Molecular Toxicology, Pharmacogenetics, Pharmacogenomics, In vitro toxicology, alternatives to animals. Use of transcriptomic and proteomic technologies in toxicology: effects of drugs & chemicals on expression of genes of drug metabolism & cellular defence. Role of nuclear receptors in gene regulation: ligand binding & protein-protein interactions. Mechanism of action of the orphan receptors PXR, CAR, VDR, RXR, PPAR. Role of the steroid hormone receptors ER & GR. Effect of polymorphic variation on inter-individual differences in xenobiotic metabolism: SNP detection in the CY3A4 gene. In vitro functional analysis: use of DNA transfection and reporter assays, use of EMSA, use of protein trap assays.

Structure-function relationships in the cytochrome P450 family of enzymes: in silico modelling of drug-enzyme interactions. Mechanism of action of endocrine disruptors: transcriptomic profiling of altered gene expression.