Professor Bruce Griffin

Research Interests

Role of human nutrition in the pathophysiology of cardiovascular disease; effects of diet on blood lipids and lipoprotein metabolism; genetic and environmental determinants of coronary atherosclerosis.

Research Studies 1996-2009

1996: Can the metabolic effects of dietary N-3 PUFA be explained by changes in the expression of lipase genes in adipose tissue?

1997: The influence of dietary N-3 PUFA on the structure, function and metabolism of TAG-rich lipoproteins in healthy individuals.

1998: Importance of alpha-linolenic acid as a source of long chain N-3 PUFA and its influence on risk factors of cardiovascular disease.

2000: Vitamin E biokinetics and metabolism in dyslipidaemia.

2000: Quantification of the optimal N-6 / N-3 ratio in the UK diet. The OPTILIP study

2003: Effect of low glycaemic index foods on blood lipids in type 2 diabetes

Impact of the amount and composition of dietary fat and carbohydrate on metabolic syndrome and CVD risk; The ‘RISCK’ Study.

2005: Effects of increased egg consumption on a weight-reducing diet on blood cholesterol & related biomarkers of CHD risk

2008: Dietary intervention study to determine the effects of prawns on serum cholesterol and related biomarkers of CHD risk

2009: How does dietary carbohydrate influence the formation of an atherogenic lipoprotein phenotype?

Research Collaborations

  • University of Reading
  • Kings College London
  • Imperial College London
  • MRC unit of Human Nutrition Research, Cambridge
  • University of Glasgow
  • Harakopio University, Athens, Greece
  • Aarhus University, Denmark

Teaching

I teach and examine on five undergraduate modules associated with BSc Degree programmes in Nutrition, Nutrition & Dietetics, Nutrition & Food Science and Biochemistry, and three MSc programmes.

  • BSc Degree programmes in Nutrition, Nutrition & Dietetics; Nutrition & Food Science, lecture topics include the Regulation & disorders of energy and lipid metabolism; Biomedical sciences; Macronutrients (dietary fats), Nutrition population groups (cardiovascular disease).

  • MSc Degree programmes in Clinical Biochemistry (lipids & lipoproteins biochemistry, molecular basis of hyperlipidaemia); Nutritional Medicine (Lipids & essential fatty acids); Toxicology (medical - oxidised lipids and trans fatty acids).

Admissions Tutor for MSc in Clinical biochemistry

Departmental Duties

Supervise MSc and PhD research programmes

Chairman for the Exam Board in Nutritional Medicine 2006 to date

Degree programme review panel member for BSc Undergraduate Framework for Lifelong Learning in Health and Social Care Practice, EIHMS, University of Surrey (2007)

Member of the Faculty’s Research Advisory Board, FHMS, University of Surrey

Affiliations

  • Biochemical Society (1985-88)
  • British Hyperlipidaemia Association (1990-2002)
  • H.E.A.R.T. UK (2002 - to date)
  • The Nutrition Society (1994 - to date)
  • British Atherosclerosis Society (1997 - to date)
  • The Royal Society of Medicine’s Forum on Lipids in Clinical Medicine (1999-2006)
  • Scottish Heart and Arterial disease Risk Prevention Group (1999-2003)
  • Registered Public Health Nutritionist (RPHNutr, 1999 - to date)

Additional Information

Editorial board membership:

  • Assistant Editor for the British Journal of Nutrition (2007 - to date)
  • Editorial Board member - Atherosclerosis (2003 - to date)

Committees:

  • British Hyperlipidaemia Association (BHA) Committee member (1999-2002)
  • Chairman for ILSI Europe’s Functional Foods Task Force meetings in Lisbon, Portugal (2003) and Bordeaux, France (2004)
  • Deputy Director of Supra-regional Assay Service (SAS) in Cardiovascular
  • Risk Assessment for the NHS Trust University of Surrey & RSCH (2003 - to date)

Contact Me

E-mail:
Phone: 01483 68 9724

Find me on campus
Room: 32 PG 00

Publications

Journal articles

  • Griffin B, Walker C, Jebb S, Moore C, Frost G, Goff L, Sanders T, Lewis F, Griffin M, Gitau R, Lovegrove J. (2018) 'APOE4 Genotype Exerts Greater Benefit in Lowering Plasma Cholesterol and Apolipoprotein B than Wild Type (E3/E3), after Replacement of Dietary Saturated Fats with Low Glycaemic Index Carbohydrates'. MDPI AG Nutrients, 10 Article number 1524

    Abstract

    We examined the impact of APOE genotype on plasma lipids and glucose in a secondary analysis of data from a five-arm, randomised controlled, parallel dietary intervention trial (‘RISCK’ study), to investigate the impact of replacing saturated fatty acids (SFA) with either monounsaturated fat (MUFA) or carbohydrate of high or low glycaemic index (GI) on CVD risk factors and insulin sensitivity. We tested the impact of APOE genotype (carriage of E2 and E4 alleles versus E3/E3), determined retrospectively, on plasma lipids, lipoproteins and glucose homeostasis at baseline (n = 469), and on the change in these variables after 24 weeks of dietary intervention (n = 389). At baseline, carriers of E2 (n = 70), E4 (n = 125) and E3/E3 (n = 274) expressed marked differences in total plasma cholesterol (TC, p = 0.001), low density lipoprotein cholesterol (LDL-C, p < 0.0001), apolipoprotein B (apo B, p < 0.0001) and total to high density lipoprotein cholesterol ratio (TC:HDL-C, p = 0.002), with plasma concentrations decreasing in the order E4 > E3/E3 > E2. Following intervention, there was evidence of a significant diet x genotype interaction with significantly greater decreases in TC (p = 0.02) and apo B (p = 0.006) among carriers of E4 when SFA was replaced with low GI carbohydrate on a lower fat diet (TC −0.28 mmol/L p = 0.03; apo B −0.1 g/L p = 0.02), and a relative increase in TC (in comparison to E3/E3) when SFA was replaced with MUFA and high GI carbohydrates (TC 0.3 mmol/L, p = 0.03). Among carriers of E2 (compared with E3/E3) there was an increase in triacylglycerol (TAG) when SFA was replaced with MUFA and low GI carbohydrates 0.46 mmol/L p = 0.001). There were no significant interactions between APOE genotype and diet for changes in indices of glucose homeostasis. In conclusion, variations in APOE genotype led to differential effects on the lipid response to the replacement of SFA with MUFA and low GI carbohydrates.

  • Griffin B, Nichols J. (2018) 'Responses to a GP survey: current controversies in diet and cardiovascular disease'. BMC BMC Family Practice, 19 Article number 150

    Abstract

    Background:

    When advising patients on diet and health, the general practitioner (GP) makes judgements based on the evidence available. Since current evidence on diet and cardiovascular disease is conflicted and confusing, we surveyed the current consensus amongst GPs. The aim of this study was to determine the views of GPs on dietary saturated fat, carbohydrates and long chain omega-3 fatty acids in the management of cardiovascular disease.

    Method:

    An online questionnaire inviting participants to comment on seven contentious statements on diet and cardiovascular disease. Questionnaire circulated to the 1800 members of South West Thames Faculty of the Royal College of General Practitioners (RCGP). Participants were invited to tick “ Agree ” , “ Disagree ” or “ Not sure ” and were encouraged to add comments for each question. The results were analysed with a combination of statistical analysis and thematic analysis of comments.

    Results:

    There were 89 responses. Most GPs seem well aware that drug treatment alone is inadequate and that dietary advice is important. However, there was con siderable disagreement about the roles of saturated fats and carbohydrates in ca rdiovascular disease and “ Not sure ” responses ranged from 12 to 40.7%. The 40. 7% related to a statement on long chain omega-3 fatty acids. Analysis of comments revealed more opinions including an awareness of the need to warn patients about trans -fatty acids.

    Conclusions:

    Although the GP response rate was poor, responders do seem to see dietary advice as part of their role but do not consider themselves as experts. Education in this area should have a higher priority.

  • Robertson M, Pedersen C, Hinton P, Mendis A, Cani P, Griffin B. (2018) 'Elevated high density lipoprotein cholesterol and low grade systemic inflammation is associated with increased gut permeability in normoglycemic men'. Elsevier Nutrition, Metabolism & Cardiovascular Diseases,

    Abstract

    Background & Aims:

    Serum lipids and lipoproteins are established biomarkers of cardiovascular disease risk that could be influenced by impaired gut barrier function via effects on the absorption of dietary and biliary cholesterol. The aim of this study was to examine the potential relationship between gut barrier function (gut permeability) and concentration of serum lipids and lipoproteins, in an ancillary analysis of serum samples taken from a previous study.

    Methods and Results:

    Serum lipids, lipoproteins and functional gut permeability, as assessed by the percentage of the urinary recovery of 51-Cr-labelled EDTA absorbed within 24h, were measured in a group of 30 healthy men. Serum lipopolysaccharide, high sensitivity C-reactive protein and interleukin-6 were also measured as markers of low-grade inflammation. The group expressed a 5- fold variation in total gut permeability (1.11 - 5.03%). Gut permeability was unrelated to the concentration of both serum total and low density lipoprotein (LDL)-cholesterol, but was positively associated with serum high density lipoprotein (HDL)-cholesterol (r=0.434, P=0.015). Serum HDL cholesterol was also positively associated with serum endotoxaemia (r=0.415, p=0.023).

    Conclusion:

    The significant association between increased gut permeability and elevated serum HDL-cholesterol is consistent with the role of HDL as an acute phase reactant, and in this situation, potentially dysfunctional lipoprotein. This finding may have negative implications for the putative role of HDL as a cardio-protective lipoprotein.

  • Umpleby M, Shojaee-Moradie F, Fielding B, Li X, Marino A, Alsini N, Isherwood C, Jackson N, Ahmad A, Stolinski M, Lovegrove J, Johnsen S, Mendis A, Wright J, Wilinska M, Hovorka R, Bell J, Thomas E, Frost G, Griffin B. (2017) 'Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets'. Portland Press Clinical Science, 131 (21), pp. 2561-2573.

    Abstract

    Dietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the effects of sugars on plasma lipoproteins. To study this further, men with NAFLD (n=11) and low liver fat ‘controls’ (n= 14) were fed two iso-energetic diets, high or low in sugars (26% or 6% total energy) for 12 weeks, in a randomised, cross-over design. Fasting plasma lipid and lipoprotein kinetics were measured after each diet by stable isotope trace-labelling. There were significant differences in the production and catabolic rates of VLDL subclasses between men with NAFLD and controls, in response to the high and low sugar diets. Men with NAFLD had higher plasma concentrations of VLDL1-triacylglycerol (TAG) after the high (P<0.02) and low sugar (P<0.0002) diets, a lower VLDL1-TAG fractional catabolic rate after the high sugar diet (P<0.01), and a higher VLDL1-TAG production rate after the low sugar diet (P<0.01), relative to controls. An effect of the high sugar diet, was to channel hepatic TAG into a higher production of VLDL1-TAG (P<0.02) in the controls, but in contrast, a higher production of VLDL2-TAG (P<0.05) in NAFLD. These dietary effects on VLDL subclass kinetics could be explained, in part, by differences in the contribution of fatty acids from intra-hepatic stores, and de novo lipogenesis. This study provides new evidence that liver fat accumulation leads to a differential partitioning of hepatic TAG into large and small VLDL subclasses, in response to high and low intakes of sugars.

  • Turner L, Poole K, Faithfull S, Griffin B. (2017) 'Current and future strategies for the nutritional management of cardiometabolic complications of androgen deprivation therapy for prostate cancer'. Cambridge University Press Nutr Res Rev, 30 (2), pp. 220-232.

    Abstract

    Androgen deprivation therapy (ADT) is used widely as part of a combined modality for the treatment of prostate cancer. However, ADT has also been associated with the development of cardiometabolic complications that can increase mortality from cardiovascular events. There is emerging evidence to suggest that ADT-related cardiometabolic risk can be mitigated by diet and lifestyle modification. While the clinical focus for a nutritional approach for achieving this effect is unclear, it may depend upon the timely assessment and targeting of dietary changes to the specific risk phenotype of the patient. The present review aims to address the metabolic origins of ADT-related cardiometabolic risk, existing evidence for the effects of dietary intervention in modifying this risk, and the priorities for future dietary strategies.

  • Cold F, Winther KH, Pastor-Barriuso R, Rayman MP, Guallar E, Nybo M, Griffin BA, Stranges S, Cold S. (2015) 'Randomised controlled trial of the effect of long-term selenium supplementation on plasma cholesterol in an elderly Danish population'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 114 (11), pp. 1807-1818.
  • Griffin BA. (2015) 'Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism.'. Proc Nutr Soc, England: 74 (3), pp. 208-214.
  • Escolà-Gil JC, Julve J, Griffin BA, Freeman D, Blanco-Vaca F. (2015) 'HDL and lifestyle interventions'. Handbook of Experimental Pharmacology, 224, pp. 569-592.
  • Johns I, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TAB, Frost G, Dornhorst A. (2014) 'Plasma free fatty acids do not provide the link between obesity and insulin resistance or beta-cell dysfunction: results of the Reading, Imperial, Surrey, Cambridge, Kings (RISCK) study'. WILEY-BLACKWELL DIABETIC MEDICINE, 31 (11), pp. 1310-1315.
  • Griffin BA. (2014) 'Nonpharmacological approaches for reducing serum low-density lipoprotein cholesterol.'. Curr Opin Cardiol, United States: 29 (4), pp. 360-365.
  • Gray J, Griffin BA. (2013) 'Eggs: Establishing the nutritional benefits'. Nutrition Bulletin, 38 (4), pp. 438-449.
  • Harman NL, Griffin BA, Davies IG. (2013) 'Separation of the principal HDL subclasses by iodixanol ultracentrifugation'. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC JOURNAL OF LIPID RESEARCH, 54 (8), pp. 2273-2281.
  • Harman NL, Griffin BA, Davies IG. (2013) 'Separation of the principal HDL subclasses by iodixanol ultracentrifugation'. Journal of Lipid Research, USA:
  • Meyer BJ, Stewart FM, Brown EA, Cooney J, Nilsson S, Olivecrona G, Ramsay JE, Griffin BA, Caslake MJ, Freeman DJ. (2013) 'Maternal Obesity Is Associated with the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester.'. J Clin Endocrinol Metab,
  • Lovegrove JA, Griffin BA. (2013) 'The acute and long-term effects of dietary fatty acids on vascular function in health and disease.'. Curr Opin Clin Nutr Metab Care,
  • Goff LM, Griffin BA, Lovegrove JA, Sanders TA, Jebb SA, Bluck LJ, Frost GS. (2013) 'Ethnic differences in beta-cell function, dietary intake and expression of the metabolic syndrome among UK adults of South Asian, black African-Caribbean and white-European origin at high risk of metabolic syndrome'. Diabetes & Vascular Disease Research,
  • Walker CG, Loos RJF, Mander AP, Jebb SA, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB, Bluck LJ. (2012) 'Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat'. Genes and Nutrition, 7 (4), pp. 529-536.
  • Griffin BA, Agewall S. (2012) 'Can increased arterial stiffness in women relative to men be explained by their progressive loss of gluteofemoral fat?'. Atherosclerosis, 224 (2), pp. 320-321.
  • Fallaize R, Wilson L, Gray J, Morgan LM, Griffin BA. (2012) 'Variation in the effects of three different breakfast meals on subjective satiety and subsequent intake of energy at lunch and evening meal'. European Journal of Nutrition, 52 (4), pp. 1353-1359.
  • Griffin BA. (2012) 'Goldilocks and the three bonds: New evidence for the conditional benefits of dietary α-linolenic acid in treating cardiovascular risk in the metabolic syndrome'. British Journal of Nutrition, 108 (4), pp. 579-580.
  • Mitchell HL, Gibbins JM, Griffin BA, Lovegrove JA, Stowell JD, Foot E. (2012) 'Food and Health Forum meeting:nutritional approaches to cardiovascular health:workshop report'. British Nutrition Foundation Nutrition Bulletin, 37, pp. 271-285.
  • Fava F, Gitau R, Griffin BA, Gibson GR, Tuohy KM, Lovegrove JA . (2012) 'The type and quality of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome 'at-risk' population.'. International Journal of Obesity,
  • AlSaleh A, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB, O'Dell SD. (2012) 'PPARγ2 gene Pro12Ala and PPARα gene Leu162Val SNPs interact with dietary intake of fat in determination of plasma lipid concentrations'. Karger Journal of Nutrigenetics and Nutrigenomics, 4 (6), pp. 354-366.
  • Walker CG, Loos RJF, Mander AP, Jebb SA, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB, Bluck LJ. (2012) 'Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat'. Genes and Nutrition, , pp. 1-8.
  • Alsaleh A, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB, O'Dell SD. (2012) 'PPARγ2 gene Pro12Ala and PPARα gene Leu162Val single nucleotide polymorphisms interact with dietary intake of fat in determination of plasma lipid concentrations'. Journal of Nutrigenetics and Nutrigenomics, 4 (6), pp. 354-366.
  • Ahmad A, Isherwood C, Fielding BA, Bell JD, Thomas EL, Frost G, Shojaee-Moradie F, Umpleby M, Griffin BA. (2012) 'Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 71 (OCE2), pp. E31-E31.
  • Griffin B. (2011) 'Eggs, dietary cholesterol and disease: Facts and folklore'. 2, pp. 237-253.

    Abstract

    The Oxford English Dictionary defines the word myth as; 'a popular idea concerning natural or historical phenomena ... that has no foundation in fact'. The popular idea in this context is that eating dietary cholesterol, typically from eggs, increases the risk of developing coronary heart disease (CHD), because it increases blood cholesterol. This contentious idea prevails, despite a lack of scientific foundation to support its existence, and almost global re-vamping of dietary recommendations to lift restrictions on the intake of cholesterol-rich foods. In an attempt to dispel the mythical status of dietary cholesterol and CHD, the following chapter will examine the role of dietary cholesterol in relation to what has been well established in terms of the relationships between blood cholesterol, diet and CHD. © 2011 Woodhead Publishing Limited All rights reserved.

  • AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB. (2011) 'Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome'. AMER SOC NUTRITION-ASN AMERICAN JOURNAL OF CLINICAL NUTRITION, 94 (1), pp. 262-269.
  • Rayman MP, Stranges S, Griffin BA, Pastor-Barriuso R, Guallar E. (2011) 'Effect of Supplementation With High-Selenium Yeast on Plasma Lipids A Randomized Trial'. AMER COLL PHYSICIANS ANNALS OF INTERNAL MEDICINE, 154 (10), pp. 656-+.
  • Walker CG, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TAB, Frost GS. (2011) 'Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis'. PUBLIC LIBRARY SCIENCE PLOS ONE, 6 (4) Article number ARTN e19146
  • Walker CG, Loos RJF, Olson AD, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB, Jebb SA, RISCK Study Grp . (2011) 'Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, 215 (2), pp. 421-427.

    Abstract

    Objective SNPs identified from genome-wide association studies associate with lipid risk markers of cardiovascular disease. This study investigated whether these SNPs altered the plasma lipid response to diet in the ‘RISCK’ study cohort. Methods Participants (n = 490) from a dietary intervention to lower saturated fat by replacement with carbohydrate or monounsaturated fat, were genotyped for 39 lipid-associated SNPs. The association of each individual SNP, and of the SNPs combined (using genetic predisposition scores), with plasma lipid concentrations was assessed at baseline, and on change in response to 24 weeks on diets. Results The associations between SNPs and lipid concentrations were directionally consistent with previous findings. The genetic predisposition scores were associated with higher baseline concentrations of plasma total (P = 0.02) and LDL (P = 0.002) cholesterol, triglycerides (P = 0.001) and apolipoprotein B (P = 0.004), and with lower baseline concentrations of HDL cholesterol (P < 0.001) and apolipoprotein A-I (P < 0.001). None of the SNPs showed significant association with the reduction of plasma lipids in response to the dietary interventions and there was no evidence of diet-gene interactions. Conclusion Results from this exploratory study have shown that increased genetic predisposition was associated with an unfavourable plasma lipid profile at baseline, but did not influence the improvement in lipid profiles by the low-saturated-fat diets.

  • Toft-Petersen AP, Tilsted HH, Aaroe J, Rasmussen K, Christensen T, Griffin BA, Aardestrup IV, Andreasen A, Schmidt EB. (2011) 'Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study'. BIOMED CENTRAL LTD LIPIDS IN HEALTH AND DISEASE, 10 Article number ARTN 21
  • Hakim OA, Shojaee-Moradie F, Hart K, Berry JL, Eastell R, Gossiel F, Hannon R, Umpleby AM, Griffin BA, Lanham-New SA. (2011) 'Vitamin D deficiency, poor bone health and the risk of CVD in Caucasian and South Asian women: analysis from the D-FINES study'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE3), pp. E100-E100.
  • Wilson L, Fallaize R, Gray J, Morgan LM, Griffin BA. (2011) 'Eggs at breakfast increase satiety and reduce the subsequent intake of energy at lunch and an evening meal relative to cereal or croissant-based breakfasts'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE6), pp. E365-E365.
  • Robertson T, Palmer R, Doyle A, Griffin B, Hampton S, Collins A. (2011) 'Morning exercise appears to promote greater fat oxidation and reduce postprandial lipaemic response more than evening exercise'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE6), pp. E394-E394.
  • Isherwood C, Ahmad A, Lovegrove JA, Frost GS, Umpleby AM, Griffin BA. (2011) 'Dietary exchange model to investigate the metabolic effects of extrinsic sugars on an atherogenic lipoprotein phenotype'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE4), pp. E221-E221.
  • Ahmad A, Isherwood C, Bell JD, Thomas EL, Frost G, Umpleby M, Griffin BA. (2011) 'Impact of liver fat on the response of plasma triacylglycerol to diets high and low in extrinsic sugars'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE6), pp. E364-E364.
  • Thorn EL, Griffin BA. (2011) 'Is the food provided in nursery schools in England adequate to meet the nutritional needs of children under five years old?'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE6), pp. E347-E347.
  • Lovegrove JA, Griffin BA. (2011) 'Can dietary modification reduce the cardiovascular complications of metabolic syndrome? 'All for one' or 'one for all'?'. Expert Review of Cardiovascular Therapy, 9 (4), pp. 413-416.
  • Griffin BA. (2011) 'Dairy, dairy, quite contrary: Further evidence to support a role for calcium in counteracting the cholesterol-raising effect of SFA in dairy foods'. British Journal of Nutrition, 105 (12), pp. 1713-1714.
  • Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A, Athyros V, de Graaf J, März W, Parhofer KG, Rini GB, Spinas GA, Tomkin GH, Tselepis AD, Wierzbicki AS, Winkler K, Florentin M, Liberopoulos E. (2011) 'European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: Executive summary'. Current Vascular Pharmacology, 9 (5), pp. 531-532.
  • AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB. (2011) 'Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk'. American Society for Biochemistry and Molecular Biology Journal of Lipid Research, 52 (12), pp. 2298-2303.

    Abstract

    Objective: The PPARG SNP rs1801282 (Pro12Ala C>G) has shown variable association with metabolic syndrome traits in healthy subjects. We investigated genotype association with plasma lipids and the influence of dietary polyunsaturated:saturated fat ratio (P:S) in subjects at increased cardiometabolic risk. Methods: Habitual dietary intake was recorded at recruitment to the RISCK Study. PPARG rs1801282 was genotyped in 466 subjects aged 30-70 y. Genotype associations with plasma lipids were assessed at recruitment, after a 4-wk high-SFA (HS) diet and a 24-wk intervention with reference (HS), high-MUFA (HM) and low-fat (LF) diets. The interaction of habitual P:S intake x genotype on plasma lipid concentrations was investigated. Results: PPARG rs1801282 G-allele frequency was 0.09. At recruitment, G-allele carriers had higher plasma total cholesterol concentration (n=415; P=0.05) after adjustment for BMI, gender, age and ethnicity. Dietary P:S ratio x genotype interaction influenced plasma LDLcholesterol (P=0.02) and triglyceride (P=0.03) concentrations. At P:S ratio 0.33, mean LDLcholesterol concentration in G-allele carriers was higher than in non-carriers, but fell between 0.34-0.65. Triglyceride concentration followed a similar pattern. After the 4-wk HS diet, Gallele carriers had higher concentrations of total cholesterol (P=0.03), LDL-cholesterol (P=0.04) and apo B (P=0.04) than non-carriers, after adjustments. After the 24-wk interventions, diet x genotype interaction did not significantly influence either LDLcholesterol (P=0.58) or triglyceride (P=0.57) concentrations. Conclusion: A high dietary P:S ratio would help to reduce plasma LDL-cholesterol and triglyceride concentrations in PPARG rs1801282 G-allele carriers at increased cardiometabolic risk.

  • Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A, Athyros V, de Graaf J, März W, Parhofer KG, Rini GB, Spinas GA, Tomkin GH, Tselepis AD, Wierzbicki AS, Winkler K, Florentin M, Liberopoulos E. (2011) '"European panel on low density lipoprotein (LDL) subclasses": A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses'. Current Vascular Pharmacology, 9 (5), pp. 533-571.
  • Jebb SA, Lovegrove JA, Griffin BA, Frost GS, Moore CS, Chatfield MD, Bluck LJ, Williams CM, Sanders TAB. (2010) 'Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 92 (4), pp. 748-758.
  • Hampton SM, Isherwood C, Kirkpatrick VJE, Lynne-Smith AC, Griffin BA. (2010) 'The influence of alcohol consumed with a meal on endothelial function in healthy individuals'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF HUMAN NUTRITION AND DIETETICS, 23 (2), pp. 120-125.
  • Isherwood C, Wong M, Jones WS, Davies IG, Griffin BA. (2010) 'LACK OF EFFECT OF COLD WATER PRAWNS ON PLASMA CHOLESTEROL AND LIPOPROTEINS IN NORMO-LIPIDAEMIC MEN'. C M B ASSOC CELLULAR AND MOLECULAR BIOLOGY, 56 (1), pp. 52-58.
  • Griffin B, Gray J. (2009) 'The nutritional properties of eggs'. Food Science and Technology, 23 (4), pp. 14-16.
  • Moore C, Gitau R, Goff L, Lewis FJ, Griffin MD, Chatfield MD, Jebb SA, Frost GS, Sanders TAB, Griffin BA, Lovegrove JA. (2009) 'Successful Manipulation of the Quality and Quantity of Fat and Carbohydrate Consumed by Free-Living Individuals Using a Food Exchange Model'. AMER SOC NUTRITIONAL SCIENCE JOURNAL OF NUTRITION, 139 (8), pp. 1534-1540.
  • Morgan LM, Griffin BA, Millward DJ, Delooy A, Fox KR, Baic S, Bonham MP, Wallace JMW, MacDonald I, Taylor MA, Truby H. (2009) 'Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors'. CAMBRIDGE UNIV PRESS PUBLIC HEALTH NUTRITION, 12 (6), pp. 799-807.
  • Gray J, Griffin B. (2009) 'Eggs and dietary cholesterol - dispelling the myth'. Nutrition Bulletin, 34 (1), pp. 66-70.
  • Rasmussen JG, Eschen RB, Aardestrup IV, Dethlefsen C, Griffin BA, Schmidt EB. (2009) 'Flow-mediated vasodilatation: Variation and interrelationships with plasma lipids and lipoproteins'. Scandinavian Journal of Clinical and Laboratory Investigation, 69 (1), pp. 156-160.
  • Griffin B. (2009) 'Lipid metabolism'. Surgery, 27 (1), pp. 1-5.

    Abstract

    Lipids are body fats that are either synthesized within cells (endogenous lipids) or derived from dietary fat (exogenous lipids). They are typically characterized by their insolubility in water, and have a diverse range of biological functions in cell membranes as phospholipids, and as a major source of stored energy in adipose tissue as triacylglycerols (TAGs). Serum lipids, including TAGs, phospholipids, cholesterol and their component fatty acids, are transported between sites of synthesis in the liver and intestine to peripheral tissues, for utilization and storage in macromolecular complexes of lipid and protein called lipoproteins. The physiology of circulating lipoproteins is described in terms of the transport of exogenous and endogenous chylomicrons and very low-density lipoproteins, respectively. These TAG-rich lipoproteins are remodelled under the action of lipoprotein lipase and lipid transfer proteins into smaller chylomicron remnants and low-density lipoproteins (LDLs). These cholesterol-rich lipoproteins deliver cholesterol back to the liver and peripheral tissues via specific membrane receptors, but share an infamous role as pro-atherogenic lipoproteins by depositing themselves and their cholesterol in artery walls. In contrast to this forward transport of cholesterol into tissues, reverse cholesterol transport describes the efflux of cholesterol out of tissues and passage back to the liver. This function protects arteries against atherosclerosis and is performed by high-density lipoproteins (HDLs). The production and breakdown of TAG-rich lipoproteins and the inter-relationship between these processes and HDL, particularly in the post-prandial period, are critical determinants of the atherogenicity of chylomicron remnants and LDLs, and the patency of HDL as a cardioprotective lipoprotein. © 2008 Elsevier Ltd. All rights reserved.

  • Mason P, Porter SC, Berry SE, Stillman P, Steele C, Kirby A, Griffin BA, Minihane AM. (2009) 'Saturated fatty acid consumption: Outlining the scale of the problem and assessing the solutions'. Nutrition Bulletin, 34 (1), pp. 74-84.
  • Griffin BA. (2009) 'Lipid Metabolism'. Surgery, 27, pp. 1-5.
  • Lloyd DAJ, Paynton SE, Bassett P, Mateos AR, Lovegrove JA, Gabe SM, Griffin BA. (2008) 'Assessment of long chain n-3 polyunsaturated fatty acid status and clinical outcome in adults receiving home parenteral nutrition'. CHURCHILL LIVINGSTONE CLINICAL NUTRITION, 27 (6), pp. 822-831.
  • Ferns G, Keti V, Griffin B. (2008) 'Investigation and management of hypertriglyceridaemia.'. J Clin Pathol, England: 61 (11), pp. 1174-1183.
  • Harman NL, Leeds AR, Griffin BA. (2008) 'Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss'. SPRINGER HEIDELBERG EUROPEAN JOURNAL OF NUTRITION, 47 (6), pp. 287-293.
  • Ferns G, Keti V, Griffin BA. (2008) 'Investigation and management of hypertriglyceridaemia'. Journal of Clinical Pathology, 61, pp. 1174-1183.
  • Griffin BA. (2008) 'How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP study'. LIPPINCOTT WILLIAMS & WILKINS CURR OPIN LIPIDOL, 19 (1), pp. 57-62.
  • Khodadadi I, Griffin BA, Thumser AEA. (2008) 'Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes.'. Academy of Medical Sciences of the I.R. Iran Arch Iran Med, 11 (1), pp. 42-49.

    Abstract

    The link between dietary fat and coronary heart disease has attracted much attention since the effect of long-chain fatty acids on gene transcription has been established. The aim of this study was to investigate the effects of long-chain fatty acids and clofibrate on mRNA levels of specific lipid metabolism-related genes and to determine their effects on global transcriptome levels in a cardiovascular cell-line.

  • Stanley JC, El Som RL, Calder PC, Griffin BA, Harris WS, Jebb SA, Lovegrove JA, Moore CS, Riemersma RA, Sanders TAB. (2007) 'UK Food Standards Agency Workshop Report: the effects of the dietary n-6 : n-3 fatty acid ratio on cardiovascular health'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 98 (6), pp. 1305-1310.
  • Griffin BA, Paynton SE, Lloyd DAJ, Gabe SM, Mateos AR, Lovegrove JA. (2007) 'Plasma long-chain n-3 PUFA status in patients receiving long-term home parenteral nutrition'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 66, pp. 92A-92A.
  • Harman NL, Pourfarzam M, Neely RDG, Griffin BA. (2007) 'Plasma sterols as markers of cholesterol absorption and synthesis: inter-relationships with plasma lipids and apoE genotype'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 66, pp. 35A-35A.
  • Paschos GK, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin BA, Votteas V, Skopouli FN. (2007) 'Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men'. European Journal of Nutrition, 46 (6), pp. 315-320.
  • Moore C, Gitau R, Frost GS, Griffin BA, Jebb SA, Sanders TA, Lovegrove JA. (2007) 'Strategy to alter the amount and composition of dietary carbohydrate and fat in free-living individuals participating in the RISCK trial'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 66, pp. 86A-86A.
  • Stanley JC, Elsom RL, Calder PC, Griffin BA, Harris WS, Jebb SA, Lovegrove JA, Moore CS, Riemersma RA, Sanders TAB. (2007) 'UK Food Standards Agency Workshop Report: The effects of the dietary'. British Journal of Nutrition, 98 (6), pp. 1305-1310.
  • Griffin MD, Sanders TA, Davies IG, Morgan LM, Millward DJ, Lewis F, Slaughter S, Cooper JA, Miller GJ, Griffin BA. (2006) 'Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study.'. Am J Clin Nutr, United States: 84 (6), pp. 1290-1298.
  • Sanders TAB, Lewis F, Slaughter S, Griffin BA, Griffin M, Davies I, Millward DJ, Cooper JA, Miller GJ. (2006) 'Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 84 (3), pp. 513-522.
  • Griffin MD, Sanders TAB, Davies IG, Lewis F, Slaughter S, Millward DJ, Griffin BA. (2006) 'The effects of altering the dietary n-6 : n-3 fatty acids ratio on insulin sensitivity, lipoprotein size and postprandial lipaemia in older UK men and women. The OPTILIP study.'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 65, pp. 88A-88A.
  • Lee A, Griffin B. (2006) 'Dietary cholesterol, eggs and coronary heart disease risk in perspective'. Nutrition Bulletin, 31 (1), pp. 21-27.
  • Sanders TAB, Gleason K, Griffin B, Miller GJ. (2006) 'Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6n-3) and docosapentaenoic acid (22:5n-6) on cardiovascular risk factors in healthy men and women'. British Journal of Nutrition, 95 (3), pp. 525-531.

Conference papers

  • Umpleby M, Shojaee-Moradie F, Fielding B, Li X, Isherwood C, Jackson N, Wilinska G, Hovorka R, Bell J, Thomas EL, Wright J, Frost GS, Griffin B. (2015) 'A DIET LOW IN SUGAR REDUCES THE PRODUCTION OF ATHEROGENIC LIPOPROTEINS IN MEN WITH HIGH LIVER FAT'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Glasgow, SCOTLAND: 83rd Congress of the European-Atherosclerosis-Society (EAS) 241 (1), pp. E46-E46.
  • Griffin BA. (2015) 'Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism'. Proceedings of the Nutrition Society, 74 (3), pp. 208-214.
  • Williams CM, Lovegrove JA, Griffin BA. (2013) 'Dietary patterns and cardiovascular disease'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, Royal Soc Med, London, ENGLAND: Joint Meeting of the Nutrition-Society and the Royal-Society-of-Medicine / Conference on Dietary Strategies for the Management of Cardiovascular Risk 72 (4), pp. 407-411.
  • Mitchell HL, Gibbins JM, Griffin BA, Lovegrove JA, Stowell JD, Foot E. (2012) 'Food and Health Forum meeting: nutritional approaches to cardiovascular health: workshop report'. Wiley British Nutrition Foundation Nutrition Bulletin, ROYAL SOCIETY OF MEDICINE, LONDON: Food and Health Forum meeting: nutritional approaches to cardiovascular helath: workshop report
  • Hakim OA, Hart K, Darling AL, Shojaee-Moradie F, Berry JL, Umpleby AM, Griffin BA, Lanham-New SA. (2012) 'Homeostatic model assessment (HOMA) in relation to lipid profiles and vitamin D status in South Asian and Caucasian women: preliminary results from D-FINES'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 71 (OCE2), pp. E70-E70.
  • Hakim O, Shojaee-Moradie F, Hart K, Berry J, Eastell R, Gossiel F, Hannon R, Umpleby M, Griffin B, Lanham-New S. (2011) 'Evidence of a link between poor bone health, low vitamin D status and CVD risk in caucasian and asian women'. ELSEVIER SCIENCE INC BONE, Athens, GREECE: 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society 48, pp. S197-S198.
  • Hakim O, Lanham-New S, Shojaee-Moradie F, Morgan L, Umpleby A, Griffin B, Berry J, Eastell R, Gossiel F, Hannon R, Hart K. (2010) 'POORER LIPID PROFILE ARE ASSOCIATED WITH INCREASED BONE RESORPTION AND PARATHYROID HORMONE: PRELIMINARY RESULTS OF THE D-FINES STUDY'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Liverpool, ENGLAND: Osteoporosis Conference 21, pp. S506-S507.
  • Hakim O, Hart K, Morgan L, Griffin B, Lanham-New S, Shojaee-Moradie F, Umpleby A, Berry J. (2010) '(PREMIER POSTER-AWARD CANDIDATE) EVIDENCE OF A LINK BETWEEN OSTEOPOROSIS RISK AND CVD IN CAUCASIAN BUT NOT ASIAN WOMEN: RESULTS OF THE D-FINES STUDY'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Liverpool, ENGLAND: Osteoporosis Conference 21, pp. S466-S467.
  • Hakim OA, Darling A, Starkey S, Wong M, Shojaee-Moradie F, Hart K, Morgan L, Berry J, Umpleby A, Griffin B, Lanham-New S. (2010) 'POOR BONE HEALTH AND INCREASED CARDIOVASCULAR DISEASE RISK: EVIDENCE OF A LINK IN THE D-FINES STUDY POPULATION'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Florence, ITALY: IOF World Congress on Osteoporosis/10th European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis 21, pp. 96-97.
  • Harman NL, Leeds AR, Griffin BA. (2009) 'INCREASED DIETARY CHOLESTEROL DOES NOT INCREASE PLASMA LOW DENSITY LIPOPROTEIN WHEN ACCOMPANIED BY WEIGHT LOSS'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Liverpool Hope Univ, Liverpool, ENGLAND: 23rd Annual Medical and Scientific Meeting of HEART-UK 207 (1), pp. 307-307.
  • Harman NL, Davies IG, Griffin BA. (2007) 'Separation of the principal HDL subclasses by iodixanol gradient ultracentrifugation'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Heriot Watt Univ, Edinburgh, SCOTLAND: 21st Annual Medical and Scientific Meeting of HEART-UK 194 (1), pp. 283-284.

Book chapters

  • Griffin B. (2011) 'Eggs, dietary cholesterol and disease: facts and folklore'. in Bain M, Nys Y, Immerseel F (eds.) Improving the Safety and Quality of Eggs and Egg Products: Volume 2 Woodhead Pub Ltd 2 (12) Article number 12 , pp. 235-253.
  • Griffin BA. (2009) 'Nutrition and Metabolism of Lipids'. in Gibney MJ (ed.) Introduction to human nutrition 2nd Edition. Blackwell Pub , pp. 86-121.

Page Owner: bss2bg
Page Created: Monday 1 June 2009 13:05:02 by t00345
Last Modified: Monday 17 August 2015 12:31:04 by m07326
Assembly date: Tue Jan 28 00:01:21 GMT 2020
Content ID: 5557
Revision: 10
Community: 1179

Rhythmyx folder: //Sites/surrey.ac.uk/Nutrition Division/People
Content type: rx:StaffProfile