Biography

• 1988             B.Sc., Biology. Federal University of Rio Grande do Sul, Porto Alegre/Brazil.
• 1994             Ph.D., Genetics and Molecular Biology. Curie Institute, Paris/France & UFRGS, Porto Alegre/Brazil.
• 1995-2000     Postdoctoral Research Fellow/Instructor, UT Southwestern Medical Center, Texas, USA
• 2001-2008     Research Scientist, Harvard School of Public Health/Massachusetts Institute of Technology, MA, USA
• 2008-2009     Research Fellow, St. George’s University of London
• 2009-current  Lecturer in Toxicology, University of Surrey

Research Interests

My research focuses on understanding the mechanisms by which exposures to endogenous and/or exogenous toxicants lead to pathology and disease. In particular, I am interested in understanding how defective repair of DNA damage can affect health, with implications to human degenerative diseases associated with aging such as cancer and neuronal degeneration.

Publications

Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, Samson LD (2009) Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci U S A. 106(3):888-93.

Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD. (2009) O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proc Natl Acad Sci U S A. 106(2):576-81.

Bugni, JM, Meira, LB, Samson, LD (2009) Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. Oncogene 2009 Feb 5;28(5):734-412.

Maor-Shoshani, A, Meira, LB, Yang, X, Samson, LD (2008) 3-Methyladenine DNA glycosylase is important for cellular resistance to psoralen interstrand cross-links. DNA Repair. 7:1399-1406

Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J. Clin. Invest. 118:2516-2525

Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A (2008) AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Res. 68:4142-4149.

Lingaraju, GM, Kartalou, M, Meira, LB, Samson, LD. (2008) Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag). DNA Repair. 7:970-982.

Longerich, S, Meira, LB, Shah, D, Samson, LD and U Storb (2007) Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination. DNA Repair. 6:1764-1773.

Dong, L, Meira, LB, Hazra, TK, Samson, LD and W Cao (2007) Oxanine DNA glycosylase activities in mammalian systems. DNA Repair. 1;7(1):128-34.

Beyer, RP, Fry, RC, Lasarev, MR, McConnachie, LA, Meira, LB, Palmer, VS, Powell, CL, Ross, PK, Bammler, TK, Bradford, BU, Cranson, AB, Cunningham, ML, Fannin, RD, Higgins, GM, Hurban, P, Kayton, RJ, Kerr, KF, Kosyk, O, Lobenhofer, EK, Sieber, SO, Vliet, PA, Weis, BK, Wolfinger, R, Woods, CG, Freedman, JH, Linney, E, Kaufmann, WK, Kavanagh, TJ, Paules, RS, Rusyn, I, Samson, LD, Spencer, PS, Suk, W, Tennant, RJ, Zarbl, H, Members of the Toxicogenomics Research Consortium (2007) Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses Toxicol. Sci. 99: 326-337.

PubMed link for complete list of publications

Teaching

BMS3002 Receptors
MSc Toxicology: TOX M001, TOX M007, TOX M009

Undergraduate lecture notes

PG lecture notes

Departmental Duties

Biosciences Library Representative