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Miss Hannah Davies


Veterinary Clinical Teaching Fellow
BVMS MRCVS, GCLT, MSc IAH, BSc (Hons),

Academic and research departments

School of Veterinary Medicine.

Publications

K Ewer, Jordan R Barrett, Sandra Belij-Rammerstorfer, Hannah Sharpe, Rebecca Makinson, Richard Morter, Amy Flaxman, Daniel Wright, Duncan Bellamy, Mustapha Bittaye, Christina Dold, Nicholas M Provine, Jeremy Aboagye, Jamie Fowler, Sarah E Silk, Jennifer Alderson, PK Aley, Brian Angus, Eleanor Berrie, Sagida Bibi, Paola Cicconi, Elizabeth Clutterbuck, Irina Chelysheva, Pedro M Folegatti, Michelle Fuskova, Catherine Green, Daniel Jenkin, Simon Kerridge, Alison M Lawrie, Angela M Minassian, ML Moore, Yama Mujadidi, Emma Plested, Ian Poulton, Maheshi Ramasamy, Hannah Robinson, Rinn Song, MD Snape, Richard Tarrant, Merryn Voysey, Marion E E Watson, A Douglas, Adrian V.S Hill, SC Gilbert, Andrew J. Pollard, Teresa Lambe, A Ali, Elizabeth Allen, MARK ALAN BAKER, E Barnes, Nicola Borthwick, A Boyd, Charlie Brown-O’Sullivan, Joshua Burgoyne, Nicholas Byard, Ingrid Cabrera Puig, Federica Cappuccini, Jee-Sun Cho, E Clark, Wendy E. M Crocker, Mehreen S Datoo, HANNAH DAVIES, Francesca R Donnellan, Susanna J Dunachie, Nick Edwards, Sean C Elias, Julie Furze, Ciaran Gilbride, G Gorini, Gaurav Gupta, Stephanie A Harris, Susanne H. C Hodgson, M Hou, Susan Jackson, KH Jones, Reshma Kailath, LJ King, Colin W Larkworthy, YU LI, Amelia M Lias, Aline Linder, Samuel Lipworth, Raquel Lopez Ramon, Meera Madhavan, Emma Marlow, J. L. Marshall, Alexander J Mentzer, HL Morrison, Nathifa Moya, Ekta Mukhopadhyay, Andrés Noé, Fay L Nugent, Dimitra Pipini, David Pulido-Gomez, Fernando Ramos Lopez, A Ritchie, Indra Rudiansyah, Stephannie Salvador, H Sanders, Iman Satti, Adam Shea, Alexandra J Spencer, Rachel Tanner, Iona Jennifer Taylor, Yrene Themistocleous, Merin Thomas, NL Tran, Adam Truby, Cheryl Turner, N Turner, Marta Ulaszewska, A Worth, Lucy Kingham-Page, Marco Polo Peralta Alvarez, Rachel Anslow, Louise Bates, Kirsten Beadon, Rebecca Beckley, Amy Beveridge, Else Margreet Bijker, L Blackwell, Jamie Burbage, Susana Camara, MA Carr, Rachel Colin-Jones, Rachel Cooper, C Cunningham, Tesfaye Demissie, Claudio Di Maso, Naomi Douglas, Rachael Drake-Brockman, R DRURY, Katherine R W Emary, Sally Felle, S Feng, Carla Ferreira Da Silva, Karen J Ford, EMMA FRANCIS, Lara Gracie, Joseph Hamlyn, Brama Hanumunthadu, DE HARRISON, Thomas C Hart, Sophia Hawkins, Jennifer Hill, Elizabeth Howe, NK Howell, ELIZABETH JONES, J Keen, Sarah Kelly, D Kerr, Liaquat Khan, Jasmin Kinch, Stanislava Koleva, Emily A Lees, Alice Lelliott, Xinxue Liu, N Marchevsky, Spyridoula Marinou, Joanne McEwan, Ella Morey, Gertraud Morshead, J Müller, CA Munro, Sarah Murphy, Philomena Mweu, Elizabeth Nuthall, Katie O’Brien, Daniel O’Connor, Peter John O’Reilly, Blanche Oguti, Piper Osborne, Nelly Owino, Kaye Parker, Katja Pfafferott, Daniel J Phillips, Samuel Provstgaard-Morys, Helen Ratcliffe, Thomas Rawlinson, Sarah Rhead, Hannah Roberts, Katherine Sanders, Laura Silva-Reyes, CHRISTINE ROLLIER, Catherine C Smith, David Smith, Lisa Stockdale, Anna Szigeti, T Thomas, Amber Thompson, Adriana Tomic, Susan Tonks, Rachel Varughese, Marije K Verheul, Iason Vichos, L Walker, CL White, RG White, Xin Yao, Christopher P Conlon, John Frater, Liliana Cifuentes, Ioana Baleanu, Emma Bolam, Elena Boland, T Brenner, Brad E Damratoski, Chandra Datta, Omar El Muhanna, RB Fisher, Pablo Galian-Rubio, Gina Hodges, Frederic Jackson, SHIQING LIU, Lisa Loew, Roisin Morgans, Susan Jane Morris, Vicki Olchawski, Catarina Oliveria, Helena Parracho, Emilia Reyes Pabon, Abdessamad Tahiri-Alaoui, K. Taylor, Paul Williams, Dalila Zizi, Edward H Arbe-Barnes, P Baker, Alexander Batten, C Downing, JM Drake, Marcus Rex English, JA Henry, Poppy Iveson, Annabel Killen, Thomas B King, Jessica P. J Larwood, Garry Mallett, Kushal Mansatta, Neginsadat Mirtorabi, Maia Patrick-Smith, James Perring, Kajal Radia, Sophie Roche, Ella Schofield, Rebecca te Water Naude, James Towner, Natalie Baker, Kevin R Bewley, Emily Brunt, Karen R Buttigieg, M Carroll, SJ Charlton, Naomi S Coombes, Michael J Elmore, Kerry Godwin, Bassam Hallis, Daniel Knott, Lorna McInroy, Imam Shaik, K Thomas, JA Tree, Caitlin L Blundell, Michelangelo Cao, D Kelly, Annina Schmid, Donal T Skelly, Andreas Themistocleous, Tao Dong, Samantha Field, ELIZABETH HAMILTON, Elizabeth J Kelly, Paul Klenerman, Julian C Knight, Yolanda Lie, Christos Petropoulos, Cynthia Sedik, Terri Wrin, Gretchen Meddaugh, Y Peng, Gavin Screaton, Elizabeth Stafford (2021)Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial, In: Nature medicine27(6)pp. 1116-1116
Amy Flaxman, N Marchevsky, Daniel Jenkin, Jeremy Aboagye, PK Aley, Brian Angus, Sandra Belij-Rammerstorfer, Sagida Bibi, Mustapha Bittaye, Federica Cappuccini, Paola Cicconi, Elizabeth Clutterbuck, SK Davies, Wanwisa Dejnirattisai, Christina Dold, K Ewer, Pedro M Folegatti, Jamie Fowler, Adrian V.S Hill, Angela M Minassian, Simon Kerridge, Juthathip Mongkolsapaya, Yama Mujadidi, Emma Plested, Maheshi Ramasamy, Hannah Robinson, H Sanders, Emma Sheehan, Holly Smith, MD Snape, Rinn Song, DR Woods, Gavin Screaton, SC Gilbert, Merryn Voysey, Andrew J. Pollard, Teresa Lambe, Syed Adlou, Robert Aley, A Ali, Rachel Anslow, MARK ALAN BAKER, P Baker, Jordan R Barrett, Louise Bates, Kirsten Beadon, Rebecca Beckley, JD Bell, Duncan Bellamy, Amy Beveridge, Cameron Bissett, L Blackwell, Heather Bletchly, A Boyd, Alice Bridges-Webb, Charlie Brown, Nicholas Byard, Susana Camara, Liliana Cifuentes Gutierrez, Andrea M Collins, Rachel Cooper, Wendy E. M Crocker, Thomas C Darton, HANNAH DAVIES, Judith Davies, Tesfaye Demissie, Claudio Di Maso, Tanya Dinesh, Francesca R Donnellan, A Douglas, Rachael Drake-Brockman, Christopher J A Duncan, Sean C Elias, Katherine R W Emary, Mutjaba Ghulam Farooq, SN Faust, Sally Felle, D Ferreira, Carla Ferreira Da Silva, A Finn, Karen J Ford, EMMA FRANCIS, Julie Furze, Michelle Fuskova, E Galiza, Ana Gibertoni Cruz, L Godfrey, A Goodman, Catherine Green, Christopher A Green, N Greenwood, DA Harrison, Thomas C Hart, Sophia Hawkins, PT Heath, Helen C Hill, Kushalinii Hillson, Bryn Horsington, M Hou, Elizabeth Howe, NK Howell, Carina Joe, ELIZABETH JONES, Mwila Kasanyinga, J Keen, Sarah Kelly, D Kerr, Liaquat Khan, Baktash Khozoee, Jasmin Kinch, Patrick Kinch, Stanislava Koleva, JT Kwok, Colin W Larkworthy, Alison M Lawrie, Rajeka Lazarus, Emily A Lees, Grace Li, Vincenzo Libri, Patrick J Lillie, Aline Linder, FW Long, Raquel Lopez Ramon, Reece Mabbett, Rebecca Makinson, Spyridoula Marinou, Emma Marlow, J. L. Marshall, Olga Mazur, Joanne McEwan, Alastair C McGregor, Jolynne Mokaya, Ella Morey, Gertraud Morshead, Richard Morter, J Müller, Philomena Mweu, Rabiullah Noristani, Nelly Owino, Marco Polo Peralta Alvarez, Abigail Platt, K Pollock, Ian Poulton, Samuel Provstgaard-Morys, David Pulido-Gomez, Matthew Rajan, Fernando Ramos Lopez, A Ritchie, Hannah Roberts, CHRISTINE ROLLIER, Indra Rudiansyah, Katherine Sanders, J Saunders, Samiullah Seddiqi, Hannah Sharpe, RK Shaw, Laura Silva-Reyes, N Singh, David Smith, Catherine C Smith, Andrew Smith, Alexandra J Spencer, Arabella S.V Stuart, R Sutherland, Anna Szigeti, K Tang, Merin Thomas, T Thomas, Amber Thompson, Emma C Thomson, Estée M Török, Mark Toshner, NL Tran, Rose Trivett, Iain Turnbull, Cheryl Turner, David P J Turner, Marta Ulaszewska, Iason Vichos, L Walker, Marion E E Watson, Conor Whelan, RG White, Sarah J Williams, Christopher J Williams, Daniel Wright, Andy Yao (2021)Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002), In: The Lancet (British edition)398(10304)pp. 981-990 Elsevier Ltd

COVID-19 vaccine supply shortages are causing concerns about compromised immunity in some countries as the interval between the first and second dose becomes longer. Conversely, countries with no supply constraints are considering administering a third dose. We assessed the persistence of immunogenicity after a single dose of ChAdOx1 nCoV-19 (AZD1222), immunity after an extended interval (44–45 weeks) between the first and second dose, and response to a third dose as a booster given 28–38 weeks after the second dose. In this substudy, volunteers aged 18–55 years who were enrolled in the phase 1/2 (COV001) controlled trial in the UK and had received either a single dose or two doses of 5 × 1010 viral particles were invited back for vaccination. Here we report the reactogenicity and immunogenicity of a delayed second dose (44–45 weeks after first dose) or a third dose of the vaccine (28–38 weeks after second dose). Data from volunteers aged 18–55 years who were enrolled in either the phase 1/2 (COV001) or phase 2/3 (COV002), single-blinded, randomised controlled trials of ChAdOx1 nCoV-19 and who had previously received a single dose or two doses of 5 × 1010 viral particles are used for comparison purposes. COV001 is registered with ClinicalTrials.gov, NCT04324606, and ISRCTN, 15281137, and COV002 is registered with ClinicalTrials.gov, NCT04400838, and ISRCTN, 15281137, and both are continuing but not recruiting. Between March 11 and 21, 2021, 90 participants were enrolled in the third-dose boost substudy, of whom 80 (89%) were assessable for reactogenicity, 75 (83%) were assessable for evaluation of antibodies, and 15 (17%) were assessable for T-cells responses. The two-dose cohort comprised 321 participants who had reactogenicity data (with prime-boost interval of 8–12 weeks: 267 [83%] of 321; 15–25 weeks: 24 [7%]; or 44–45 weeks: 30 [9%]) and 261 who had immunogenicity data (interval of 8–12 weeks: 115 [44%] of 261; 15–25 weeks: 116 [44%]; and 44–45 weeks: 30 [11%]). 480 participants from the single-dose cohort were assessable for immunogenicity up to 44–45 weeks after vaccination. Antibody titres after a single dose measured approximately 320 days after vaccination remained higher than the titres measured at baseline (geometric mean titre of 66·00 ELISA units [EUs; 95% CI 47·83–91·08] vs 1·75 EUs [1·60–1·93]). 32 participants received a late second dose of vaccine 44–45 weeks after the first dose, of whom 30 were included in immunogenicity and reactogenicity analyses. Antibody titres were higher 28 days after vaccination in those with a longer interval between first and second dose than for those with a short interval (median total IgG titre: 923 EUs [IQR 525–1764] with an 8–12 week interval; 1860 EUs [917–4934] with a 15–25 week interval; and 3738 EUs [1824–6625] with a 44–45 week interval). Among participants who received a third dose of vaccine, antibody titres (measured in 73 [81%] participants for whom samples were available) were significantly higher 28 days after a third dose (median total IgG titre: 3746 EUs [IQR 2047–6420]) than 28 days after a second dose (median 1792 EUs [IQR 899–4634]; Wilcoxon signed rank test p=0·0043). T-cell responses were also boosted after a third dose (median response increased from 200 spot forming units [SFUs] per million peripheral blood mononuclear cells [PBMCs; IQR 127–389] immediately before the third dose to 399 SFUs per milion PBMCs [314–662] by day 28 after the third dose; Wilcoxon signed rank test p=0·012). Reactogenicity after a late second dose or a third dose was lower than reactogenicity after a first dose. An extended interval before the second dose of ChAdOx1 nCoV-19 leads to increased antibody titres. A third dose of ChAdOx1 nCoV-19 induces antibodies to a level that correlates with high efficacy after second dose and boosts T-cell responses. UK Research and Innovation, Engineering and Physical Sciences Research Council, National Institute for Health Research, Coalition for Epidemic Preparedness Innovations, National Institute for Health Research Oxford Biomedical Research Centre, Chinese Academy of Medical Sciences Innovation Fund for Medical Science, Thames Valley and South Midlands NIHR Clinical Research Network, AstraZeneca, and Wellcome.