Dr Daan van der Veen
Lecturer in Sleep & Chronobiology
Qualifications: MSc, PhD
Email: D.VanderVeen@surrey.ac.uk
Room no: 11 AY 02
Further information
Biography
2012 – present Lecturer in Sleep & Chronobiology - University of Surrey, Guildford, UK
2011 – 2012 Postdoctoral researcher - University of Notre Dame, Notre Dame, USA
2007 – 2010 Postdoctoral researcher - University of Surrey, Guildford, UK
2007 PhD - Department of Chronobiology, University of Groningen, the Netherlands
2001 MSc in Behavioural and Neural Sciences - University of Groningen, the Netherlands
Research Interests
Member of the Sleep, Chronobiology and Addiction Research Group
- Circadian and ultradian rhythms
- Environmental and temporal control of gene expression
- Light and food entrainment
- Metabolism
- Sleep, cognition and clock genes
Publications
Journal articles
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(2012) 'A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging.'. Wiley Obesity (Silver Spring), doi: 10.1038/oby.2012.78
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(2012) 'Cardiac atrial circadian rhythms in PERIOD2::LUCIFERASE and per1:luc mice: amplitude and phase responses to glucocorticoid signaling and medium treatment.'. PLoS One, United States: 7 (10)Full text is available at: http://epubs.surrey.ac.uk/736483/
Abstract
Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1(luc) or PER2(LUC)) and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2(LUC), but not per1(luc) is rhythmic in atrial tissue, while both per1(luc) and PER2(LUC) exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1(luc) and PER2(LUC) bioluminescence amplitudes were increased in response to DEX treatment, and the PER2(LUC) amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue.
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(2012) 'A 24-hour temporal profile of in vivo brain and heart pet imaging reveals a nocturnal peak in brain 18F-fluorodeoxyglucose uptake.'. PLoS One, United States: 7 (2)Full text is available at: http://epubs.surrey.ac.uk/346771/
Abstract
Using positron emission tomography, we measured in vivo uptake of (18)F-fluorodeoxyglucose (FDG) in the brain and heart of C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data describe a significant, high amplitude rhythm in FDG uptake throughout the whole brain, peaking at the mid-dark phase of the light-dark cycle, which is the active phase for nocturnal mice. Under these conditions, heart FDG uptake did not vary with time of day, but did show biological variation throughout the 24-hour period for measurements within the same mice. FDG uptake was scanned at different times of day within an individual mouse, and also compared to different times of day between individuals, showing both biological and technical reproducibility of the 24-hour pattern in FDG uptake. Regional analysis of brain FDG uptake revealed especially high amplitude rhythms in the olfactory bulb and cortex, while low amplitude rhythms were observed in the amygdala, brain stem and hypothalamus. Low amplitude 24-hour rhythms in regional FDG uptake may be due to multiple rhythms with different phases in a single brain structure, quenching some of the amplitude. Our data show that the whole brain exhibits significant, high amplitude daily variation in glucose uptake in living mice. Reports applying the 2-deoxy-D[(14)C]-glucose method for the quantitative determination of the rates of local cerebral glucose utilization indicate only a small number of brain regions exhibiting a day versus night variation in glucose utilization. In contrast, our data show 24-hour patterns in glucose uptake in most of the brain regions examined, including several regions that do not show a difference in glucose utilization. Our data also emphasizes a methodological requirement of controlling for the time of day of scanning FDG uptake in the brain in both clinical and pre-clinical settings, and suggests waveform normalization of FDG measurements at different times of the day.
- . (2011) 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol,
- . (2011) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.'. J Pineal Res,
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(2011) 'Behavioral responses to combinations of timed light, food availability, and ultradian rhythms in the common vole (Microtus arvalis).'. Informa Healthcare Chronobiol Int, England: 28 (7), pp. 563-571.Full text is available at: http://epubs.surrey.ac.uk/285509/
Abstract
Light is the main entraining signal of the central circadian clock, which drives circadian organization of activity. When food is made available during only certain parts of the day, it can entrain the clock in the liver without changing the phase of the central circadian clock. Although a hallmark of food entrainment is a behavioral anticipation of food availability, the extent of behavioral alterations in response to food availability has not been fully characterized. The authors have investigated interactions between light and temporal food availability in the timing of activity in the common vole. Temporally restricted food availability enhanced or attenuated re-entrainment to a phase advance in light entrainment when it was shifted together with the light or remained at the same time of day, respectively. When light-entrained behavior was challenged with temporal food availability cycles with a different period, two distinct activity components were observed. More so, the present data indicate that in the presence of cycles of different period length of food and light, an activity component emerged that appeared to be driven by a free-running (light-entrainable) clock. Because the authors have previously shown that in the common vole altering activity through running-wheel availability can alter the effectiveness of food availability to entrain the clock in the liver, the authors included running-wheel availability as a parameter that alters the circadian/ultradian balance in activity. In the current protocols, running-wheel availability enhanced the entraining potential of both light and food availability in a differential way. The data presented here show that in the vole activity is a complex of individually driven components and that this activity is, itself, an important modulator of the effectiveness of entraining signals such as light and food.
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(2010) 'Light-Dependent Behavioral Phenotypes in PER3-Deficient Mice'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 25 (1), pp. 3-8.Full text is available at: http://epubs.surrey.ac.uk/142841/
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(2008) 'SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro.'. BMC J Circadian Rhythms, England: 6 (5)Full text is available at: http://epubs.surrey.ac.uk/285510/
Abstract
Circadian organisation of behavioural and physiological rhythms in mammals is largely driven by the clock in the suprachiasmatic nuclei (SCN) of the hypothalamus. In this clock, a molecular transcriptional repression and activation mechanism generates near 24 hour rhythms. One of the outputs of the molecular clock in specific SCN neurons is arginine-vasopressin (AVP), which is responsive to transcriptional activation by clock gene products. As negative regulators, the protein products of the period genes are thought to repress transcriptional activity of the positive limb after heterodimerisation with CRYPTOCHROME. When both the Per1 and Per2 genes are dysfunctional by targeted deletion of the PAS heterodimer binding domain, mice lose circadian organization of behaviour upon release into constant environmental conditions. To which degree the period genes are involved in the control of AVP output is unknown.
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(2008) 'Circadian rhythms of C-FOS expression in the suprachiasmatic nuclei of the common vole (Microtus arvalis)'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 25 (4), pp. 481-499.Full text is available at: http://epubs.surrey.ac.uk/285516/
- . (2006) 'Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms'. NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103 (9), pp. 3393-3398.
- . (2005) 'Circadian dynamics of vasopressin in mouse selection lines: Translation and release in the SCN'. ELSEVIER SCIENCE BV BRAIN RESEARCH, 1060 (1-2), pp. 16-25.
Conference papers
- . (2012) 'A role for PERIOD3 in sleep/wake rhythms: photic responses in humanised knock-in mice and gene expression correlates of PER3 expression'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 333-333.
- . (2012) 'PERIOD3 VNTR POLYMORPHISM MODIFIES SLEEPINESS DURING REAL ROAD DRIVING'. AMER ACAD SLEEP MEDICINE SLEEP, Boston, MA: 26th Annual Meeting of the Association-of-Professional-Sleep-Societies (APSS) 35, pp. A109-A109.
Book chapters
- . (2011) 'Sleep-dependent learning'. in Jarvis P (ed.) The Routledge International Handbook of Learning Routledge Article number 27
Teaching
- BMS2054 ANIMAL NUTRITION, TOXICOLOGY AND PHARMACOLOGY
- BMS3066 BIOLOGICAL RHYTHMS
- BMS3064 NEUROSCIENCE 2
- TOX M008 PRACTICAL TOXICOLOGY
