Dr Barbara Fielding

Senior Research Fellow

Qualifications: BSc, MPhil, PhD

Email: b.fielding@surrey.ac.uk
Phone: Work: 01483 68 8649
Room no: 21 PGM 00

Office hours

Office hours - Monday to Thursday

Contact details - 01483 688649

Biography
Research
Publications
More...

Biography

After obtaining my BSc in Biology at the University of York, I worked in the Dept of Child Health, University of Manchester based at The Royal Manchester Children’s Hospital. My research initially focussed on the appearance of the cortisol circadian rhythm in children and then urinary albumin excretion in diabetic children. I obtained an MPhil in Manchester and then moved to Oxford where I studied for a PhD on the action of the enzyme lipoprotein lipase with Prof Keith Frayn.

I set up a mass spectrometry lab at OCDEM (University of Oxford) in 2003 which enabled me to collaborate widely, including Cambridge in the UK (MRC CORD) and in Europe through a ‘Framework 7’ collaboration (HEPADIP).

I joined the University of Surrey in 2010 from the University of Oxford where I still work with Fredrik Karpe’s group through a part-time contract.

Research Interests

My main interest is human fatty metabolism - how this is impaired in obesity and type 2 diabetes and how it is affected by diet. Using fatty acid stable isotope tracers combined with arterio-venous measurements in Oxford we have shown how adipose tissue fatty acid metabolism is down-regulated in obesity with concomitant failure to deposit meal fatty acids. I am interested in how hepatic and adipose tissue fatty acid metabolism relates to abdominal obesity in women and how this relationship is affected by menopausal status.

In Prof Margot Umpleby’s lab, I have set up some of the isotopic techniques that I have developed in Oxford and we are using them in on-going projects at Surrey. For example the isotopic desaturation index allows us to estimate the action of the enzyme stearoyl CoA desaturase (SCD) in relation to carbohydrate intake. The product of SCD, palmitoleic acid, is associated with insulin resistance. I am also interested in vitamin D metabolism and how vitamin D status is impaired in obesity.

Stable isotope techniques can be applied to many in vivo and in vitro systems and we are fortunate to have many past and present world-wide collaborations.

Publications

Journal articles

Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA. (2012) 'Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.'. Nutr Metab Cardiovasc Dis,
doi: 10.1016/j.numecd.2012.11.003
Theytaz F, Egli L, Campos V, Tappy L, Noguchi Y, Nishikata N, Buehler T, Kreis R, Boesch C, Hodson L, Fielding B, Patterson BW, Mittendorfer B. (2012) 'Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans'. American Journal of Clinical Nutrition, 96 (5), pp. 1008-1016.
doi: 10.3945/ajcn.112.035139
Sevastianova K, Santos A, Kotronen A, Makkonen J, Olkkonen VM, Yki-Jar vinen H, Gylling H, Silander K, Peltonen M, Hakkarainen A, Lundbom J, Lundbom N, Romeo S, Fielding BA, Rissanen A. (2012) 'Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans'. American Journal of Clinical Nutrition, 96 (4), pp. 727-734.
doi: 10.3945/ajcn.112.038695
Hodson L, Fielding BA. (2012) 'Stearoyl-CoA desaturase: rogue or innocent bystander?'. Prog Lipid Res, 52 (1), pp. 15-42.
doi: 10.1016/j.plipres.2012.08.002
Pinnick KE, Neville MJ, Fielding BA, Frayn KN, Karpe F, Hodson L. (2012) 'Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.'. American Diabetes Association Diabetes, United States: 61 (6), pp. 1399-1403.
doi: 10.2337/db11-1810
Full text is available at: http://epubs.surrey.ac.uk/713144/

Abstract

The expansion of lower-body adipose tissue (AT) is paradoxically associated with reduced cardiovascular disease and diabetes risk. We examined whether the beneficial metabolic properties of lower-body AT are related to the production and release of the insulin-sensitizing lipokine palmitoleate (16:1n-7). Using venoarterial difference sampling, we investigated the relative release of 16:1n-7 from lower-body (gluteofemoral) and upper-body (abdominal subcutaneous) AT depots. Paired gluteofemoral and abdominal subcutaneous AT samples were analyzed for triglyceride fatty acid composition and mRNA expression. Finally, the triglyceride fatty acid composition of isolated human preadipocytes was determined. Relative release of 16:1n-7 was markedly higher from gluteofemoral AT compared with abdominal subcutaneous AT. Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogenous 16:1n-7 production, was more highly expressed in gluteofemoral AT and was associated with greater enrichment of 16:1n-7. Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher content of SCD1-derived fatty acids. We demonstrate that human gluteofemoral AT plays a major role in determining systemic concentrations of the lipokine palmitoleate. Moreover, this appears to be an inherent feature of gluteofemoral AT. We propose that the beneficial metabolic properties of lower-body AT may be partly explained by the intrinsically greater production and release of palmitoleate.
Costet P, Ehrenborg E, Fisher R, Fielding B, Groen A, Kardassis D, Malle E, Mulder M, Niemeier A, Norata GD, Hansen AT, Eckardstein AV. (2012) 'European Lipoprotein Club: Report of the 35th ELC Annual Conference (Tutzing, 10th-13th September 2012)'. Atherosclerosis,
doi: 10.1016/j.atherosclerosis.2012.11.030
Ardilouze J-L, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F. (2012) 'Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation'. Diabetes and Metabolism, 38 (1), pp. 27-33.
doi: 10.1016/j.diabet.2011.06.005
Bernini F, Costet P, Ehrenborg E, Fisher R, Fielding B, Freeman D, Groen A, Malle E, Mulder M, Niemeier A, Hansen AT, von Eckardstein A. (2012) 'European Lipoprotein Club: Report of the 34th ELC annual conference, Tutzing, 5-8 September 2011'. Atherosclerosis, 221 (1), pp. 287-293.
doi: 10.1016/j.atherosclerosis.2011.12.002
Fielding B. (2011) 'Nutrition Society Cuthbertson Medal Lecture: Tracing the fate of dietary fatty acids: Metabolic studies of postprandial lipaemia in human subjects'. Proceedings of the Nutrition Society, 70 (3), pp. 342-350.
doi: 10.1017/S002966511100084X
Full text is available at: http://epubs.surrey.ac.uk/7810/

Abstract

Most postprandial studies have investigated the response of a single meal, yet the ingestion of sequential meals is more typical in a Western society. The aim of this review is to explain how natural and stable isotope tracers of fatty acids have been used to investigate the metabolism of dietary fat after single and multiple meals, with a focus on in vivo measurements of adipose tissue metabolism. When stable isotope tracers are combined with arteriovenous difference measurements, very specific measurements of metabolic flux across tissues can be made. We have found that adipose tissue is a net importer of dietary fat for 5 h following a single test meal and for most of the day during a typical three-meal eating pattern. When dietary fat is cleared from plasma, some fatty acids spillover into the plasma and contribute up to 50% of postprandial plasma NEFA concentrations. Therefore, plasma NEFA concentrations after a meal reflect the balance between intracellular and extracellular lipolysis in adipose tissue. This balance is altered after the acute ingestion of fructose. The enzyme lipoprotein lipase is a key modulator of fatty acid flux in adipose tissue and its rate of action is severely diminished in obese men. In conclusion, in vivo studies of human metabolism can quantify the way that adipose tissue fatty acid trafficking modulates plasma lipid concentrations. This has implications for the flux of fatty acids to tissues that are susceptible to ectopic fat deposition such as the liver and muscle. © 2011 The Authors.
Fernandez C, Schuhmann K, Herzog R, Fielding B, Frayn K, Shevchenko A, James P, Holm C, Strom K. (2011) 'Altered Desaturation and Elongation of Fatty Acids in Hormone-Sensitive Lipase Null Mice'. PUBLIC LIBRARY SCIENCE PLOS ONE, 6 (6) Article number ARTN e21603
doi: 10.1371/journal.pone.0021603
Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA. (2011) 'Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 105 (6), pp. 857-865.
doi: 10.1017/S0007114510004472
Full text is available at: http://epubs.surrey.ac.uk/713146/
McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F. (2011) 'Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity A Driver for Ectopic Fat Deposition?'. AMER DIABETES ASSOC DIABETES, 60 (1), pp. 47-55.
doi: 10.2337/db10-0867
Bernini F, Costet P, Ehrenborg E, Fisher R, Fielding B, Freeman D, Groen A, Malle E, Mulder M, Niemeier A, Hansen AT, von Eckardstein A. (2011) 'European Lipoprotein Club: Report of the 34th ELC annual conference, Tutzing, 5-8 September 2011'. Atherosclerosis,
Ardilouze J-L, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F. (2011) 'Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation'. Diabetes and Metabolism,
doi: 10.1016/j.diabet.2011.06.005
Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttila J, Seppanen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Oresic M, Yki-Jarvinen H. (2010) 'Splanchnic Balance of Free Fatty Acids, Endocannabinoids, and Lipids in Subjects With Nonalcoholic Fatty Liver Disease'. W B SAUNDERS CO-ELSEVIER INC GASTROENTEROLOGY, 139 (6), pp. 1961-U232.
doi: 10.1053/j.gastro.2010.06.064
McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN. (2010) 'Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids'. AMER DIABETES ASSOC DIABETES, 59 (10), pp. 2465-2473.
doi: 10.2337/db10-0678
Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding BA, Frayn KN, Karpe F. (2010) 'Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 299 (4), pp. E584-E592.
doi: 10.1152/ajpendo.00272.2010
Iozzo P, Bucci M, Roivainen A, Nagren K, Jaervisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P. (2010) 'Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals'. W B SAUNDERS CO-ELSEVIER INC GASTROENTEROLOGY, 139 (3), pp. 846-U203.
doi: 10.1053/j.gastro.2010.05.039
Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Nagren K, Solin O, Nuutila P. (2010) 'Increased Brain Fatty Acid Uptake in Metabolic Syndrome'. AMER DIABETES ASSOC DIABETES, 59 (9), pp. 2171-2177.
doi: 10.2337/db09-0138
Lundbom J, Hakkarainen A, Fielding B, Soderlund S, Westerbacka J, Taskinen M-R, Lundbom N. (2010) 'Characterizing human adipose tissue lipids by long echo time H-1-MRS in vivo at 1.5 Tesla: validation by gas chromatography'. WILEY-BLACKWELL NMR IN BIOMEDICINE, 23 (5), pp. 466-472.
doi: 10.1002/nbm.1483
Egli L, Theytaz F, Campos V, Hodson L, Schneiter P, Fielding B, Tappy L. (2010) 'Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Males'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, 24
Pinnick K, Neville M, Clark A, Fielding B. (2010) 'Reversibility of Metabolic and Morphological Changes Associated With Chronic Exposure of Pancreatic Islet beta-Cells to Fatty Acids'. WILEY-LISS JOURNAL OF CELLULAR BIOCHEMISTRY, 109 (4), pp. 683-692.
doi: 10.1002/jcb.22445
Adiels M, Larsson T, Sutton P, Taskinen M-R, Boren J, Fielding BA. (2010) 'Optimization of N-methyl-N-[tert-butyldimethylsilyl]- trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins'. JOHN WILEY & SONS LTD RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24 (5), pp. 586-592.
doi: 10.1002/rcm.4422
Hodson L, Fielding BA. (2010) 'Trafficking and partitioning of fatty acids: the transition from fasted to fed state'. FUTURE MEDICINE LTD CLINICAL LIPIDOLOGY, 5 (1), pp. 131-144.
doi: 10.2217/CLP.09.72
Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Le K-A, Schneiter P, Bortolotti M, Frayn KN, Tappy L. (2010) 'Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 104 (8), pp. 1139-1147.
doi: 10.1017/S000711451000190X
Lundbom J, Heikkinen S, Fielding B, Hakkarainen A, Taskinen M-R, Lundbom N. (2009) 'PRESS echo time behavior of triglyceride resonances at 1.5 T: Detecting omega-3 fatty acids in adipose tissue in vivo'. ACADEMIC PRESS INC ELSEVIER SCIENCE JOURNAL OF MAGNETIC RESONANCE, 201 (1), pp. 39-47.
doi: 10.1016/j.jmr.2009.07.026
Kotronen A, Seppala-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Javinen H. (2009) 'Liver fat and lipid oxidation in humans'. WILEY-BLACKWELL PUBLISHING, INC LIVER INTERNATIONAL, 29 (9), pp. 1439-1446.
doi: 10.1111/j.1478-3231.2009.02076.x
Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F. (2009) 'Fasted to Fed Trafficking of Fatty Acids in Human Adipose Tissue Reveals a Novel Regulatory Step for Enhanced Fat Storage'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 94 (5), pp. 1781-1788.
doi: 10.1210/jc.2008-2090
Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA. (2009) 'Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 296 (1), pp. E64-E71.
doi: 10.1152/ajpendo.90730.2008
Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F. (2008) 'Fatty Acid Metabolism in Patients with PPAR gamma Mutations'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 93 (11), pp. 4462-4470.
doi: 10.1210/jc.2007-2356
Fernandez C, Lindholm M, Krogh M, Lucas S, Larsson S, Osmark P, Berger K, Boren J, Fielding B, Frayn K, Holm C. (2008) 'Disturbed cholesterol homeostasis in hormone-sensitive lipase-null mice'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 295 (4), pp. E820-E831.
doi: 10.1152/ajpendo.90206.2008
Karpe E, Ruge T, Hodson L, Fielding B, Humphreys SM, Dennis L, Cheeseman J, Frayn KN. (2008) 'Regulation of fat storage in human subcutaneous adipose tissue over a 24-hour period'. SPRINGER DIABETOLOGIA, 51, pp. S20-S20.
doi: 10.1007/s00125-008-1117-6
Hodson L, Skeaff CM, Fielding BA. (2008) 'Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake'. PERGAMON-ELSEVIER SCIENCE LTD PROGRESS IN LIPID RESEARCH, 47 (5), pp. 348-380.
doi: 10.1016/j.plipres.2008.03.003
Bickerton AST, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJM, Gilbert M, Humphreys SM, Karpe F, Frayn KN. (2008) 'Adipose tissue fatty acid metabolism in insulin-resistant men'. SPRINGER DIABETOLOGIA, 51 (8), pp. 1466-1474.
doi: 10.1007/s00125-008-1040-x
Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF-F, Gilbert M, Karpe F, Frayn KN. (2008) 'Reduced oxidation of dietary fat after a short term high-carbohydrate diet'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 87 (4), pp. 824-831.
Chong MF-F, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA. (2008) 'Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 87 (4), pp. 817-823.
Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. (2008) 'Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition'. NATURE PUBLISHING GROUP OBESITY, 16 (3), pp. 522-530.
doi: 10.1038/oby.2007.110
Riserus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F. (2008) 'Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatly acid oxidation in moderately obese men'. AMER DIABETES ASSOC DIABETES, 57 (2), pp. 332-339.
doi: 10.2337/db07-1318
Hodson L, Bickerton AST, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA. (2007) 'The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women - Studies in the postprandial state'. AMER DIABETES ASSOC DIABETES, 56 (10), pp. 2433-2441.
doi: 10.2337/db07-0654
Chong MF-F, Fielding BA, Frayn KN. (2007) 'Mechanisms for the acute effect of fructose on postprandial lipemia'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 85 (6), pp. 1511-1520.
Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN. (2007) 'Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation'. PORTLAND PRESS LTD BIOCHEMICAL SOCIETY TRANSACTIONS, Royal Vet Coll, London, ENGLAND: 35, pp. 472-476.
Chong MFF, Fielding BA, Frayn KN. (2007) 'Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, Aberdeen, SCOTLAND: 66 (1), pp. 52-59.
doi: 10.1017/S0029665107005290
Gutierrez E, Wiggins D, Fielding B, Gould AP. (2007) 'Specialized hepatocyte-like cells regulate Drosophila lipid metabolism'. NATURE PUBLISHING GROUP NATURE, 445 (7125), pp. 275-280.
doi: 10.1038/nature05382
Bickerton AST, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2007) 'Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period'. AMER DIABETES ASSOC DIABETES, 56 (1), pp. 168-176.
doi: 10.2337/db06-0822
Tan GD, Neville MJ, Liverani E, Humphreys SM, Currie JM, Dennis L, Fielding BA, Karpe F. (2006) 'The in vivo effects of the Pro12Ala PPAR gamma 2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank'. SPRINGER DIABETOLOGIA, 49 (1), pp. 158-168.
doi: 10.1007/s00125-005-0044-z
Moffitt JH, Fielding BA, Evershed R, Berstan R, Currie JM, Clark A. (2005) 'Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro'. SPRINGER DIABETOLOGIA, 48 (9), pp. 1819-1829.
doi: 10.1007/s00125-005-1861-9
Frayn KN, Fielding BA, Karpe F. (2005) 'Adipose tissue fatty acid metabolism and cardiovascular disease'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 16 (4), pp. 409-415.
doi: 10.1097/01.mol.0000171919.62129.6b
Riserus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F. (2005) 'Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans - Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma'. AMER DIABETES ASSOC DIABETES, 54 (5), pp. 1379-1384.
doi: 10.2337/diabetes.54.5.1379
Karpe F, Fielding BA, Coppack SW, Lawrence VJ, Macdonald IA, Frayn KN. (2005) 'Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo'. AMER DIABETES ASSOC DIABETES, 54 (5), pp. 1297-1303.
doi: 10.2337/diabetes.54.5.1297
Tan GD, Fielding BA, Currie JM, Humphreys SM, Desage M, Frayn K, Laville M, Vidal H, Karpe F. (2005) 'The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes'. SPRINGER DIABETOLOGIA, 48 (1), pp. 83-95.
doi: 10.1007/s00125-004-1619-9
Fielding BA, Frayn KN. (2004) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 15 (4), pp. 483-485.
doi: 10.1097/01.mol.0000137234.30514.18
Ardilouze JL, Fielding BA, Curry JM, Frayn KN, Karpe F. (2004) 'Role of leptin in regulating nitric oxide production and membrane microviscosity - Response'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, 109 (22), pp. E316-E316.
Frayn KN, Ardilouze JL, Fielding BA, Karpe F. (2004) 'Coupling of metabolism and cardiovascular responses'. PORTLAND PRESS CLINICAL SCIENCE, 106 (5), pp. 547-548.
doi: 10.1042/CS20030409
Ardilouze JL, Karpe F, Currie JM, Frayn KN, Fielding BA. (2004) 'Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 28 (2), pp. 228-233.
doi: 10.1038/sj.ijo.0802541
Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. (2004) 'Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, 109 (1), pp. 47-52.
doi: 10.1161/01.CIR.0000105681.70455.73
Smith RD, Kelly CNM, Fielding BA, Hauton D, Silva KDRR, Nydahl MC, Miller GJ, Williams CM. (2003) 'Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects'. C A B I PUBLISHING BRITISH JOURNAL OF NUTRITION, 90 (3), pp. 597-606.
doi: 10.1079/BJN2003953
Fielding BA, Frayn KN. (2003) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 14 (4), pp. 389-391.
doi: 10.1097/01.mol.0000083770.66245.76
Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW. (2003) 'Integrative physiology of human adipose tissue'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 27 (8), pp. 875-888.
doi: 10.1038/sj.ijo.0802326
Nydahl MC, Smith RD, Kelly CNM, Fielding BA, Williams CM. (2003) 'Achievement of dietary fatty acid intakes in long-term controlled intervention studies: approach and methodology'. C A B I PUBLISHING PUBLIC HEALTH NUTRITION, 6 (1), pp. 31-40.
doi: 10.1079/PHN2002365
Beysen C, Belcher AK, Karpe F, Fielding BA, Herrera E, Frayn KN. (2003) 'Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 284 (1), pp. E18-E24.
doi: 10.1152/ajpendo.00113.2002
Robertson MD, Jackson KG, Fielding BA, Williams CM, Frayn KN. (2002) 'Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women.'. Br J Nutr, England: 88 (6), pp. 635-640.
doi: 10.1079/BJN2002729
Jackson KG, Robertson MD, Fielding BA, Frayn KN, Williams CM. (2002) 'Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 76 (5), pp. 942-949.
Beysen C, Karpe F, Fielding BA, Clark A, Levy JC, Frayn KN. (2002) 'Interaction between specific fatty acids, GLP-1 and insulin secretion in humans'. SPRINGER-VERLAG DIABETOLOGIA, 45 (11), pp. 1533-1541.
doi: 10.1007/s00125-002-0964-9
Fielding BA, Frayn KN. (2002) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 13 (5), pp. 573-575.
doi: 10.1097/00041433-200210000-00014
Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LKM, Frayn KN. (2002) 'Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity'. AMER DIABETES ASSOC DIABETES, 51 (8), pp. 2467-2473.
doi: 10.2337/diabetes.51.8.2467
Robertson MD, Jackson KG, Fielding BA, Morgan LM, Williams CM, Frayn KN. (2002) 'Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 76 (1), pp. 232-238.
Karpe F, Fielding BA, Ardilouze JL, Ilic V, Macdonald IA, Frayn KN. (2002) 'Effects of insulin on adipose tissue blood flow in man'. CAMBRIDGE UNIV PRESS JOURNAL OF PHYSIOLOGY-LONDON, 540 (3), pp. 1087-1093.
doi: 10.1113/jphysiol.2001.013358
Summers LKM, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, Frayn KN. (2002) 'Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity'. SPRINGER-VERLAG DIABETOLOGIA, 45 (3), pp. 369-377.
doi: 10.1007/s00125-001-0768-3
Karpe F, Fielding BA, Ilic V, Humphreys SM, Frayn KN. (2002) 'Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 26 (1), pp. 1-5.
doi: 10.1038/sj.ijo.0801843
Moher HE, Tan G, Fielding BA, Carey GB. (2001) 'Arterio-venous (AV) difference of cyclic adenosine monophosphate (cAMP) serosa human adipose tissue in vivo'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, 15 (4), pp. A299-A299.
Griffin BA, Fielding BA. (2001) 'Postprandial lipid handling'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 4 (2), pp. 93-98.
doi: 10.1097/00075197-200103000-00002
Jackson KG, Robertson MD, Fielding BA, Frayn KN, Williams CM. (2001) 'Second meal effect: modified sham feeding does not provoke the release of stored triacylglycerol from a previous high-fat meal'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 85 (2), pp. 149-156.
doi: 10.1079/BJN2000226
Robertson MD, Jackson KG, Williams CM, Fielding BA, Frayn KN. (2001) 'Prolonged effects of modified sham feeding on energy substrate mobilization'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 73 (1), pp. 111-117.
Kalant D, Phelis S, Fielding BA, Frayn KN, Cianflone K, Sniderman AD. (2000) 'Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 41 (12), pp. 1963-1968.
Fielding BA, Frayn KN. (2000) 'Lipid metabolism - Editorial comment'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 11 (6), pp. 657-659.
doi: 10.1097/00041433-200012000-00014
Fielding BA, Reid G, Grady M, Humphreys SM, Evans K, Frayn KN. (2000) 'Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 83 (6), pp. 597-604.
doi: 10.1017/S0007114500000763
Summers LKM, Barnes SC, Fielding BA, Beysen C, Ilic V, Humphreys SM, Frayn KN. (2000) 'Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 71 (6), pp. 1470-1477.
Fielding BA, Frayn KN. (2000) 'Lipid metabolism'. Current Opinion in Lipidology, 11 (6), pp. 657-659.
doi: 10.1097/00041433-200012000-00014
Jackson KG, Robertson MD, Deane LO, Fielding BA, Frayn KN, Williams CM. (2000) 'The effect of modified sham-feeding meals of varying fat content on postprandial triacylglycerol, insulin and glucose responses.'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, 59, pp. 14A-14A.
Robertson MD, Jackson KG, Williams CM, Fielding BA, Frayn KN. (2000) 'Modified sham feeding of a modest-fat meal suppresses plasma non-esterified fatty acids.'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, 59, pp. 123A-123A.
Summers LKM, Fielding BA, Herd SL, Ilic V, Clark ML, Quinlan PT, Frayn KN. (1999) 'Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 40 (10), pp. 1890-1898.
Summers LKM, Fielding BA, Ilic V, Clark ML, Frayn KN. (1999) 'The relationship between insulin sensitivity and postprandial adipose tissue lipid metabolism'. SPRINGER VERLAG DIABETOLOGIA, 42, pp. A205-A205.
Fielding BA, Samra JS, Ravell CL, Frayn KN. (1999) 'Metabolism of individual fatty acids during infusion of a triacylglycerol emulsion'. AMER OIL CHEMISTS SOC A O C S PRESS LIPIDS, 34 (6), pp. 535-541.
doi: 10.1007/s11745-999-0395-3
Fielding BA, Frayn KN. (1999) 'Lipid metabolism'. Current Opinion in Lipidology, 10 (1), pp. 73-75.
doi: 10.1097/00041433-199902000-00013
Fielding BA, Frayn KN. (1998) 'Lipoprotein lipase and the disposition of dietary fatty acids'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 80 (6), pp. 495-502.
Summers LKM, Fielding BA, Ilic V, Frayn KN. (1998) 'The relationship between body mass index, abdominal fat distribution, insulin sensitivity and plasma lipids'. SPRINGER VERLAG DIABETOLOGIA, 41, pp. A347-A347.
Evans K, Kuusela PJ, Cruz ML, Wilhelmova I, Fielding BA, Frayn KN. (1998) 'Rapid chylomicron appearance following sequential meals: effects of second meal composition'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 79 (5), pp. 425-429.
doi: 10.1079/BJN19980072
Saleh J, Summers LKM, Cianflone K, Fielding BA, Sniderman AD, Frayn KN. (1998) 'Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 39 (4), pp. 884-891.
Summers LKM, Fielding BA, Ilic V, Quinlan PT, Frayn KN. (1998) 'The effect of triacylglycerol fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 79 (2), pp. 141-147.
doi: 10.1079/BJN19980025
Frayn KN, Fielding BA, Summers LKM. (1997) 'Investigation of human adipose tissue metabolism in vivo'. J ENDOCRINOLOGY LTD JOURNAL OF ENDOCRINOLOGY, ARGENTEUIL, FRANCE: 155 (2), pp. 187-189.
doi: 10.1677/joe.0.1550187
Frayn KN, Summers LKM, Fielding BA. (1997) 'Regulation of the plasma non-esterified fatty acid concentration in the postprandial state'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, ROYAL SOC MED, LONDON, ENGLAND: 56 (2), pp. 713-721.
doi: 10.1079/PNS19970071
Halliwell KJ, Fielding BA, Samra JS, Humphreys SM, Frayn KN. (1996) 'Release of individual fatty acids from human adipose tissue in vivo after an overnight fast'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 37 (9), pp. 1842-1848.
Phillips DIW, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R. (1996) 'Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects'. W B SAUNDERS CO METABOLISM-CLINICAL AND EXPERIMENTAL, 45 (8), pp. 947-950.
doi: 10.1016/S0026-0495(96)90260-7
Frayn KN, Fielding BA, Humphreys SM, Coppack SW. (1996) 'Nutritional influences on human adipose-tissue metabolism'. PORTLAND PRESS BIOCHEMICAL SOCIETY TRANSACTIONS, UNIV ABERDEEN, ABERDEEN, SCOTLAND: 24 (2), pp. 422-426.
Fielding BA, Callow J, Owen RM, Samra JS, Matthews DR, Frayn KN. (1996) 'Postprandial lipemia: The origin of an early peak studied by specific dietary fatty acid intake during sequential meals'. AMER SOC CLIN NUTRITION INC AMERICAN JOURNAL OF CLINICAL NUTRITION, 63 (1), pp. 36-41.
Fielding BA, Humphreys SM, Shadid S, Frayn KN. (1995) 'Plasma mono-, di- and triacylglycerol measurements in a study of fat uptake by human adipose tissue in vivo.'. Biochem Soc Trans, ENGLAND: 23 (3)
Frayn KN, Coppack SW, Fielding BA, Humphreys SM. (1995) 'Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization.'. Adv Enzyme Regul, ENGLAND: 35, pp. 163-178.
Fielding BA, Humphreys SM, Shadid S, Frayn KN. (1995) 'Arterio-venous differences across human adipose tissue for mono-, di- and triacylglycerols before and after a high-fat meal'. Endocrinology and Metabolism, 2 (1), pp. 13-17.
Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O, Coppack SW. (1994) 'Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition.'. Am J Physiol, UNITED STATES: 266 (3 Pt 1), pp. E308-E317.
Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O, Coppack SW. (1994) 'Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition'. American Journal of Physiology - Endocrinology and Metabolism, 266 (3 29-3)
Griffiths AJ, Humphreys SM, Clark ML, Fielding BA, Frayn KN. (1994) 'Immediate metabolic availability of dietary fat in combination with carbohydrate.'. Am J Clin Nutr, UNITED STATES: 59 (1), pp. 53-59.
Fielding BA, Humphreys SM, Frayn KN. (1993) 'Mono- and di-acylglycerol concentrations in human plasma in relation to lipoprotein lipase activity.'. Biochem Soc Trans, ENGLAND: 21 ( Pt 3) (3)
FIELDING BA, HUMPHREYS SM, ALLMAN RFC, FRAYN KN. (1993) 'MONOACYLGLYCEROL, DIACYLGLYCEROL, AND TRIACYLGLYCEROL CONCENTRATIONS IN HUMAN PLASMA - EFFECTS OF HEPARIN INJECTION AND OF A HIGH-FAT MEAL'. ELSEVIER SCIENCE BV CLINICA CHIMICA ACTA, 216 (1-2), pp. 167-173.
doi: 10.1016/0009-8981(93)90149-X
Fielding BA, Humphreys SM, Allman RF, Frayn KN. (1993) 'Mono-, di- and triacylglycerol concentrations in human plasma: effects of heparin injection and of a high-fat meal.'. Clin Chim Acta, NETHERLANDS: 216 (1-2), pp. 167-173.
DHAR H, FIELDING BA, CLARK ML, FRAYN KN. (1990) 'TURBIDITY IN IMMUNOTURBIDIMETRIC ASSAY - REPLY'. ROYAL SOC MEDICINE SERVICES LTD ANNALS OF CLINICAL BIOCHEMISTRY, 27, pp. 509-509.
Dhar H, Fielding BA, Clark ML, Frayn KN. (1990) 'Background turbidity changes during the estimation of urinary albumin.'. Ann Clin Biochem, ENGLAND: 27 ( Pt 2), pp. 161-162.
DAVIES AG, PRICE DA, POSTLETHWAITE RJ, FIELDING BA. (1985) 'URINE ALBUMIN EXCRETION IN DIABETICS'. LANCET LTD LANCET, 1 (8426), pp. 466-467.
DAVIES AG, PRICE DA, POSTLETHWAITE RJ, ADDISON GM, BURN JL, FIELDING BA. (1985) 'RENAL-FUNCTION IN DIABETES-MELLITUS'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 60 (4), pp. 299-304.
PRICE DA, CLOSE GC, FIELDING BA. (1984) 'AGE OF APPEARANCE OF CIRCADIAN-RHYTHM IN SALIVARY CORTISOL-LEVELS'. WILLIAMS & WILKINS PEDIATRIC RESEARCH, 18 (1), pp. 118-118.
DAVIES AG, POSTLETHWAITE RJ, PRICE DA, BURN JL, HOULTON CA, FIELDING BA. (1984) 'URINARY ALBUMIN EXCRETION IN SCHOOL-CHILDREN'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 59 (7), pp. 625-630.
DAVIES AG, PRICE DA, HOULTON CA, BURN JL, FIELDING BA, POSTLETHWAITE RJ. (1984) 'CONTINUOUS SUBCUTANEOUS INSULIN INFUSION IN DIABETES-MELLITUS - A YEARS PROSPECTIVE TRIAL'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 59 (11), pp. 1027-1033.
FIELDING BA, PRICE DA, HOULTON CA. (1983) 'ENZYME-IMMUNOASSAY FOR URINARY ALBUMIN'. AMER ASSOC CLINICAL CHEMISTRY CLINICAL CHEMISTRY, 29 (2), pp. 355-357.
PRICE DA, CLOSE GC, FIELDING BA. (1983) 'AGE OF APPEARANCE OF CIRCADIAN-RHYTHM IN SALIVARY CORTISOL VALUES IN INFANCY'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 58 (6), pp. 454-456.
FIELDING BA, HOULTON CA, PRICE DA, POSTLETHWAITE RJ. (1983) 'AN ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR THE MEASUREMENT OF URINARY ALBUMIN'. SPRINGER VERLAG EUROPEAN JOURNAL OF PEDIATRICS, 140 (2), pp. 207-207.

Conference papers

Banerjee R, Rial BF, Suttie J, Lewandowski A, Robson MD, Schneider J, Hodson L, Fielding B, Collier JD, Barnes E, Neubauer S. (2012) 'WAIST CIRCUMFERENCE GREATER THAN 90CM IS A RISK FACTOR FOR HEPATIC STEATOSIS IN OTHERWISE HEALTHY ADULTS - A 3 TESLA MAGNETIC RESONANCE SPECTROSCOPY STUDY'. JOURNAL OF HEPATOLOGY, 56, pp. S504-S504.
Egli L, Theytaz F, Campos V, Hodson L, Schneiter P, Fielding B, Tappy L. (2012) 'Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Males'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, San Diego, CA: Experimental Biology Meeting 26
Lord SR, Collins J, Fielding B, Buffa F, Karpe F, Harris A. (2011) 'METFORMIN'S EFFECTS ON BREAST CANCER LIPID METABOLISM'. OXFORD UNIV PRESS ANNALS OF ONCOLOGY, Brussels, BELGIUM: Conference on Improving Care and Knowledge through Translational Research (IMPAKT) Breast Cancer 22, pp. 31-31.
Kotronen A, Westerbacka J, Fielding BA, Wahren J, Hodson L, Seppanen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Frayn KN, Oresic M, Yki-Jarvinen H. (2010) 'Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53, pp. S104-S104.
Karmi AC, Viljanen A, Borra R, Fielding B, Viljanen T, Frayn K, Iozzo P, Nuutila P. (2009) 'The effect of weight loss on intra-abdominal fatty acid metabolism in metabolic syndrome'. SPRINGER DIABETOLOGIA, Vienna, AUSTRIA: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 52, pp. S75-S75.
Riserus U, Sprecher D, Jonson T, Olson E, Hirschberg S, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum J, Cheeseman J, Fielding B, Moore N, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Keith F, Karpe F. (2007) 'PPAR-delta activation reverses multiple metabolic abnormalities, reduces oxidative stress and promotes fat oxidation in obese humans'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Budapest, HUNGARY: 15th European Congress on Obesity 31 (9), pp. 1487-1487.
Hodson L, Fielding BA, Milne RW, Karpe F, Frayn KN. (2007) 'Insulin resistance reduces the contribution of systemic plasma non-esterified fatty acids into very low-density lipoprotein triacylglycerol'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPPLEMENTS, Helsinki, FINLAND: 76th Congress of the European-Atherosclerosis-Society 8 (1), pp. 9-10.
doi: 10.1016/S1567-5688(07)70981-9
Marinou K, Hodson L, Frayn KN, Karpe F, Fielding BA. (2007) 'Sources of fatty acids for 3-hydroxybutyrate production differ during short-term fasting in men and women'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPPLEMENTS, Helsinki, FINLAND: 76th Congress of the European-Atherosclerosis-Society 8 (1), pp. 23-24.
doi: 10.1016/S1567-5688(07)71031-0
Karpe F, Bickerton A, Fielding B, Hodson L, Ruge T, Frayn K. (2007) 'Abnormalities in fatty acid storage and delivery in the metabolic syndrome'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Budapest, HUNGARY: 15th European Congress on Obesity 31, pp. S6-S6.
Hodson L, Ruge T, Milne R, Fielding BA, Frayn KN, Karpe F. (2006) 'Dietary fat is a major contributor to VLDL production in the fed state in humans'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Univ Kent, Canterbury, ENGLAND: 20th Annual Medical and Scientific Meeting of HEART UK 188 (1), pp. S3-S4.
Roberts R, Bickerton A, Fielding BA, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2006) 'Reduced oxidation of dietary fat after a short term high-carbohydrate diet'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Univ Kent, Canterbury, ENGLAND: 20th Annual Medical and Scientific Meeting of HEART UK 188 (1), pp. S3-S3.
Chong MFF, Bickerton A, Roberts R, Karpe F, Hodson L, Fielding B, Frayn K. (2006) 'De novo lipogenesis (DNL) occurs after a 3-day eucaloric low-fat, high-carbohydrate (HC) solid food diet'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, San Francisco, CA: Experimental Biology 2006 Meeting 20 (5), pp. A1022-A1023.
Fielding BA, Hodson L, Roberts R, Bickerton A, Karpe E, Frayn KN. (2005) 'Use of a stable isotope technique to estimate postprandial chylomicron triacylglycerol concentrations without physical separation of the particles'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A197-A197.
Bickerton AST, Roberts R, Fielding BA, Blaakl E, Wagenmakers AJM, Gilbert M, Karpel E, Frayn KN. (2005) 'Adipose tissue fatty acid metabolism and the metabolic syndrome'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A231-A232.
Hodson L, Fielding BA, Bickerton A, Roberts R, Milne RW, Frayn KN, Karpe E. (2005) 'Incorporation of exogenous and endogenous fatty acids into very low-density lipoprotein (VLDL): a study using stable isotope and immunoaffinity techniques in humans'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A233-A233.
Bickerton A, Roberts R, Fielding B, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2004) 'Fatty acid oxidation in the metabolic syndrome'. ELSEVIER SCI IRELAND LTD ATHEROSCLEROSIS, Univ Bath, Bath, ENGLAND: 18th Annual Medical and Scientific Meeting of HEART UK 175 (2), pp. S7-S7.
Moffitt JH, Fielding B, Currie J, Clark A. (2004) 'Triacylglycerol formed in islet beta cells exposed to fatty acids do not contribute to decreased viability except in cells forming predominantly tripalmitin'. SPRINGER DIABETOLOGIA, Munich, GERMANY: 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 47, pp. A176-A176.
Fielding BA, Roberts R, Bickerton A, Karpe F, Gilbert M, Frayn KN. (2004) 'Comparison of GC-MS and GC-cIRMS for the measurement of [C-13] palmitate enrichment in a stable isotope study in vivo in man'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S165-S165.
Frayn KN, Fielding BA, Macdonald IA, Coppack SW, Lawrence V, Karpe F. (2004) 'Pulsatile blood flow and lipolysis in human adipose tissue'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S81-S81.
Roberts R, Bickerton A, Fielding BA, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2004) 'A new protocol to study fatty acid metabolism in muscle and adipose tissue in subjects with the metabolic syndrome'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S165-S165.
Sniderman AD, Cianflone K, Summers L, Fielding B, Frayn K. (1997) 'The acylation-stimulating protein pathway and regulation of postprandial metabolism'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, ROYAL SOC MED, LONDON, ENGLAND: Symposium on Postprandial Lipid Metabolism 56 (2), pp. 703-712.
doi: 10.1079/PNS19970070
Frayn KN, Fielding BA, Samra JS, Summers LKM, Kinney JM, Tucker HN. (1997) 'Extracellular metabolic regulation in adipose tissue'. LIPPINCOTT-RAVEN PUBL PHYSIOLOGY, STRESS, AND MALNUTRITION, AMSTERDAM, NETHERLANDS: 3rd Conference on Physiology, Stress, and Malnutrition, pp. 303-323.
FIELDING BA, HUMPHREYS SM, SHADID S, FRAYN KN. (1995) 'PLASMA MONOACYLGLYCEROL, DIACYLGLYCEROL AND TRIACYLGLYCEROL MEASUREMENTS IN A STUDY OF FAT UPTAKE BY HUMAN ADIPOSE-TISSUE IN-VIVO'. PORTLAND PRESS BIOCHEMICAL SOCIETY TRANSACTIONS, LEICESTER, ENGLAND: 654th Meeting of the Biochemical-Society 23 (3), pp. S487-S487.

Affiliations

Senior Researcher/part-time contract at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford

Member of the Editorial Board of the British Journal of Nutrition

Treasurer of the European Lipoprotein Club

Awards
In 2010, I was awarded the Cuthbertson Medal by the Nutrition Society for my work in human nutrition and metabolism.