Protein discovery could switch off cardiovascular disease

Tuesday 13 March 2012

Researchers from Queen Mary, University of London and the University of Surrey have found a protein inside blood vessels with an ability to protect the body from substances which cause cardiovascular disease.

“Heart and circulatory disease is the UK’s biggest killer. Discovering that the protein pregnane X receptor (PXR) could protect blood vessels has major implications for the prevention of cardiovascular disease,” said Dr Karen Swales, based at the University of Surrey.

The findings, published online in the journal Cardiovascular Research, have revealed PXR can switch on different protective pathways in the blood vessels.

Dr David Bishop-Bailey, based at Queen Mary’s William Harvey Research Institute, said they found the protein was able to sense a wide variety of drugs, foreign chemicals and food products in the blood and switch on specific pathways to deal with them.

“We’ve known for a long time that this protein has an important role sorting out waste products in the liver - now we believe it could have an important role in protecting the body against cardiovascular disease,” he said.  

Dr Karen Swales added “We knew if PXR played similar protective roles in blood vessels to those in liver, it could protect the vessels from damage caused by harmful substances in the blood.”

The researchers used human tissue and blood vessel cells in culture and found PXR was present and active.

“We introduced specific PXR activating drugs and saw a co-ordinated increase in metabolising and anti-oxidant enzyme pathways,” Dr Bishop-Bailey explained.

“Since blood travels everywhere in the body, PXR has the potential to provide protection not just through its actions in the liver, but anywhere in the entire body. If we can work out how to manipulate PXR to turn on detoxification and antioxidant pathways in blood vessels, we may be a step closer to preventing our nation’s biggest killer.”

Media Enquiries

Peter La, Press Office at the University of Surrey, Tel: +44 (0)1483 689191, or Email

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