Biography

BSc Biology, Royal Holloway and Bedford New College, University of London

PhD Immunology, University College London, University of London

Research Interests

Current research interests lie in understanding the role of the inflammatory acute phase proteins in innate immune responses to infection and in inflammatory disease and how they may interact with the acquired immune response. This can be further divided into (i) The effect of acute phase proteins on host cells particularly in relation to inflammatory disease (ii) Host cell receptors used by acute phase proteins for pathogen uptake and (iii) The role of acute phase proteins on pathogen survival.

Research Collaborations

Dr Graham Stewart

Professor Johnjoe McFadden

Ernesto Oviedo-Orta and the Cardiovascular research group

Publications

Refereed articles

1. Shams, S., Shafi, S., Bodman-Smith, K., Williams, P., Mehta, S. and Ferns, G. 2008. Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: Association with established cardiovascular risk factors. Clin. Chim. Acta. 395: 42-46.

2. Casey, R., Newcombe, J., McFadden, J. and Bodman-Smith, K.B. 2008. The acute phase reactant C-reactive protein binds to phosphorylcholine-expressing Neisseria meningitidis and increases uptake by human phagocytes. Infect. Immun; 76(3): 1298-1304.

3. Karam, M. C., Hamdan, H. G., Abi Chedid, N. A., Bodman-Smith, K. B. and Baroody, G. M. 2007. Interleukin-10 reduces hyperalgesia and the level of interleukin-1b in BALB/c mice infected with Leishmania major with no major effect on the level of interleukin-6. J. Neuroimmunol; 183(1-2): 43-49.

4. Karam, M., Bodman-Smith, K. B., Eales-Reynolds, L-J. and Baroody, G. 2006. Low Dose of Leishmania major causes hyperalgesia in mice during early infection accompanied by the upregulation of interleukin-1 beta and interleukin-6. Exp. Parasitol; 113: 168-173.

5. Eales-Reynolds, L-J. and Bodman-Smith, K. 2005. Blended Learning: Investigation of its Effectiveness at encouraging deeper learning in an introductory science course. Innovation and Development in Learning Teaching and Support: New and different ways in supporting teaching and learning. ISBN: 1-86137-425-9. 51-57.

6. Rodriguez, J. A., Bodman-Smith, K. B. and Raynes, J. G. 2004. Neutrophil responses to C-reactive protein are not dependent on polymorphism R/H131 of human FcRIIa. Clin. Exp. Immmunol; 138: 271-277.

7. Bodman-Smith, K. B., Gregory, R., Harrison, P. T. and Raynes J. G. 2004. FcRIIa expression with FcRI results in C-reactive protein- and IgG-mediated phagocytosis. J. Leukocyte Biol. 75: 1029-1035.

8. Bodman-Smith, K. B., Mbuchi, M., Culley, F. J., Bates, P. A. and Raynes, J. R. 2002. C-reactive protein mediated phagocytosis of Leishmania donovani promastigotes does not alter parasite survival or macrophage responses. Parasite Immunnol; 24; 447-454.

9. Bodman-Smith, K. B., Melendez, A., Campbell, I., Harrison, P., Allen, J. A. and Raynes, J. G. 2002. C-reactive protein mediated phagocytosis and phospholipase D signalling through the high affinity receptor for IgG (FcRI). Immunol; 107: 252-260.

Chapters

1. Sumar, N., Bodman, K. B. and Rudd, P. 1993. Detection of disease-related glycoforms by lectins. In: Lectins and glycobiology. Eds. Gabius H. J. and Gabius S. Springer-Verlag Press, Berlin. 158-174.

2. Roitt, I. M., Dwek, R. A., Parekh, R. B., Rademacher, T. W., Warren, C., Alavi, A., Axford, J. S., Bodman, K., Bond, A., Colaco, B., Cooke, A., Delves, P., Hay, F. C., Isenberg, D. A., Lydyard, P. M., MacKenzie, L., Rook, G., Smith, M., Sumar, N. and Tsoulfa, G. 1990. The significance of changes in IgG carbohydrates in Rheumatoid Arthritis and Tuberculosis. In: Molecular aspects of Immune Response and Infectious Diseases. Eds. Kiyono, H. and Jirillo, E. Chapter 9: 77-82.

Letters

1. Axford, J. S., Bodman, K., Hay, F. C., Isenberg, D. A., Lydyard, P. M., MacKenzie, L., Roitt, I. M., Sumar, N., Rook, G. Dwek, R. A., et al. 1989. Comment on the article by Tomana et al. Arthritis Reum; 32(2): 235-236.

Reviews

1. Bodman, K. B. and Roitt, I. M. 1994. The pathophysiology of rheumatoid arthritis. Fund.
Clin. Immunol; 2: 73-81.

2. Sumar, N., Bodman, K. B. and Rudd, P. 1994. Lectins as indicators of disease. In: Tools for glycobiology, Oxford Glycosystems catalogue: 38-40.

3. Roitt, I. M., Hutchings, P. R., Dawe, K. I., Sumar, N., Bodman, K. B. and Cooke, A. 1992. The forces driving autoimmune disease. J. Autoimm; suppl.A: 11-26.

4. Roitt, I. M., Dwek, R. A., Parekh, R. B., Rademacher, T. W., Alavi, A., Axford, J. S., Bodman, K. B., Bond, A., Cooke, A., Hay, F. C., Isenberg, D., Lydyard, P., MacKenzie, L., Rook, G., Smith, M. and Sumar, N. 1988. Changes in carbohydrate structure of IgG in rheumatoid arthritis. Recenti Progressi in Medicin; 79: 314-317.

Published Abstracts

1. Jenson, J., Casey, R., Newcombe, J., Bodman-Smith, M., McFadden J. and Bodman-Smith, K. 2008. Dendritic cell responses to C-reactive protein-opsonised Neisseria meningitidis. Immunol: Immunology; (suppl. 1):.

2. Beeton, L., Bodman-Smith, K., Ferns, G. and Green F. R. 2007. Interleukin-6 promoter polymorphisms exert a co-operative influence on chromatin remodelling and IL-6 mRNA expression in a monocyte-derived macrophage model of inflammation. Atherosclerosis; In Press.

3. Casey, R., McFadden, J., Newcombe, J., Bodman-Smith, M. and Bodman-Smith, K. 2007. C-reactive protein binds to Neisseria menigitidis and affects macrophage responses to infection. Immunology; 120 (suppl. 1): 20.

4. Beeton, L., Khwaja, H., Bodman-Smith, K., Ferns, G. and Green, F. 2006. Genetic variation in the interleukin-6 promoter influences the macrophage inflammatory response. Vascular Pharmacology; 45(3): e3.

5. Beeton, L., Tomlin, P., Bodman-Smith, K., Ferns, G. and Green, F. 2006. Inhibitory effect of statins on IL6 mRNA expression in THP-1 cells subjected to an inflammatory stimulus. Vascular Pharmacology. Vascular Pharmacology; 45(3):e16-e17.

6. Beeton, L., Khwaja, H., Bodman-Smith, K., Ferns, G. and Green, F. 2006. Interleukin-6 promoter polymorphisms influence the inter-individual macrophage inflammatory response. Atherosclerosis; 7 (suppl. 3): 289.

7. Casey, R., Newcombe, J., McFadden, J. and Bodman-Smith K. 2005. The interaction of C-reactive protein with Neisseria menigitidis. Immunol; 116 (suppl 1): 77.

8. Eales-Reynolds, L-J. and Bodman-Smith, K. B. 2005. Application of variation theory in
higher education. In press. Proceedings of the TLHE meeting, Canada, June 2005.

9. Eales-Reynolds, L-J. and Bodman-Smith, K. B. 2004. Blended Learning: Investigation of its effectiveness at encouraging deeper learning in an introductory science course. Proceedings of the TLHE 2004 Conference, Singapore.

10. Bodman-Smith, K. B., Gregory, R., Harrison, P. and Raynes, J. G. 2003. C-reactive protein binds human FcRIIa and FcRIIb and is able to influence phagocytosis of erythrocytes by FcRI transfected cells. Immunol; 110 (suppl. 1): 28.

Teaching

Main contributions

Undergraduate

BMS2002 Practical Biochemstry and Immunology (Module Organiser)

BMS2007 Introduction to Immmunology

BMS3006 Clinical Immunology (Module Organiser)

BMS3044 Immunohaematology and Transfusion science (Module Organiser)

Postraduate

MSc Medical Microbiology

MM104 Introduction to Immunology (Module Organiser)

MM109 Practical Immunology

Other contributions 

Undergraduate

Postgraduate