Dr Alfred Thumser
Senior Lecturer in Biochemistry
Qualifications: BSc; BSc (Med) (Hons); PhD
Email: a.thumser@surrey.ac.uk
Phone: Work: 01483 68 6383
Room no: 26 AY 04
Office hours
08:30-17:30
Further information
Biography
2012-present: Senior Lecturer in Biochemistry, Faculty of Healthy and Medical Sciences, University of Surrey, United Kingdom
2000 - 2012: Lecturer in Biochemistry, Faculty of Healthy and Medical Sciences, University of Surrey, United Kingdom
1997 - 2000: Post-Doctoral Research Associate; Dept. Nutritional Sciences, Cook College, Rutgers, The State University of New Jersey, U.S.A.
1992 - 1996: Post-Doctoral Research Assistant; Dept. Biochemistry, University of Southampton, United Kingdom.
1990 - 1991: Medical Corps (Clinical laboratories, Wynberg Military Hospital, South Africa)
1990: Ph.D., Dept. Medical Biochemistry (University of Cape Town, South Africa). Title: The Glutathione S-Transferases: Inhibition, Activation, Binding and Kinetics.
1984: B.Sc.(Med.)(Hons.), Medical Biochemistry (University of Cape Town).
1983: B.Sc., with majors in Biochemistry and Microbiology (University of Cape Town).
1980: Matriculation, Deutsche Schule Kapstadt (German school), Cape Town
Research Interests
Overview:
My research interests are motivated by interests in endogenous and xenobiotic metabolism, and the role of enzymes in these processes. In this respect I am trying to establish a metabolomics (metabolic profiling) research group with different Ph.D. research students currently investigating the mechanisms by which xenobiotics interfere with endogenous metabolism and energy supply. Collaborative projects are investigating the role of enzymes in electrochemical fuel cells, and metabolic processes linked to circadian rhythms.
Metabolomics / metabonomics / metabolite profiling: Mass spectrometric (MS) and metabolomic approaches to analysing drug action and toxicity
The effects of drugs and toxins in cell culture systems are being investigated and analysed with state-of-the-art liquid chromatography / mass spectrometry (LC-MS) equipment. Multivariate data analysis and metabolic modelling approaches (systems biology) are used to interpret experimental data. Current work has been focussed on rigorously establishing the experimental and analytical techniques in the metabolomics laboratory. Studies on the hepatotoxic effects of drugs are in progress. A separate programme is investigating the circadian profiles of blood and urine metabolites in human subjects
Enzyme Fuel Cells
We are investigating the use of various enzymes, e.g. glucose oxidase and bilirubin oxidase, in electrochemical fules cells. The end-point of these studies is to produce fuel cells with sufficient power to be used in electrical devices, including implantable devices.
Research Collaborations
Prof Bob Slade, Dr John Varcoe and Dr Claudio Avignone-Rossa: Enzymatic fuel cells (electrochemistry)
Prof Debra Skene: Circadian rhythms and metabolomics
Publications
Journal articles
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(2012) 'Identification of Human Plasma Metabolites Exhibiting Time-of-Day Variation Using an Untargeted Liquid Chromatography-Mass Spectrometry Metabolomic Approach.'. Informa Healthcare Chronobiol Int, England: 29 (7), pp. 868-881.Full text is available at: http://epubs.surrey.ac.uk/721493/
Abstract
Although daily rhythms regulate multiple aspects of human physiology, rhythmic control of the metabolome remains poorly understood. The primary objective of this proof-of-concept study was identification of metabolites in human plasma that exhibit significant 24-h variation. This was assessed via an untargeted metabolomic approach using liquid chromatography-mass spectrometry (LC-MS). Eight lean, healthy, and unmedicated men, mean age 53.6 (SD ± 6.0) yrs, maintained a fixed sleep/wake schedule and dietary regime for 1 wk at home prior to an adaptation night and followed by a 25-h experimental session in the laboratory where the light/dark cycle, sleep/wake, posture, and calorific intake were strictly controlled. Plasma samples from each individual at selected time points were prepared using liquid-phase extraction followed by reverse-phase LC coupled to quadrupole time-of-flight MS analysis in positive ionization mode. Time-of-day variation in the metabolites was screened for using orthogonal partial least square discrimination between selected time points of 10:00 vs. 22:00 h, 16:00 vs. 04:00 h, and 07:00 (d 1) vs. 16:00 h, as well as repeated-measures analysis of variance with time as an independent variable. Subsequently, cosinor analysis was performed on all the sampled time points across the 24-h day to assess for significant daily variation. In this study, analytical variability, assessed using known internal standards, was low with coefficients of variation <10%. A total of 1069 metabolite features were detected and 203 (19%) showed significant time-of-day variation. Of these, 34 metabolites were identified using a combination of accurate mass, tandem MS, and online database searches. These metabolites include corticosteroids, bilirubin, amino acids, acylcarnitines, and phospholipids; of note, the magnitude of the 24-h variation of these identified metabolites was large, with the mean ratio of oscillation range over MESOR (24-h time series mean) of 65% (95% confidence interval [CI]: 49-81%). Importantly, several of these human plasma metabolites, including specific acylcarnitines and phospholipids, were hitherto not known to be 24-h variant. These findings represent an important baseline and will be useful in guiding the design and interpretation of future metabolite-based studies. (Author correspondence: Jooern.Ang@icr.ac.uk or Florence.Raynaud@icr.ac.uk ).
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(2012) 'An optimised glucose oxidase bioelectrode exhibiting high performance direct electron transfer.'. Royal Society of Chemistry Phys Chem Chem Phys, England: 14 (27), pp. 9582-9585.doi: 10.1039/c2cp41651dFull text is available at: http://epubs.surrey.ac.uk/722284/
Abstract
A glucose oxidase (GOd) bioelectrode exhibiting high performance, direct electron transfer (DET) has been prepared. Unprecedented redox peak current densities of 1 mA cm(-2) were observed alongside a clear electrochemical response to glucose. This system shows potential as a low cost, high performance enzymatic bioelectrode.
- . (2012) 'COX-2 SPECIFIC INHIBITORS FROM LEDEBOURIA OVATIFOLIA AND LEDEBOURIA SOCIALIS (HYACINTHACEAE:HYACINTHOIDEAE)'. PHARMACEUTICAL BIOLOGY, 50 (5), pp. 569-569.
- . (2012) 'NOVEL TRITERPENOID DERIVATIVES FROM EUCOMIS BICOLOR (HYACINTHACEAE: HYACINTHOIDEAE)'. PHARMACEUTICAL BIOLOGY, 50 (5), pp. 645-645.
- . (2012) 'COX-2 SPECIFIC INHIBITION FROM NATURAL PRODUCT (E)-HINOKIRESINOL AND A FACILE SYNTHESIS OF 3-VINYLPHENYLINDANES'. PHARMACEUTICAL BIOLOGY, 50 (5), pp. 649-649.
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(2012) 'Characterization of Rhodamine-123 as a Tracer Dye for Use In In vitro Drug Transport Assays'. Public Library of Science PLoS One, 7 (3) Article number e33253 Full text is available at: http://epubs.surrey.ac.uk/412936/
Abstract
Fluorescent tracer dyes represent an important class of sub-cellular probes and allow the examination of cellular processes in real-time with minimal impact upon these processes. Such tracer dyes are becoming increasingly used for the examination of membrane transport processes as they are easy-to-use, cost effective probe substrates for a number of membrane protein transporters. Rhodamine 123, a member of the rhodamine family of flurone dyes, has been used to examine membrane transport by the ABCB1 gene product, MDR1. MDR1 is viewed as the archetypal drug transport protein, and is able to efflux a large number of clinically relevant drugs. In addition, ectopic activity of MDR1 has been associated with the development of multiple drug resistance phenotype, which results in a poor patient response to therapeutic intervention. It is thus important to be able to examine the potential for novel compounds to be MDR1 substrates. Given the increasing use rhodamine 123 as a tracer dye for MDR1, a full characterisation of its spectral properties in a range of in vitro assay-relevant media is warranted. Herein, we determine λmax for excitation and emission or rhodamine 123 and its metabolite rhodamine 110 in commonly used solvents and extraction buffers, demonstrating that fluorescence is highly dependent on the chemical environment: Optimal parameters are 1% (v/v) methanol in HBSS, with λex=505nm, λem=525nm. We characterise the uptake of rhodamine 123 into cells, via both passive and active processes, and demonstrate that this occurs primarily through OATP1A2-mediated facilitated transport at concentrations below 2µM, and via micelle-mediated passive diffusion above this. Finally, we quantify the intracellular sequestration and metabolism of rhodamine 123, demonstrating that these are both cell line-dependent factors that may influence the interpretation of transport assays.
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(2012) 'Dynamic changes in the microbial community composition in microbial fuel cells fed with sucrose'. Springer Applied Microbiology and Biotechnology, 93 (1), pp. 423-437.Full text is available at: http://epubs.surrey.ac.uk/46272/
Abstract
The performance and dynamics of the bacterial communities in the biofilm and suspended culture in the anode chamber of sucrose-fed microbial fuel cells (MFCs) were studied by using denaturing gradient gel electrophoresis (DGGE) of PCR-amplified partial 16S rRNA genes followed by species identification by sequencing. The power density of MFCs was correlated to the relative proportions of species obtained from DGGE analysis in order to detect bacterial species or taxonomic classes with important functional role in electricity production. Although replicate MFCs showed similarity in performance, cluster analysis of DGGE profiles revealed differences in the evolution of bacterial communities between replicate MFCs. No correlation was found between the proportion trends of specific species and the enhancement of power output. However, in all MFCs, putative exoelectrogenic denitrifiers and sulphate-reducers accounted for approximately 24% of the bacterial biofilm community at the end of the study. Pareto-Lorenz evenness distribution curves extracted from the DGGE patterns obtained from time course samples indicated community structures where shifts between functionally similar species occur, as observed within the predominant fermentative bacteria. These results suggest the presence of functional redundancy within the anodic communities, a probable indication that stable MFC performance can be maintained in changing environmental conditions. The capability of bacteria to adapt to electricity generation might be present among a wide range of bacteria.
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(2011) 'The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes.'. Xenobiotica, England: 41 (7), pp. 519-529.Full text is available at: http://epubs.surrey.ac.uk/7258/
Abstract
The therapeutic class of HMG-CoA reductase inhibitors, the statins are central agents in the treatment of hypercholesterolaemia and the associated conditions of cardiovascular disease, obesity and metabolic syndrome. Although statin therapy is generally considered safe, a number of known adverse effects do occur, most commonly treatment-associated muscular pain. In vitro evidence also supports the potential for drug-drug interactions involving this class of agents, and to examine this a ligand-binding assay was used to determine the ability of six clinically used statins for their ability to directly activate the nuclear receptors pregnane X-receptor (PXR), farnesoid X-receptor (FXR) and constitutive androstane receptor (CAR), demonstrating a relative activation of PXR>FXR>CAR. Using reporter gene constructs, we demonstrated that this order of activation is mirrored at the transcriptional activation level, with PXR-mediated gene activation being pre-eminent. Finally, we described a novel regulatory loop, whereby activation of FXR by statins increases PXR reporter gene expression, potentially enhancing PXR-mediated responses. Delineating the molecular interactions of statins with nuclear receptors is an important step in understanding the full biological consequences of statin exposure. This demonstration of their ability to directly activate nuclear receptors, leading to nuclear receptor cross-talk, has important potential implications for their use within a polypharmacy paradigm.
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(2011) 'Spatiotemporal development of the bacterial community in a tubular longitudinal microbial fuel cell'. SPRINGER APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 90 (3), pp. 1179-1191.Full text is available at: http://epubs.surrey.ac.uk/375309/
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(2011) 'Metabolomic Profiling Can Differentiate Between Bactericidal Effects of Free and Polymer Bound Halogen'. Wiley-Blackwell Journal of Applied Polymer Science, 119 (2), pp. 709-718.doi: 10.1002/app.32731
- . (2011) 'A role for microbial palladium nanoparticles in extracellular electron transfer.'. Angew Chem Int Ed Engl, Germany: 50 (2), pp. 427-430.
- . (2011) 'Spatiotemporal development of the bacterial community in a tubular longitudinal microbial fuel cell'. Applied Microbiology and Biotechnology, , pp. 1-13.
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(2010) 'Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3-ascorbate complex'. ELSEVIER Food Chemistry, 123 (2), pp. 281-285.Full text is available at: http://epubs.surrey.ac.uk/7253/
Abstract
It has been well documented that ascorbate enhances iron uptake, with a proposed mechanism based on reduction to the more absorbable ferrous form. We have performed a study on the effects of ascorbate on ferric iron uptake in the human epithelial Caco-2 cell-line. Ascorbate increased uptake in a concentration-dependent manner with a significant difference between iron uptake and reduction. Uptake kinetics are characteristic of a non-essential activator and the formation of an Fe3+–ascorbate complex. This investigation provides evidence that ascorbate enhances the apical uptake of ferric iron into Caco-2 cells through the formation of a Fe3+–ascorbate complex.
- . (2010) 'Tissue-specific Functions in the Fatty Acid-binding Protein Family'. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC JOURNAL OF BIOLOGICAL CHEMISTRY, 285 (43), pp. 32679-32683.
- . (2010) 'Periplasmic hydrogenases role for extracellular electron transfer'. ACS National Meeting Book of Abstracts,
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(2010) 'Applicability of the P19CL6 cells as a model of cardiomyocytes - A transcriptome analysis'. Health, 2 (1), pp. 24-31.Full text is available at: http://epubs.surrey.ac.uk/1950/
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(2009) 'A comparative study of the single crystal X-ray determination and molecular modelling of the binding of oligomycin to ATP Synthase'. ELSEVIER SCI LTD Computational Biology and Chemistry, 33 (3), pp. 189-195.Full text is available at: http://epubs.surrey.ac.uk/7265/
Abstract
Recently published X-ray structures of three common forms, A, B and C, of oligomycin, including absolute configurations, are investigated to examine their binding to ATP Synthase. The X-ray studies reveal regions with differences in three-dimensional structure and hydrogen bonding propensity between the oligomycins, which may be associated with their potential to bind to sites on ATP Synthase. Computational docking studies carried out using MOE with the X-ray structures and an homology model of the FO domain of ATP Synthase from Escherichia coli, are used to derive an induced fit pocket. Docking of all oligomycins to this pocket indicate that the B and C forms bind more tightly than the A form. Consideration of the single crystal X-ray data alone indicate the B form may be the best inhibitor and that O(24) is the most important ligating group for binding, this is supported by the docking data. The latter reveals Asn214 and other key proton translocating residues to be the main residues contacted by the inhibitor. These data allow the binding modes of different forms of oligomycin to be deduced from X-ray single crystal data supported by molecular modelling and computational docking studies.
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(2009) 'Factors affecting the performance of microbial fuel cells for sulfur pollutants removal'. ELSEVIER ADVANCED TECHNOLOGY BIOSENSORS & BIOELECTRONICS, 24 (7), pp. 1931-1936.Full text is available at: http://epubs.surrey.ac.uk/1693/
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(2009) 'A one-compartment fructose/air biological fuel cell based on direct electron transfer'. ELSEVIER ADVANCED TECHNOLOGY BIOSENSORS & BIOELECTRONICS, 25 (2), pp. 326-331.Full text is available at: http://epubs.surrey.ac.uk/375313/
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(2009) 'Direct electron transfer of glucose oxidase immobilized in an ionic liquid reconstituted cellulose-carbon nanotube matrix'. ELSEVIER SCIENCE SA BIOELECTROCHEMISTRY, 77 (1), pp. 64-68.Full text is available at: http://epubs.surrey.ac.uk/375314/
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(2008) 'A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF APPLIED MICROBIOLOGY, 105 (6), pp. 2058-2064.Full text is available at: http://epubs.surrey.ac.uk/1949/
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(2008) 'Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes'. ACAD MEDICAL SCIENCES I R IRAN ARCHIVES OF IRANIAN MEDICINE, 11 (1), pp. 42-49.Full text is available at: http://epubs.surrey.ac.uk/1954/
- . (2007) 'Characterization of a BODIPY-labeled fluorescent fatty acid analogue. Binding to fatty acid-binding proteins, intracellular localization, and metabolism.'. Mol Cell Biochem, Netherlands: 299 (1-2), pp. 67-73.
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(2000) 'The fatty acid transport function of fatty acid-binding proteins'. ELSEVIER SCIENCE BV Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1486 (1), pp. 28-44.Full text is available at: http://epubs.surrey.ac.uk/7254/
Abstract
The intracellular fatty acid-binding proteins (FABPs) comprise a family of 14–15 kDa proteins which bind long-chain fatty acids. A role for FABPs in fatty acid transport has been hypothesized for several decades, and the accumulated indirect and correlative evidence is largely supportive of this proposed function. In recent years, a number of experimental approaches which more directly examine the transport function of FABPs have been taken. These include molecular level in vitro modeling of fatty acid transfer mechanisms, whole cell studies of fatty acid uptake and intracellular transfer following genetic manipulation of FABP type and amount, and an examination of cells and tissues from animals engineered to lack expression of specific FABPs. Collectively, data from these studies have provided strong support for defining the FABPs as fatty acid transport proteins. Further studies are necessary to elucidate the fundamental mechanisms by which cellular fatty acid trafficking is modulated by the FABPs.
- . (2000) 'Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 41 (4), pp. 647-656.
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(1999) 'Binding of recombinant rat liver fatty acid-binding protein to small anionic phospholipid vesicles results in ligand release: A model for interfacial binding and fatty acid targeting'. AMER CHEMICAL SOC BIOCHEMISTRY, 38 (51), pp. 16932-16940.doi: 10.1021/bi991926q
- . (1998) 'Monoacylglycerol binding to human serum albumin: Evidence that monooleoylglycerol binds at the dansylsarcosine site'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 39 (5), pp. 1033-1038.
- . (1997) 'A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis'. PERGAMON-ELSEVIER SCIENCE LTD BIOCHEMICAL PHARMACOLOGY, 53 (3), pp. 433-435.
- . (1996) 'The binding of cholesterol and bile salts to recombinant rat liver fatty acid-binding protein'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 320, pp. 729-733.
- . (1996) 'Mutations of recombinant rat liver fatty acid-binding protein at residues 102 and 122 alter its structural integrity and affinity for physiological ligands'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 314, pp. 943-949.
- . (1995) 'THE BINDING OF NATURAL AND FLUORESCENT LYSOPHOSPHOLIPIDS TO WILD-TYPE AND MUTANT RAT-LIVER FATTY-ACID-BINDING PROTEIN AND ALBUMIN'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 307, pp. 305-311.
- . (1994) 'THE BINDING OF LYSOPHOSPHOLIPIDS TO RAT-LIVER FATTY-ACID-BINDING PROTEIN AND ALBUMIN'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 301, pp. 801-806.
- . (1994) 'CHARACTERIZATION OF BINDING AND STRUCTURAL-PROPERTIES OF RAT-LIVER FATTY-ACID-BINDING PROTEIN USING TRYPTOPHAN MUTANTS'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 300, pp. 827-833.
- . (1994) 'HEME PEPTIDE/PROTEIN INTERACTION .6. THE KINETIC MECHANISMS OF THE INTERACTIONS WITH, AND INHIBITION OF ENZYMATIC-ACTIVITY OF THE HUMAN ERYTHROCYTE GLUTATHIONE-S-TRANSFERASE ISOENZYME-RHO-(P), BY HEME OCTAPEPTIDE, NONAPEPTIDE, AND UNDECAPEPTIDE MP-8/-9/-11'. ELSEVIER SCIENCE INC JOURNAL OF INORGANIC BIOCHEMISTRY, 53 (3), pp. 157-168.
- . (1994) 'EFFECT ON LIGAND-BINDING OF ARGININE MUTATIONS IN RECOMBINANT RAT-LIVER FATTY-ACID-BINDING PROTEIN'. PORTLAND PRESS BIOCHEMICAL JOURNAL, 297, pp. 103-107.
- . (1993) 'KINETIC MECHANISM OF HUMAN ERYTHROCYTE ACIDIC ISOENZYME-RHO'. ELSEVIER SCIENCE BV BIOCHIMICA ET BIOPHYSICA ACTA, 1203 (1), pp. 115-120.
- . (1993) 'HEME-PEPTIDE-PROTEIN INTERACTIONS .5. THE HEME UNDECAPEPTIDE MICROPEROXIDASE-11 (FE3+MP-11) HUMAN SERUM-ALBUMIN (HSA) REACTION IN AQUEOUS METHANOLIC SOLUTION - A SIMPLE SYSTEM DEMONSTRATING THE EFFECT OF HYDROPHOBICITY ON LIGAND RELEASE FROM A LIGAND-PROTEIN COMPLEX'. ELSEVIER SCIENCE INC JOURNAL OF INORGANIC BIOCHEMISTRY, 50 (1), pp. 1-7.
- . (1990) 'REVERSIBLE INHIBITION OF RAT HEPATIC GLUTATHIONE-S-TRANSFERASE 1-2 BY BILIRUBIN'. PERGAMON-ELSEVIER SCIENCE LTD BIOCHEMICAL PHARMACOLOGY, 40 (7), pp. 1563-1568.
- . (1988) 'HALOTHANE - INHIBITION AND ACTIVATION OF RAT HEPATIC GLUTATHIONE S-TRANSFERASES'. PERGAMON-ELSEVIER SCIENCE LTD BIOCHEMICAL PHARMACOLOGY, 37 (10), pp. 1903-1908.
- . (1987) 'REVERSIBLE INHIBITION AND ACTIVATION OF HEPATIC GSH S-TRANSFERASES BY ETHYLENE DIBROMIDE'. PERGAMON-ELSEVIER SCIENCE LTD PHARMACOLOGY & THERAPEUTICS, 33 (1), pp. 85-88.
Conference papers
- . (2009) 'Impact of transporter-mediated uptake on statin-induced gene expression in human Huh7 cells'. ELSEVIER IRELAND LTD TOXICOLOGY, Univ Warwick, Coventry, ENGLAND: Annual Congress of the British-Toxicological-Society 262 (1), pp. 20-21.
- . (2007) 'Influence of metabolic stimuli on transcriptional regulation by Hepatocyte Nuclear Factor 4 alpha'. SPRINGER DIABETOLOGIA, Amsterdam, NETHERLANDS: 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes 50, pp. S238-S239.
- . (2006) 'Evolution of the fatty acid-binding protein family: An ordered increase in gene number, correlating to more refined mechanisms of lipid processing'. ELSEVIER IRELAND LTD TOXICOLOGY, Univ Warwick, Coventry, ENGLAND: Joint Congress of the British-Toxicology-Society/29th Annual Meeting of the United-Kingdom-Environmental-Mutagen-Society 226 (1), pp. 73-74.
- . (2001) 'Collision-mediated transfer of long-chain fatty acids by neural tissue fatty acid-binding proteins (FABP) - Studies with fluorescent analogs'. HUMANA PRESS INC JOURNAL OF MOLECULAR NEUROSCIENCE, BETHESDA, MARYLAND: International Workshop on Brain Uptake and Utilization of Fatty Acids 16 (2-3), pp. 143-150.
- . (1998) 'Liver fatty acid binding protein (FABP) binds to anionic phospholipid vesicles with release of ligand'. PORTLAND PRESS BIOCHEMICAL SOCIETY TRANSACTIONS, UNIV SOUTHAMPTON, HANTS, ENGLAND: 665th Meeting of the Royal-Irish-Academy-Lecture on Peptide Metabolism in Cytoplasm of Brain Cells 26 (3), pp. S238-S238.
Teaching
- Level 1: BMS1030 Biochemistry:
- Level 2: BMS2035 Enzymology & Metabolism
- Level 3: BMS3052 Biochemistry - Receptors and Energy Metabolism
- Undergraduate research projects
- MSc research projects (Clinical Biochemistry; Toxicology)
- MSc Toxicology: Debate on scientific ethics (part of the Key Skills course)
- MSc Clin. Biochem. (M5)
Departmental Duties
MSc Clinical Biochemistry: Programme Director
Module co-ordinator: BMS2035 Enzymes and Metabolism
Module co-ordinator: BMS3052 Biochemistry - Receptors and Energy Metabolism
Module co-ordinator: MSc Clinical Biochemistry
PhD supervisor
Affiliations
Biochemical Society (United Kingdom)
In Vitro Toxicology Society (Committee Secretary)
