Current Research

Current Research Activity

Sleep and Cognition

  • Sleep and the cognitive decline associated with sleep loss differ between individuals
  •  We discovered that
    • A primate-specific polymorphism in the circadian clock gene PERIOD3 predicts
      •  Sleep characteristics
      • Cognitive decline due to sleep loss
    • This provides a unique opportunity to
      • better understand the mechanisms
      • underlying individual differences
      • by which this clock gene influences sleep and cognition
    • Identify novel biomarkers
    • Develop novel countermeasures for cognitive decline associated with sleep loss and circadian misalignment

Approach
Data Collection: Human

  • Genotype ~ 1,500 people for the PER3 polymorphism
  • Stratify study population (n=72) according to PER3 genotype
  • Perturb sleep and circadian rhythmicity
    • Forced desynchrony protocol
    • Sleep restriction/extension followed by ‘extended nightshift’
  • Assess cognition and sleep physiology
  • Obtain samples for the analysis of
    • Endocrine markers of circadian rhythmicity
    • Cell culture studies of circadian rhythms in vitro
    • PERIOD3 protein rhythms
    • Genome wide gene expression profiling by microarray

Data Analysis

  • Merge data:
  • Sleep physiology
    • Circadian physiology
    • Cognition
    • Gene expression profiling
  • Bioinformatics and modelling approaches
  • Identify metabolic and signalling pathways related to
    • PER3 genotype related differences
    • Other individual differences

Contact Us

Surrey Sleep Research Centre/
Surrey Clinical Research Centre
Egerton Road
Guildford GU2 7XP
United Kingdom
T: +44 (0)1483 682502
E: sleep@surrey.ac.uk

Page Owner: bss1dd
Page Created: Wednesday 29 July 2009 14:44:14 by t00345
Last Modified: Monday 9 June 2014 10:49:22 by kj0008
Expiry Date: Friday 1 October 2010 17:07:53
Assembly date: Fri Sep 19 17:01:30 BST 2014
Content ID: 10855
Revision: 3
Community: 1020