Cognitive control in obsessive-compulsive disorder: an fMRI study before and after repetitive transcranial magnetic stimulation
Stella de Wit
- When?
- Tuesday 13 November 2012, 16.00 to 17.00
- Where?
- 01AC02
- Open to:
- Public, Staff, Students
- Speaker:
- Stella de Wit
The increased emotional reactivity to disease-specific stimuli seen in patients with obsessive-compulsive disorder (OCD) may be due a failure of cognitive control mediated by the dorsal prefrontal cortex. Additionally, endophenotype studies in unaffected relatives of OCD patients may uncover heritable traits related to the genetic susceptibility to OCD. In this talk data will be presented on the neural correlates of cognitive control assessed in a sample of 40 medication-free OCD patients, their unaffected siblings and matched healthy controls, that performed a response inhibition, a working memory and an emotion regulation task during functional MRI scanning. Furthermore, the effects of high-frequency (10Hz) and low-frequency (1Hz) repetitive transcranial magnetic stimulation (rTMS) versus sham rTMS over left dorsal PFC on emotion regulation in OCD patients and controls, respectively, will be discussed.
Stella J. de Wit
University of Amsterdam
Stella J. de Wit studied medicine at the University of Amsterdam, the Netherlands. She is currently a PhD-student in the Neuropsychiatry lab of Odile van den Heuvel and Ysbrand van der Werf at the department of Psychiatry at the VU University Medical Center in Amsterdam. Her work focuses on the neural correlates of cognitive control in obsessive-compulsive disorder, its modulation with rTMS, and its use in endophenotype studies of OCD.