Professor Margot Umpleby

Head of Diabetes & Metabolic Medicine

Qualifications: BA (Cantab), PhD

Email: m.umpleby@surrey.ac.uk
Phone: Work: 01483 68 8579
Room no: 31 PGM 00

Biography
Research
Publications
Teaching
Duties
More...

Biography

Professor Umpleby obtained her first degree in Biochemistry from the University of Cambridge and her PhD from the University of London. She held various academic appointments between 1982 and 2005 at UMDS subsequently Kings College London. She was appointed Professor of Human Metabolism at Surrey University in 2005. She is a member of the Medical Research Council College of Experts and is Associate Editor of the journal Growth hormone and IGF Research. In 2005 her research group was awarded the International Award for Excellence in Published Clinical Research in the Journal of Clinical Endocrinology & Metabolism for their paper describing the role of IGF-I in the control of metabolism in type 1 diabetes.

She is an international expert on the use of stable isotopes for the study of human metabolism. Her research aims to understand the mechanisms that lead to insulin resistance and abnormalities in fatty acid and lipoprotein metabolism in diabetes, obesity, metabolic syndrome and non alcoholic fatty liver disease. She works in partnership with researchers in the division of Nutrition and with clinicians at the Royal Surrey County Hospital. Her research group also works closely with the Pharmaceutical Industry in the investigation of new treatments.

Her expertise has led to collaborations worldwide and over 90 peer reviewed publications. She has received over £3.5m in research funding in the last 10 years from the BBSRC, Wellcome Trust, BHF, Heart Research UK, Diabetes UK, European Foundation for the Study of Diabetes and the Pharmaceutical industry.

Research Interests

The research strategy of the department focuses on:

• understanding the underlying mechanisms that lead to metabolic abnormalities in diabetes, obesity, metabolic syndrome and non alcoholic fatty liver disease.

• the translation of this understanding into effective treatment.

We are uniquely able to conduct this research strategy due to our expertise in the use of stable isotope techniques, and their measurement by mass spectrometry which can determine in vivo the rates of synthesis, disposal and conversion of metabolites in the body.

• We offer research training leading to the postgraduate degrees of MPhil, PhD or MD.

Current research programme

An in vivo and in vitro investigation of intestinal triacylglycerol metabolism (funded by Heart Research UK; PI Mike Stolinski))

Investigation of endogenous and exogenous postprandial TRL kinetics in the Metabolic Syndrome (funded by British Heart Foundation; PI Margot Umpleby)

Role of resistant starch in the treatment of insulin resistance (funded by Diabetes UK; PI Denise Robertson)

The effect of insulin detemir on energy balance, postprandial nutrient handling, body fat distribution and adipose tissue metabolism and gene expression in patients with type 2 diabetes (funded by Novo Nordisk; PI David Russell-Jones)

Partial sleep restriction and insulin resistance; development of a physiological sleep-protocol for field use (funded by Diabetes UK; PI Denise Robertson)

The effects of exercise training on visceral fat, insulin sensitivity, β-cell function and triglyceride kinetics in patients with non-alcoholic fatty liver disease (NAFLD). (funded by European Foundation for the Study of Diabetes; PI Fariba Shojaee-Moradie)

How does dietary carbohydrate influence the formation of an atherogenic lipoprotein phenotype? (funded by BBSRC; Joint Nutrition/PGMS funding; PGMS PI Margot Umpleby)

Publications

Journal articles

Elleri D, Allen JM, Harris J, Kumareswaran K, Nodale M, Leelarathna L, Acerini CL, Haidar A, Wilinska ME, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. (2013) 'Absorption patterns of meals containing complex carbohydrates in type 1 diabetes.'. Diabetologia,
doi: 10.1007/s00125-013-2852-x
Robertson MD, Russell-Jones D, Umpleby AM, Dijk D-J. (2013) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men'. Metabolism: Clinical and Experimental, 62 (2), pp. 204-211.
doi: 10.1016/j.metabol.2012.07.016
Haidar A, Hovorka R, Potocka E, Umpleby AM, Boulet B. (2012) 'Estimating postprandial glucose fluxes using hierarchical Bayes modelling'. Computer Methods and Programs in Biomedicine, 108 (1), pp. 102-112.
doi: 10.1016/j.cmpb.2012.01.010
Li X, Umpleby AM, Stolinski M. (2012) 'Development of a method to measure preβHDL and αHDL apoA-I enrichment for stable isotopic studies of HDL kinetics'. Lipids, 47 (10), pp. 1011-1018.
doi: 10.1007/s11745-012-3703-0
Robertson MD, Russell-Jones D, Umpleby AM, Dijk DJ. (2012) 'Effects of three weeks of mild sleep restriction implemented in the home environment on multiple metabolic and endocrine markers in healthy young men.'. Metabolism,
doi: 10.1016/j.metabol.2012.07.016
Backhouse K, Sarac I, Shojaee-Moradie F, Stolinski M, Robertson MD, Wright J, Russell-Jones D, Umpleby AM, Frost GS, Bell JD, Thomas EL. (2012) 'Fatty acid flux and oxidation are increased by rimonabant in obese women'. Metabolism: Clinical and Experimental, 61 (9), pp. 1220-1223.
doi: 10.1016/j.metabol.2012.02.012
Backhouse K, Sarac I, Shojaee-Moradie F, Stolinski M, Robertson MD, Frost GS, Bell JD, Thomas EL, Wright JW, Russell-Jones D, Umpleby AM. (2012) 'Fatty acid flux and oxidation are increased by rimonabant in obese women'. Elsevier Metabolism, 61 (9), pp. 1220-1223.
doi: 10.1016/j.metabol.2012.02.012
Robertson MD, Wright JW, Loizon E, Debard C, Vidal H, Shojaee-Moradie F, Russell-Jones D, Umpleby AM. (2012) 'Insulin-sensitizing effects on muscle and adipose tissue after dietary fiber intake in men and women with metabolic syndrome.'. J Clin Endocrinol Metab, United States: 97 (9), pp. 3326-3332.
doi: 10.1210/jc.2012-1513
Haidar A, Elleri D, Allen JM, Harris J, Kumareswaran K, Nodale M, Acerini CL, Wilinska ME, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. (2012) 'Validity of triple- and dual-tracer techniques to estimate glucose appearance.'. Am J Physiol Endocrinol Metab, United States: 302 (12), pp. E1493-E1501.
doi: 10.1152/ajpendo.00581.2011
Giannoulis MG, Martin FC, Nair KS, Umpleby AM, Sonksen P. (2012) 'Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?'. Endocr Rev, United States: 33 (3), pp. 314-377.
doi: 10.1210/er.2012-1002
Jones H, Wong CK, Burgess MI, Pugh CJ, George K, Umpleby M, Shojaee-Moradie F, Kemp GJ, Cuthbertson DJ. (2012) 'Exercise Training Does Not Enhance Diastolic Function In Non-alcoholic Fatty Liver Disease Patients'. LIPPINCOTT WILLIAMS & WILKINS MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, pp. 725-725.
doi: 10.1249/01.mss.0000417529.22755.ed
Sarac I, Backhouse K, Shojaee-Moradie F, Stolinski M, Robertson MD, Bell JD, Thomas EL, Hovorka R, Wright J, Umpleby AM. (2012) 'Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men.'. The Endocrine Society J Clin Endocrinol Metab, 97 (7), pp. 2475-2481.
doi: 10.1210/jc.2011-3248
Full text is available at: http://epubs.surrey.ac.uk/710495/

Abstract

Context:High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in very-low-density lipoprotein 1 (VLDL(1))- and VLDL(2)-TG and fatty acid kinetics.Objective:Our objective was to investigate whether there are differences in VLDL(1)- and VLDL(2)-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease.Research Design and Methods:Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL(1)-TG and VLDL(2)-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging.Participants:Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG.Results:The women had lower visceral fat and higher sc fat than the men (P < 0.001 and P < 0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P < 0.03). VLDL(2)-TG PR corrected for fat-free mass was higher in the women (P < 0.001). VLDL(2)-TG and VLDL(2)-cholesterol pools were higher in the women (P < 0.001 and P < 0.008). VLDL(1)-TG FCR and PR and VLDL(2)-TG FCR were not different between genders.Conclusion:Fatty acid and VLDL(2)-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels.
Das S, Umpleby M, Shahmanesh M. (2012) 'Antiretroviral therapy can be associated with increase in LDL apolipoprotein-B residence time without increase in LDL-apo-B oxidation and glycation'. WILEY-BLACKWELL HIV MEDICINE, 13, pp. 50-50.
doi: 10.1111/j.1468-1293.2011.01009.x
Haidar A, Potocka E, Boulet B, Umpleby AM, Hovorka R. (2012) 'Estimating postprandial glucose fluxes using hierarchical Bayes modelling.'. Comput Methods Programs Biomed,
doi: 10.1016/j.cmpb.2012.01.010
Murphy HR, Elleri D, Allen JM, Harris J, Simmons D, Rayman G, Temple RC, Umpleby AM, Dunger DB, Haidar A, Nodale M, Wilinska ME, Hovorka R. (2012) 'Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy.'. Diabetologia, Germany: 55 (2), pp. 282-293.
doi: 10.1007/s00125-011-2363-6
McGee KC, Shahmanesh M, Boothby M, Nightingale P, Gathercole LL, Tripathi G, Harte AL, Shojaee-Moradie F, Umpleby AM, Das S, Al-Daghri NM, McTernan PG, Tomlinson JW. (2012) 'Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones.'. Antivir Ther, England: 17 (3), pp. 495-507.
doi: 10.3851/IMP2017
Zachariah S, Sheldon B, Shojaee-Moradie F, Jackson NC, Backhouse K, Johnsen S, Jones RH, Umpleby AM, Russell-Jones DL. (2011) 'Insulin detemir reduces weight gain as a result of reduced food intake in patients with type 1 diabetes.'. American Diabetes Association Diabetes Care, United States: 34 (7), pp. 1487-1491.
doi: 10.2337/dc11-0098
Full text is available at: http://epubs.surrey.ac.uk/710270/

Abstract

Insulin detemir lacks the usual propensity for insulin to cause weight gain. We investigated whether this effect was a result of reduced energy intake and/or increased energy expenditure.
Birzniece V, Meinhardt UJ, Umpleby MA, Handelsman DJ, Ho KKY. (2011) 'Interaction between testosterone and growth hormone on whole-body protein anabolism occurs in the liver'. Journal of Clinical Endocrinology and Metabolism, 96 (4), pp. 1060-1067.
doi: 10.1210/jc.2010-2521
Murphy HR, Elleri D, Allen JM, Harris J, Simmons D, Rayman G, Temple RC, Umpleby AM, Dunger DB, Haidar A, Nodale M, Wilinska ME, Hovorka R. (2011) 'Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy'. Diabetologia, , pp. 1-12.
Regan FM, Williams RM, McDonald A, Umpleby AM, Acerini CL, O'Rahilly S, Hovorka R, Semple RK, Dunger DB. (2010) 'Treatment with Recombinant Human Insulin-Like Growth Factor (rhIGF)-I/rhIGF Binding Protein-3 Complex Improves Metabolic Control in Subjects with Severe Insulin Resistance'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 95 (5), pp. 2113-2122.
doi: 10.1210/jc.2009-2088
Whyte MB, Jackson NC, Shojaee-Moradie F, Treacher DF, Beale RJ, Jones RH, Umpleby AM. (2010) 'Metabolic effects of intensive insulin therapy in critically ill patients'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 298 (3), pp. E697-E705.
doi: 10.1152/ajpendo.00407.2009
Regan FM, Williams RM, McDonald A, Umpleby AM, Acerini CL, O'Rahilly S, Hovorka R, Semple RK, Dunger DB. (2010) 'Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistance (Journal of Clinical Endocrinology and Metabolism (2010) 95, (2113-2122))'. Journal of Clinical Endocrinology and Metabolism, 95 (8), pp. 4101-4101.
doi: 10.1210/jc.2009-2088
Smeeton F, Moradie FS, Jones RH, Westergaard L, Haahr H, Umpleby AM, Russell-Jones DL. (2009) 'Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes'. SPRINGER DIABETOLOGIA, 52 (11), pp. 2317-2323.
doi: 10.1007/s00125-009-1487-4
Higham CE, Rowles S, Russell-Jones D, Umpleby AM, Trainer PJ. (2009) 'Pegvisomant Improves Insulin Sensitivity and Reduces Overnight Free Fatty Acid Concentrations in Patients with Acromegaly'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 94 (7), pp. 2459-2463.
doi: 10.1210/jc.2008-2086
Brackenridge AL, Jackson N, Jefferson W, Stolinski M, Shojaee-Moradie F, Hovorka R, Umpleby AM, Russell-Jones D. (2009) 'Effects of rosiglitazone and pioglitazone on lipoprotein metabolism in patients with Type 2 diabetes and normal lipids'. WILEY-BLACKWELL PUBLISHING, INC DIABETIC MEDICINE, 26 (5), pp. 532-539.
doi: 10.1111/j.1464-5491.2009.02729.x
Full text is available at: http://epubs.surrey.ac.uk/711084/
Boothby M, McGee KC, Tomlinson JW, Gathercole LL, McTernan PG, Shojaee-Moradie F, Umpleby AM, Nightingale P, Shahmanesh M. (2009) 'Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, 14 (8), pp. 1089-1100.
doi: 10.3851/IMP1457
Stolinski M, Alam S, Jackson NC, Shojaee-Moradie F, Pentecost C, Jefferson W, Christ ER, Jones RH, Umpleby AM. (2008) 'Effect of 6-month supervised exercise on low-density lipoprotein apolipoprotein B kinetics in patients with type 2 diabetes mellitus'. W B SAUNDERS CO-ELSEVIER INC METABOLISM-CLINICAL AND EXPERIMENTAL, 57 (11), pp. 1608-1614.
doi: 10.1016/j.metabol.2008.06.018
Murphy R, Baptista J, Holly J, Umpleby AM, Ellard S, Harries LW, Crolla J, Cundy T, Hattersley AT. (2008) 'Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 Gene'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 93 (11), pp. 4373-4380.
doi: 10.1210/jc.2008-0819
Giannoulis MG, Jackson N, Shojaee-Moradie F, Nair KS, Sonksen PH, Martin FC, Umpleby AM. (2008) 'The effects of growth hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men: A randomized controlled trial'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 93 (8), pp. 3066-3074.
doi: 10.1210/jc.2007-2695
Full text is available at: http://epubs.surrey.ac.uk/1671/
Burt MG, Johannsson G, Umpleby AM, Chisholm DJ, Ho KKY. (2008) 'Impact of growth hormone and dehydroepiandrosterone on protein metabolism in glucocorticoid-treated patients'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 93 (3), pp. 688-695.
doi: 10.1210/jc.2007-2333
Burt MG, Gibney J, Hoffman DM, Umpleby AM, Ho KKY. (2008) 'Relationship between GH-induced metabolic changes and changes in body composition: A dose and time course study in GH-deficient adults'. CHURCHILL LIVINGSTONE GROWTH HORMONE & IGF RESEARCH, 18 (1), pp. 55-64.
doi: 10.1016/j.ghir.2007.07.005
Zachariah S, Brackenridge A, Shojaee-Moradie F, Camuncho-Hubner C, Umpleby AM, Russell-Jones D. (2007) 'The mechanism of non-islet cell hypoglycaemia caused by tumour-produced IGF-II'. BLACKWELL PUBLISHING CLINICAL ENDOCRINOLOGY, 67 (4), pp. 637-638.
doi: 10.1111/j.1365-2265.2007.02938.x
Burt MG, Johannsson G, Umpleby AM, Chisholm DJ, Ho KKY. (2007) 'Impact of acute and chronic low-dose glucocorticoids on protein metabolism'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 92 (10), pp. 3923-3929.
doi: 10.1210/jc.2007-0951
Holt HB, Wild SH, Wareham N, Ekelund U, Umpleby M, Shojaee-Moradie F, Holt RIG, Phillips DI, Byrne CD. (2007) 'Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity'. SPRINGER DIABETOLOGIA, 50 (8), pp. 1698-1706.
doi: 10.1007/s00125-007-0705-1
Holt HB, Wild SH, Postle AD, Zhang J, Koster G, Umpleby M, Shojaee-Moradie F, Dewbury K, Wood PJ, Phillips DI, Byrne CD. (2007) 'Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men'. SPRINGER DIABETOLOGIA, 50 (5), pp. 1024-1032.
doi: 10.1007/s00125-007-0629-9
Gibney J, Wolthers T, Burt MG, Leung K-C, Umpleby AM, Ho KKY. (2007) 'Protein metabolism in acromegaly: Differential effects of short- and long-term treatment'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 92 (4), pp. 1479-1484.
doi: 10.1210/jc.2006-0664
Shojaee-Moradie F, Baynes KCR, Pentecost C, Bell JD, Thomas EL, Jackson NC, Stolinski M, Whyte M, Lovell D, Bowes SB, Gibney J, Jones RH, Umpleby AM. (2007) 'Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism'. SPRINGER DIABETOLOGIA, 50 (2), pp. 404-413.
doi: 10.1007/s00125-006-0498-7
Giannoulis MG, Jackson N, Shojaee-Moradie F, Sonksen PH, Martin FC, Umpleby AM. (2006) 'Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: A randomised controlled trial'. CHURCHILL LIVINGSTONE GROWTH HORMONE & IGF RESEARCH, 16 (5-6), pp. 308-317.
doi: 10.1016/j.ghir.2006.08.001
Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, Acerini CL, Umpleby AM, Dunger DB. (2006) 'Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes'. AMER DIABETES ASSOC DIABETES, 55 (8), pp. 2365-2370.
doi: 10.2337/db05-1646
Baynes KCR, Nicholas MD, Shojaee-Moradie F, Umpleby AM, Giannoulis MG. (2006) 'Acute regulation of plasma leptin by isoprenaline in lean and obese fasted subjects'. BLACKWELL PUBLISHING DIABETES OBESITY & METABOLISM, 8 (4), pp. 412-418.
doi: 10.1111/j.1463-1326.2005.00517.x
Christ ER, Cummings MH, Stolinski M, Jackson N, Lumb PJ, Wierzbicki AS, Sonksen PH, Russell-Jones DL, Umpleby AM. (2006) 'Low-density lipoprotein apolipoprotein B100 turnover in hypopituitary patients with GH deficiency: a stable isotope study'. BIO SCIENTIFICA LTD EUROPEAN JOURNAL OF ENDOCRINOLOGY, 154 (3), pp. 459-466.
doi: 10.1530/eje.1.02105
Das S, Shahmanesh M, Stolinski M, Shojaee-Moradie F, Jefferson W, Jackson NC, Cobbold M, Nightingale P, Umpleby AM. (2006) 'In treatment-naive and antiretroviral-treated subjects with HIV, reduced plasma adiponectin is associated with a reduced fractional clearance rate of VLDL, IDL and LDL apolipoprotein B-100'. SPRINGER DIABETOLOGIA, 49 (3), pp. 538-542.
doi: 10.1007/s00125-005-0085-3
Brackenridge A, Pearson ER, Shojaee-Moradie F, Hattersley AT, Russell-Jones D, Umpleby AM. (2006) 'Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1 beta and -1 alpha mutations'. AMER DIABETES ASSOC DIABETES, 55 (2), pp. 405-411.
doi: 10.2337/diabetes.55.02.06.db05-1019
Giannoulis MG, Sonksen PH, Umpleby M, Breen L, Pentecost C, Whyte M, McMillan CV, Bradley C, Martin FC. (2006) 'The effects of growth hormone and/or testosterone in healthy elderly men: A randomized controlled trial'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 91 (2), pp. 477-484.
doi: 10.1210/jc.2005-0957
Healy ML, Gibney J, Pentecost C, Croos P, Russell-Jones DL, Sonken PH, Umpleby AM. (2006) 'Effects of high-dose growth hormone on glucose and glycerol metabolism at rest and during exercise in endurance-trained athletes'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 91 (1), pp. 320-327.
doi: 10.1210/jc.2005-0916
Amin R, Williams RM, Frystyk J, Umpleby M, Matthews D, Orskov H, Dalton RN, Dunger DB. (2005) 'Increasing urine albumin excretion is associated with growth hormone hypersecretion and reduced clearance of insulin in adolescents and young adults with type 1 diabetes: The Oxford Regional Prospective Study'. BLACKWELL PUBLISHING LTD CLINICAL ENDOCRINOLOGY, 62 (2), pp. 137-144.
doi: 10.1111/j.1365-2265.2005.02185.x
Yuen K, Frystyk J, Umpleby M, Fryklund L, Dunger D. (2004) 'Changes in free rather than total insulin-like growth factor-I enhance insulin sensitivity and suppress endogenous peak growth hormone (GH) release following short-term low-dose GH administration in young healthy adults'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 89 (8), pp. 3956-3964.
doi: 10.1210/jc.2004-0300
Williams RM, Amin R, Shojaee-Moradie F, Umpleby M, Ong KK, Acerini CL, Dunger DB. (2002) 'The effects of the specific growth hormone antagonist Pegvisomant on the GH/IGF-I axis and insulin sensitivity in adolescents with TIDM'. AMER DIABETES ASSOC DIABETES, 51, pp. A117-A117.
Hordern VM, Wright JE, Umpleby M, Jacobsen L, Draeger E, Russell-Jones DL. (2002) 'Stable isotope studies show differences in effect of insulin detemir and NPH insulin on hepatic glucose output and peripheral glucose uptake after subcutaneous administration in subjects with type1 diabetes'. AMER DIABETES ASSOC DIABETES, 51, pp. A292-A292.
Wolthers T, Hoffman DM, Nugent AG, Duncan MW, Umpleby M, Ho KKY. (2001) 'Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 281 (6), pp. E1191-E1196.
Hordern V, Wright J, Umpleby M, Jacobsen L, Russell-Jones D. (2001) 'Stable isotope studies show effect of insulin detemir and NPH on hepatic glucose output and peripheral glucose uptake after subcutaneous administration in healthy subjects'. AMER DIABETES ASSOC DIABETES, 50, pp. A504-A505.
Carroll PV, Umpleby M, Alexander EL, Egel VA, Callison KV, Sonksen PH, Russell-Jones DL. (1998) 'Recombinant human insulin-like growth factor-I (rhIGF-I) therapy in adults with type 1 diabetes mellitus: effects on IGFs, IGF-binding proteins, glucose levels and insulin treatment'. BLACKWELL SCIENCE LTD CLINICAL ENDOCRINOLOGY, 49 (6), pp. 739-746.
doi: 10.1046/j.1365-2265.1998.00600.x
Joseph SE, Heaton N, Potter D, Pernet A, Umpleby M, Amiel SA. (1998) 'Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation.'. SPRINGER VERLAG DIABETOLOGIA, 41, pp. A68-A68.
Carroll PV, Umpleby M, Ward GS, Imuere S, Alexander E, Dunger D, Sonksen PH, RussellJones DL. (1997) 'rhIGF-I administration reduces insulin requirements, decreases growth hormone secretion, and improves the lipid profile in adults with IDDM'. AMER DIABETES ASSOC DIABETES, 46 (9), pp. 1453-1458.
doi: 10.2337/diabetes.46.9.1453
Carroll P, Christ E, Gowrie I, Jackson N, Hovorka R, Albany E, Bowes S, Umpleby M, Sonksen P, RussellJones D. (1997) 'Daily rhIGF-I augments the anabolic effect of insulin in adults with IDDM.'. AMER DIABETES ASSOC DIABETES, 46, pp. 945-945.
Salomon F, Umpleby M, Cuneo RC, Sonksen PH. (1997) 'Protein, fat and glucose metabolism during treatment with recombinant human growth hormone in adults with growth hormone deficiency. Short-and long-term effects'. BAILLIERE TINDALL ENDOCRINOLOGY AND METABOLISM, 4 (2), pp. 121-128.
Bowes SB, Umpleby M, Cummings MH, Jackson NC, Carroll PV, Lowy C, Sonksen PH, RussellJones DL. (1997) 'The effect of recombinant human growth hormone on glucose and leucine metabolism in Cushing's syndrome'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 82 (1), pp. 243-246.
doi: 10.1210/jc.82.1.243
RussellJones DL, Umpleby M. (1996) 'Protein anabolic action of insulin, growth hormone and insulin-like growth factor I'. SCANDINAVIAN UNIVERSITY PRESS EUROPEAN JOURNAL OF ENDOCRINOLOGY, 135 (6), pp. 631-642.
WATTS GF, CUMMINGS MH, UMPLEBY M, QUINEY J, NAOUMOVA R, THOMPSON GR, SONKSEN PH. (1995) 'SIMVASTATIN DECREASES THE HEPATIC SECRETION OF VERY-LOW-DENSITY LIPOPROTEIN APOLIPOPROTEIN B-100 IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS'. BLACKWELL SCIENCE LTD EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 25 (8), pp. 559-567.
doi: 10.1111/j.1365-2362.1995.tb01746.x
CUMMINGS MH, WATTS GF, UMPLEBY M, HENNESSY TR, QUINEY J, SONKSEN PH. (1995) 'INCREASED HEPATIC SECRETION OF VERY-LOW-DENSITY-LIPOPROTEIN APOLIPOPROTEIN B-100 IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA - A STABLE-ISOTOPE STUDY'. ELSEVIER SCI PUBL IRELAND LTD ATHEROSCLEROSIS, 113 (1), pp. 79-89.
doi: 10.1016/0021-9150(94)05430-Q
CUMMINGS MH, WATTS GF, PAL C, UMPLEBY M, HENNESSY TR, NAOUMOVA R, SONKSEN PH. (1995) 'INCREASED HEPATIC SECRETION OF VERY-LOW-DENSITY LIPOPROTEIN APOLIPOPROTEIN B-100 IN OBESITY - A STABLE-ISOTOPE STUDY'. PORTLAND PRESS CLINICAL SCIENCE, 88 (2), pp. 225-233.
RUSSELLJONES D, UMPLEBY M, HENNESEY T, BOWES SB, HOPKINS KD, JACKSON NC, KELLY J, THOMASON MJ, SHOJAEEMORADIE F, JONES RH, SONKSEN PH. (1993) 'INTRAVENOUS INSULIN-LIKE GROWTH FACTOR-I (IGF-I) UNLIKE INSULIN INCREASES WHOLE-BODY PROTEIN-SYNTHESIS IN NORMAL VOLUNTEERS'. AMER DIABETES ASSOC DIABETES, 42, pp. A37-A37.
SONKSEN PH, SALOMON F, CUNEO R, UMPLEBY M, BOWES S. (1991) 'CARDIAC CACHEXIA'. BRITISH MED JOURNAL PUBL GROUP BRITISH MEDICAL JOURNAL, 302 (6778), pp. 725-726.

Conference papers

Elleri D, Allen JM, Harris J, Haidar A, Kumareswaran K, Leelarathna L, Nodale M, Wilinska ME, Weston J, Acerini CL, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. (2011) 'Glucose appearance of large evening meals with low and high glycaemic load in type 1 diabetes'. SPRINGER DIABETOLOGIA, Lisbon, PORTUGAL: 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 54, pp. S54-S54.
Alsini N, Shojaee-Moradie F, Sheldon B, Robertson MD, Russell-Jones DL, Umpleby AM, Wright J. (2011) 'Effect of insulin detemir on adipocyte lipid metabolism in patients with type 2 diabetes'. SPRINGER DIABETOLOGIA, Lisbon, PORTUGAL: 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 54, pp. S236-S237.
Hakim O, Shojaee-Moradie F, Hart K, Berry J, Eastell R, Gossiel F, Hannon R, Umpleby M, Griffin B, Lanham-New S. (2011) 'Evidence of a link between poor bone health, low vitamin D status and CVD risk in caucasian and asian women'. ELSEVIER SCIENCE INC BONE, Athens, GREECE: 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society 48, pp. S197-S198.
doi: 10.1016/j.bone.2011.03.698
Das S, Shahmansh M, Umpleby M. (2011) 'Antiretroviral therapy can be associated with increase in LDL apolipoprotein-B residence time without increase in LDL-apo-B oxidation and glycation'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, 16, pp. A11-A12.
Shojaee-Moradie F, Backhouse K, Sarac I, Stoliniski M, Robertson D, Bell JD, Thomas EL, Russell-Jones D, Umpleby M. (2010) 'Fatty acid oxidation rate is higher in obese women than obese men'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53
Zachariah S, Sheldon B, Shojaee-Moradie E, Jackson N, Backhouse K, Johnsen S, Umpleby M, Russell-Jones D. (2010) 'Mechanism for the differential effect of the long-acting insulin analog detemir on weight in patients with type 1 diabetes'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53
Elleri D, Harris J, Kumareswaran K, Allen JM, Haidar A, Nodale M, Swamy A, Wilinska ME, Weston J, Acerini CL, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. (2010) 'Glucose appearance of large slowly-absorbed evening meal containing complex carbohydrates (CHO) in type 1 diabetes (T1D)'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53
Haidar A, Elleri D, Allen JM, Harris J, Kumareswaran K, Nodale M, Acerini CL, Wilinska ME, Jackson N, Umpleby AM, Evans ML, Dunger DB, Hovorka R. (2010) 'Triple tracer (TT) and double tracer (DT) techniques are reliable methods to estimate glucose appearance in type 1 diabetes'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53
Li X, Stolinski M, Jackson NC, Umpleby MA. (2010) 'A NOVEL METHOD FOR THE MEASUREMENT OF PRE beta HDL AND alpha HDL KINETICS WITH STABLE ISOTOPIC LABELLING TECHNIQUES'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPPLEMENTS, Hamburg, GERMANY: 78th Congress of the European-Atherosclerosis-Society 11 (2), pp. 7-7.
Potocka E, Hovorka R, Baughman RA, Klein O, Dellweg SM, Umpleby AM, Haworth PC, Mills RJ, Boss AH, Richardson PC. (2010) 'Characterization of Metabolism Parameters Following Technosphere (R) Insulin and Insulin Lispro'. AMER DIABETES ASSOC DIABETES, Orlando, FL: 70th Annual Meeting of the American-Diabetes-Association 59, pp. A413-A413.
Potocka E, Hovorka R, Baughman R, Umpleby M, Diaz M, Chen R, Cassidy J, Boss A, Richardson P. (2009) 'Technosphere insulin suppresses endogenous glucose production earlier than a rapid-acting analogue (lispro) and an inhaled insulin (Exubera (R))'. SPRINGER DIABETOLOGIA, Vienna, AUSTRIA: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 52, pp. S374-S374.
Li X, Stolinski M, Jackson N, Umpleby M. (2009) 'Pre beta and alpha HDL kinetics measured by a stable isotopic and two step electrophoresis technique'. SPRINGER DIABETOLOGIA, Vienna, AUSTRIA: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 52, pp. S490-S490.
Sarac I, Backhouse K, Shojaee-Moradie F, Robertson D, Stolinski M, Umpleby M. (2009) 'The effect of rimonabant on resting energy expenditure, insulin sensitivity, plasma lipids and adipokines concentrations'. WILEY-BLACKWELL PUBLISHING, INC BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Brighton, ENGLAND: Meeting of the British-Pharmacological-Society, Clinical Pharmacology Section 68 (2), pp. 285-285.
Potocka E, Hovorka R, Baughman RA, Umpleby M, Diaz MLM, Chen R, Boss AH, Richardson PC. (2009) 'AFRESA (TM) Suppresses Endogenous Glucose Production Earlier Than a Rapid-Acting Analog (Lispro) and Inhaled Exubera (R)'. AMER DIABETES ASSOC DIABETES, New Orleans, LA: 69th Annual Meeting of the American-Diabetes-Association 58, pp. A61-A61.
Shahmanesh M, Das S, Umpleby M. (2009) 'Pre-treatment alterations in lipoprotein metabolism predict changes in blood lipids after antiretroviral therapy'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, Philadelphia, PA: 11th International Workshop on AdverseDrug Reactions and Co-Morbidities in HIV 14 (7), pp. A56-A56.
Sun F, Stolinski M, Shojaee-Moradie F, Hovorka R, Umpleby AM. (2008) 'Measurement of postprandial triacylglycerol kinetics in both endogenous and exogenous lipoproteins using a novel immunoaffinity chromatography method'. SPRINGER DIABETOLOGIA, 51, pp. S300-S300.
Li X, Stolinski M, Shojaee-Moradie F, Jackson N, Umpleby M. (2008) 'DEVELOPMENT OF A METHOD TO MEASURE HIGH DENSITY LIPOPROTEIN KINETICS USING STABLE ISOTOPES'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPP, 9 (1), pp. 28-28.
doi: 10.1016/S1567-5688(08)70104-1
Boothby M, Umpleby AM, Shojaee-Moradie F, Tomlinson JW, Gathercole LL, McGee K, Das S, Shahmanesh M. (2008) 'HIV infection significantly reduces lipoprotein lipase which remains low after 6 months of antiretroviral therapy'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, London, ENGLAND: 10th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 13 (8), pp. A57-A57.
Byrne CDT, Holt HB, Wild SH, Wareham N, Ekelund U, Umpleby M, Shojaee-Moradie E, Holt RIG, Phillips DI. (2007) 'Differential impact of fatness, fitness and physical activity energy expenditure on whole body, liver and fat insulin sensitivity'. SPRINGER DIABETOLOGIA, Amsterdam, NETHERLANDS: 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes 50, pp. S255-S255.
Smeeton FJ, Shojaee-Moradie E, Jackson N, Jones RH, Umpleby AM, Russell-Jones D. (2007) 'Is insulin detemir hepatoselective when compared to NPH insulin using stable isotope methodology at plasma glucose concentrations of less than 4 mmol/l?'. SPRINGER DIABETOLOGIA, Amsterdam, NETHERLANDS: 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes 50, pp. S24-S25.
Sun F, Stolinski M, Shojaee-Moradie F, Umpleby AM. (2007) 'Measurement of endogenous and exogenous triacylglycerol kinetics in the fed and fasted states'. PORTLAND PRESS LTD BIOCHEMICAL SOCIETY TRANSACTIONS, Royal Vet Coll, London, ENGLAND: Conference on Diet and Cardiovascular Health - Chylomicron Remnants and Their Emerging Roles in Vascular Dysfunction in Atherogenesis 35, pp. 482-483.
Smeeton FJ, Shojaee-Moradie F, Jackson N, Westergaard L, Endahl L, Haahr H, Umpleby AM, Russell-Jones D. (2007) 'No difference in cognitive function, symptoms or counter-regulatory responses after induced hypoglycaemia in subjects with type 1 diabetes'. AMER DIABETES ASSOC DIABETES, Chicago, IL: 67th Annual Meeting of the American-Diabetes-Association 56, pp. A168-A168.
Stolinski M, Li X, Lo A, Shojaee-Moradie F, Alam S, Wheeler B, Pentecost C, Jackson N, Jefferson W, Umpleby M. (2006) 'A supervised exercise programme increases HDL ApoA-1 production rate in type 2 diabetes'. SPRINGER DIABETOLOGIA, Copenhagen, DENMARK: 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) 49, pp. 324-324.
Sharma R, Tigas S, Rauchhaus M, Poole-Wilson PP, Coats AJ, Umpleby M, Carroll PV, Anker SD. (2005) 'Substrate metabolism in patients with chronic heart failure with and without cachexia'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, Dallas, TX: 78th Annual Scientific Session of the American-Heart-Association 112 (17), pp. U660-U660.
Shahmanesh M, Das S, Shojaee-Moradie F, Stolinski M, Jefferson W, Jackson N, Gilleran G, Crabtree NJ, Nightingale P, Cramb R, Umpleby M. (2004) 'The reduction in serum adiponectin levels in HIV patients correlates with apolipoprotein-B clearance'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, Washington, DC: 6th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 9 (6), pp. L62-L63.
Whyte M, Jackson N, Shojaee-moradie F, Beale R, Treacher D, Carroll P, Jones RH, Umpleby M. (2004) 'The effect of insulin therapy on glucose production rate, glucose uptake, lipolysis and proteolysis in non-surgical ICU patients'. SPRINGER DIABETOLOGIA, Munich, GERMANY: 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 47, pp. A216-A216.
Umpleby M, Shojaee-Moradie F, Das S, Stolinski M, Jefferson W, Jackson N, Cramb R, Shahmanesh M. (2004) 'Adiponectin levels are reduced in HIV infection and after treatment and correlate with VLDL and IDL apolipoprotein B fractional catabolic rate'. SPRINGER DIABETOLOGIA, Munich, GERMANY: 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 47, pp. A233-A234.
Das S, Stolinski M, Jefferson W, Jackson N, Gilleran G, O'Connor M, Cramb R, Shahmanesh M, Umpleby M. (2003) 'The relationship between fat distribution and VLDL and IDL metabolism in HIV-infected adults'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, Paris, FRANCE: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 8 (4), pp. L52-L52.
Das S, Stolinski M, Jefferson W, Jackson N, Gilleran G, O'Connor M, Cramb R, Umpleby M, Shahmanesh M. (2003) 'Effects of HIV infection, antiviral treatment and body fat changes on V-LDL-apolipoprotein-B metabolism'. INT MEDICAL PRESS LTD ANTIVIRAL THERAPY, Paris, FRANCE: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 8 (4), pp. L6-L7.
Hordern V, Wright J, Umpleby M, Jacobsen L, Russell-Jones D. (2003) 'Stable isotope studies show differences in effect of lnsulin detemir and NPH on hepatic glucose output after subcutaneous administration in subjects with type 2 diabetes mellitus'. AMER DIABETES ASSOC DIABETES, NEW ORLEANS, LOUISIANA: 63rd Scientific Sessions of the American-Diabetes-Association 52, pp. A547-A547.
Williams R, Amin R, Shojaee-Moradie F, Umpleby M, Acerini C, Dunger D. (2003) 'Effects of the specific growth hormone receptor antagonist Pegvisomant on insulin sensitivity & lipid metabolism in adolescents with T1DM'. AMER DIABETES ASSOC DIABETES, NEW ORLEANS, LOUISIANA: 63rd Scientific Sessions of the American-Diabetes-Association 52, pp. A334-A334.

Teaching

Module leader MSc Clinical Biochemistry-M3 Pathophysiology 2

Undergraduate

Level 3: BMS3039 Regulation of metabolism, lipoproteins and diabetes

: BMS 3016 Nutrition Research Methodology

Undergraduate research projects

Postgraduate

MSc Clinical Biochemistry

MSc research projects

Departmental Duties

Cardiovascular Disease, Diabetes and Metabolism Theme Leader

Member of Faculty Research Committee

Member of University Research Committee

Chair of MD Review Committee

Affiliations

Member Diabetes UK

Member European Association for study of Diabetes