Projects

What is IPROCOM about?

What is IPROCOM about?

IPROCOM runs 15 cross-linked individual research projects involving 12 Early Stage Researches (ESRs, equivalent to PhDs) for 36 months and 3 Experienced Researchers (ERs, equivalent to postdocs) for 18-24 months as detailed below.

 

ESR1: Multi-scale materials characterization of particles and powders. The objectives are to experimentally characterise particle and powder properties using a wide range of techniques, to identify critical particle characteristics that dominate bulk powder properties, and to investigate powder mixing and quantify the mixing dynamics and microstructures of mixtures. ESR1 will be based at the University of Surrey, UK.

ESR2: Impact of powder properties & system design on roll compaction. The aim of this project is to explore how material properties, roll compactor type and process parameters affect the roll compaction process, for which ribbon properties produced using various types of roll compactors available in IPROCOM and microscopic flow patterns of particles during roll compaction with different system designs will be characterized. ERS2 will be hosted at Heinrich-Heine-University, Germany.

ESR3: Roll compaction scale-up. The objectives are to perform a systematic study of roll compaction using roll compactors of different scales and to identify the design space for roll compaction. ERS3 will be hosted at Heinrich-Heine-University, Germany.

ESR4: Milling of roll compacted ribbons & die compaction. The objective is to explore how ribbon properties and milling conditions affect the granule properties. Microscopic study on fundamental milling mechanisms will be performed.  ESR4 will also perform compaction experiments using both feed powders and produced granules. ESR4 will be based at Ecole des Mines d'Albi, France. 

ESR5: DEM modelling of powder mixing. The objectives are to analyse powder filling processes using DEM, and to assess flow rate and uniformity, and how particle properties and process conditions will affect the properties of the powder bed in roll compaction. DEM models will be further developed to explore the effects of particle shape, cohesion, agglomeration and electrostatic interactions. ESR5 will be hosted at Research Centre Pharmaceutical Engineering GmbH, Graz, Austria.

ESR6: FEM modelling of roll compaction. The objective is to develop predictive models using FEM , which can be used to identify the critical material properties and process parameters controlling the quality of granules. The effects of powder properties and roll compactor types will be investigated. ESR6 will be based at Ecole des Mines d'Albi, France.

ESR7: DEM modelling of ribbon milling. This project aims to explore the fundamental microscopic mechanisms of ribbon milling using DEM. How ribbon properties and milling conditions affect the microscopic behaviour of milling will be explored. ESR7 will be based at the University of Surrey, UK.

ESR8: DEM and FEM modelling of die filling and compaction of powders and granules. The goal of this project is to predict final compact properties using a combination of DEM and FEM. A systematic investigation  will be performed to examine how granule properties and process parameters affect the die filling behaviour and the subsequent powder compaction and ejection.  ESR8 will be hosted at Fraunhofer Institute for Mechanics of Materials IWM, Germany.

ESR9: ComputationaI Intelligence (CI) modelling of powder mixing. The objectives of this project are to develop a robust computational intelligence (CI) platform together with ESRs 10-12 and to identify critical particle properties (CPPs) and critical process variables (CPVs) that dominate bulk powder characteristics.   ESR9 will be based at Vysoka Skola Banska - Technicka Univerzita Ostrava, Czech Republic. & MIR Labs.

ESR10: CI modelling of roll compaction. The objectives of this project are to develop a robust CI platform together with ESRs 9, 11, 12, to model roll compaction processes and to identify critical powder properties and CPVs controlling ribbon characteristics. ESR10 will be hosted at Babes-Bolyai University, Romania.

ESR11: CI modelling of milling of ribbons. The objectives are to develop a robust CI platform together with ESRs 9, 10, 12, to model the ribbon milling process, to predict granule properties based on ribbon parameters and milling conditions, and to identify vital information on critical materials and process variables. ESR11 will be based at Jagiellonian University, Poland.

ESR12: CI modelling of die compaction. This project aims to develop a robust CI platform together with ESRs 9-11 and to model the powder compaction process, from which critical granules and granulation parameters together with process variables will be identified. ESR11 will  also be based at Jagiellonian University, Poland.

ER1: Characterisation of powder properties using DEM.  The objective of ER1 is to characterise bulk powder properties based on the properties of single particles using DEM and to work closely with other ESRs/ERs to devise a multi-scale numerical platform for particulate product manufacturing. ER1 (24 months) will be based at Johnson Matthey plc., UK.

ER2: DEM modelling of powder mixing. The objectives of this project are to assess how uniformly particles of different properties can be mixed  and to simulate the mixing behaviour of various powders and to investigate the mixing and segregation phenomena using DEM. The effect of packing structure of mixtures on the bulk powder behaviour will also be examined. ER2 (18 months) will be hosted at Research Centre Pharmaceutical Engineering GmbH, Graz, Austria.

ER3: Population balance modeling of ribbon milling. The objectives are to develop a population balance model for analysing ribbon milling processes, and to investigate how the ribbon properties, mill type and milling conditions affect the granule size. ER3  (24 months) will be hosted at AstraZeneca plc., Sweden.