Translational Research is one of the latest Government's key words; nowadays, if you want to get a grant then your scientific research needs to be translated into practical applications that have impact.  Working within a commercial environment is not straightforward but it is a two-way street, often the practical application helps to further drive the research. The application of neural computing to help industry address some pressing business needs has the potential to improve its performance in a number of keys areas. Over 15-years of delivering innovation into business, a series of projects and approaches are discussed.  Some have been successes, some have been failures, but what is the common theme?