Drug Design, Cancer & Toxicity Publications

2011
Bailey, I., G. G. Gibson, K. Plant, M. Graham and N. Plant. A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16a-Carbonitrile. PLOS ONE 2011; 6(2): e16703.

2010
Comins, C., J. Spicer, A. Protheroe, V. Roulstone, K. Twigger, C. M. White, R. Vile, A. Melcher, M. C. Coffey, K. L. Mettinger, G. Nuovo, D. E. Cohn, M. Phelps, K. J. Harrington and H. S. Pandha. REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer. Clin. Cancer Res. 2010; 16(22): 5564-5572.

Daniels, T. R., Neacato, II, J. A. Rodriguez, H. S. Pandha, R. Morgan and M. L. Penichet. Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. Leukemia 2010; 24(9): 1555-1565.

Kolodkin, A. N., F. J. Bruggeman, N. Plant, M. J. Mone, B. M. Bakker, M. J. Campbell, J. P. T. M. van Leeuwen, C. Carlberg, J. L. Snoep and H. V. Westerhoff. Design principles of nuclear receptor signaling: how complex networking improves signal transduction. Mol. Sys. Biol. 2010; 6: 446.

Morgan, R., L. Plowright, K. J. Harrington, A. Michael and H. S. Pandha. Targeting HOX and PBX transcription factors in ovarian cancer. BMC Cancer 2010; 10: 89.

2009
Ismail, M., S. Bokaee, R. Morgan, J. Davies, K. J. Harrington and H. Pandha. Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy. Brit. J. Cancer 2009; 100(12): 1889-1895.

Klapacz, J., L. B. Meira, D. G. Luchetti, J. A. Calvo, R. T. Bronson, W. Edelmann and L. D. Samson. O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proc. Natl. Acad. Sci. USA 2009; 106(2): 576-581.

Meira, L. B., C. A. Moroski-Erkul, S. L. Green, J. A. Calvo, R. T. Bronson, D. Shah and L. D. Samson. Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc. Natl. Acad. Sci. USA 2009; 106(3): 888-893.

Ortiz-Sanchez, E., T. R. Daniels, G. Helguera, O. Martinez-Maza, B. Bonavida and M. L. Penichet. Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species. Leukemia 2009; 23(1): 59-70.

Plowright, L., K. J. Harrington, H. S. Pandha and R. Morgan. HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer. Brit. J. Cancer 2009; 100(3): 470-475.

Sooriakumaran, P., H. M. Coley, S. B. Fox, P. Macanas-Pirard, D. P. Lovell, A. Henderson, C. G. Eden, P. D. Miller, S. E. Langley and R. W. Laing. A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. Anticancer Res. 2009; 29(5): 1483-1488.

2008
Hanlon, N., N. Coldham, A. Gielbert, N. Kuhnert, M. J. Sauer, L. J. Kingi and C. Ioannides. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Br. J. Nutr. 2008; 99(3): 559-564.

Johnson, D. J., A. Owen, N. Plant, P. G. Bray and S. A. Ward. Drug-regulated gene expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors. Antimicrob. Agents Chemother. 2008; 52(4): 1438-1445.

Meira, L. B., J. M. Bugni, S. L. Green, C. W. Lee, B. Pang, D. Borenshtein, B. H. Rickman, A. B. Rogers, C. A. Moroski-Erkul, J. L. McFaline, D. B. Schauer, P. C. Dedon, J. G. Fox and L. D. Samson. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J. Clin. Invest. 2008; 118(7): 2516-2525.

Prestwich, R. J., F. Errington, E. J. Ilett, R. S. M. Morgan, K. J. Scott, T. Kottke, J. Thompson, E. E. Morrison, K. J. Harrington, H. S. Pandha, P. J. Selby, R. G. Vile and A. A. Melcher. Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity. Clin. Cancer Res. 2008; 14(22): 7358-7366.

Pushparajah, D. S., M. Umachandran, K. E. Plant, N. Plant and C. Ioannides. Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: Studies using precision-cut tissue slices. Mut. Res. 2008; 640(1-2): 153-161.

2007
Morgan, R., P. M. Pirard, L. Shears, J. Sohal, R. Pettengell and H. S. Pandha. Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma. Cancer Res. 2007; 67(12): 5806-5813.

Waffo, A. F. K., P. H. Coombes, N. R. Crouch, D. A. Mulholland, S. M. M. El Amin and P. J. Smith. Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae : Toddalioideae) of southern Africa. Phytochemistry 2007; 68(5): 663-667.