After completing an undergraduate degree in Molecular Biology and Biotechnology (1st Class Hon.) and a further MSc in Chemical Pathology, University of Cape Coast and Kwame Nkrumah University of Science & Technology, respectively in Ghana, Isaac started his PhD at Aston University, UK in October, 2016 before transferring to the University of Surrey, UK in April, 2017. He had already in his masters studies, researched on the role of diet(i.e Ghanaian locally consumed vegetable oils) in glucose and cholesterol metabolism using in vivo model of diabetes before awarded the prestigious commonwealth scholarship by the Commonwealth Scholarship Commission, UK to pursue a PhD research to understand how certain gut microbiota affect specific odd chain fatty acids metabolism which have been found to reduce diabetes and cardio-metabolic risk. Isaac is employing a range of different approaches such as PCR, HOMA-IR/oral glucose challenge studies, GC-FID/GC-MS, cell culture, dietary intervention, Next generation sequencing, stereology. He is part of a cross-multidisciplinary team researching to find solutions to the increasing rate of obesity and related metabolic diseases and translate them for better health of millions affected. Isaac overall goal is to understand the mechanisms underlying the risk of type 2 diabetes and obesity and develop interventions to avert them through the use of dietary model of these conditions.
My main research interest is to understand the mechanisms underlying the risk for Type 2 diabetes and obesity and develop interventions for these risk factors through the use of dietary models of these diseases.
I am specifically interested in understanding the:
Role of diet in glucose and lipid metabolism
Mechanism of dietary effect on glucose and lipid metabolism
In this horizon-scanning review, we have compiled available evidence on the effects of protein malnutrition on OCFA production, arising from loss in mitochondrial, peroxisomal and gut microbiota function, and its association with lipid accumulation in the liver. The methyl donor amino acid composition of dietary protein is an important contributor to liver function and lipid storage; the presence and abundance of dietary branched chain amino acids can modulate the composition and metabolic activity of the gut microbiome and on the other hand, can affect protective OCFA and SCFA production in the liver. In preclinical animal models fed with low protein diets, specific amino acid supplementation can ameliorate fatty liver disease. The association between low dietary protein intake and fatty liver disease is underexplored and merits further investigation, particularly in vulnerable groups with dietary protein restriction in developing countries.