Professor Andrew Nisbet
Email: a.nisbet@surrey.ac.uk
Phone: Work: 01483 68 9413
Room no: 27 BC 04
Further information
Publications
Highlights
- . (2012) 'Physics-aspects of dose accuracy in high dose rate (HDR) brachytherapy: Source dosimetry, treatment planning, equipment performance and in vivo verification techniques'. Journal of Contemporary Brachytherapy, 4 (2), pp. 81-91.
- . (2012) 'Modelling and detecting tumour oxygenation levels.'. PLoS One, United States: 7 (6)
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(2011) 'Volumetric modulated arc therapy: a review of current literature and clinical use in practice.'. Br J Radiol, England: 84 (1007), pp. 967-996.doi: 10.1259/bjr/22373346
- . (2011) 'Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001.'. Elsevier Radiotherapy and Oncology, Ireland: 100 (2), pp. 176-183.
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(2011) 'DESIGN CONCEPT FOR A NOVEL SQUID-BASED MICRODOSEMETER'. OXFORD UNIV PRESS RADIATION PROTECTION DOSIMETRY, Verona, ITALY: 15th International Symposium on Microdosimetry 143 (2-4), pp. 427-431.doi: 10.1093/rpd/ncq475
- . (2008) 'Cardiac dose from tangential breast cancer radiotherapy in the year 2006'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72 (2), pp. 501-507.
- . (2007) 'Cardiac exposures in breast cancer radiotherapy: 1950s-1990s'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69 (5), pp. 1484-1495.
Journal articles
- . (2013) 'Verification of high dose rate brachytherapy dose distributions with EBT3 Gafchromic film quality control techniques.'. Phys Med Biol, England: 58 (3), pp. 497-511.
- . (2012) 'Review of doped silica glass optical fibre: Their TL properties and potential applications in radiation therapy dosimetry'. Applied Radiation and Isotopes, 71 (SUPPL.), pp. 2-11.
- . (2012) 'Volumetric-modulated arc therapy (RapidArc) vs. conventional fixed-field intensity-modulated radiotherapy for (18)F-FDG-PET-guided dose escalation in oropharyngeal cancer: A planning study.'. Med Dosim,
- . (2012) 'A simple approach for EPID dosimetric calibration to overcome the effect of image-lag and ghosting'. Applied Radiation and Isotopes, 70 (7), pp. 1154-1157.
- . (2012) 'Establishment of Ge-doped optical fibres as thermoluminescence dosimeters for brachytherapy.'. Elsevier Appl Radiat Isot, England: 70 (7), pp. 1158-1161.
- . (2012) 'Comparison of the TL fading characteristics of Ge-doped optical fibres and LiF dosimeters'. Elsevier Appl Radiat Isot, 70 (7), pp. 1384-1387.
- . (2012) 'Establishment of Ge-doped optical fibres as thermoluminescence dosimeters for brachytherapy'. Applied Radiation and Isotopes, 70 (7), pp. 1158-1161.
- . (2012) 'An investigation of the thermoluminescence of Ge-doped SiO optical fibres for application in interface radiation dosimetry'. Applied Radiation and Isotopes, 70 (7), pp. 1436-1441.
- . (2012) 'A comparison of protocols for external beam radiotherapy beam calibrations.'. Appl Radiat Isot, England: 70 (7), pp. 1331-1336.
- . (2012) 'Comparison of the TL fading characteristics of Ge-doped optical fibres and LiF dosimeters'. Applied Radiation and Isotopes, 70 (7), pp. 1384-1387.
- . (2012) 'A comparison of protocols for external beam radiotherapy beam calibrations'. Applied Radiation and Isotopes, 70 (7), pp. 1331-1336.
- . (2012) 'A simple approach for EPID dosimetric calibration to overcome the effect of image-lag and ghosting.'. Appl Radiat Isot, England: 70 (7), pp. 1154-1157.
- . (2012) 'Physics-aspects of dose accuracy in high dose rate (HDR) brachytherapy: Source dosimetry, treatment planning, equipment performance and in vivo verification techniques'. Journal of Contemporary Brachytherapy, 4 (2), pp. 81-91.
- . (2012) 'Review of doped silica glass optical fibre: their TL properties and potential applications in radiation therapy dosimetry.'. Appl Radiat Isot, England: 71 Suppl, pp. 2-11.
- . (2012) 'Modelling and detecting tumour oxygenation levels.'. PLoS One, United States: 7 (6)
- . (2011) 'An investigation of the thermoluminescence of Ge-doped SiO(2) optical fibres for application in interface radiation dosimetry.'. Applied Radiation and Isotopes,
- .
(2011) 'Volumetric modulated arc therapy: a review of current literature and clinical use in practice.'. Br J Radiol, England: 84 (1007), pp. 967-996.doi: 10.1259/bjr/22373346
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(2011) 'The effect of 6 and 15 MV on intensity-modulated radiation therapy prostate cancer treatment: plan evaluation, tumour control probability and normal tissue complication probability analysis, and the theoretical risk of secondary induced malignancies.'. British Institute of Radiology British Journal of Radiology, 85 (1012), pp. 423-432.doi: 10.1259/bjr/24514638Full text is available at: http://epubs.surrey.ac.uk/712610/
Abstract
Objective: To investigate the effect of 6 and 15 MV photon energies on intensity-modulated radiation therapy (IMRT) prostate cancer treatment plan outcome and to compare the theoretical risks of secondary induced malignancies. Methods: Separate prostate cancer IMRT plans were prepared for 6 and 15 MV beams. Organ equivalent doses were obtained through thermoluminescent dosimeter (TLD) measurements in a Rando phantom. The neutron dose contribution at 15 MV was measured using polyallyl-diglycol-carbonate (PADC) neutron track etch detectors. Risk coefficients from ICRP Report 103 were used to compare the risk of fatal secondary induced malignancies in out-of-field organs and tissues for 6 and 15 MV. For the bladder and the rectum, a comparative evaluation of the risk using three separate models was carried out. Dose-volume parameters for the rectum, bladder and prostate planning-target-volume were evaluated, as well as normal tissue complication probability (NTCP) and tumour control probability (TCP) calculations. Results: There is a small increased theoretical risk of developing a fatal cancer from 6 MV compared with 15 MV, taking into account all the organs. Dose-volume parameters for the rectum and bladder show that 15 MV results in better volume sparing in the regions below 70 Gy, but the volume exposed increases slightly beyond this in comparison to 6 MV, resulting in a higher NTCP for the rectum of 3.6% versus 3.0% (p = 0.166). Conclusion: The choice to treat using IMRT at 15 MV should not be excluded, but should be based on risk versus benefit, considering the age and life expectancy of the patient together with the relative risk of radiation-induced cancer and NTCPs.
- . (2011) 'Investigation of the use of Ge-doped optical fibre for in vitro IMRT prostate dosimetry'. Elsevier Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 652 (1), pp. 819-823.
- . (2011) 'Cardiac dose estimates from Danish and Swedish breast cancer radiotherapy during 1977-2001.'. Elsevier Radiotherapy and Oncology, Ireland: 100 (2), pp. 176-183.
- . (2011) 'Dose-rate and the reciprocity law: TL response of Ge-doped SiO2 optical fibers at therapeutic radiation doses'. Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 652 (1), pp. 891-895.
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(2011) 'Design Concept for a novel SQUID based Micobolometer'. Oxford University Press Radiation Protection Dosimetry, 143 (2-4), pp. 427-431.doi: 10.1093/rpd/ncq475Full text is available at: http://epubs.surrey.ac.uk/712662/
- . (2010) 'Simulation of tissue activity curves of Cu-64-ATSM for sub-target volume delineation in radiotherapy'. IOP PUBLISHING LTD PHYSICS IN MEDICINE AND BIOLOGY, 55 (3), pp. 681-694.
- . (2010) 'An investigation of the response of the radiochromic dosimeter PRESAGE™ to irradiation by 62 MeV protons'. Journal of Physics: Conference Series, 250, pp. 155-159.
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(2010) 'The potential of Ge-doped optical fibre TL dosimetry for 3D verification of high energy IMRT photon beams'. ELSEVIER SCIENCE BV NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Melbourne, AUSTRALIA: 619 (1-3), pp. 157-162.Full text is available at: http://epubs.surrey.ac.uk/712616/
- . (2010) 'Electron dosimetry in the presence of small cavities'. Journal of Physics: Conference Series, 250, pp. 447-451.
- . (2010) 'AFM and uni-axial testing of pericardium exposed to radiotherapy doses'. Elsevier Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 652 (1), pp. 874-877.
- . (2010) 'Ge-doped optical fibres as thermoluminescence dosimeters for kilovoltage X-ray therapy irradiations'. Elsevier Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 652 (1), pp. 834-837.
- . (2009) 'Dosimetry of the microSelectron-HDR Ir-192 source using PRESAGE (TM) and optical CT'. PERGAMON-ELSEVIER SCIENCE LTD APPLIED RADIATION AND ISOTOPES, 67 (3), pp. 419-422.
- . (2009) 'Cardiac doses from Swedish breast cancer radiotherapy since the 1950s'. ELSEVIER IRELAND LTD RADIOTHERAPY AND ONCOLOGY, 90 (1), pp. 127-135.
- . (2009) 'An attempt to determine the saturation dose for PRESAGE'. Journal of Physics: Conference Series, 164 (1) Article number 012043
- . (2008) 'Evaluating commercial image registration packages for radiotherapy treatment planning'. PERGAMON-ELSEVIER SCIENCE LTD APPLIED RADIATION AND ISOTOPES, 66 (12), pp. 1948-1953.
- . (2008) 'Cardiac dose from tangential breast cancer radiotherapy in the year 2006'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 72 (2), pp. 501-507.
- . (2007) 'Cardiac exposures in breast cancer radiotherapy: 1950s-1990s'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69 (5), pp. 1484-1495.
- . (2007) 'Cardiac irradiation in breast radiotherapy'. ELSEVIER SCIENCE LONDON CLINICAL ONCOLOGY, 19 (4), pp. S3-S3.
- . (2004) 'Dosimetric verification of a commercial collapsed cone algorithm in simulated clinical situations.'. Radiother Oncol, Ireland: 73 (1), pp. 79-88.
- . (2004) 'The clinical implications of the collapsed cone planning algorithm'. ELSEVIER SCIENCE LONDON CLINICAL ONCOLOGY, 16 (2), pp. 148-154.
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(2004) 'Experiences of a proactive IR(ME)R inspection in radiotherapy.'. British Institute of Radiology British Journal of Radiology, England: 77 (916), pp. 329-332.doi: 10.1259/bjr/30494498Full text is available at: http://epubs.surrey.ac.uk/712611/
Abstract
The Ionizing Radiation (Medical Exposure) Regulations 2000, IR(ME)R, apply to the safety of the patient referred for a medical exposure to ionizing radiation. In Scotland, the Scottish Executive (Department of Health) is responsible for carrying out inspections of compliance with these regulations. IR(ME)R specifically addresses issues concerned with Employer's duties, responsibilities of the Practitioner, Operator and Referrer, justification of individual medical exposures for diagnosis and treatment, optimization of all procedures, clinical audit and adequate training of all duty holders. A proactive IR(ME)R inspection of the Clinical Oncology Department, Raigmore Hospital, Inverness, was carried out in November 2001 by inspectors based at the Department of Health, London, and seconded by the Scottish Executive, Department of Health. The aim of the inspection was to assess the degree of compliance with the regulations. In this case study the experiences of a proactive inspection are described in detail and some of the important elements of implementing IR(ME)R in a department that operates an ISO 9000-2000 Quality Management System addressed. The identification of IR(ME)R Duty Holders' responsibilities is one important aspect which may be inadequately described by the existing Quality Management System documentation. Other key elements of the inspection include the methods of authorizing the justification, the importance of the treatment prescription sheets in the demonstration of compliance with IR(ME)R, patient identification and pregnancy questions and dose recording procedures. The integration of the standard operating procedures as described in Schedule 1 of the regulations is also important. Where the existing Quality Management System documentation is written to include the IR(ME)R requirements of duty holder's responsibilities and the allocation of all the important tasks, then there is no need to re-badge these documents for IR(ME)R purposes. IR(ME)R encourages departments to focus on the safety of the patient and to document good practice. In order to comply, departments will have to show evidence of optimization of their procedures and must address the clinical governance issues associated with delivery of treatment.
- . (2001) 'Radiotherapy equipment--purchase or lease?'. Br J Radiol, England: 74 (884), pp. 735-744.
- . (2000) 'A collision prevention software tool for complex three-dimensional isocentric set-ups.'. Br J Radiol, ENGLAND: 73 (869), pp. 537-541.
- . (1999) 'An evaluation of epoxy resin phantom materials for megavoltage photon dosimetry.'. Phys Med Biol, ENGLAND: 44 (5), pp. 1125-1132.
- . (1998) 'An experimental evaluation of recent electron dosimetry codes of practice'. IOP PUBLISHING LTD PHYSICS IN MEDICINE AND BIOLOGY, 43 (8), pp. 1999-2014.
- . (1998) 'A dosimetric intercomparison of kilovoltage X-rays, megavoltage photons and electrons in the Republic of Ireland.'. Radiother Oncol, IRELAND: 48 (1), pp. 95-101.
- . (1998) 'An evaluation of epoxy resin phantom materials for electron dosimetry.'. Phys Med Biol, ENGLAND: 43 (6), pp. 1523-1528.
- . (1998) 'Spectral reconstruction of clinical megavoltage photon beams and the implications of spectral determination on the dosimetry of such beams.'. Phys Med Biol, ENGLAND: 43 (6), pp. 1507-1521.
- . (1998) 'Polarity and ion recombination correction factors for ionization chambers employed in electron beam dosimetry.'. Phys Med Biol, ENGLAND: 43 (2), pp. 435-443.
- . (1997) 'A dosimetric intercomparison of electron beams in UK radiotherapy centres'. IOP PUBLISHING LTD PHYSICS IN MEDICINE AND BIOLOGY, 42 (12), pp. 2393-2409.
Conference papers
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(2011) 'Investigating radionuclide source shielding performance using Ge-doped optical fibre thermoluminescence dosimeters'. American Institute of Physics AIP Conference Proceedings, Quito, Ecuador: IX LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS 1423, pp. 401-405.doi: 10.1063/1.3688835
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(2011) 'DESIGN CONCEPT FOR A NOVEL SQUID-BASED MICRODOSEMETER'. OXFORD UNIV PRESS RADIATION PROTECTION DOSIMETRY, Verona, ITALY: 15th International Symposium on Microdosimetry 143 (2-4), pp. 427-431.doi: 10.1093/rpd/ncq475
- . (2010) 'Development of a Microbolometer for Microdosimetry.'. Elsevier Radiotherapy and Oncology (Vol 96, Suppl 1), Barcelona, Spain: ESTRO 29, pp. S453-S453.
- . (2010) 'CBCt Evaluation of Interfraction Changes in Rectal and Bladder Volume in Prostate Cancer patients Receiving IG-IMRT'. Elsevier Radiotherapy & Oncology, Barcelona, Spain: ESTRO 29 96 (Supplement 1), pp. S 395-S 395.
- . (2010) 'Development of a Microbolometer for Microdosimetry'. Elsevier Radiotherapy & Oncology, Barcelona, Spain: ESTRO 29 96 (Supplement 1), pp. S 453-S 453.
- . (2010) '18F-FDG-PET Guided dose painting IMRT in oropharyngeal SCC: TCP and NTCP variations with dose and automated segmentation'. Oxford : Elsevier Radiotherapy & Oncology, Barcelona, Spain: ESTRO29 96 (Supplement 1), pp. S 308-S 308.
- . (2010) 'A mathematical approach towards simulating a realistic tissue activity curve of Cu-64-ATSM for the purpose of sub-target volume delineation in radiotherapy'. ELSEVIER SCIENCE BV NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Melbourne, AUSTRALIA: 11th International Symposium on Radiation Physics 619 (1-3), pp. 283-286.
- . (2010) 'Effect of penetrating ionising radiation on the mechanical properties of pericardium'. ELSEVIER SCIENCE BV NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, Melbourne, AUSTRALIA: 11th International Symposium on Radiation Physics 619 (1-3), pp. 356-360.
- . (2010) 'Effect of window level on target volume delineation in treatment planning'. PERGAMON-ELSEVIER SCIENCE LTD APPLIED RADIATION AND ISOTOPES, Czech Tech univ, Prague, CZECH REPUBLIC: 7th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Application 68 (4-5), pp. 602-604.
- . (2010) 'Viscosity changes in hyaluronic acid: Irradiation and rheological studies'. PERGAMON-ELSEVIER SCIENCE LTD APPLIED RADIATION AND ISOTOPES, Czech Tech univ, Prague, CZECH REPUBLIC: 7th International Topical Meeting on Industrial Radiation and Radioisotope Measurement Application 68 (4-5), pp. 746-750.
- . (2010) 'Impact of Intrafraction Motion on TCP and Rectal NTCP Values in Patients Receiving IG-IMRT for Prostate Cancer'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, San Diego, CA: 52nd Annual Meeting of the American-Society-For-Radiation-Oncology 78 (3), pp. S363-S364.
- . (2010) 'A Dose-response Relationship for the Incidence of Radiation-related Heart Disease'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, San Diego, CA: 52nd Annual Meeting of the American-Society-For-Radiation-Oncology 78 (3), pp. S49-S50.
- . (2010) 'CBCT Evaluation of Dose-Volume Changes in Contralateral Parotid Gland during Head and Neck IG-IMRT'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, San Diego, CA: 52nd Annual Meeting of the American-Society-For-Radiation-Oncology 78 (3), pp. S481-S482.
- . (2010) 'CBCT Evaluation of Dose-Volume Changes in Contralateral Parotid Gland during Head and Neck IG-IMRT'. ELSEVIER SCIENCE INC INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, San Diego, CA: 52nd Annual Meeting of the American-Society-For-Radiation-Oncology 78 (3), pp. S481-S482.
- . (2009) 'Computational simulation of tumour hypoxia as applied to radiation therapy applications'. IFMBE Proceedings, Munich, Germany: World Congress on Medical Physics and Biomedical Engineering 25 (1), pp. 64-66.
- . (2009) 'The Effect of Beam Energy on IMRT Treatment Plans and the Risk of Secondary-induced Malignancies'. Elsevier Clinical Oncology (Vol 21(3), Suppl 1), Cardiff, Wales: UK Radiation Oncology Conference (UKRO), pp. 246-246.
- . (2009) 'A Study of the Inherent Limitations of Image Fusion Software in Volume Delineation for Radiotherapy'. Elsevier Clinical Oncology (Vol 21(3), Suppl 1), Cardiff, Wales: UK Radiation Oncology Conference (UKRO), pp. 267-267.
- . (2007) 'Comparison of two prostate seed brachytherapy techniques using dosimetric analysis'. ELSEVIER IRELAND LTD RADIOTHERAPY AND ONCOLOGY, Barcelona, SPAIN: 9th Biennial Meeting on Physics and Radiation Technology for Clinical Radiotherapy 84, pp. S144-S145.
- . (2007) 'Dosimetry based on radiotherapy treatment planning'. RADIATION RESEARCH SOC RADIATION RESEARCH, Pacific Grove, CA: American-Statistical-Association-Conference on Radiation and Health 167 (3), pp. 359-359.
- . (2006) 'A radiobiological and clinical assessment of quality assurance tolerances in head and neck radiotherapy techniques'. ELSEVIER IRELAND LTD RADIOTHERAPY AND ONCOLOGY, Leipzig, GERMANY: Conference of the Spanish-Portuguese-and -Latin-American-Association 81, pp. S460-S460.
- . (2006) 'Heart and coronary artery doses from breast radiotherapy'. ELSEVIER IRELAND LTD RADIOTHERAPY AND ONCOLOGY, Leipzig, GERMANY: Conference of the Spanish-Portuguese-and -Latin-American-Association 81, pp. S283-S283.
- . (2003) 'The Scottish plus radiotherapy dosimetry audit system: recent results and pilot audit studies for MLC dosimetry and in-vivo dosimetry'. ELSEVIER IRELAND LTD RADIOTHERAPY AND ONCOLOGY, Geneva, SWITZERLAND: 7th Biennial Meeting on Physics and Radiation Technology for Clinical Radiotherapy 68, pp. S26-S26.
Book chapters
- . (2012) 'Electron Beam Physics'. in Sibtain A, Morgan A, MacDougall N (eds.) Physics for Clinical Oncology Oxford University Press, USA Article number 9 , pp. 102-113.

