.2006.06.031
  • Wyatt JK, Dijk DJ, Ritz-De Cecco A, Ronda JM, Czeisler CA. (2006) 'Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent'. AMER ACADEMY SLEEP MEDICINE SLEEP, 29 (5), pp. 609-618.
  • Cropley M, Dijk D-J, Stanley N. (2006) 'Job strain, work rumination, and sleep in school teachers'. PSYCHOLOGY PRESS EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY, 15 (2), pp. 181-196.
    doi: 10.1080/13594320500513913
  • Dijk D-J. (2006) 'Sleep of aging women and men: Back to basics'. AMER ACADEMY SLEEP MEDICINE SLEEP, 29 (1), pp. 12-13.
  • Wulff K, Joyce E, Middleton B, Dijk DJ, Foster RG. (2006) 'The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: A case report'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, Frankfurt, GERMANY: 23 (1-2), pp. 485-495.
    doi: 10.1080/07420520500545987
  • Klerman EB, Dijk DJ. (2005) 'Interindividual variation in sleep duration and its association with sleep debt in young adults'. AMER ACAD SLEEP MEDICINE SLEEP, 28 (10), pp. 1253-1259.
  • Dijk DJ, von Schantz M. (2005) 'Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 20 (4), pp. 279-290.
    doi: 10.1177/1748730405278292
  • Groeger JA, Dijk DJ. (2005) 'Consolidating consolidation? Sleep stages, memory systems, and procedures'. CAMBRIDGE UNIV PRESS BEHAV BRAIN SCI, 28 (1), pp. 73-+.
  • Groeger JA, Zijlstra FRH, Dijk DJ. (2004) 'Sleep quantity, sleep difficulties and their perceived consequences in a representative sample of some 2000 British adults'. BLACKWELL PUBLISHING LTD JOURNAL OF SLEEP RESEARCH, 13 (4), pp. 359-371.
    doi: 10.1111/j.1365-2869.2004.00418.x
  • Rajaratnam SM, Middleton B, Stone BM, Arendt J, Dijk DJ. (2004) 'Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans.'. J Physiol, England: 561 (Pt 1), pp. 339-351.
    doi: 10.1113/jphysiol.2004.073742
  • Perrin F, Peigneux P, Fuchs S, Verhaeghe S, Laureys S, Middleton B, Degueldre C, Del Fiore G, Vandewalle G, Balteau E, Poirrier R, Moreau V, Luxen A, Maquet P, Dijk DJ. (2004) 'Nonvisual responses to light exposure in the human brain during the circadian night.'. Curr Biol, England: 14 (20), pp. 1842-1846.
    doi: 10.1016/j.cub.2004.09.082
  • Dijk D-J, Larkin W. (2004) 'Fatigue and performance models: General background and commentary on the circadian alertness simulator for fatigue risk assessment in transportation'. Aviation Space and Environmental Medicine, 75 (SUPPL.1)
  • Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. (2004) 'Older people awaken more frequently but fall back asleep at the same rate as younger people'. AMER ACADEMY SLEEP MEDICINE SLEEP, 27 (4), pp. 793-798.
  • Rajaratnam SMW, Dijk DJ, Middleton B, Stone BM, Arendt J. (2004) 'Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones (vol 88, pg 4303, 2003)'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 89 (6), pp. 2997-2997.
  • Wyatt JK, Cajochen C, Ritz-De Cecco A, Czeisler CA, Dijk DJ. (2004) 'Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness'. AMER ACADEMY SLEEP MEDICINE SLEEP, 27 (3), pp. 374-381.
  • Dijk DJ, Larkin W. (2004) 'Fatigue and performance models: general background and commentary on the circadian alertness simulator for fatigue risk assessment in transportation.'. Aviat Space Environ Med, United States: 75 (3 Suppl), pp. A119-A121.
  • Rajaratnam SMW, Dijk D-J, Middleton B, Stone BM, Arendt J. (2004) 'Erratum: Melatonin phase-shifts human Circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones (The Journal of Clinical Endocrinology and Metabolism (2003) 88 (4303-4309))'. Journal of Clinical Endocrinology and Metabolism, 89 (6), pp. 2997-2997.
  • Cropley M, Dijk D-J, Stanley N. (2004) 'The effects of ruminative thinking about work on sleep'. Psychology and Health, 19 (SUPPL. 1), pp. 36-36.
  • Cajochen C, Jewett ME, Dijk DJ. (2003) 'Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation.'. J Pineal Res, Denmark: 35 (3), pp. 149-157.
  • Rajaratnam SM, Dijk DJ, Middleton B, Stone BM, Arendt J. (2003) 'Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones.'. J Clin Endocrinol Metab, United States: 88 (9), pp. 4303-4309.
  • Phipps-Nelson J, Redman JR, Dijk DJ, Rajaratnam SM. (2003) 'Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance.'. Sleep, United States: 26 (6), pp. 695-700.
  • Warman VL, Dijk DJ, Warman GR, Arendt J, Skene DJ. (2003) 'Phase advancing human circadian rhythms with short wavelength light'. ELSEVIER SCI IRELAND LTD NEUROSCIENCE LETTERS, 342 (1-2), pp. 37-40.
    doi: 10.1016/S0304-3940(03)00223-4
  • Cropley M, Dijk DJ. (2003) 'Sleep--is the 24/7 lifestyle leaving us seriously short?'. J Fam Health Care, England: 13 (5), pp. 114-115.
  • Wyatt JK, Dijk DJ, Czeisler CA. (2002) 'Negative effects of wake duration, circadian phase, and caffeine administration on self-assessment'. AMER ACAD SLEEP MEDICINE SLEEP, 25, pp. A425-A426.
  • Rajaratnam SM, Dijk DJ, Middleton B, Stone B, Arendt J. (2002) 'Rapid and persistent phase advance of human sleep and biological rhythms by melatonin in a 16-h night/8-h day protocol'. AMER ACAD SLEEP MEDICINE SLEEP, 25, pp. A188-A189.
  • Khalsa SB, Conroy DA, Duffy JF, Czeisler CA, Dijk DJ. (2002) 'Sleep- and circadian-dependent modulation of REM density.'. J Sleep Res, England: 11 (1), pp. 53-59.
  • Duffy JF, Dijk DJ. (2002) 'Getting through to circadian oscillators: why use constant routines?'. J Biol Rhythms, United States: 17 (1), pp. 4-13.
  • Dijk DJ, Lockley SW. (2002) 'Integration of human sleep-wake regulation and circadian rhythmicity.'. J Appl Physiol, United States: 92 (2), pp. 852-862.
    doi: 10.1152/japplphysiol.00924.2001
  • Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk DJ, Czeisler CA. (2002) 'Peak of circadian melatonin rhythm occurs later within the sleep of older subjects.'. Am J Physiol Endocrinol Metab, United States: 282 (2), pp. E297-E303.
    doi: 10.1152/ajpendo.00268.2001
  • Dijk DJ, Lockley SW. (2002) 'Functional Genomics of Sleep and Circadian Rhythm - Invited review: Integration of human sleep-wake regulation and circadian rhythmicity'. AMER PHYSIOLOGICAL SOC JOURNAL OF APPLIED PHYSIOLOGY, 92 (2), pp. 852-862.
  • Dijk D-J, Lockley SW. (2002) 'Invited review: Integration of human sleep-wake regulation and circadian rhythmicity'. Journal of Applied Physiology, 92 (2), pp. 852-862.
  • Cajochen C, Wyatt JK, Czeisler CA, Dijk DJ. (2002) 'Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness.'. Neuroscience, United States: 114 (4), pp. 1047-1060.
  • Wright KP, Hughes RJ, Kronauer RE, Dijk DJ, Czeisler CA. (2001) 'Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans.'. Proc Natl Acad Sci U S A, United States: 98 (24), pp. 14027-14032.
    doi: 10.1073/pnas.201530198
  • Dijk DJ, Neri DF, Wyatt JK, Ronda JM, Riel E, Ritz-De Cecco A, Hughes RJ, Elliott AR, Prisk GK, West JB, Czeisler CA. (2001) 'Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights.'. Am J Physiol Regul Integr Comp Physiol, United States: 281 (5), pp. R1647-R1664.
  • Dijk DJ, Duffy JF, Czeisler CA. (2001) 'Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phases.'. Sleep, United States: 24 (5), pp. 565-577.
  • Elliott AR, Shea SA, Dijk DJ, Wyatt JK, Riel E, Neri DF, Czeisler CA, West JB, Prisk GK. (2001) 'Microgravity reduces sleep-disordered breathing in humans.'. Am J Respir Crit Care Med, United States: 164 (3), pp. 478-485.
  • Lockley SW, Dijk DJ, Arendt J, Skene DJ. (2001) 'Circadian and sleep-wake dependent control of alertness, mood and performance in field studies of blind subjects'. AMER ACAD SLEEP MEDICINE SLEEP, 24, pp. A4-A4.
  • Klerman EB, Hughes RJ, Dijk DJ. (2001) 'Sleep debt in healthy young individuals is inversely related to habitual sleep duration and associated with excessive daytime sleepiness'. AMER ACAD SLEEP MEDICINE SLEEP, 24, pp. A122-A122.
  • Duffy JF, Winkelman JW, Riel E, Dijk DJ, Czeisler CA. (2001) 'Circadian modulation of PLMS'. AMER ACAD SLEEP MEDICINE SLEEP, 24, pp. A100-A101.
  • Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. (2001) 'Circadian phase resetting in older people by ocular bright light exposure.'. J Investig Med, United States: 49 (1), pp. 30-40.
  • Cajochen C, Zeitzer JM, Czeisler CA, Dijk DJ. (2000) 'Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness.'. Behav Brain Res, NETHERLANDS: 115 (1), pp. 75-83.
  • Zeitzer JM, Duffy JF, Klerman EB, Shanahan TL, Dijk DJ, Czeisler CA. (2000) 'Plasma melatonin concentrations decline with age? Reply'. EXCERPTA MEDICA INC AMERICAN JOURNAL OF MEDICINE, 109 (4), pp. 345-345.
    doi: 10.1016/S0002-9343(00)00518-0
  • Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. (2000) 'Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression.'. J Physiol, ENGLAND: 526 Pt 3, pp. 695-702.
  • Czeisler CA, Dijk DJ, Kronauer RE, Brown EN, Duffy JF, Allan JS, Shanahan TL, Rimmer DW, Ronda JM, Mitchell JF, Silva EJ, Emens JS. (2000) 'Is there an intrinsic period of the circadian clock? Response.'. Science, UNITED STATES: 288 (5469), pp. 1174-1175.
  • Dijk DJ, Duffy JF, Czeisler CA. (2000) 'Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep.'. Chronobiol Int, UNITED STATES: 17 (3), pp. 285-311.
  • Dijk DJ. (2000) 'Age, rhythm and bedroom lamps'. SOC ED SCIENTIFIQUES RECHERCHE, , pp. 44-45.
  • Dijk D-J. (2000) 'Reply to technical note: Nonlinear interactions between circadian and homeostatic processes: Models or metrics? (Journal of Biological Rhythms 14:6 (604-608))'. Journal of Biological Rhythms, 15 (2), pp. 186-186.
  • Dijk D-J, Kronauer R. (2000) 'Commentary: Models of sleep regulation: Successes and continuing challenges (Journal of Biological Rhythms 14:6 (569-576))'. Journal of Biological Rhythms, 15 (2), pp. 186-186.
  • Campbell S, Czeisler CA, Dijk D-J, Kronauer RE, Brown EN, Duffy JF, Allan JS, Shanahan TL, Rimmer DW, Ronda JM, Mitchell JF, Silva EJ, Emens JS. (2000) 'Is there an intrinsic period of the circadian clock? [3] (multiple letters)'. Science, 288 (5469), pp. 1174-1175.
    doi: 10.1126/science.288.5469.1174
  • Dijk DJ, Jewett ME, Czeisler CA, Kronauer RE. (1999) 'Reply to technical note: nonlinear interactions between circadian and homeostatic processes: models or metrics?'. J Biol Rhythms, UNITED STATES: 14 (6), pp. 604-605.
  • Dijk DJ, Kronauer RE. (1999) 'Commentary: models of sleep regulation: successes and continuing challenges.'. J Biol Rhythms, UNITED STATES: 14 (6), pp. 569-573.
  • Zeitzer JM, Daniels JE, Duffy JF, Klerman EB, Shanahan TL, Dijk DJ, Czeisler CA. (1999) 'Do plasma melatonin concentrations decline with age?'. Am J Med, UNITED STATES: 107 (5), pp. 432-436.
  • Wyatt JK, Ritz-De Cecco A, Czeisler CA, Dijk DJ. (1999) 'Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day.'. Am J Physiol, UNITED STATES: 277 (4 Pt 2), pp. R1152-R1163.
  • Dijk DJ. (1999) 'Circadian variation of EEG power spectra in NREM and REM sleep in humans: dissociation from body temperature.'. J Sleep Res, ENGLAND: 8 (3), pp. 189-195.
  • Cajochen C, Khalsa SB, Wyatt JK, Czeisler CA, Dijk DJ. (1999) 'EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss.'. Am J Physiol, UNITED STATES: 277 (3 Pt 2), pp. R640-R649.
  • Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk DJ, Kronauer RE. (1999) 'Stability, precision, and near-24-hour period of the human circadian pacemaker.'. Science, UNITED STATES: 284 (5423), pp. 2177-2181.
  • Kelly TL, Neri DF, Grill JT, Ryman D, Hunt PD, Dijk DJ, Shanahan TL, Czeisler CA. (1999) 'Nonentrained circadian rhythms of melatonin in submariners scheduled to an 18-hour day.'. J Biol Rhythms, UNITED STATES: 14 (3), pp. 190-196.
  • Dijk DJ, Duffy JF, Riel E, Shanahan TL, Czeisler CA. (1999) 'Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.'. J Physiol, ENGLAND: 516 ( Pt 2), pp. 611-627.
  • Dijk DJ, Duffy JF. (1999) 'Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics.'. Ann Med, ENGLAND: 31 (2), pp. 130-140.
  • Jewett ME, Dijk DJ, Kronauer RE, Dinges DF. (1999) 'Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness.'. Sleep, UNITED STATES: 22 (2), pp. 171-179.
  • Duffy JF, Dijk DJ, Hall EF, Czeisler CA. (1999) 'Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people.'. J Investig Med, UNITED STATES: 47 (3), pp. 141-150.
  • Jewett ME, Wyatt JK, Ritz-De Cecco A, Khalsa SB, Dijk DJ, Czeisler CA. (1999) 'Time course of sleep inertia dissipation in human performance and alertness.'. J Sleep Res, ENGLAND: 8 (1), pp. 1-8.
  • Wei HG, Riel E, Czeisler CA, Dijk DJ. (1999) 'Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects.'. Neurosci Lett, IRELAND: 260 (1), pp. 29-32.
  • Cajochen C, Foy R, Dijk DJ. (1999) 'Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans.'. Sleep Res Online, United States: 2 (3), pp. 65-69.
  • Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. (1998) 'Nonphotic entrainment of the human circadian pacemaker (vol 43, pg R991, 1998)'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 275 (6)
  • Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. (1998) 'Later endogenous circadian temperature nadir relative to an earlier wake time in older people.'. Am J Physiol, UNITED STATES: 275 (5 Pt 2), pp. R1478-R1487.
  • Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. (1998) 'Later endogenous circadian temperature nadir relative to an earlier wake time in older people'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 275 (5), pp. R1478-R1487.
  • Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. (1998) 'Nonphotic entrainment of the human circadian pacemaker.'. Am J Physiol, UNITED STATES: 274 (4 Pt 2), pp. R991-R996.
  • Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. (1998) 'Nonphotic entrainment of the human circadian pacemaker'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 274 (4), pp. R991-R996.
  • Klerman EB, Rimmer DW, Dijk D-J, Kronauer RE, Rizzo III JF, Czeisler CA. (1998) 'Erratum: Nonphotic entrainment of the human circadian pacemaker (American Journal of Physiology - Regulatory and Integrative Physiology (April 1998) 274:43 (R991-R996))'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 275 (2 44-2)
  • Klerman EB, Rimmer DW, Dijk D-J, Kronauer RE, Rizzo III JF, Czeisler CA. (1998) 'Erratum: Nonphotic entrainment of the human circadian pacemaker (American Journal of Physiology (R991-R996))'. American Journal of Physiology - Renal Physiology, 275 (6 44-6)
  • Dijk DJ, Shanahan TL, Duffy JF, Ronda JM, Czeisler CA. (1997) 'Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans.'. J Physiol, ENGLAND: 505 ( Pt 3), pp. 851-858.
  • Dijk DJ, Cajochen C. (1997) 'Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG.'. J Biol Rhythms, UNITED STATES: 12 (6), pp. 627-635.
  • Werth E, Achermann P, Dijk DJ, Borbély AA. (1997) 'Spindle frequency activity in the sleep EEG: individual differences and topographic distribution.'. Electroencephalogr Clin Neurophysiol, IRELAND: 103 (5), pp. 535-542.
  • Aeschbach D, Dijk DJ, Borbély AA. (1997) 'Dynamics of EEG spindle frequency activity during extended sleep in humans: relationship to slow-wave activity and time of day.'. Brain Res, NETHERLANDS: 748 (1-2), pp. 131-136.
  • Boivin DB, Czeisler CA, Dijk DJ, Duffy JF, Folkard S, Minors DS, Totterdell P, Waterhouse JM. (1997) 'Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects.'. Arch Gen Psychiatry, UNITED STATES: 54 (2), pp. 145-152.
  • Dijk DJ. (1996) 'Internal rhythms in humans'. ACADEMIC PRESS LTD SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 7 (6), pp. 831-836.
    doi: 10.1006/scdb.1996.0101
  • Landolt HP, Roth C, Dijk DJ, Borbély AA. (1996) 'Late-afternoon ethanol intake affects nocturnal sleep and the sleep EEG in middle-aged men.'. J Clin Psychopharmacol, UNITED STATES: 16 (6), pp. 428-436.
  • Landolt HP, Dijk DJ, Achermann P, Borbély AA. (1996) 'Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men.'. Brain Res, NETHERLANDS: 738 (2), pp. 205-212.
  • Brunner DP, Kräuchi K, Dijk DJ, Leonhardt G, Haug HJ, Wirz-Justice A. (1996) 'Sleep electroencephalogram in seasonal affective disorder and in control women: effects of midday light treatment and sleep deprivation.'. Biol Psychiatry, UNITED STATES: 40 (6), pp. 485-496.
    doi: 10.1016/0006-3223(95)00656-7
  • Werth E, Dijk DJ, Achermann P, Borbély AA. (1996) 'Dynamics of the sleep EEG after an early evening nap: experimental data and simulations.'. Am J Physiol, UNITED STATES: 271 (3 Pt 2), pp. R501-R510.
  • Werth E, Dijk DJ, Achermann P, Borbely AA. (1996) 'Dynamics of the sleep EEG after an early evening nap: Experimental data and simulations'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 271 (3), pp. R501-R510.
  • Driver HS, Dijk DJ, Werth E, Biedermann K, Borbély AA. (1996) 'Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women.'. J Clin Endocrinol Metab, UNITED STATES: 81 (2), pp. 728-735.
  • Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. (1996) 'Simulations of light effects on the human circadian pacemaker: Implications for assessment of intrinsic period'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 270 (1), pp. R271-R282.
  • Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. (1996) 'Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period.'. Am J Physiol, UNITED STATES: 270 (1 Pt 2), pp. R271-R282.
  • Czeisler CA, Dijk DJ. (1995) 'Use of bright light to treat maladaptation to night shift work and circadian rhythm sleep disorders.'. J Sleep Res, 4 (S2), pp. 70-73.
  • Dijk DJ, Roth C, Landolt HP, Werth E, Aeppli M, Achermann P, Borbély AA. (1995) 'Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity.'. Neurosci Lett, IRELAND: 201 (1), pp. 13-16.
  • Achermann P, Werth E, Dijk DJ, Borbely AA. (1995) 'Time course of sleep inertia after nighttime and daytime sleep episodes.'. Arch Ital Biol, ITALY: 134 (1), pp. 109-119.
  • Dijk DJ. (1995) 'EEG slow waves and sleep spindles: windows on the sleeping brain.'. Behav Brain Res, NETHERLANDS: 69 (1-2), pp. 109-116.
  • Boulos Z, Campbell SS, Lewy AJ, Terman M, Dijk DJ, Eastman CI. (1995) 'Light treatment for sleep disorders: consensus report. VII. Jet lag.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 167-176.
  • Campbell SS, Eastman CI, Terman M, Lewy AJ, Boulos Z, Dijk DJ. (1995) 'Light treatment for sleep disorders: consensus report. I. Chronology of seminal studies in humans.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 105-109.
  • DIJK DJ. (1995) 'CIRCADIAN REGULATION OF SLEEP PROPENSITY, SLEEP STRUCTURE AND ALERTNESS - A SYMPHONY OF PARADOXES'. REED HEALTHCARE COMMUNICATIONS ACTA NEUROPSYCHIATRICA, 7 (2), pp. 24-26.
  • Eastman CI, Boulos Z, Terman M, Campbell SS, Dijk DJ, Lewy AJ. (1995) 'Light treatment for sleep disorders: consensus report. VI. Shift work.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 157-164.
  • Campbell SS, Terman M, Lewy AJ, Dijk DJ, Eastman CI, Boulos Z. (1995) 'Light treatment for sleep disorders: consensus report. V. Age-related disturbances.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 151-154.
  • Terman M, Lewy AJ, Dijk DJ, Boulos Z, Eastman CI, Campbell SS. (1995) 'Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 135-147.
  • Campbell SS, Dijk DJ, Boulos Z, Eastman CI, Lewy AJ, Terman M. (1995) 'Light treatment for sleep disorders: consensus report. III. Alerting and activating effects.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 129-132.
  • Dijk DJ, Boulos Z, Eastman CI, Lewy AJ, Campbell SS, Terman M. (1995) 'Light treatment for sleep disorders: consensus report. II. Basic properties of circadian physiology and sleep regulation.'. J Biol Rhythms, UNITED STATES: 10 (2), pp. 113-125.
  • Landolt HP, Dijk DJ, Gaus SE, Borbély AA. (1995) 'Caffeine reduces low-frequency delta activity in the human sleep EEG.'. Neuropsychopharmacology, UNITED STATES: 12 (3), pp. 229-238.
    doi: 10.1016/0893-133X(94)00079-F
  • Dijk DJ, Czeisler CA. (1995) 'Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans.'. J Neurosci, UNITED STATES: 15 (5 Pt 1), pp. 3526-3538.
  • Landolt HP, Moser S, Wieser HG, Borbély AA, Dijk DJ. (1995) 'Intracranial temperature across 24-hour sleep-wake cycles in humans.'. Neuroreport, ENGLAND: 6 (6), pp. 913-917.
  • Landolt HP, Werth E, Borbély AA, Dijk DJ. (1995) 'Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night.'. Brain Res, NETHERLANDS: 675 (1-2), pp. 67-74.
  • Aeschbach D, Dijk DJ, Trachsel L, Brunner DP, Borbély AA. (1994) 'Dynamics of slow-wave activity and spindle frequency activity in the human sleep EEG: effect of midazolam and zopiclone.'. Neuropsychopharmacology, UNITED STATES: 11 (4), pp. 237-244.
  • Kattler H, Dijk DJ, Borbély AA. (1994) 'Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans.'. J Sleep Res, 3 (3), pp. 159-164.
  • Aeschbach D, Cajochen C, Tobler I, Dijk DJ, Borbély AA. (1994) 'Sleep in a sitting position: effect of triazolam on sleep stages and EEG power spectra.'. Psychopharmacology (Berl), GERMANY: 114 (2), pp. 209-214.
  • DIJK DJ, CZEISLER CA. (1994) 'BODY-TEMPERATURE IS ELEVATED DURING THE REBOUND OF SLOW-WAVE SLEEP FOLLOWING 40-H OF SLEEP-DEPRIVATION ON A CONSTANT ROUTINE (VOL 2, PG 117, 1993)'. BLACKWELL SCIENCE LTD JOURNAL OF SLEEP RESEARCH, 3 (1), pp. 64-64.
  • Franken P, Dijk DJ, Tobler I, Borbély AA. (1994) 'High-frequency components of the rat electrocorticogram are modulated by the vigilance states.'. Neurosci Lett, IRELAND: 167 (1-2), pp. 89-92.
  • Dijk DJ, Czeisler CA. (1994) 'Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans.'. Neurosci Lett, IRELAND: 166 (1), pp. 63-68.
  • Dijk D-J, Czeisler CA. (1994) 'Body temperature is elevated during the rebound of slow-wave sleep following 40-h of sleep deprivation on a constant routine (J. Sleep Res., Volume 2, Number 3, pp. 117-120, September 1993)'. Journal of Sleep Research, 3 (1), pp. 64-64.
  • Dijk DJ, Hayes B, Czeisler CA. (1993) 'Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation.'. Brain Res, NETHERLANDS: 626 (1-2), pp. 190-199.
  • Dijk DJ, Czeisler CA. (1993) 'Body temperature is elevated during the rebound of slow-wave sleep following 40-h of sleep deprivation on a constant routine.'. J Sleep Res, 2 (3), pp. 117-120.
  • BEERSMA D, DIJK DJ. (1993) 'SELECTIVE SWS SUPPRESSION DOES NOT AFFECT THE TIME-COURSE OF CORE BODY-TEMPERATURE IN MEN (VOL 1, PG 201, 1992)'. BLACKWELL SCIENCE LTD JOURNAL OF SLEEP RESEARCH, 2 (3), pp. 186-186.
  • KLEIN T, MARTENS H, DIJK DJ, KRONAUER RE, SEELY EW, CZEISLER CA. (1993) 'CHRONIC NON-24-HOUR CIRCADIAN-RHYTHM SLEEP DISORDER IN A BLIND MAN WITH A REGULAR 24-HOUR SLEEP-WAKE SCHEDULE (VOL 16, PG 333, 1993)'. AMER SLEEP DISORDERS ASSOC SLEEP, 16 (5), pp. 510-510.
  • Klein T, Martens H, Dijk DJ, Kronauer RE, Seely EW, Czeisler CA. (1993) 'Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.'. Sleep, UNITED STATES: 16 (4), pp. 333-343.
  • Brunner DP, Dijk DJ, Borbély AA. (1993) 'Repeated partial sleep deprivation progressively changes in EEG during sleep and wakefulness.'. Sleep, UNITED STATES: 16 (2), pp. 100-113.
  • Achermann P, Dijk DJ, Brunner DP, Borbély AA. (1993) 'A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations.'. Brain Res Bull, UNITED STATES: 31 (1-2), pp. 97-113.
  • Beersma D, Dijk D-J. (1993) 'Erratum: Selective SWS suppression does not affect the time course of core body temperature in men (J. Sleep Res., Volume 1, Number 3, September 1992, pp. 201-204)'. Journal of Sleep Research, 2 (3), pp. 186-186.
  • Dijk DJ, Brunner DP, Aeschbach D, Tobler I, Borbély AA. (1992) 'The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists.'. Neuropsychopharmacology, UNITED STATES: 7 (3), pp. 225-232.
  • Beersma DG, Dijk DJ. (1992) 'Selective SWS suppression does not affect the time course of core body temperature in men.'. J Sleep Res, 1 (3), pp. 201-204.
  • Cajochen C, Dijk DJ, Borbély AA. (1992) 'Dynamics of EEG slow-wave activity and core body temperature in human sleep after exposure to bright light.'. Sleep, UNITED STATES: 15 (4), pp. 337-343.
  • Dijk DJ, Duffy JF, Czeisler CA. (1992) 'Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance.'. J Sleep Res, ENGLAND: 1 (2), pp. 112-117.
  • Johnson MP, Duffy JF, Dijk DJ, Ronda JM, Dyal CM, Czeisler CA. (1992) 'Short-term memory, alertness and performance: a reappraisal of their relationship to body temperature.'. J Sleep Res, ENGLAND: 1 (1), pp. 24-29.
  • Dijk DJ, Cajochen C, Tobler I, Borbély AA. (1991) 'Sleep extension in humans: sleep stages, EEG power spectra and body temperature.'. Sleep, UNITED STATES: 14 (4), pp. 294-306.
  • Franken P, Dijk DJ, Tobler I, Borbély AA. (1991) 'Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature.'. Am J Physiol, UNITED STATES: 261 (1 Pt 2), pp. R198-R208.
  • Tobler I, Dijk DJ, Jaggi K, Borbély AA. (1991) 'Effects on night-time motor activity and performance in the morning after midazolam intake during the night.'. Arzneimittelforschung, GERMANY: 41 (6), pp. 581-583.
  • Dijk DJ, Brunner DP, Borbély AA. (1991) 'EEG power density during recovery sleep in the morning.'. Electroencephalogr Clin Neurophysiol, IRELAND: 78 (3), pp. 203-214.
  • Dijk DJ, Cajochen C, Borbély AA. (1991) 'Effect of a single 3-hour exposure to bright light on core body temperature and sleep in humans.'. Neurosci Lett, NETHERLANDS: 121 (1-2), pp. 59-62.
  • Dijk DJ, Strijkstra A, Daan S, Beersma DG, Van den Hoofdakker RH. (1991) 'Effect of clomipramine on sleep and EEG power spectra in the diurnal rodent Eutamias sibiricus.'. Psychopharmacology (Berl), GERMANY: 103 (3), pp. 375-379.
  • Brunner DP, Dijk DJ, Münch M, Borbély AA. (1991) 'Effect of zolpidem on sleep and sleep EEG spectra in healthy young men.'. Psychopharmacology (Berl), GERMANY: 104 (1), pp. 1-5.
  • Brunner DP, Dijk DJ, Borbély AA. (1990) 'A quantitative analysis of phasic and tonic submental EMG activity in human sleep.'. Physiol Behav, UNITED STATES: 48 (5), pp. 741-748.
  • Dijk DJ, Brunner DP, Beersma DG, Borbély AA. (1990) 'Electroencephalogram power density and slow wave sleep as a function of prior waking and circadian phase.'. Sleep, UNITED STATES: 13 (5), pp. 430-440.
  • Beersma DG, Dijk DJ, Blok CG, Everhardus I. (1990) 'REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity.'. Electroencephalogr Clin Neurophysiol, IRELAND: 76 (2), pp. 114-122.
  • Brunner DP, Dijk DJ, Tobler I, Borbély AA. (1990) 'Effect of partial sleep deprivation on sleep stages and EEG power spectra: evidence for non-REM and REM sleep homeostasis.'. Electroencephalogr Clin Neurophysiol, IRELAND: 75 (6), pp. 492-499.
  • Dijk DJ, Brunner DP, Borbély AA. (1990) 'Time course of EEG power density during long sleep in humans.'. Am J Physiol, UNITED STATES: 258 (3 Pt 2), pp. R650-R661.
  • Trachsel L, Dijk DJ, Brunner DP, Klene C, Borbély AA. (1990) 'Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule.'. Neuropsychopharmacology, UNITED STATES: 3 (1), pp. 11-18.
  • Dijk DJ, Beersma DG, Bloem GM. (1989) 'Sex differences in the sleep EEG of young adults: visual scoring and spectral analysis.'. Sleep, UNITED STATES: 12 (6), pp. 500-507.
  • Dijk DJ, Beersma DG, Daan S, van den Hoofdakker RH. (1989) 'Effects of seganserin, a 5-HT2 antagonist, and temazepam on human sleep stages and EEG power spectra.'. Eur J Pharmacol, NETHERLANDS: 171 (2-3), pp. 207-218.
  • Dijk DJ, Beersma DG, van den Hoofdakker RH. (1989) 'All night spectral analysis of EEG sleep in young adult and middle-aged male subjects.'. Neurobiol Aging, UNITED STATES: 10 (6), pp. 677-682.
  • Dijk DJ, Beersma DG. (1989) 'Effects of SWS deprivation on subsequent EEG power density and spontaneous sleep duration.'. Electroencephalogr Clin Neurophysiol, IRELAND: 72 (4), pp. 312-320.
  • Dijk DJ, Daan S. (1989) 'Sleep EEG spectral analysis in a diurnal rodent: Eutamias sibiricus.'. J Comp Physiol A, GERMANY, WEST: 165 (2), pp. 205-215.
  • Dijk DJ, Beersma DG, Daan S, Lewy AJ. (1989) 'Bright morning light advances the human circadian system without affecting NREM sleep homeostasis.'. Am J Physiol, UNITED STATES: 256 (1 Pt 2), pp. R106-R111.
  • Van Oortmerssen GA, Dijk DJ, Schuurman T. (1987) 'Studies in wild house mice. II. Testosterone and aggression.'. Horm Behav, UNITED STATES: 21 (2), pp. 139-152.
  • van den Hoofdakker RH, Beersma DG, Dijk DJ. (1987) 'The significance of sleep physiological disturbances in depression.'. Acta Psychiatr Belg, BELGIUM: 87 (3), pp. 302-316.
  • Dijk DJ, Visscher CA, Bloem GM, Beersma DG, Daan S. (1987) 'Reduction of human sleep duration after bright light exposure in the morning.'. Neurosci Lett, NETHERLANDS: 73 (2), pp. 181-186.
  • Dijk DJ, Beersma DG, Daan S. (1987) 'EEG power density during nap sleep: reflection of an hourglass measuring the duration of prior wakefulness.'. J Biol Rhythms, UNITED STATES: 2 (3), pp. 207-219.
  • Dijk DJ, Beersma DG, Daan S, Bloem GM, Van den Hoofdakker RH. (1987) 'Quantitative analysis of the effects of slow wave sleep deprivation during the first 3 h of sleep on subsequent EEG power density.'. Eur Arch Psychiatry Neurol Sci, GERMANY, WEST: 236 (6), pp. 323-328.
  • DAAN S, BEERSMA DGM, DIJK DJ. (1986) 'SLEEP CYCLE OR REM-SLEEP GENERATOR'. CAMBRIDGE UNIV PRESS BEHAVIORAL AND BRAIN SCIENCES, 9 (3), pp. 402-403.
  • Van den Hoofdakker RH, Beersma DG, Dijk DJ. (1986) 'Sleep disorders in depression.'. Eur Neurol, SWITZERLAND: 25 Suppl 2, pp. 66-70.
  • DIJK DJ, BEERSMA DGM, BLOEM GM, DAAN S, VANDENHOOFDAKKER RH. (1985) 'THE TIME COURSE OF EEG POWER-DENSITY DURING NIGHT AND DAY SLEEP IN RELATION TO THE 2 PROCESS MODEL OF SLEEP REGULATION'. SWETS ZEITLINGER PUBLISHERS JOURNAL OF INTERDISCIPLINARY CYCLE RESEARCH, 16 (4), pp. 248-249.
  • VANOORTMERSSEN GA, BENUS I, DIJK DJ. (1985) 'STUDIES IN WILD HOUSE MICE - GENOTYPE-ENVIRONMENT INTERACTIONS FOR ATTACK LATENCY'. E J BRILL NETHERLANDS JOURNAL OF ZOOLOGY, 35 (1-2), pp. 155-169.
  • Bolhuis JJ, Fitzgerald RE, Dijk DJ, Koolhaas JM. (1984) 'The corticomedial amygdala and learning in an agonistic situation in the rat.'. Physiol Behav, UNITED STATES: 32 (4), pp. 575-579.

Conference papers

  • Hasan S, Winsky-Sommerer R, Dijk D-J, Archer SN. (2012) 'Sleep in transgenic mouse models for a polymorphism in the human PER3 gene'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 79-79.
  • Price LLA, Khazova M, Ohagan JB, Santhi N, Dijk D-J. (2012) 'Developing an architectural dosimetry protocol for residential properties in circadian sleep research'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 199-199.
  • Arbon EL, Lazar AS, Lo JC, Slak A, Mccabe PJ, Boyle J, Archer SN, Dijk D-J. (2012) 'Individual differences in sleep revisited: stability across sleep restriction, extension and total sleep loss'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 207-208.
  • Jaspar M, Meyer C, Muto V, Shaffii-Le Bourdiec A, Kusse C, Vandewalle G, Collette F, Archer S, Dijk D-J, Maquet P. (2012) 'Influence of sleep homeostasis and circadian rhythm on executive discriminative ability during a constant routine'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 328-328.
  • Groeger JA, Lo JC, Santhi N, Arbon EL, Lazar A, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) ''Trait-like' susceptibility to sleep loss varies with circadian phase and the task used to index vulnerable-resilient sleep-deprived performance'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 36-37.
  • Dijk D-J. (2012) 'Individual differences in the circadian regulation of sleep'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 88-88.
  • Shaffii-Le Bourdiec A, Muto V, Jaspar M, Kusse C, Foret A, Archer SN, Le Bourdiec F, Vandewalle G, Collette F, Dijk DJ, Maquet P. (2012) 'Difference in neural correlates of discrimination during sleep deprivation in PER3 homozygous'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of circadian phase and prior partial sleep deprivation on executive functions during total sleep deprivation are modulated by PER3 polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 41-41.
  • Muto V, Meyer C, Jaspar M, Shaffii-Le Bourdiec A, Kusse C, Foret A, Vandewalle G, Collette F, Archer S, Dijk D-J, Maquet P. (2012) 'Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during a constant routine'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 327-328.
  • Lazar A, Santhi N, Lo J, Slak A, Hasan S, Von Schantz M, Archer S, Dijk D-J. (2012) 'The circadian and homeostatic regulation of sleep spindle activity: effect of the PER3 VNTR polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
  • Van der Veen DR, Dijk D-J, Archer SN. (2012) 'A role for PERIOD3 in sleep/wake rhythms: photic responses in humanised knock-in mice and gene expression correlates of PER3 expression'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 333-333.
  • Boyle J, Dijk D-J. (2012) 'Pharmacology of sleep- and wake-promoting compounds in humans: novel trials'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 47-48.
  • Mccarthy A, Edgar DM, Dijk D-J. (2012) 'Defining rat and human sleep bout parameters using distribution fit statistics'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 197-197.
  • Schwarz JF, Ingre M, Anund A, Fors C, Karlsson JG, Kecklund G, Van der Veen DR, Archer SN, Dijk D, Akerstedt T. (2012) 'PERIOD3 VNTR POLYMORPHISM MODIFIES SLEEPINESS DURING REAL ROAD DRIVING'. AMER ACAD SLEEP MEDICINE SLEEP, Boston, MA: 26th Annual Meeting of the Association-of-Professional-Sleep-Societies (APSS) 35, pp. A109-A109.
  • Klerman EB, Dijk D. (2012) 'ASSESSMENT OF THE ABILITY TO RECOVER SLEEP AFTER SLEEP DEPRIVATION IN A SLEEP SATIATION PROTOCOL'. AMER ACAD SLEEP MEDICINE SLEEP, Boston, MA: Annual Meeting of the Associated-Professional-Sleep-Societies (APSS) 35, pp. A60-A61.
  • Duffy JF, Cain SW, Chang A, Phillips AJ, Munch MY, Gronfier C, Wyatt JK, Dijk D, Wright KP, Czeisler CA. (2011) 'SEX DIFFERENCE IN INTRINSIC CIRCADIAN PERIOD IN HUMANS'. SLEEP, 34, pp. A307-A307.
  • Dijk DJ. (2009) 'Electrophysiological characteristics and regulation of SWS'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Istanbul, TURKEY: 22nd Congress of the European-College-of-Neuropsychopharmacology 19, pp. S716-S716.
  • Herron K, Dijk D-J, Dean P, Seiss E, Sterr A. (2009) 'EEG-DERIVED BIOMARKERS FOR DAYTIME SLEEPINESS IN PATIENTS WITH CHRONIC STROKE'. WILEY-BLACKWELL PUBLISHING, INC PSYCHOPHYSIOLOGY, Berlin, GERMANY: 49th Annual Meeting of the Society-for-Psychophysiological-Research 46, pp. S108-S108.
  • Eriksson M, Kerr D, Mills SL, Coppini DV, Dijk D, Boyle J. (2009) 'Objective Evidence of Poor Sleep and Daytime Consequences in Diabetic Patients with Painful Diabetic Peripheral Neuropathy When Compared with Healthy Controls: A Polysomnography Study'. AMER DIABETES ASSOC DIABETES, New Orleans, LA: 69th Annual Meeting of the American-Diabetes-Association 58, pp. A224-A224.
  • Lo JC, Dijk D, Groeger JA. (2009) 'THE EFFECTS OF AN IMMEDIATE NAP VERSUS A DELAYED NAP ON DECLARATIVE MEMORY CONSOLIDATION'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A409-A409.
  • Klerman E, Wang W, Kronauer RE, Duffy JF, Czeisler CA, Dijk D. (2009) 'AGE-RELATED CHANGES IN SLEEP MAINTENANCE QUANTIFIED USING SURVIVAL ANALYSES OF SLEEP AND WAKE BOUTS'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A121-A121.
  • Kronauer RE, Wang W, Duffy JF, Czeisler CA, Wyatt JK, Dijk D, Klerman EB. (2009) 'SURVIVAL ANALYSES OF SLEEP AND WAKE BOUTS REVEAL DIFFERENTIAL REGULATION OF THE MAINTENANCE OF NREM AND REM SLEEP'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Scoieties 32, pp. A22-A22.
  • Klerman E, Wang W, Kronauer RE, Dijk D. (2009) 'EFFECTS OF AGING AND SLEEP EXTENSION ON SLEEP MAINTENANCE QUANTIFIED USING SURVIVAL ANALYSES OF SLEEP AND WAKE BOUTS'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A115-A115.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk D, Maquet P. (2009) 'MODULATION OF FMRI ASSESSED BRAIN RESPONSES TO BLUE AND GREEN LIGHT BY SLEEP HOMFOSTASIS, CIRCADIAN PHASE AND PER3 POLYMORPHISM'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A1-A1.
  • Groeger JA, Lo JC, Dijk D. (2009) 'DIFFERENTIAL DISRUPTION OF EXECUTIVE FUNCTION, ON WAKING FROM MORNING AND AFTERNOON NAPS, IN SLEEP RESTRICTED SUBJECTS'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A405-A405.
  • Bettica PU, Squassante L, Groeger JA, Gennery B, Dijk D. (2009) 'HYPNOTIC EFFECTS OF SB-649868, AN OREXIN ANTAGONIST, AND ZOLPIDEM IN A MODEL OF SITUATIONAL INSOMNIA'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A40-A40.
  • Hartmann JA, Thorne HC, Groeger JA, Dijk D. (2009) 'EFFECTS OF SLEEP LOSS AND CIRCADIAN MISALIGNMENT ON PERFORMANCE AND ALERTNESS: A COMPARISON OF OBJECTIVE AND SUBJECTIVE MEASURES'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A60-A60.
  • Cohen DA, Wyatt JK, Wang W, Kronauer RE, Dijk D, Czeisler CA, Klerman EB. (2009) 'VIGILANCE PERFORMANCE IS DETERMINED BY AN INTERACTION AMONG ACUTE HOMEOSTATIC, CHRONIC HOMEOSTATIC, AND CIRCADIAN MECHANISMS'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A153-A154.
  • Vandewalle G, Archer S, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'Polymorphism in period3 predicts fMRI-assessed inter-individual differences in the effects of sleep deprivation'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • Groeger JA, Lo JC, Dijk D. (2008) 'Dissociable effects of recent and enduring sleep quality on reported everyday affect and function: a structural equation modeling approach'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 236-236.
  • Krystal A, Walsh J, Cooper J, Schaefer K, Dijk D. (2008) 'Efficacy of eszopiclone relative to zolpidem in patients with primary insomnia: a responder analysis of objective sleep outcomes'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 210-210.
  • Lo JC, Dijk D, Groeger JA. (2008) 'Napping and paired associate declarative memory: effects of semantic relatedness and level of learning'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 11-11.
  • James LM, Dijk D, Boyle J, Calder N, Iannone R, Palcza J, Renger J. (2008) 'Effects of a single dose of modafinil on EEG during the MWT during acute sleep deprivation'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 206-206.
  • Dijk D. (2008) 'Role of clock genes in sleep homeostasis in humans'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 30-30.
  • Viola AU, James LM, Schlangen LJ, Dijk D. (2008) 'Blue-enriched light improves self-reported alertness and performance in the workplace'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 117-117.
  • Wulff K, Joyce EM, Middleton B, Foster RG, Dijk D. (2008) 'Sleep and rest/activity cycle disturbances in schizophrenia patients in comparison to unemployed healthy controls'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 76-77.
  • Thorne HC, Jones KH, Archer AN, Dijk D. (2008) 'Spectral composition of daily light exposure in young adults in summer and winter'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 115-115.
  • Groeger JA, Lo JC, Viola AU, Schantz MV, Archer SN, Dijk D. (2008) 'Period3 and the effects of sleep deprivation on executive function: the importance of circadian phase'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 1-1.
  • Dijk D. (2008) 'Reduction in sleep propensity with ageing'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 63-63.
  • Dijk D, Walsh J, Cooper J, Amato D, Schaefer K, Krystal A. (2008) 'Efficacy of eszopiclone and zolpidem in patients with primary insomnia: a responder analysis of objective sleep outcomes'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Barcelona, SPAIN: 21st Congress of the European-College-of-Neuropsychopharmacology 18, pp. S577-S578.
    doi: 10.1016/S0924-977X(08)70883-6
  • Dijk D. (2008) 'Neural mechanisms of sleep and wakefulness: implications for insomnia treatment'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Barcelona, SPAIN: 21st Congress of the European-College-of-Neuropsychopharmacology 18, pp. S603-S603.
    doi: 10.1016/S0924-977X(08)70942-8
  • Wulff K, Joyce E, Middleton B, Foster R, Dijk D-J. (2008) 'Circadian activity and sleep cycle disturbances in schizophrenia patients in comparison to unemployed healthy controls'. CAMBRIDGE UNIV PRESS INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Munich, GERMANY: 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP) 11, pp. 150-150.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'A period 3 polymorphism predicts FMRI assessed brain responses following sleep loss'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A111-A111.
  • Herron K, Dijk D, Ellis J, Sanders J, Sterr A. (2008) 'Sleep actigraphy in brain injured patients with chronic low functioning upper limb hemiparesis'. Glasgow, SCOTLAND : Wiley-Blackwell Publishing, Inc Psychology: 19th Congress of the European-Sleep-Research-Society, pp. 102-102.
  • Dean DA, Wyatt JK, Dijk D, Czeisler CA, Klerman EB. (2008) 'Quantifying practice effects within groups and individuals: Examples from a month long forced desynchrony protocol'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A54-A54.
  • Herron K, Dijk D, Ellis J, Sanders J, Sterr A. (2008) 'Sleep correlates of motor recovery in chronic stroke: a pilot study using sleep diaries and actigraphy'. Glasgow, SCOTLAND : Wiley-Blackwell Publishing, Inc Psychology: 19th Congress of the European-Sleep-Research-Society, pp. 103-103.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A107-A107.
  • Wulff K, Joyce EM, Middleton B, Foster RG, Dijk DJ. (2007) 'Sleep and circadian activity/rest disturbances in schizophrenia patients in comparison to unemployed healthy controls'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vienna, AUSTRIA: 20th Congress of the European-College-of-Neuropsychopharmacology 17, pp. S415-S416.
    doi: 10.1016/S0924-977X(07)70623-5
  • Wulff K, Joyce EM, Middleton B, Dijk DJ, Foster RG. (2007) 'Sleep in schizophrenia'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Sofia, BULGARIA: 9th Regional Meeting of the European-College-of-Neuropsychopharmacology 17, pp. S136-S137.
    doi: 10.1016/S0924-977X(07)70119-0
  • Dijk D, Groeger J, Stanley N, Deacon S. (2007) 'Effect of selective SWS/SWA disruption and age on daytime sleep propensity and its time course in healthy subjects aged 20-83'. AMER ACAD SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the American-Professional-Sleep-Societies 30, pp. A253-A254.
  • Groeger J, Deacon S, Stanley N, Snyder E, Legters A, Dijk D. (2007) 'Sizing the effect of selective SWS/SWA disruption on objective and subjective daytime sleep propensity, mood, executive function, sustained attention, working memory and overnight memory consolidation'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A134-A134.
  • Archer S, Viola A, Von Schantz M, Dijk D. (2007) 'Endogenous circadian rhythm of PER3 RNA in human leucocytes: Association with sleep timing, melatonin rhythm, and PER3 genotype'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A55.
  • Dijk D, Stanley N, Groeger J, Legters A, Deacon S. (2007) 'Gaboxadol reduces the detrimental effects of traffic noise on sleep: A randomised, double-blind, placebo-controlled, parallel group study in healthy subjects'. AMER ACAD SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the American-Professional-Sleep-Societies 30, pp. A253-A253.
  • Groeger J, Lo J, Viola A, Von Schantz M, Archer S, Dijk D. (2007) 'PER3 polymorphism predictssusceptibility to sleep deprivation-induced impairment of early morning executive performance'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A54.
  • Walsh J, Lundahl J, Dijk D, Deacon S. (2006) 'Gaboxadol improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomnia'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 195-196.
  • Dijk D. (2006) 'Individual differences in habitual sleep duration and circadian sleep regulation'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 22-22.
  • Dijk D, Groeger J, Deacon S, Stanley N. (2006) 'Age-related reduction in daytime sleep propensity'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 183-184.
  • Vandewalle G, Gais S, Schabus M, Balteau E, Albouy G, Sterpenich V, Dijk D, Maquet P. (2006) 'Superiority of blue (470 nm) light in eliciting non-image forming brain responses during auditory working memory in humans: a fMRI study'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 54-54.
  • Dijk D, Stanley N, Groeger J, Deacon S. (2006) 'Selective SWS/SWA deprivation is associated with increased daytime sleep propensity in young, middle-aged and older men and women'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 250-251.
  • Jones KH, Ellis J, Von Schantz M, Skene DJ, Dijk D, Archer SN. (2006) 'Age-related change in the association between a variable number tandem repeat polymorphism in the (PER3) gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 97-98.
  • Dijk DJ, Groeger J, Deacon S, Stanley N. (2006) 'Association between individual differences in slow wave sleep, slow wave activity and sleep continuity in young, middle-aged and older men and women'. ELSEVIER SCIENCE BV EUROPEAN NEUROPSYCHOPHARMACOLOGY, Paris, FRANCE: 19th Congress of the European-College-of-Neuropsychopharmacology 16, pp. S538-S538.
    doi: 10.1016/S0924-977X(06)70749-0
  • Viola AU, Archer SN, Groeger JA, Skene DJ, Von Schantz M, Dijk DJ. (2006) 'Polymorphism in the clock gene PER3 predicts sleep structure and EEG power spectra'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 53-53.
  • Aeschbach D, Lockyer BJ, Dijk D, Lockley SW, Nuwayser ES, Nichols LD, Czeisler CA. (2006) 'Approaching an endogenous melatonin secretion profile to improve daytime sleep by dermal melatonin delivery'. AMER ACADEMY SLEEP MEDICINE SLEEP, Salt Lake City, UT: 20th Annual Meeting of the Associated-Professional-Sleep-Societies 29, pp. A41-A42.
  • Walsh J, Deacon S, Dijk D, Lundahl J. (2006) 'Gaboxadol improves sleep onset and maintenance and enhances low frequency components of NREM sleep EEG in a model of transient insomnia'. AMER ACADEMY SLEEP MEDICINE SLEEP, Salt Lake City, UT: 20th Annual Meeting of the Associated-Professional-Sleep-Societies 29, pp. A244-A244.
  • Klerman E, Dijk D. (2006) 'Changes in mood and performance during sleep extension in younger and older people'. AMER ACADEMY SLEEP MEDICINE SLEEP, Salt Lake City, UT: 20th Annual Meeting of the Associated-Professional-Sleep-Societies 29, pp. A374-A374.
  • Klerman E, Dijk D. (2006) 'Aging: Asymptotic sleep duration during extended sleep opportunities'. AMER ACADEMY SLEEP MEDICINE SLEEP, Salt Lake City, UT: 20th Annual Meeting of the Associated-Professional-Sleep-Societies 29, pp. A35-A35.
  • Emegbo S, Stanley N, Dijk D, Hindmarch I. (2005) 'Differential effects of gender on sleep continuity during experimental fragmentation of sleep'. AMER ACADEMY SLEEP MEDICINE SLEEP, Denver, CO: 19th Annual Meeting of the Associated-Professional-Sleep-Societies 28, pp. A144-A144.
  • Mazza M, Dijk D, Klerman EB. (2004) 'Alertness and performance in older and younger adults during 16, 28, and 52 hours of sleep deprivation'. AMER ACADEMY SLEEP MEDICINE SLEEP, Philadelphia, PA: 18th Annual Meeting of the Associated-Professional-Sleep-Societies 27, pp. 154-155.
  • Klerman EB, Dijk D. (2004) 'Sleep during a bedrest extension protocol in older and younger individuals'. AMER ACADEMY SLEEP MEDICINE SLEEP, Philadelphia, PA: 18th Annual Meeting of the Associated-Professional-Sleep-Societies 27, pp. 129-130.
  • Whittlef C, Smith MR, Pilsworth SN, Dijk DJ, Mahowald MW. (2003) 'Do we practice what we preach? Shiftwork and sleepiness in the Association of Polysomnographic Technologists (APT)'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A95-A95.
  • Cropley M, Dijk D, Stanley N. (2003) 'The effects of rumination about work issues during leisure time on sleep: A two day diary study'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A305-A305.
  • Dijk DJ, Kinney JM, Tucker HN. (1997) 'Light, circadian rhythms, and the homeostatic regulation of human sleep'. LIPPINCOTT-RAVEN PUBL PHYSIOLOGY, STRESS, AND MALNUTRITION, AMSTERDAM, NETHERLANDS: 3rd Conference on Physiology, Stress, and Malnutrition, pp. 55-78.

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