Cardiovascular Disease, Diabetes & Metabolism Research Theme
Within the Faculty of Health and Medical Sciences, there are approximately 20 academic members of staff who are actively engaged in research related to the cardiovascular system.
This multidisciplinary theme focuses on the study of the pathophysiological mechanisms underlying cardiovascular disease and metabolic diseases such as obesity and diabetes. The theme brings together scientists and physicians with expertise in cell and molecular biology, immunology, physiology, nutrition and appetite regulation, drug development, chemistry, and the regulation of sleep and circadian rhythms.
We aim to translate this understanding into effective treatment with improved nutrition regimes and drug treatment which targets the underlying abnormalities and the development of diagnostic methods including molecular bio-markers.
Our state of the art facilities include functional genomics, proteomics and metabonomics suites, a mass spectrometry unit for measurement of stable isotopes for in vivo kinetic studies and in vitro facilities for celllular electrophysiology and imaging. Clinical studies are undertaken in our Clinical Research Centre which has twelve individual rooms and a 12-bedded ward with full clinical/sleep monitoring ability or in the Metabolic Research Unit at the Diabetes Centre, Royal Surrey County Hospital, adjacent to the new purpose-designed academic building for postgraduate medicine.
Key Areas of Research
Redox-signalling of endothelial dysfunction
The immune system in atherosclerosis
The genetics of cardiovascular disease
Arrhythmias and contractile dysfunction
Circadian rhythms and cardiovascular function
Vitamin D, insulin resistance and diabetes
Lipid metabolism in obesity and diabetes
Nutritional intervention in cardiometabolic disorders
Resistant starch in insulin resistance and diabetes
