Dr Barbara Fielding

Research Interests

My main interest is human fatty metabolism - how this is impaired in obesity and type 2 diabetes and how it is affected by diet. Using fatty acid stable isotope tracers combined with arterio-venous measurements in Oxford we have shown how adipose tissue fatty acid metabolism is down-regulated in obesity with concomitant failure to deposit meal fatty acids. I am interested in how hepatic and adipose tissue fatty acid metabolism relates to abdominal obesity in women and how this relationship is affected by menopausal status.

Fatty acids in tissues and cells can be used as biomarkers of intake and I am using this technique in a variety of projects. I am also interested in the in vivo synthesis of n-3 fatty acids and currently have a PhD project investigating this in men and women (in collaboration with the University of Southampton) funded by the BBSRC DTP and the Rank Prize Funds.

In Prof Margot Umpleby’s lab, I have set up some of the isotopic techniques that I have developed in Oxford and we are using them in on-going projects at Surrey. For example the isotopic desaturation index allows us to estimate the action of the enzyme stearoyl CoA desaturase (SCD) in relation to carbohydrate intake. The product of SCD, palmitoleic acid, is associated with insulin resistance. I am also interested in vitamin D metabolism and how vitamin D status is impaired in obesity.

Teaching

Module organiser for ‘Fundamentals of Human Nutrition’, Human Nutrition MSc programme and ‘Lipids and Essential Fatty acids’, Nutritional Medicine MSc programme. I teach on the Human Nutrition and Health, and Clinical Science MScs as well as the Biomedical Science Undergraduate programme.

Departmental Duties

I organise the postgraduate research seminar series. This allows students to present their work at all stages of their research.

Affiliations

  • Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford
  • Member of the Editorial Board of the British Journal of Nutrition
  • Treasurer of the European Lipoprotein Club

Awards

In 2010, I was awarded the Cuthbertson Medal by the Nutrition Society for my work in human nutrition and metabolism.

Contact Me

E-mail:
Phone: 01483 68 8649

Find me on campus
Room: 31 PG 00


My office hours

Monday to Thursday

Publications

Journal articles

  • Umpleby M, Shojaee-Moradie F, Fielding BA, Liu X, Marino A, Alsini N, Isherwood CM, Jackson N, Ahmad A, Stolinski M, Lovegrove J, Johnsen S, Mendis A, Wright J, Wilinska M, Hovorka R, Bell J, Thomas E, Frost G, Griffin BA. (2017) 'Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets'. Portland Press Clinical Science, 131 (21), pp. 2561-2573.

    Abstract

    Dietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the effects of sugars on plasma lipoproteins. To study this further, men with NAFLD (n=11) and low liver fat 'controls' (n= 14) were fed two iso-energetic diets, high or low in sugars (26% or 6% total energy) for 12 weeks, in a randomised, cross-over design. Fasting plasma lipid and lipoprotein kinetics were measured after each diet by stable isotope trace-labelling. There were significant differences in the production and catabolic rates of VLDL subclasses between men with NAFLD and controls, in response to the high and low sugar diets. Men with NAFLD had higher plasma concentrations of VLDL1-triacylglycerol (TAG) after the high ( P <0.02) and low sugar ( P <0.0002) diets, a lower VLDL1-TAG fractional catabolic rate after the high sugar diet ( P <0.01), and a higher VLDL1-TAG production rate after the low sugar diet ( P <0.01), relative to controls. An effect of the high sugar diet, was to channel hepatic TAG into a higher production of VLDL1-TAG ( P <0.02) in the controls, but in contrast, a higher production of VLDL2-TAG ( P <0.05) in NAFLD. These dietary effects on VLDL subclass kinetics could be explained, in part, by differences in the contribution of fatty acids from intra-hepatic stores, and de novo lipogenesis. This study provides new evidence that liver fat accumulation leads to a differential partitioning of hepatic TAG into large and small VLDL subclasses, in response to high and low intakes of sugars.

  • Umpleby M, Shojaee-Moradie F, Fielding B, Li X, Marino A, Alsini N, Isherwood C, Jackson N, Ahmad A, Stolinski M, Lovegrove J, Johnsen S, Mendis A, Wright J, Wilinska M, Hovorka R, Bell J, Thomas E, Frost G, Griffin B. (2017) 'Impact of liver fat on the differential partitioning of hepatic triacylglycerol into VLDL subclasses on high and low sugar diets'. Portland Press Clinical Science,

    Abstract

    Dietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the effects of sugars on plasma lipoproteins. To study this further, men with NAFLD (n=11) and low liver fat ‘controls’ (n= 14) were fed two iso-energetic diets, high or low in sugars (26% or 6% total energy) for 12 weeks, in a randomised, cross-over design. Fasting plasma lipid and lipoprotein kinetics were measured after each diet by stable isotope trace-labelling. There were significant differences in the production and catabolic rates of VLDL subclasses between men with NAFLD and controls, in response to the high and low sugar diets. Men with NAFLD had higher plasma concentrations of VLDL1-triacylglycerol (TAG) after the high (P<0.02) and low sugar (P<0.0002) diets, a lower VLDL1-TAG fractional catabolic rate after the high sugar diet (P<0.01), and a higher VLDL1-TAG production rate after the low sugar diet (P<0.01), relative to controls. An effect of the high sugar diet, was to channel hepatic TAG into a higher production of VLDL1-TAG (P<0.02) in the controls, but in contrast, a higher production of VLDL2-TAG (P<0.05) in NAFLD. These dietary effects on VLDL subclass kinetics could be explained, in part, by differences in the contribution of fatty acids from intra-hepatic stores, and de novo lipogenesis. This study provides new evidence that liver fat accumulation leads to a differential partitioning of hepatic TAG into large and small VLDL subclasses, in response to high and low intakes of sugars.

  • Fielding BA. (2017) 'Omega-3 index as a prognosis tool in cardiovascular disease'. Wolters Kluwer Health, Inc. Current Opinion in Clinical Nutrition and Metabolic Care,
    [ Status: Accepted ]

    Abstract

    Purpose of review In 2004, the ‘omega-3 index’ was described as the sum of eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3) in red blood cells (RBCs) as an index of coronary heart disease mortality. This review outlines new evidence to support the omega-3 index as a tool to inform disease prognosis. Recent findings Recent studies have reported differential metabolism of EPA and DHA. High dose supplementation with EPA and DHA led to increased levels of RBC DHA that were associated with decreased liver fat. EPA and DHA in RBCs were associated with reduced mortality in a prospective study of patients with cardiac disease; the strongest association was with EPA. A diet containing 9.5 g alpha linolenic acid lead to an increase in EPA but not DHA status in middle aged women. Summary: Dietary intake or supplementation studies with n-3 fatty acids should include measurement of n-3 status in a standardised way. The omega-3 index, reflecting EPA and DHA status throughout the body, is convenient and may be appropriate in some cases, but since EPA and DHA assimilate differently in membranes, and have different potency, measurement of individual fatty acid composition in RBCs may be more informative

  • Steenson S, Umpleby M, Lovegrove J, Jackson K, Fielding BA. (2017) 'Role of the enterocyte in fructose-induced hypertriglyceridaemia'. MDPI AG Nutrients, 9 (4) Article number 349

    Abstract

    Abstract: Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level, which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL), emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. The influence of fructose consumption on several aspects of enterocyte lipid metabolism are discussed, including de novo lipogenesis, apolipoprotein B48 and CM-TG production, based on the findings of animal and human isotopic tracer studies. Methodological issues affecting the interpretation of fructose studies conducted to date are highlighted, including the accurate separation of CM and VLDL. Although the available evidence to date is limited, disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia often associated with fructose consumption.

  • Markkula S, Lyons D, Yueh C, Riches C, Hurst P, Fielding BA, Heisler L, Evans M. (2016) 'Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats'. Endocrine Society Endocrinology, 157 (12), pp. 4669-4676.

    Abstract

    Specialized metabolic-sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counter regulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal mediating responses to changes in glucose, other substrates and hormones. The role of ROS in the brain’s control of glucose homeostasis remains unclear. We hypothesized that hydrogen peroxide (H2O2), a relatively stable form of ROS, acts as a sensor of neuronal glucose consumption and availability and that lowering brain H2O2 with the enzyme catalase would lead to systemic responses increasing blood glucose. During hyperinsulinemic euglycemic clamps in rats, ICV catalase infusion resulted in increased hepatic glucose output, which was associated with reduced neuronal activity in the arcuate nucleus of the hypothalamus (ARC). Electrophysiological recordings revealed a subset of ARC neurons expressing pro-opiomelanocortin (POMC) that were inhibited by catalase and excited by H2O2. During hypoglycemic clamps, ICV catalase increased glucagon and epinephrine responses to hypoglycemia, consistent with perceived lower glucose levels. Our data suggest that H2O2 represents an important metabolic cue which, through tuning the electrical activity of key neuronal populations such as POMC neurons, may have a role in the brain’s influence of glucose homeostasis and energy balance.

  • Hodson L, Banerjee R, Rial B, Arlt W, Adiels M, Boren J, Marinou K, Fisher C, Mostad IL, Stratton IM, Barrett PHR, Chan DC, Watts GF, Harnden K, Karpe F, Fielding BA. (2015) 'Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women'. WILEY-BLACKWELL JOURNAL OF THE AMERICAN HEART ASSOCIATION, 4 (10) Article number ARTN e002258
  • Irvine NA, Lillycrop KA, Fielding B, Torrens C, Hanson MA, Burdge GC. (2015) 'Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells'. Prostaglandins Leukotrienes and Essential Fatty Acids,
    [ Status: Accepted ]
  • Loh NY, Neville MJ, Marinou K, Hardcastle SA, Fielding BA, Duncan EL, McCarthy MI, Tobias JH, Gregson CL, Karpe F, Christodoulides C. (2015) 'LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.'. Cell Metab, United States: 21 (2), pp. 262-272.
  • Sibbons C, Boyle L, Burdge GC, Umpleby M, Lilycrop KA, Hartwick CA, Lanham-New S, Hart K, Fielding BA. (2015) 'Evaluation of fatty acid status in children of different nationalities'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 74 (OCE1), pp. E94-E94.
  • Hart KH, Boyle L, Hartwick CA, Moreno L, Lanham-New SA, Fielding B. (2015) 'Live, eat, sleep football? Body size and composition and beliefs about physical activity in an international cohort of school-aged boys participating in regular team sport'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 74 (OCE1), pp. E97-E97.
  • Bucci M, Karmi AC, Iozzo P, Fielding BA, Viljanen A, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Frayn KN, Nuutila P. (2014) 'Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome'. Diabetologia, 58 (1), pp. 158-164.
  • Bucci M, Karmi AC, Iozzo P, Badeau RM, Borra R, Saunavaara V, Pham T, Hannukainen JC, Kalliokoski K, Haaparanta-Solin M, Viljanen T, Parkkola R, Nuutila P, Fielding BA, Frayn KN, Viljanen A. (2014) 'Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome'. Diabetologia,
  • Harjes U, Bridges E, McIntyre A, Fielding BA, Harris AL. (2014) 'Fatty acid-binding protein 4, a point of convergence for angiogenic and metabolic signaling pathways in endothelial cells.'. J Biol Chem, United States: 289 (33), pp. 23168-23176.
  • Marinou K, Hodson L, Vasan SK, Fielding BA, Banerjee R, Brismar K, Koutsilieris M, Clark A, Neville MJ, Karpe F. (2014) 'Structural and functional properties of deep abdominal subcutaneous adipose tissue explain its association with insulin resistance and cardiovascular risk in men'. Diabetes Care, 37 (3), pp. 821-829.
  • Hodson L, Harnden K, Banerjee R, Rial B, Marinou K, Karpe F, Fielding BA. (2014) 'Lower resting and total energy expenditure in post-menopausal compared with pre-menopausal women matched for abdominal obesity'. e3 Edition. Cambridge University Press The British Journal of Nutrition: an international journal of nutritional science, 3, pp. 1-9.
  • Moore JB, Gunn PJ, Fielding BA. (2014) 'The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease.'. Nutrients, Switzerland: 6 (12), pp. 5679-5703.
  • Hodson L, Harnden K, Banerjee R, Real B, Marinou K, Karpe F, Fielding BA. (2014) 'Lower resting and total energy expenditure in postmenopausal compared with premenopausal women matched for abdominal obesity.'. J Nutr Sci, England: 3
  • Sell H, Blueher M, Kloeting N, Schlich R, Willems M, Ruppe F, Knoefel WT, Dietrich A, Fielding BA, Arner P, Frayn KN, Eckel J. (2013) 'Adipose Dipeptidyl Peptidase-4 and Obesity Correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro'. AMER DIABETES ASSOC DIABETES CARE, 36 (12), pp. 4083-4090.
  • Hodson L, Neville M, Chong MFF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA. (2013) 'Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies'. Nutrition, Metabolism and Cardiovascular Diseases, 23 (11), pp. 1128-1133.
  • Egli L, Lecoultre V, Theytaz F, Campos V, Hodson L, Schneiter P, Mittendorfer B, Patterson BW, Fielding BA, Gerber PA, Giusti V, Berneis K, Tappy L. (2013) 'Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Subjects'. AMER DIABETES ASSOC DIABETES, 62 (7), pp. 2259-2265.
  • Costet P, Ehrenborg E, Fisher R, Fielding B, Groen A, Kardassis D, Malle E, Mulder M, Niemeier A, Norata GD, Hansen AT, Eckardstein AV. (2013) 'European Lipoprotein Club: Report of the 35th ELC Annual Conference (Tutzing, 10th-13th September 2012)'. Atherosclerosis, 226 (2), pp. 510-516.
  • Hodson L, Neville M, Chong MF, Rogers I, Huda SS, Freeman DJ, Frayn KN, Fielding BA. (2012) 'Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies.'. Nutr Metab Cardiovasc Dis,
  • Theytaz F, Noguchi Y, Egli L, Campos V, Buehler T, Hodson L, Patterson BW, Nishikata N, Kreis R, Mittendorfer B, Fielding B, Boesch C, Tappy L. (2012) 'Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans'. American Journal of Clinical Nutrition, 96 (5), pp. 1008-1016.
  • Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K, Peltonen M, Romeo S, Lundbom J, Lundbom N, Olkkonen VM, Gylling H, Fielding BA, Rissanen A, Yki-Jar̈vinen H. (2012) 'Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans'. American Journal of Clinical Nutrition, 96 (4), pp. 727-734.
  • Hodson L, Fielding BA. (2012) 'Stearoyl-CoA desaturase: rogue or innocent bystander?'. Prog Lipid Res, 52 (1), pp. 15-42.
  • Pinnick KE, Neville MJ, Fielding BA, Frayn KN, Karpe F, Hodson L. (2012) 'Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans.'. American Diabetes Association Diabetes, United States: 61 (6), pp. 1399-1403.

    Abstract

    The expansion of lower-body adipose tissue (AT) is paradoxically associated with reduced cardiovascular disease and diabetes risk. We examined whether the beneficial metabolic properties of lower-body AT are related to the production and release of the insulin-sensitizing lipokine palmitoleate (16:1n-7). Using venoarterial difference sampling, we investigated the relative release of 16:1n-7 from lower-body (gluteofemoral) and upper-body (abdominal subcutaneous) AT depots. Paired gluteofemoral and abdominal subcutaneous AT samples were analyzed for triglyceride fatty acid composition and mRNA expression. Finally, the triglyceride fatty acid composition of isolated human preadipocytes was determined. Relative release of 16:1n-7 was markedly higher from gluteofemoral AT compared with abdominal subcutaneous AT. Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogenous 16:1n-7 production, was more highly expressed in gluteofemoral AT and was associated with greater enrichment of 16:1n-7. Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher content of SCD1-derived fatty acids. We demonstrate that human gluteofemoral AT plays a major role in determining systemic concentrations of the lipokine palmitoleate. Moreover, this appears to be an inherent feature of gluteofemoral AT. We propose that the beneficial metabolic properties of lower-body AT may be partly explained by the intrinsically greater production and release of palmitoleate.

  • Bernini F, Costet P, Ehrenborg E, Fisher R, Fielding B, Freeman D, Groen A, Malle E, Mulder M, Niemeier A, Hansen AT, von Eckardstein A. (2012) 'European Lipoprotein Club: Report of the 34th ELC annual conference, Tutzing, 5-8 September 2011'. Atherosclerosis, 221 (1), pp. 287-293.
  • Ardilouze J-L, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F. (2012) 'Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation'. Diabetes and Metabolism, 38 (1), pp. 27-33.
  • Ahmad A, Isherwood C, Fielding BA, Bell JD, Thomas EL, Frost G, Shojaee-Moradie F, Umpleby M, Griffin BA. (2012) 'Individuals with moderately raised liver fat show a greater increase in liver fat in response to a high sugar diet'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 71 (OCE2), pp. E31-E31.
  • Costet P, Ehrenborg E, Fisher R, Fielding B, Groen A, Kardassis D, Malle E, Mulder M, Niemeier A, Norata GD, Hansen AT, Eckardstein AV. (2012) 'European Lipoprotein Club: Report of the 35th ELC Annual Conference (Tutzing, 10th-13th September 2012)'. Atherosclerosis,
  • Fielding B. (2011) 'Nutrition Society Cuthbertson Medal Lecture: Tracing the fate of dietary fatty acids: Metabolic studies of postprandial lipaemia in human subjects'. Proceedings of the Nutrition Society, 70 (3), pp. 342-350.

    Abstract

    Most postprandial studies have investigated the response of a single meal, yet the ingestion of sequential meals is more typical in a Western society. The aim of this review is to explain how natural and stable isotope tracers of fatty acids have been used to investigate the metabolism of dietary fat after single and multiple meals, with a focus on in vivo measurements of adipose tissue metabolism. When stable isotope tracers are combined with arteriovenous difference measurements, very specific measurements of metabolic flux across tissues can be made. We have found that adipose tissue is a net importer of dietary fat for 5 h following a single test meal and for most of the day during a typical three-meal eating pattern. When dietary fat is cleared from plasma, some fatty acids spillover into the plasma and contribute up to 50% of postprandial plasma NEFA concentrations. Therefore, plasma NEFA concentrations after a meal reflect the balance between intracellular and extracellular lipolysis in adipose tissue. This balance is altered after the acute ingestion of fructose. The enzyme lipoprotein lipase is a key modulator of fatty acid flux in adipose tissue and its rate of action is severely diminished in obese men. In conclusion, in vivo studies of human metabolism can quantify the way that adipose tissue fatty acid trafficking modulates plasma lipid concentrations. This has implications for the flux of fatty acids to tissues that are susceptible to ectopic fat deposition such as the liver and muscle. © 2011 The Authors.

  • Fernandez C, Schuhmann K, Herzog R, Fielding B, Frayn K, Shevchenko A, James P, Holm C, Strom K. (2011) 'Altered Desaturation and Elongation of Fatty Acids in Hormone-Sensitive Lipase Null Mice'. PUBLIC LIBRARY SCIENCE PLOS ONE, 6 (6) Article number ARTN e21603
  • Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA. (2011) 'Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 105 (6), pp. 857-865.
  • McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F. (2011) 'Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity A Driver for Ectopic Fat Deposition?'. AMER DIABETES ASSOC DIABETES, 60 (1), pp. 47-55.
  • Hodson L, Banerjee R, Cheeseman J, Karpe F, Fielding BA. (2011) 'A large waist circumference is associated with higher liver fat in healthy pre-menopausal women in the absence of classical biochemical risk factors for CVD'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 70 (OCE4), pp. E229-E229.
  • Ardilouze J-L, Sotorník R, Dennis LA, Fielding BA, Frayn KN, Karpe F. (2011) 'Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation'. Diabetes and Metabolism,
  • Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttila J, Seppanen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Oresic M, Yki-Jarvinen H. (2010) 'Splanchnic Balance of Free Fatty Acids, Endocannabinoids, and Lipids in Subjects With Nonalcoholic Fatty Liver Disease'. W B SAUNDERS CO-ELSEVIER INC GASTROENTEROLOGY, 139 (6), pp. 1961-U232.
  • McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN. (2010) 'Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids'. AMER DIABETES ASSOC DIABETES, 59 (10), pp. 2465-2473.
  • Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding BA, Frayn KN, Karpe F. (2010) 'Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 299 (4), pp. E584-E592.
  • Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Nagren K, Solin O, Nuutila P. (2010) 'Increased Brain Fatty Acid Uptake in Metabolic Syndrome'. AMER DIABETES ASSOC DIABETES, 59 (9), pp. 2171-2177.
  • Iozzo P, Bucci M, Roivainen A, Nagren K, Jaervisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P. (2010) 'Fatty Acid Metabolism in the Liver, Measured by Positron Emission Tomography, Is Increased in Obese Individuals'. W B SAUNDERS CO-ELSEVIER INC GASTROENTEROLOGY, 139 (3), pp. 846-U203.
  • Lundbom J, Hakkarainen A, Fielding B, Soderlund S, Westerbacka J, Taskinen M-R, Lundbom N. (2010) 'Characterizing human adipose tissue lipids by long echo time H-1-MRS in vivo at 1.5 Tesla: validation by gas chromatography'. WILEY-BLACKWELL NMR IN BIOMEDICINE, 23 (5), pp. 466-472.
  • Egli L, Theytaz F, Campos V, Hodson L, Schneiter P, Fielding B, Tappy L. (2010) 'Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Males'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, 24
  • Adiels M, Larsson T, Sutton P, Taskinen M-R, Boren J, Fielding BA. (2010) 'Optimization of N-methyl-N-[tert-butyldimethylsilyl]- trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins'. JOHN WILEY & SONS LTD RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 24 (5), pp. 586-592.
  • Pinnick K, Neville M, Clark A, Fielding B. (2010) 'Reversibility of Metabolic and Morphological Changes Associated With Chronic Exposure of Pancreatic Islet beta-Cells to Fatty Acids'. WILEY-LISS JOURNAL OF CELLULAR BIOCHEMISTRY, 109 (4), pp. 683-692.
  • Hodson L, Fielding BA. (2010) 'Trafficking and partitioning of fatty acids: the transition from fasted to fed state'. FUTURE MEDICINE LTD CLINICAL LIPIDOLOGY, 5 (1), pp. 131-144.
  • Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Le K-A, Schneiter P, Bortolotti M, Frayn KN, Tappy L. (2010) 'Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load'. CAMBRIDGE UNIV PRESS BRITISH JOURNAL OF NUTRITION, 104 (8), pp. 1139-1147.
  • Lundbom J, Heikkinen S, Fielding B, Hakkarainen A, Taskinen M-R, Lundbom N. (2009) 'PRESS echo time behavior of triglyceride resonances at 1.5 T: Detecting omega-3 fatty acids in adipose tissue in vivo'. ACADEMIC PRESS INC ELSEVIER SCIENCE JOURNAL OF MAGNETIC RESONANCE, 201 (1), pp. 39-47.
  • Kotronen A, Seppala-Lindroos A, Vehkavaara S, Bergholm R, Frayn KN, Fielding BA, Yki-Javinen H. (2009) 'Liver fat and lipid oxidation in humans'. WILEY-BLACKWELL PUBLISHING, INC LIVER INTERNATIONAL, 29 (9), pp. 1439-1446.
  • Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F. (2009) 'Fasted to Fed Trafficking of Fatty Acids in Human Adipose Tissue Reveals a Novel Regulatory Step for Enhanced Fat Storage'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 94 (5), pp. 1781-1788.
  • Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA. (2009) 'Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 296 (1), pp. E64-E71.
  • Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F. (2008) 'Fatty Acid Metabolism in Patients with PPAR gamma Mutations'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 93 (11), pp. 4462-4470.
  • Fernandez C, Lindholm M, Krogh M, Lucas S, Larsson S, Osmark P, Berger K, Boren J, Fielding B, Frayn K, Holm C. (2008) 'Disturbed cholesterol homeostasis in hormone-sensitive lipase-null mice'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 295 (4), pp. E820-E831.
  • Hodson L, Skeaff CM, Fielding BA. (2008) 'Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake'. PERGAMON-ELSEVIER SCIENCE LTD PROGRESS IN LIPID RESEARCH, 47 (5), pp. 348-380.
  • Karpe E, Ruge T, Hodson L, Fielding B, Humphreys SM, Dennis L, Cheeseman J, Frayn KN. (2008) 'Regulation of fat storage in human subcutaneous adipose tissue over a 24-hour period'. SPRINGER DIABETOLOGIA, 51, pp. S20-S20.
  • Bickerton AST, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJM, Gilbert M, Humphreys SM, Karpe F, Frayn KN. (2008) 'Adipose tissue fatty acid metabolism in insulin-resistant men'. SPRINGER DIABETOLOGIA, 51 (8), pp. 1466-1474.
  • Roberts R, Bickerton AS, Fielding BA, Blaak EE, Wagenmakers AJ, Chong MF-F, Gilbert M, Karpe F, Frayn KN. (2008) 'Reduced oxidation of dietary fat after a short term high-carbohydrate diet'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 87 (4), pp. 824-831.
  • Chong MF-F, Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN, Fielding BA. (2008) 'Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 87 (4), pp. 817-823.
  • Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA. (2008) 'Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition'. NATURE PUBLISHING GROUP OBESITY, 16 (3), pp. 522-530.
  • Riserus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F. (2008) 'Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatly acid oxidation in moderately obese men'. AMER DIABETES ASSOC DIABETES, 57 (2), pp. 332-339.
  • Hodson L, Bickerton AST, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA. (2007) 'The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women - Studies in the postprandial state'. AMER DIABETES ASSOC DIABETES, 56 (10), pp. 2433-2441.
  • Chong MF-F, Fielding BA, Frayn KN. (2007) 'Mechanisms for the acute effect of fructose on postprandial lipemia'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 85 (6), pp. 1511-1520.
  • Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN. (2007) 'Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation'. PORTLAND PRESS LTD BIOCHEMICAL SOCIETY TRANSACTIONS, Royal Vet Coll, London, ENGLAND: 35, pp. 472-476.
  • Chong MFF, Fielding BA, Frayn KN. (2007) 'Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, Aberdeen, SCOTLAND: 66 (1), pp. 52-59.
  • Gutierrez E, Wiggins D, Fielding B, Gould AP. (2007) 'Specialized hepatocyte-like cells regulate Drosophila lipid metabolism'. NATURE PUBLISHING GROUP NATURE, 445 (7125), pp. 275-280.
  • Bickerton AST, Roberts R, Fielding BA, Hodson L, Blaak EE, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2007) 'Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period'. AMER DIABETES ASSOC DIABETES, 56 (1), pp. 168-176.
  • Tan GD, Neville MJ, Liverani E, Humphreys SM, Currie JM, Dennis L, Fielding BA, Karpe F. (2006) 'The in vivo effects of the Pro12Ala PPAR gamma 2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank'. SPRINGER DIABETOLOGIA, 49 (1), pp. 158-168.
  • Moffitt JH, Fielding BA, Evershed R, Berstan R, Currie JM, Clark A. (2005) 'Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro'. SPRINGER DIABETOLOGIA, 48 (9), pp. 1819-1829.
  • Frayn KN, Fielding BA, Karpe F. (2005) 'Adipose tissue fatty acid metabolism and cardiovascular disease'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 16 (4), pp. 409-415.
  • Riserus U, Tan GD, Fielding BA, Neville MJ, Currie J, Savage DB, Chatterjee VK, Frayn KN, O'Rahilly S, Karpe F. (2005) 'Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans - Link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma'. AMER DIABETES ASSOC DIABETES, 54 (5), pp. 1379-1384.
  • Karpe F, Fielding BA, Coppack SW, Lawrence VJ, Macdonald IA, Frayn KN. (2005) 'Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo'. AMER DIABETES ASSOC DIABETES, 54 (5), pp. 1297-1303.
  • Tan GD, Fielding BA, Currie JM, Humphreys SM, Desage M, Frayn K, Laville M, Vidal H, Karpe F. (2005) 'The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes'. SPRINGER DIABETOLOGIA, 48 (1), pp. 83-95.
  • Fielding BA, Frayn KN. (2004) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 15 (4), pp. 483-485.
  • Ardilouze JL, Fielding BA, Curry JM, Frayn KN, Karpe F. (2004) 'Role of leptin in regulating nitric oxide production and membrane microviscosity - Response'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, 109 (22), pp. E316-E316.
  • Frayn KN, Ardilouze JL, Fielding BA, Karpe F. (2004) 'Coupling of metabolism and cardiovascular responses'. PORTLAND PRESS CLINICAL SCIENCE, 106 (5), pp. 547-548.
  • Ardilouze JL, Karpe F, Currie JM, Frayn KN, Fielding BA. (2004) 'Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 28 (2), pp. 228-233.
  • Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. (2004) 'Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, 109 (1), pp. 47-52.
  • Smith RD, Kelly CNM, Fielding BA, Hauton D, Silva KDRR, Nydahl MC, Miller GJ, Williams CM. (2003) 'Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects'. C A B I PUBLISHING BRITISH JOURNAL OF NUTRITION, 90 (3), pp. 597-606.
  • Fielding BA, Frayn KN. (2003) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 14 (4), pp. 389-391.
  • Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW. (2003) 'Integrative physiology of human adipose tissue'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 27 (8), pp. 875-888.
  • Nydahl MC, Smith RD, Kelly CNM, Fielding BA, Williams CM. (2003) 'Achievement of dietary fatty acid intakes in long-term controlled intervention studies: approach and methodology'. C A B I PUBLISHING PUBLIC HEALTH NUTRITION, 6 (1), pp. 31-40.
  • Beysen C, Belcher AK, Karpe F, Fielding BA, Herrera E, Frayn KN. (2003) 'Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans'. AMER PHYSIOLOGICAL SOC AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 284 (1), pp. E18-E24.
  • Robertson MD, Jackson KG, Fielding BA, Williams CM, Frayn KN. (2002) 'Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women.'. Br J Nutr, England: 88 (6), pp. 635-640.
  • Beysen C, Karpe F, Fielding BA, Clark A, Levy JC, Frayn KN. (2002) 'Interaction between specific fatty acids, GLP-1 and insulin secretion in humans'. SPRINGER-VERLAG DIABETOLOGIA, 45 (11), pp. 1533-1541.
  • Jackson KG, Robertson MD, Fielding BA, Frayn KN, Williams CM. (2002) 'Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 76 (5), pp. 942-949.
  • Fielding BA, Frayn KN. (2002) 'Lipid metabolism'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 13 (5), pp. 573-575.
  • Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LKM, Frayn KN. (2002) 'Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity'. AMER DIABETES ASSOC DIABETES, 51 (8), pp. 2467-2473.
  • Robertson MD, Jackson KG, Fielding BA, Morgan LM, Williams CM, Frayn KN. (2002) 'Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 76 (1), pp. 232-238.
  • Karpe F, Fielding BA, Ardilouze JL, Ilic V, Macdonald IA, Frayn KN. (2002) 'Effects of insulin on adipose tissue blood flow in man'. CAMBRIDGE UNIV PRESS JOURNAL OF PHYSIOLOGY-LONDON, 540 (3), pp. 1087-1093.
  • Summers LKM, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, Frayn KN. (2002) 'Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity'. SPRINGER-VERLAG DIABETOLOGIA, 45 (3), pp. 369-377.
  • Karpe F, Fielding BA, Ilic V, Humphreys SM, Frayn KN. (2002) 'Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, 26 (1), pp. 1-5.
  • Moher HE, Tan G, Fielding BA, Carey GB. (2001) 'Arterio-venous (AV) difference of cyclic adenosine monophosphate (cAMP) serosa human adipose tissue in vivo'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, 15 (4), pp. A299-A299.
  • Griffin BA, Fielding BA. (2001) 'Postprandial lipid handling'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 4 (2), pp. 93-98.
  • Jackson KG, Robertson MD, Fielding BA, Frayn KN, Williams CM. (2001) 'Second meal effect: modified sham feeding does not provoke the release of stored triacylglycerol from a previous high-fat meal'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 85 (2), pp. 149-156.
  • Robertson MD, Jackson KG, Williams CM, Fielding BA, Frayn KN. (2001) 'Prolonged effects of modified sham feeding on energy substrate mobilization'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 73 (1), pp. 111-117.
  • Fielding BA, Frayn KN. (2000) 'Lipid metabolism - Editorial comment'. LIPPINCOTT WILLIAMS & WILKINS CURRENT OPINION IN LIPIDOLOGY, 11 (6), pp. 657-659.
  • Kalant D, Phelis S, Fielding BA, Frayn KN, Cianflone K, Sniderman AD. (2000) 'Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 41 (12), pp. 1963-1968.
  • Summers LKM, Barnes SC, Fielding BA, Beysen C, Ilic V, Humphreys SM, Frayn KN. (2000) 'Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, 71 (6), pp. 1470-1477.
  • Fielding BA, Reid G, Grady M, Humphreys SM, Evans K, Frayn KN. (2000) 'Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 83 (6), pp. 597-604.
  • Robertson MD, Jackson KG, Williams CM, Fielding BA, Frayn KN. (2000) 'Modified sham feeding of a modest-fat meal suppresses plasma non-esterified fatty acids.'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, 59, pp. 123A-123A.
  • Jackson KG, Robertson MD, Deane LO, Fielding BA, Frayn KN, Williams CM. (2000) 'The effect of modified sham-feeding meals of varying fat content on postprandial triacylglycerol, insulin and glucose responses.'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, 59, pp. 14A-14A.
  • Fielding BA, Frayn KN. (2000) 'Lipid metabolism'. Current Opinion in Lipidology, 11 (6), pp. 657-659.
  • Summers LKM, Fielding BA, Herd SL, Ilic V, Clark ML, Quinlan PT, Frayn KN. (1999) 'Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 40 (10), pp. 1890-1898.
  • Summers LKM, Fielding BA, Ilic V, Clark ML, Frayn KN. (1999) 'The relationship between insulin sensitivity and postprandial adipose tissue lipid metabolism'. SPRINGER VERLAG DIABETOLOGIA, 42, pp. A205-A205.
  • Fielding BA, Samra JS, Ravell CL, Frayn KN. (1999) 'Metabolism of individual fatty acids during infusion of a triacylglycerol emulsion'. AMER OIL CHEMISTS SOC A O C S PRESS LIPIDS, 34 (6), pp. 535-541.
  • Fielding BA, Frayn KN. (1999) 'Lipid metabolism'. Current Opinion in Lipidology, 10 (1), pp. 73-75.
  • Fielding BA, Frayn KN. (1998) 'Lipoprotein lipase and the disposition of dietary fatty acids'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 80 (6), pp. 495-502.
  • Summers LKM, Fielding BA, Ilic V, Frayn KN. (1998) 'The relationship between body mass index, abdominal fat distribution, insulin sensitivity and plasma lipids'. SPRINGER VERLAG DIABETOLOGIA, 41, pp. A347-A347.
  • Evans K, Kuusela PJ, Cruz ML, Wilhelmova I, Fielding BA, Frayn KN. (1998) 'Rapid chylomicron appearance following sequential meals: effects of second meal composition'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 79 (5), pp. 425-429.
  • Saleh J, Summers LKM, Cianflone K, Fielding BA, Sniderman AD, Frayn KN. (1998) 'Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 39 (4), pp. 884-891.
  • Summers LKM, Fielding BA, Ilic V, Quinlan PT, Frayn KN. (1998) 'The effect of triacylglycerol fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue'. C A B INTERNATIONAL BRITISH JOURNAL OF NUTRITION, 79 (2), pp. 141-147.
  • Frayn KN, Fielding BA, Summers LKM. (1997) 'Investigation of human adipose tissue metabolism in vivo'. J ENDOCRINOLOGY LTD JOURNAL OF ENDOCRINOLOGY, ARGENTEUIL, FRANCE: 155 (2), pp. 187-189.
  • Frayn KN, Summers LKM, Fielding BA. (1997) 'Regulation of the plasma non-esterified fatty acid concentration in the postprandial state'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, ROYAL SOC MED, LONDON, ENGLAND: 56 (2), pp. 713-721.
  • Halliwell KJ, Fielding BA, Samra JS, Humphreys SM, Frayn KN. (1996) 'Release of individual fatty acids from human adipose tissue in vivo after an overnight fast'. LIPID RESEARCH INC JOURNAL OF LIPID RESEARCH, 37 (9), pp. 1842-1848.
  • Phillips DIW, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R. (1996) 'Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects'. W B SAUNDERS CO METABOLISM-CLINICAL AND EXPERIMENTAL, 45 (8), pp. 947-950.
  • Frayn KN, Fielding BA, Humphreys SM, Coppack SW. (1996) 'Nutritional influences on human adipose-tissue metabolism'. PORTLAND PRESS BIOCHEMICAL SOCIETY TRANSACTIONS, UNIV ABERDEEN, ABERDEEN, SCOTLAND: 24 (2), pp. 422-426.
  • Fielding BA, Callow J, Owen RM, Samra JS, Matthews DR, Frayn KN. (1996) 'Postprandial lipemia: The origin of an early peak studied by specific dietary fatty acid intake during sequential meals'. AMER SOC CLIN NUTRITION INC AMERICAN JOURNAL OF CLINICAL NUTRITION, 63 (1), pp. 36-41.
  • Fielding BA, Humphreys SM, Shadid S, Frayn KN. (1995) 'Plasma mono-, di- and triacylglycerol measurements in a study of fat uptake by human adipose tissue in vivo.'. Biochem Soc Trans, ENGLAND: 23 (3)
  • Fielding BA, Humphreys SM, Shadid S, Frayn KN. (1995) 'Arterio-venous differences across human adipose tissue for mono-, di- and triacylglycerols before and after a high-fat meal'. Endocrinology and Metabolism, 2 (1), pp. 13-17.
  • Frayn KN, Coppack SW, Fielding BA, Humphreys SM. (1995) 'Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization.'. Adv Enzyme Regul, ENGLAND: 35, pp. 163-178.
  • Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O, Coppack SW. (1994) 'Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition.'. Am J Physiol, UNITED STATES: 266 (3 Pt 1), pp. E308-E317.
  • Frayn KN, Shadid S, Hamlani R, Humphreys SM, Clark ML, Fielding BA, Boland O, Coppack SW. (1994) 'Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition'. American Journal of Physiology - Endocrinology and Metabolism, 266 (3 29-3)
  • Griffiths AJ, Humphreys SM, Clark ML, Fielding BA, Frayn KN. (1994) 'Immediate metabolic availability of dietary fat in combination with carbohydrate.'. Am J Clin Nutr, UNITED STATES: 59 (1), pp. 53-59.
  • Fielding BA, Humphreys SM, Frayn KN. (1993) 'Mono- and di-acylglycerol concentrations in human plasma in relation to lipoprotein lipase activity.'. Biochem Soc Trans, ENGLAND: 21 ( Pt 3) (3)
  • Fielding BA, Humphreys SM, Allman RF, Frayn KN. (1993) 'Mono-, di- and triacylglycerol concentrations in human plasma: effects of heparin injection and of a high-fat meal.'. Clin Chim Acta, NETHERLANDS: 216 (1-2), pp. 167-173.
  • FIELDING BA, HUMPHREYS SM, ALLMAN RFC, FRAYN KN. (1993) 'MONOACYLGLYCEROL, DIACYLGLYCEROL, AND TRIACYLGLYCEROL CONCENTRATIONS IN HUMAN PLASMA - EFFECTS OF HEPARIN INJECTION AND OF A HIGH-FAT MEAL'. ELSEVIER SCIENCE BV CLINICA CHIMICA ACTA, 216 (1-2), pp. 167-173.
  • DHAR H, FIELDING BA, CLARK ML, FRAYN KN. (1990) 'TURBIDITY IN IMMUNOTURBIDIMETRIC ASSAY - REPLY'. ROYAL SOC MEDICINE SERVICES LTD ANNALS OF CLINICAL BIOCHEMISTRY, 27, pp. 509-509.
  • Dhar H, Fielding BA, Clark ML, Frayn KN. (1990) 'Background turbidity changes during the estimation of urinary albumin.'. Ann Clin Biochem, ENGLAND: 27 ( Pt 2), pp. 161-162.
  • DAVIES AG, PRICE DA, POSTLETHWAITE RJ, FIELDING BA. (1985) 'URINE ALBUMIN EXCRETION IN DIABETICS'. LANCET LTD LANCET, 1 (8426), pp. 466-467.
  • DAVIES AG, PRICE DA, POSTLETHWAITE RJ, ADDISON GM, BURN JL, FIELDING BA. (1985) 'RENAL-FUNCTION IN DIABETES-MELLITUS'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 60 (4), pp. 299-304.
  • PRICE DA, CLOSE GC, FIELDING BA. (1984) 'AGE OF APPEARANCE OF CIRCADIAN-RHYTHM IN SALIVARY CORTISOL-LEVELS'. WILLIAMS & WILKINS PEDIATRIC RESEARCH, 18 (1), pp. 118-118.
  • DAVIES AG, PRICE DA, HOULTON CA, BURN JL, FIELDING BA, POSTLETHWAITE RJ. (1984) 'CONTINUOUS SUBCUTANEOUS INSULIN INFUSION IN DIABETES-MELLITUS - A YEARS PROSPECTIVE TRIAL'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 59 (11), pp. 1027-1033.
  • DAVIES AG, POSTLETHWAITE RJ, PRICE DA, BURN JL, HOULTON CA, FIELDING BA. (1984) 'URINARY ALBUMIN EXCRETION IN SCHOOL-CHILDREN'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 59 (7), pp. 625-630.
  • FIELDING BA, PRICE DA, HOULTON CA. (1983) 'ENZYME-IMMUNOASSAY FOR URINARY ALBUMIN'. AMER ASSOC CLINICAL CHEMISTRY CLINICAL CHEMISTRY, 29 (2), pp. 355-357.
  • FIELDING BA, HOULTON CA, PRICE DA, POSTLETHWAITE RJ. (1983) 'AN ENZYME-LINKED IMMUNOSORBENT-ASSAY FOR THE MEASUREMENT OF URINARY ALBUMIN'. SPRINGER VERLAG EUROPEAN JOURNAL OF PEDIATRICS, 140 (2), pp. 207-207.
  • PRICE DA, CLOSE GC, FIELDING BA. (1983) 'AGE OF APPEARANCE OF CIRCADIAN-RHYTHM IN SALIVARY CORTISOL VALUES IN INFANCY'. BRITISH MED JOURNAL PUBL GROUP ARCHIVES OF DISEASE IN CHILDHOOD, 58 (6), pp. 454-456.

Conference papers

  • Umpleby M, Shojaee-Moradie F, Fielding B, Li X, Isherwood C, Jackson N, Wilinska G, Hovorka R, Bell J, Thomas EL, Wright J, Frost GS, Griffin B. (2015) 'A DIET LOW IN SUGAR REDUCES THE PRODUCTION OF ATHEROGENIC LIPOPROTEINS IN MEN WITH HIGH LIVER FAT'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Glasgow, SCOTLAND: 83rd Congress of the European-Atherosclerosis-Society (EAS) 241 (1), pp. E46-E46.
  • Maldonado EM, Fielding BA, Fisher CP, Moore JB. (2015) 'Quantitative lipid profiling of the early response to either fructose or glucose in an in vitro model of steatosis'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, 74 (OCE5), pp. E282-E282.
  • Hartwick CA, Moreno L, Fisberg M, Hart K, Fielding B, Lenham-New S, Richards Z. (2014) 'An international study of food behavior and nutritional status of children from 21 countries'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, San Diego, CA: Experimental Biology Meeting 28 (1)
  • Egli L, Theytaz F, Campos V, Hodson L, Schneiter P, Fielding B, Tappy L. (2012) 'Exercise Prevents Fructose-Induced Hypertriglyceridemia in Healthy Young Males'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, San Diego, CA: Experimental Biology Meeting 26
  • Banerjee R, Rial BF, Suttie J, Lewandowski A, Robson MD, Schneider J, Hodson L, Fielding B, Collier JD, Barnes E, Neubauer S. (2012) 'WAIST CIRCUMFERENCE GREATER THAN 90CM IS A RISK FACTOR FOR HEPATIC STEATOSIS IN OTHERWISE HEALTHY ADULTS - A 3 TESLA MAGNETIC RESONANCE SPECTROSCOPY STUDY'. JOURNAL OF HEPATOLOGY, 56, pp. S504-S504.
  • Lord SR, Collins J, Fielding B, Buffa F, Karpe F, Harris A. (2011) 'METFORMIN'S EFFECTS ON BREAST CANCER LIPID METABOLISM'. OXFORD UNIV PRESS ANNALS OF ONCOLOGY, Brussels, BELGIUM: Conference on Improving Care and Knowledge through Translational Research (IMPAKT) Breast Cancer 22, pp. 31-31.
  • Kotronen A, Westerbacka J, Fielding BA, Wahren J, Hodson L, Seppanen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Frayn KN, Oresic M, Yki-Jarvinen H. (2010) 'Splanchnic balance of free fatty acids, endocannabinoids and lipids in subjects with NAFLD'. SPRINGER DIABETOLOGIA, Stockholm, SWEDEN: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 53, pp. S104-S104.
  • Karmi AC, Viljanen A, Borra R, Fielding B, Viljanen T, Frayn K, Iozzo P, Nuutila P. (2009) 'The effect of weight loss on intra-abdominal fatty acid metabolism in metabolic syndrome'. SPRINGER DIABETOLOGIA, Vienna, AUSTRIA: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 52, pp. S75-S75.
  • Riserus U, Sprecher D, Jonson T, Olson E, Hirschberg S, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum J, Cheeseman J, Fielding B, Moore N, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Keith F, Karpe F. (2007) 'PPAR-delta activation reverses multiple metabolic abnormalities, reduces oxidative stress and promotes fat oxidation in obese humans'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Budapest, HUNGARY: 15th European Congress on Obesity 31 (9), pp. 1487-1487.
  • Hodson L, Fielding BA, Milne RW, Karpe F, Frayn KN. (2007) 'Insulin resistance reduces the contribution of systemic plasma non-esterified fatty acids into very low-density lipoprotein triacylglycerol'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPPLEMENTS, Helsinki, FINLAND: 76th Congress of the European-Atherosclerosis-Society 8 (1), pp. 9-10.
  • Marinou K, Hodson L, Frayn KN, Karpe F, Fielding BA. (2007) 'Sources of fatty acids for 3-hydroxybutyrate production differ during short-term fasting in men and women'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS SUPPLEMENTS, Helsinki, FINLAND: 76th Congress of the European-Atherosclerosis-Society 8 (1), pp. 23-24.
  • Karpe F, Bickerton A, Fielding B, Hodson L, Ruge T, Frayn K. (2007) 'Abnormalities in fatty acid storage and delivery in the metabolic syndrome'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Budapest, HUNGARY: 15th European Congress on Obesity 31, pp. S6-S6.
  • Roberts R, Bickerton A, Fielding BA, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2006) 'Reduced oxidation of dietary fat after a short term high-carbohydrate diet'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Univ Kent, Canterbury, ENGLAND: 20th Annual Medical and Scientific Meeting of HEART UK 188 (1), pp. S3-S3.
  • Hodson L, Ruge T, Milne R, Fielding BA, Frayn KN, Karpe F. (2006) 'Dietary fat is a major contributor to VLDL production in the fed state in humans'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Univ Kent, Canterbury, ENGLAND: 20th Annual Medical and Scientific Meeting of HEART UK 188 (1), pp. S3-S4.
  • Chong MFF, Bickerton A, Roberts R, Karpe F, Hodson L, Fielding B, Frayn K. (2006) 'De novo lipogenesis (DNL) occurs after a 3-day eucaloric low-fat, high-carbohydrate (HC) solid food diet'. FEDERATION AMER SOC EXP BIOL FASEB JOURNAL, San Francisco, CA: Experimental Biology 2006 Meeting 20 (5), pp. A1022-A1023.
  • Fielding BA, Hodson L, Roberts R, Bickerton A, Karpe E, Frayn KN. (2005) 'Use of a stable isotope technique to estimate postprandial chylomicron triacylglycerol concentrations without physical separation of the particles'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A197-A197.
  • Hodson L, Fielding BA, Bickerton A, Roberts R, Milne RW, Frayn KN, Karpe E. (2005) 'Incorporation of exogenous and endogenous fatty acids into very low-density lipoprotein (VLDL): a study using stable isotope and immunoaffinity techniques in humans'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A233-A233.
  • Bickerton AST, Roberts R, Fielding BA, Blaakl E, Wagenmakers AJM, Gilbert M, Karpel E, Frayn KN. (2005) 'Adipose tissue fatty acid metabolism and the metabolic syndrome'. SPRINGER DIABETOLOGIA, Athens, GREECE: 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes 48, pp. A231-A232.
  • Moffitt JH, Fielding B, Currie J, Clark A. (2004) 'Triacylglycerol formed in islet beta cells exposed to fatty acids do not contribute to decreased viability except in cells forming predominantly tripalmitin'. SPRINGER DIABETOLOGIA, Munich, GERMANY: 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes 47, pp. A176-A176.
  • Bickerton A, Roberts R, Fielding B, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2004) 'Fatty acid oxidation in the metabolic syndrome'. ELSEVIER SCI IRELAND LTD ATHEROSCLEROSIS, Univ Bath, Bath, ENGLAND: 18th Annual Medical and Scientific Meeting of HEART UK 175 (2), pp. S7-S7.
  • Frayn KN, Fielding BA, Macdonald IA, Coppack SW, Lawrence V, Karpe F. (2004) 'Pulsatile blood flow and lipolysis in human adipose tissue'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S81-S81.
  • Roberts R, Bickerton A, Fielding BA, Blaak E, Wagenmakers AJM, Gilbert M, Karpe F, Frayn KN. (2004) 'A new protocol to study fatty acid metabolism in muscle and adipose tissue in subjects with the metabolic syndrome'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S165-S165.
  • Fielding BA, Roberts R, Bickerton A, Karpe F, Gilbert M, Frayn KN. (2004) 'Comparison of GC-MS and GC-cIRMS for the measurement of [C-13] palmitate enrichment in a stable isotope study in vivo in man'. NATURE PUBLISHING GROUP INTERNATIONAL JOURNAL OF OBESITY, Prague, CZECH REPUBLIC: 13th European Congress on Obesity 28, pp. S165-S165.
  • Sniderman AD, Cianflone K, Summers L, Fielding B, Frayn K. (1997) 'The acylation-stimulating protein pathway and regulation of postprandial metabolism'. C A B INTERNATIONAL PROCEEDINGS OF THE NUTRITION SOCIETY, ROYAL SOC MED, LONDON, ENGLAND: Symposium on Postprandial Lipid Metabolism 56 (2), pp. 703-712.
  • Frayn KN, Fielding BA, Samra JS, Summers LKM. (1997) 'Extracellular metabolic regulation in adipose tissue'. LIPPINCOTT-RAVEN PUBL PHYSIOLOGY, STRESS, AND MALNUTRITION, AMSTERDAM, NETHERLANDS: 3rd Conference on Physiology, Stress, and Malnutrition, pp. 303-323.
  • FIELDING BA, HUMPHREYS SM, SHADID S, FRAYN KN. (1995) 'PLASMA MONOACYLGLYCEROL, DIACYLGLYCEROL AND TRIACYLGLYCEROL MEASUREMENTS IN A STUDY OF FAT UPTAKE BY HUMAN ADIPOSE-TISSUE IN-VIVO'. PORTLAND PRESS BIOCHEMICAL SOCIETY TRANSACTIONS, LEICESTER, ENGLAND: 654th Meeting of the Biochemical-Society 23 (3), pp. S487-S487.

Theses and dissertations

  • Mohamed Zam NR. (2017) Physico-chemical properties of fish proteins recovered from waste streams..
    [ Status: Approved ]

    Abstract

    Food security can be improved by reducing post-harvest losses in sustainable food product chains. About 50% of fish is lost during filleting, including significant levels of high quality protein (10–23% (w/w)), which may be a source for biofunctional peptides. The fish processing waste protein hydrolysate can be a potential solution for minimizing the environmental issues related to marine processing products, and act as an alternative to producing value added fish processing by products. The main aim of this study was to investigate the physicochemical properties of fish processing waste streams from Atlantic Mackerel (Scomber scombrus) and mixed fish by membrane separation. Protein hydrolysates of Atlantic Mackerel (Scomber scombrus) and mixed fish from fish waste streams were prepared by enzymatic hydrolysis using pepsin and pancreatin and measured for their antioxidant and functional properties. The chemical composition (moisture, protein, total lipids and ash) of the Atlantic mackerel and Nile Perch (Lates niloticus) fish fillets (FF) compared to fish waste (FW) was also investigated. Protein fractions from the fish waste samples were separated by using the TFF cogent μscale ultrafiltration system from Millipore, and parameters including transmembrane pressure (TMP) on flux excursion, protein performance scalability, mass transfer analysis, as well as hold up volume were studied. The mechanism of antioxidant activity was studied by DPPH, FRAP, FTC and TBARS assays. It was demonstrated that fish waste water protein hydrolysate especially for Atlantic Mackerel showed good antioxidant activities by the Ferric Thiocyanate (FTC) and Thiobarbituric acid Reactive substances (TBARS) methods and compared well with other antioxidants (BHA, ascorbic acid and trolox). There was significant difference (p<0.05) between samples and negative control (no antioxidant). DPPH scavenging activity increased with the extract concentration in the range of 1.5-26 %. In FRAP assay, both sample showed that there was an increase in absorbance with an increase in concentration. Structural and thermodynamic changes in fish waste samples were also determined by FT-Raman spectroscopy, differential scanning calorimetry (DSC) and small deformation rheology respectively. The DSC thermograms from the samples indicated that fish waste samples may be comparable. Moreover in fish waste sample hydrolysates, the same trends were obtained in 10 kDa AM and MF fractions. Fish waste samples espe

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