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Dr Simon Archer

Reader in Chronobiology, Biochemistry Admissions Tutor, Sleep Chronobiology and Neurodisorders Theme Leader

Qualifications: BSc, PhD

Email:
Phone: Work: 01483 68 6408
Room no: 03 AY 02

Office hours

By appoinment

Further information

Biography

Dr Archer received his BSc in Biological Sciences from the University of Sussex and his PhD in Zoology from the University of Bristol, where he studied photoreceptor visual pigment absorbance spectra and colour vision polymorphisms. As a postdoctoral fellow at Bristol, he cloned some of the first visual pigment opsin genes, before moving to Sardinia on a EU Fellowship to help to set up the International Marine Centre (IMC) at Oristano, where he was Group Leader of Molecular Sensory Ecology. He then joined chronobiology researchers at Surrey, where he is now a Reader in Chronobiology. His current research interests include the molecular aspects of the circadian clock and sleep homeostat systems. He is particularly interested in how polymorphisms in sleep and circadian genes can affect gene expression and function, and be associated with inter-individual differences in sleep and circadian-related phenotypes, in both humans and animal models.

Dr Archer has published over 45 peer-reviewed papers and invited reviews, and edited two books. He is a member of the British Sleep Society, the European Sleep Research Society, and the Society for Research on Biological Rhythms.

Research Interests

 

  • Human sleep and circadian genetics
  • Human sleep and circadian genotype-phenotype associations
  • Transgenic sleep and circadian models
  • Circadian clock gene expression

Current Research Funding

BBSRC New Investigator Award (2007-2010) 'Genetic and phenotypic outputs of the circadian clock in Per3 knock-out and humanised Per3 knock-in mice. S N Archer (PI)

BBSRC (2008-2011). 'Circadian and homeostatic contributions to physiology, cognition and genome-wide expression in human and mouse variants of the PER3 VNTR polymorphism'. D-J Dijk (PI), J Groeger, S N Archer, M von Schantz, C P Smith, & J Johnston

AFOSR (2008-2011). 'Cognitive vulnerability following extended wakefullness in defined genotypes''. D-J Dijk (PI), J Groeger, S N Archer, M von Schantz, C P Smith & A Kierzek

Philips Lighting (2009-2010) Evaluation of evening light regimes which minimise suppression of melatonin and the nocturnal increase in sleepiness but maintain visual function, D-J Dijk (PI) & S N Archer, £144,593

Publications

Highlights

  • Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010) 'Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (5), pp. 695-701.
    Full text is available at: http://epubs.surrey.ac.uk/207034/

    Abstract

    Study Objectives: To screen the PER3 promoter for polymorphisms and investigate the phenotypic associations of these polymorphisms with diurnal preference, delayed sleep phase disorder/syndrome (DSPD/DSPS), and their effects on reporter gene expression. Design: Interspecific comparison was used to define the approximate extent of the PER3 promoter as the region between the transcriptional start site and nucleotide position −874. This region was screened in DNA pools using PCR and direct sequencing, which was also used to screen DNA from individual participants. The different promoter alleles were cloned into a luciferase expression vector and a deletion library created. Promoter activation was measured by chemiluminescence. Setting: N/A Patients or Participants: DNA samples were obtained from volunteers with defined diurnal preference (3 x 80, selected from a pool of 1,590), and DSPD patients (n = 23). Interventions: N/A Measurements and Results: We verified three single nucleotide polymorphisms (G −320T, C −319A, G −294A), and found a novel variable number tandem repeat (VNTR) polymorphism (−318 1/2 VNTR). The −320T and −319A alleles occurred more frequently in DSPD compared to morning (P = 0.042 for each) or evening types (P = 0.006 and 0.033). The allele combination TA2G was more prevalent in DSPD compared to morning (P = 0.033) or evening types (P = 0.002). Luciferase expression driven by the TA2G combination was greater than for the more common GC2A (P < 0.05) and the rarer TA1G (P < 0.001) combinations. Deletion reporter constructs identified two enhancer regions (−703 to −605, and −283 to −80). Conclusions: Polymorphisms in the PER3 promoter could affect its expression, leading to potential differences in the observed functions of PER3.

  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D-J. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.
    doi: 10.1523/JNEUROSCI.0229-09.2009
    Full text is available at: http://epubs.surrey.ac.uk/289609/
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk D-J. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.
    Full text is available at: http://epubs.surrey.ac.uk/285505/

    Abstract

    Study Objectives: Individual sleep timing differs and is governed partly by circadian oscillators, which may be assessed by hormonal markers, or by clock gene expression. Clock gene expression oscillates in peripheral tissues, including leukocytes. The study objective was to determine whether the endogenous phase of these rhythms, assessed in the absence of the sleep-wake and light-dark cycle, correlates with habitual sleep-wake timing. Design: Observational, cross-sectional. Setting: Home environment and Clinical Research Center. Participants: 24 healthy subjects aged 25.0 ± 3.5 (SD) years. Measurements: Actigraphy and sleep diaries were used to characterize sleep timing. Circadian rhythm phase and amplitude of plasma melatonin, cortisol, and BMAL1, PER2, and PER3 expression were assessed during a constant routine. Results: Circadian oscillations were more robust for PER3 than for BMAL1 or PER2. Average peak timings were 6:05 for PER3, 8:06 for PER2, 15:06 for BMAL1, 4:20 for melatonin, and 10:49 for cortisol. Individual sleep-wake timing correlated with the phases of melatonin and cortisol. Individual PER3 rhythms correlated significantly with sleep-wake timing and the timing of melatonin and cortisol, but those of PER2 and BMAL1 did not reach significance. The correlation between sleep timing and PER3 expression was stronger in individuals homozygous for the variant of the PER3 polymorphism that is associated with morningness. Conclusions: Individual phase differences in PER3 expression during a constant routine correlate with sleep timing during entrainment. PER3 expression in leukocytes represents a useful molecular marker of the circadian processes governing sleep-wake timing.

  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk D-J. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURRENT BIOLOGY, 17 (7), pp. 613-618.
    doi: 10.1016/j.cub.2007.01.073

Journal articles

  • Lazar AS, Santhi N, Hasan S, Lo JC, Johnston JD, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res,
    doi: 10.1111/jsr.12001
  • Adan A, Adan A, Archer SN, Hidalgo MP, Hidalgo MP, Di Milia L, Natale V, Randler C. (2012) 'Circadian typology: A comprehensive review'. Chronobiology International, 29 (9), pp. 1153-1175.
    doi: 10.3109/07420528.2012.719971
  • Santhi N, Thorne HC, Van Der Veen DR, Archer SN, Dijk D-J, Johnsen S, Mills SL, Hommes V, Schlangen LJM. (2012) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans'. Journal of Pineal Research, 53 (1), pp. 47-59.
    doi: 10.1111/j.1600-079X.2011.00970.x
  • Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ. (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
    doi: 10.3109/07420528.2011.641193
  • Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ. (2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J, United States: 26 (6), pp. 2414-2423.
    doi: 10.1096/fj.11-201699
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase.'. PLoS One, United States: 7 (9)
    doi: 10.1371/journal.pone.0045987
  • Viola AU, Chellappa SL, Pugin F, Götz T, Cajochen C, Chellappa SL, Archer SN, Dijk D-J. (2012) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: Effect of a PER3 polymorphism'. Neurobiology of Aging, 33 (5)
    doi: 10.1016/j.neurobiolaging.2011.10.024
  • Viola AU, Chellappa SL, Archer SN, Pugin F, Götz T, Dijk DJ, Cajochen C. (2011) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiol Aging, United States: 33 (5), pp. 1010.e17-1010.e27.
    doi: 10.1016/j.neurobiolaging.2011.10.024
  • Hasan S, van der Veen DR, Winsky-Sommerer R, Dijk DJ, Archer SN. (2011) 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol, United States: 301 (6), pp. R1821-R1830.
    doi: 10.1152/ajpregu.00260.2011
  • Santhi N, Thorne HC, van der Veen DR, Johnsen S, Mills SL, Hommes V, Schlangen LJ, Archer SN, Dijk DJ. (2011) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.'. J Pineal Res, Denmark: 53 (1), pp. 47-59.
    doi: 10.1111/j.1600-079X.2011.00970.x
  • Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM. (2011) 'Sleep Quality and Diurnal Preference in a Sample of Young Adults: Associations With 5HTTLPR, PER3, and CLOCK 3111'. WILEY-BLACKWELL AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 156B (6), pp. 681-690.
    doi: 10.1002/ajmg.b.31210
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P. (2011) 'Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.'. J Biol Rhythms, United States: 26 (3), pp. 249-259.
    doi: 10.1177/0748730411401736
    Full text is available at: http://epubs.surrey.ac.uk/289613/

    Abstract

    Light is a powerful modulator of cognition through its long-term effects on circadian rhythmicity and direct effects on brain function as identified by neuroimaging. How the direct impact of light on brain function varies with wavelength of light, circadian phase, and sleep homeostasis, and how this differs between individuals, is a largely unexplored area. Using functional MRI, we compared the effects of 1 minute of low-intensity blue (473 nm) and green light (527 nm) exposures on brain responses to an auditory working memory task while varying circadian phase and status of the sleep homeostat. Data were collected in 27 subjects genotyped for the PER3 VNTR (12 PER3(5/5) and 15 PER3(4/4) ) in whom it was previously shown that the brain responses to this task, when conducted in darkness, depend on circadian phase, sleep homeostasis, and genotype. In the morning after sleep, blue light, relative to green light, increased brain responses primarily in the ventrolateral and dorsolateral prefrontal cortex and in the intraparietal sulcus, but only in PER3(4/4) individuals. By contrast, in the morning after sleep loss, blue light increased brain responses in a left thalamofrontoparietal circuit to a larger extent than green light, and only so in PER3(5/5) individuals. In the evening wake maintenance zone following a normal waking day, no differential effect of 1 minute of blue versus green light was observed in either genotype. Comparison of the current results with the findings observed in darkness indicates that light acts as an activating agent particularly under those circumstances in which and in those individuals in whom brain function is jeopardized by an adverse circadian phase and high homeostatic sleep pressure.

  • Dijk D-J, Archer SN. (2010) 'PERIOD3, circadian phenotypes, and sleep homeostasis'. W B SAUNDERS CO LTD SLEEP MEDICINE REVIEWS, 14 (3), pp. 151-160.
    doi: 10.1016/j.smrv.2009.07.002
  • Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010) 'Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (5), pp. 695-701.
    Full text is available at: http://epubs.surrey.ac.uk/207034/

    Abstract

    Study Objectives: To screen the PER3 promoter for polymorphisms and investigate the phenotypic associations of these polymorphisms with diurnal preference, delayed sleep phase disorder/syndrome (DSPD/DSPS), and their effects on reporter gene expression. Design: Interspecific comparison was used to define the approximate extent of the PER3 promoter as the region between the transcriptional start site and nucleotide position −874. This region was screened in DNA pools using PCR and direct sequencing, which was also used to screen DNA from individual participants. The different promoter alleles were cloned into a luciferase expression vector and a deletion library created. Promoter activation was measured by chemiluminescence. Setting: N/A Patients or Participants: DNA samples were obtained from volunteers with defined diurnal preference (3 x 80, selected from a pool of 1,590), and DSPD patients (n = 23). Interventions: N/A Measurements and Results: We verified three single nucleotide polymorphisms (G −320T, C −319A, G −294A), and found a novel variable number tandem repeat (VNTR) polymorphism (−318 1/2 VNTR). The −320T and −319A alleles occurred more frequently in DSPD compared to morning (P = 0.042 for each) or evening types (P = 0.006 and 0.033). The allele combination TA2G was more prevalent in DSPD compared to morning (P = 0.033) or evening types (P = 0.002). Luciferase expression driven by the TA2G combination was greater than for the more common GC2A (P < 0.05) and the rarer TA1G (P < 0.001) combinations. Deletion reporter constructs identified two enhancer regions (−703 to −605, and −283 to −80). Conclusions: Polymorphisms in the PER3 promoter could affect its expression, leading to potential differences in the observed functions of PER3.

  • van der Veen DR, Archer SN. (2010) 'Light-Dependent Behavioral Phenotypes in PER3-Deficient Mice'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 25 (1), pp. 3-8.
    doi: 10.1177/0748730409356680
    Full text is available at: http://epubs.surrey.ac.uk/142841/
  • Barclay NL, Eley TC, Buysse DJ, Archer SN, Gregory AM. (2010) 'DIURNAL PREFERENCE AND SLEEP QUALITY: SAME GENES? A STUDY OF YOUNG ADULT TWINS'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 27 (2), pp. 278-296.
    doi: 10.3109/07420521003663801
    Full text is available at: http://epubs.surrey.ac.uk/145880/
  • Van der Veen DR, Archer SN. (2010) 'Light-dependent behavioral phenotypes in PER3-deficient mice (vol 25, pg 3, 2010)'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 25 (2), pp. 150-150.
    doi: 10.1177/0748730410364011
  • Staples VSL, Archer SN, Arber S, Skene DJ. (2009) 'Daily light exposure profiles in older non-resident extreme morning and evening types'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, 18 (4), pp. 466-471.
    doi: 10.1111/j.1365-2869.2009.00762.x
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D-J. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE JOURNAL OF NEUROSCIENCE, 29 (25), pp. 7948-7956.
    doi: 10.1523/JNEUROSCI.0229-09.2009
    Full text is available at: http://epubs.surrey.ac.uk/289609/
  • Dijk D-J, Archer SN. (2009) 'Light, Sleep, and Circadian Rhythms: Together Again'. PUBLIC LIBRARY SCIENCE PLOS BIOLOGY, 7 (6) Article number ARTN e1000145
    doi: 10.1371/journal.pbio.1000145
    Full text is available at: http://epubs.surrey.ac.uk/2608/
  • Ellis J, von Schantz M, Jones KHS, Archer SN. (2009) 'Association between Specific Diurnal Preference Questionnaire Items and PER3 VNTR Genotype'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 26 (3) Article number PII 910356950 , pp. 464-473.
    doi: 10.1080/07420520902820970
  • Dijk D-J, Archer SN. (2009) 'Circadian and Homeostatic Regulation of Human Sleep and Cognitive Performance and Its Modulation by PERIOD3'. Sleep Medicine Clinics, 4 (2), pp. 111-125.
    doi: 10.1016/j.jsmc.2009.02.001
  • Pugin F, Viola AU, Chellappa SL, Archer S, Dijk DJ, Cajochen C. (2009) 'Can Per3 Length Polymorphism Predict Sleep Duration in Older Individuals?'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 255-255.
    doi: 10.1159/000230666
  • Thorne HC, Jones KH, Peters SP, Archer SN, Dijk D-J. (2009) 'Daily and Seasonal Variation in the Spectral Composition of Light Exposure in Humans'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 26 (5) Article number PII 913454756 , pp. 854-866.
    doi: 10.1080/07420520903044315
    Full text is available at: http://epubs.surrey.ac.uk/289608/
  • Skene DJ, Sletten TL, Ackermann K, Herljevic M, Lederle KA, Middleton B, Archer SN, Revell VL. (2009) 'LIGHT AND THE HUMAN CIRCADIAN TIMING SYSTEM: AGE-RELATED CHANGES'. SPRINGER TOKYO JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, pp. 37-37.
  • Ackermann K, Sletten TL, Revell VL, Archer SN, Skene DJ. (2009) 'Blue-Light Phase Shifts PER3 Gene Expression in Human Leukocytes'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 26 (4) Article number PII 911212256 , pp. 769-779.
    doi: 10.1080/07420520902929045
  • Viola AU, James LM, Archer SN, Dijk D-J. (2008) 'PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 295 (5), pp. H2156-H2163.
    doi: 10.1152/ajpheart.00662.2008
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk D-J. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.
    Full text is available at: http://epubs.surrey.ac.uk/285505/

    Abstract

    Study Objectives: Individual sleep timing differs and is governed partly by circadian oscillators, which may be assessed by hormonal markers, or by clock gene expression. Clock gene expression oscillates in peripheral tissues, including leukocytes. The study objective was to determine whether the endogenous phase of these rhythms, assessed in the absence of the sleep-wake and light-dark cycle, correlates with habitual sleep-wake timing. Design: Observational, cross-sectional. Setting: Home environment and Clinical Research Center. Participants: 24 healthy subjects aged 25.0 ± 3.5 (SD) years. Measurements: Actigraphy and sleep diaries were used to characterize sleep timing. Circadian rhythm phase and amplitude of plasma melatonin, cortisol, and BMAL1, PER2, and PER3 expression were assessed during a constant routine. Results: Circadian oscillations were more robust for PER3 than for BMAL1 or PER2. Average peak timings were 6:05 for PER3, 8:06 for PER2, 15:06 for BMAL1, 4:20 for melatonin, and 10:49 for cortisol. Individual sleep-wake timing correlated with the phases of melatonin and cortisol. Individual PER3 rhythms correlated significantly with sleep-wake timing and the timing of melatonin and cortisol, but those of PER2 and BMAL1 did not reach significance. The correlation between sleep timing and PER3 expression was stronger in individuals homozygous for the variant of the PER3 polymorphism that is associated with morningness. Conclusions: Individual phase differences in PER3 expression during a constant routine correlate with sleep timing during entrainment. PER3 expression in leukocytes represents a useful molecular marker of the circadian processes governing sleep-wake timing.

  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk D-J. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURRENT BIOLOGY, 17 (7), pp. 613-618.
    doi: 10.1016/j.cub.2007.01.073
  • Jones KHS, Ellis J, Von Schantz M, Skene DJ, Dijk D-J, Archer SN. (2007) 'Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (1), pp. 12-16.
    doi: 10.1111/j.1365-2869.2007.00561.x
  • Hogben AL, Ellis J, Archer SN, von Schantz M. (2007) 'Conscientiousness is a predictor of diurnal preference.'. Chronobiol Int, United States: 24 (6), pp. 1249-1254.
    doi: 10.1080/07420520701791596
  • Hogben AL, Archer SN, Von Schantz M, Ellis J, Von Schantz M. (2007) 'Conscientiousness is a predictor of diurnal preference'. Chronobiology International, 24 (6), pp. 1249-1254.
    doi: 10.1080/07420520701791596
  • von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. SPRINGER JOURNAL OF MOLECULAR EVOLUTION, 62 (6), pp. 701-707.
    doi: 10.1007/s00239-005-0185-1
  • Carpen JD, von Schantz M, Smits M, Skene DJ, Archer SN. (2006) 'A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans'. SPRINGER TOKYO JOURNAL OF HUMAN GENETICS, 51 (12), pp. 1122-1125.
    doi: 10.1007/s10038-006-0060-y
    Full text is available at: http://epubs.surrey.ac.uk/145882/
  • Von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. Journal of Molecular Evolution, 62 (6), pp. 701-707.
    doi: 10.1007/s00239-005-0185-1
  • Jenkins A, Archer SN, von Schantz M. (2005) 'Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene Period3'. SAGE PUBLICATIONS LTD JOURNAL OF BIOLOGICAL RHYTHMS, 20 (5), pp. 470-472.
    doi: 10.1177/0748730405278442
  • Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M. (2005) 'A single-nucleotide polymorphism in the 5 '-untranslated region of the hPER2 gene is associated with diurnal preference'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 14 (3), pp. 293-297.
    doi: 10.1111/j.1365-2869.2005.00471.x
  • Van Der Heijden KB, Blok MJ, Spee K, Curfs LM, Archer SN, Smits MG, Gunning WB, Van Der Heijden KB. (2005) 'No evidence to support an association of PER3 clock gene polymorphism with ADHD-related idiopathic chronic sleep onset insomnia'. Biological Rhythm Research, 36 (5), pp. 381-388.
    doi: 10.1080/09291010500218449
  • Carpen JD, Archer SN, Skene DJ, Von Schantz M, Smits M. (2005) 'A single-nucleotide polymorphism in the 5′-untranslated region of the hPER2 gene is associated with diurnal preference'. Journal of Sleep Research, 14 (3), pp. 293-297.
    doi: 10.1111/j.1365-2869.2005.00471.x
  • Jenkins A, Archer SN, Von Schantz M. (2005) 'Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene Period3'. Journal of Biological Rhythms, 20 (5), pp. 470-472.
    doi: 10.1177/0748730405278442
  • Archer SN, Ahuja P, Caffe R, Mikol C, Foster RG, van Veen T, von Schantz M. (2004) 'Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells'. BLACKWELL PUBLISHING LTD EUROPEAN JOURNAL OF NEUROSCIENCE, 19 (11), pp. 2923-2930.
    doi: 10.1111/j.1460-9568.2004.03417.x
  • von Schantz M, Archer SN. (2003) 'Clocks, genes and sleep'. ROYAL SOC MEDICINE PRESS LTD JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 96 (10), pp. 486-489.
    doi: 10.1258/jrsm.96.10.486
  • Archer SN, Robilliard DL, Skene DJ, Arendt J, Von Schantz M, Smits M, Williams A, Von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. Sleep, 26 (4), pp. 413-415.
    Full text is available at: http://epubs.surrey.ac.uk/2847/

    Abstract

    Study Objectives: To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. Design: Subjects were genotyped using polymerase chain reaction. Patients or Participants: Subjects with defined diurnal preference as determined by the Horne-Östberg questionnaire and patients with delayed sleep phase syndrome. Measurements and Results: The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the delayed sleep phase syndrome patients, 75% of whom were homozygous. Conclusion: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.

  • Von Schantz M, Archer SN. (2003) 'Clocks, genes and sleep'. Journal of the Royal Society of Medicine, 96 (10), pp. 486-489.
    doi: 10.1258/jrsm.96.10.486
  • Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, von Schantz M. (2002) 'The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects'. BLACKWELL PUBLISHING LTD JOURNAL OF SLEEP RESEARCH, 11 (4), pp. 305-312.
    doi: 10.1046/j.1365-2869.2002.00320.x
  • Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Skene DJ, Von Schantz M, Leger D, Smits MG, Williams A. (2002) 'The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects'. Journal of Sleep Research, 11 (4), pp. 305-312.
    doi: 10.1046/j.1365-2869.2002.00320.x
  • Archer S, Hope A, Partridge JC. (1995) 'The molecular basis for the green-blue sensitivity shift in the rod visual pigments of the European eel'. ROYAL SOC PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 262 (1365), pp. 289-295.
    doi: 10.1098/rspb.1995.0208
  • ARCHER SN, LYTHGOE JN, HALL L. (1992) 'ROD OPSIN CDNA SEQUENCE FROM THE SAND GOBY (POMATOSCHISTUS-MINUTUS) COMPARED WITH THOSE OF OTHER VERTEBRATES'. ROYAL SOC PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 248 (1321), pp. 19-25.
    doi: 10.1098/rspb.1992.0037
  • PARTRIDGE JC, ARCHER SN, VANOOSTRUM J. (1992) 'SINGLE AND MULTIPLE VISUAL PIGMENTS IN DEEP-SEA FISHES'. CAMBRIDGE UNIV PRESS JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM, 72 (1), pp. 113-130.
  • ARCHER SN, LYTHGOE JN. (1990) 'THE VISUAL PIGMENT BASIS FOR CONE POLYMORPHISM IN THE GUPPY, POECILIA-RETICULATA'. PERGAMON-ELSEVIER SCIENCE LTD VISION RESEARCH, 30 (2), pp. 225-233.
    doi: 10.1016/0042-6989(90)90038-M
  • Partridge JC, Shand J, Archer SN, Lythgoe JN, van Groningen-Luyben WAHM. (1989) 'Interspecific variation in the visual pigments of deep-sea fishes'. Journal of Comparative Physiology A, 164 (4), pp. 513-529.
    doi: 10.1007/BF00610445
  • ARCHER SN, ENDLER JA, LYTHGOE JN, PARTRIDGE JC. (1987) 'VISUAL PIGMENT POLYMORPHISM IN THE GUPPY POECILIA-RETICULATA'. PERGAMON-ELSEVIER SCIENCE LTD VISION RESEARCH, 27 (8), pp. 1243-1252.
    doi: 10.1016/0042-6989(87)90200-8

Conference papers

  • Jaspar M, Meyer C, Muto V, Shaffii-Le Bourdiec A, Kusse C, Vandewalle G, Collette F, Archer S, Dijk D-J, Maquet P. (2012) 'Influence of sleep homeostasis and circadian rhythm on executive discriminative ability during a constant routine'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 328-328.
  • Arbon EL, Lazar AS, Lo JC, Slak A, Mccabe PJ, Boyle J, Archer SN, Dijk D-J. (2012) 'Individual differences in sleep revisited: stability across sleep restriction, extension and total sleep loss'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 207-208.
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of circadian phase and prior partial sleep deprivation on executive functions during total sleep deprivation are modulated by PER3 polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 41-41.
  • Groeger JA, Lo JC, Santhi N, Arbon EL, Lazar A, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) ''Trait-like' susceptibility to sleep loss varies with circadian phase and the task used to index vulnerable-resilient sleep-deprived performance'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 36-37.
  • Muto V, Meyer C, Jaspar M, Shaffii-Le Bourdiec A, Kusse C, Foret A, Vandewalle G, Collette F, Archer S, Dijk D-J, Maquet P. (2012) 'Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during a constant routine'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 327-328.
  • Shaffii-Le Bourdiec A, Muto V, Jaspar M, Kusse C, Foret A, Archer SN, Le Bourdiec F, Vandewalle G, Collette F, Dijk DJ, Maquet P. (2012) 'Difference in neural correlates of discrimination during sleep deprivation in PER3 homozygous'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
  • Lazar A, Santhi N, Lo J, Slak A, Hasan S, Von Schantz M, Archer S, Dijk D-J. (2012) 'The circadian and homeostatic regulation of sleep spindle activity: effect of the PER3 VNTR polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
  • Van der Veen DR, Dijk D-J, Archer SN. (2012) 'A role for PERIOD3 in sleep/wake rhythms: photic responses in humanised knock-in mice and gene expression correlates of PER3 expression'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 333-333.
  • Hasan S, Winsky-Sommerer R, Dijk D-J, Archer SN. (2012) 'Sleep in transgenic mouse models for a polymorphism in the human PER3 gene'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 79-79.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk D, Maquet P. (2009) 'MODULATION OF FMRI ASSESSED BRAIN RESPONSES TO BLUE AND GREEN LIGHT BY SLEEP HOMFOSTASIS, CIRCADIAN PHASE AND PER3 POLYMORPHISM'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Societies 32, pp. A1-A1.
  • Groeger JA, Lo JC, Viola AU, Schantz MV, Archer SN, Dijk D. (2008) 'Period3 and the effects of sleep deprivation on executive function: the importance of circadian phase'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 1-1.
  • Von Schantz W, Carpen JD, Gibson M, Lim G, Johnston J, Skene DJ, Archer SN. (2008) 'Analysis of the PER3 promoter and haplotypes that associate with diurnal preference and delayed sleep phase disorder'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 80-80.
  • Vandewalle G, Archer S, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'Polymorphism in period3 predicts fMRI-assessed inter-individual differences in the effects of sleep deprivation'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • Vaughan V, Archer S, Skene DJ, Arber S. (2008) 'Daily light exposure profiles in older extreme morning and evening types'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 73-73.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A107-A107.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'A period 3 polymorphism predicts FMRI assessed brain responses following sleep loss'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A111-A111.
  • Groeger J, Lo J, Viola A, Von Schantz M, Archer S, Dijk D. (2007) 'PER3 polymorphism predictssusceptibility to sleep deprivation-induced impairment of early morning executive performance'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A54.
  • Archer S, Viola A, Von Schantz M, Dijk D. (2007) 'Endogenous circadian rhythm of PER3 RNA in human leucocytes: Association with sleep timing, melatonin rhythm, and PER3 genotype'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A55.
  • Jones KH, Ellis J, Von Schantz M, Skene DJ, Dijk D, Archer SN. (2006) 'Age-related change in the association between a variable number tandem repeat polymorphism in the (PER3) gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 97-98.
  • Von Schantz M, Archer SN. (2006) 'Genetic aspects of delayed sleep phase syndrome (DSPS)'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 5-5.
  • Vaughan V, Meadows R, Archer SN, Skene DJ, Arber S. (2006) 'Diurnal preference in couples: negotiating sleep timing'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 95-95.
  • Viola AU, Archer SN, Groeger JA, Skene DJ, Von Schantz M, Dijk DJ. (2006) 'Polymorphism in the clock gene PER3 predicts sleep structure and EEG power spectra'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 53-53.
  • Archer SN, Robillard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A109-A109.
  • Archer SN, Lucas RJ, Thompson S, Foster RG, von Schantz M. (2002) 'Identification of a novel retinal kinase with promoter elements affected by circadian clock proteins'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, FT LAUDERDALE, FLORIDA: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology 43, pp. U308-U308.

Teaching

 

BMS1007 - Practical Cell & Molecular Biology (Module coordinator)

BMS2023 - Analytical Biochemistry

BMS3034 - Biological Rhythms

BMS3042 - Neuroscience: From Molecules to Mind

MSc Clinical Biochemistry

Departmental Duties

 

Biochemistry Admissions Tutor

Sleep, Chronobiology & Neurodisorders Theme Leader

Affiliations

 

British Sleep Society - member

European Sleep Research Society - member

Society for Research on Biological Rhythms - member