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Dr Mohammed Sani Isyaka


Postgraduate Research Student

Academic and research departments

Department of Chemistry.

My publications

Publications

Isyaka Sani M., Langat Moses K., Mas-Clare Eduard, Mbala Blaise M., Mvingu Bienvenu K., Mulholland Dulcie A. (2019) Ent-abietane and ent-pimarane diterpenoids from Croton mubango (Euphorbiaceae), Phytochemistry 170 112217 Elsevier
Twelve ent-abietane and two ent-pimarane diterpenoids were isolated from the leaves of Croton mubango Müll. Arg. (Euphorbiaceae) collected in the Democratic Republic of the Congo. 2²-Hydroxy-ent-abieta-7,13-dien-3-one, 15-hydroxy-ent-abieta-7,13-dien-3-one, 13±,15-dihydroxy-ent-abieta-8(14)-en-3-one, 2²,9,13-trihydroxy-ent-abieta-7-en-3-one, 2²,7²-dihydroxy-ent-abieta-8,11,13-trien-3-one, 15-hydroxy-ent-abieta-8,11,13-trien-3-one and ent-pimara-8(14),15-dien-3-one and the ent-forms of the previously reported normal series diterpenoids, ent-abieta-8,11,13-trien-3-one, 7²-hydroxy-ent-abieta-8,11,13-trien-3-one, 3±-hydroxy-ent-abieta-8,11,13-triene, 15-hydroxy-ent-abieta-8,11,13-triene and 6²-hydroxy-ent-abieta-8,11,13-triene are reported here for the first time. Structures were established using HRESIMS, FTIR, NMR, DP4+ probability calculations and by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Ent-pimara-8(14), 15-dien-3-one, showed antiproliferative activity against melanoma (MALME-3M), renal (UO-31) and ovarian cancer cell lines (IGROV1) at a concentration of 10?5 M in the NCI 60 screen.