Poxvirus infection: early events and novel diagnostic tools
Applications are invited for you to join the laboratory of Dr Carlos Maluquer de Motes to study the biology and replication of poxviruses in collaboration with Dr David Ulaeto’s group at the Defence Science and Technology Laboratory (DSTL)
Start date1 October 2019
This is a fully-funded PhD studentship that includes stipend of £15,000, approved fees and a consumables budget.
Funding sourceThe University of Surrey and the Defence Science and Technology Laboratory (DSTL)
You will study the early events that take place upon poxvirus entry and will design strategies to exploit these in the generation of novel tools for the detection and quantitation of multiple poxvirus species.
Poxviruses and asfarviruses are viruses of huge medical and economic importance. Unlike other DNA viruses, they replicate their DNA in the cytosol and carry their own machinery for DNA and mRNA synthesis. Some (e.g. Vaccinia virus) are promiscuous for many species, while others are fastidious and/or slow-growing (e.g. Lumpy Skin Disease virus). For fastidious viruses, quantitating the viable virus is time consuming and sometimes relies upon subjective assessment. This proposal will study the early events that take place during poxvirus infection both from the viral and cellular angle, and exploit this information for the development of novel tools for the detection of pox/asfarviruses. This is a fundamental project that uses molecular biology, genetics and virology techniques to develop novel sophisticated tools that will read viral infection. The methodology will allow to quantitate slow-growing, fastidious viruses; to isolate viruses that are poorly adapted to grow in culture; and to develop high-throughput in vitro assays of virus activity and clinical samples.
Related linksMaluquer Lab
You must have obtained, or be about to obtain, a first or 2:1 UK honours degree in an related area (e.g. biomedicine, biochemistry or microbiology). A degree and/or research experience is desirable.
You must have a passion for scientific research and be willing to face intellectual challenges and wish to learn and develop scientific skills. The ability to work both independently and as part of a team, coupled with excellent communication, organisational and problem solving skills are essential.
How to apply
Applications can be made through the Biosciences and Medicine PhD course page.
The following documents will need to be provided in your application:
- Scanned copies of signed/stamped qualifications (certificates or transcripts) to show how you meet, or expect to meet, the entry requirements
- Evidence of your English language level (if English is not your first language)
- A copy of your passport
- Your CV
- A personal statement (including the reasons why you have applied for this studentship and what you hope to achieve by undertaking this PhD)
- Contact details of 2 referees.
Biosciences and Medicine PhD