Exploring the role of inflammation in common eye diseases

Aims and objectives

The aim of this project is to determine the role of ocular inflammation in common retinal diseases and to establish whether novel therapeutic targets have the potential to improve outcomes.

Potential benefits

The primary objective of this project is to gain a greater insight into the factors controlling inflammation in the retina.

We aim to use this information to identify new potential therapeutic targets and to test new treatment strategies to prevent, attenuate or reverse ocular diseases that have an inflammatory component, including some of the most common causes of blindness in the Western world, such as diabetic eye disease, age-related macular degeneration and uveitis. Current therapeutic approaches for treating these diseases offer some benefit but are often only partially effective and are frequently associated with serious side-effects. These diseases, therefore, continue to represent a significant socioeconomic burden in the UK and the industrialised world and consequently there continues to be an urgent need to identify novel targets and generate new therapeutic strategies. This project will use animal models of ocular inflammation to assess and test new treatment modalities emerging from the biomedical mechanistic knowledge gained from the approaches outlined above.