Investigating the role of pericytes in exercise-induced pulmonary haemorrhage disease and progression

This project sits at the cutting edge of equine biomedical research and aims to transform our understanding of a condition that significantly impacts racehorse welfare and performance. Building on the supervisory groups emerging molecular insights into EIPH,  the project will explore microvasulaturedysfunction  in the initiation and progression of disease, with the ultimate goal of identifying novel therapeutic targets and strategies to improve clinical outcomes. The successful candidate will develop skills in 3D cell culture models, multi-omics and more. 

We are seeking a highly motivated and curious candidate with a strong interest in translational veterinary research. The ideal applicant will bring enthusiasm for interdisciplinary science, a willingness to engage with both laboratory and clinically relevant research, and a commitment to improving animal health and welfare. Experience in cell biology, vascular biology, or molecular techniques would be advantageous, but above all, we are looking for someone with drive, critical thinking skills, and a passion for discovery.

Exercise-induced pulmonary haemorrhage (EIPH) affects 50–75% of racehorses in fast work and is a major cause of poor performance and, in severe cases, sudden death. Despite its high prevalence, the mechanisms driving disease onset and progression remain poorly understood, limiting effective treatment options.

EIPH shares features with the human condition pulmonary arterial hypertension (PAH), where dysfunction of vascular support cells—pericytes—drives pathology. Pericytes play a key role in maintaining microvascular stability and lung integrity, yet their role in EIPH has not been explored. This project will provide the first comprehensive investigation of pericytes in equine EIPH, with the aim of identifying novel therapeutic targets to improve racehorse health and welfare. The project aims to define the role of pericytes in the pathogenesis and progression of EIPH and evaluate their potential as therapeutic targets. The successful candidate will gain interdisciplinary training in molecular biology, transcriptomics, bioinformatics, advanced imaging, and 3D cell culture, within a collaborative and well-supported research environment.

We are seeking a highly motivated candidate with a strong interest in vascular biology, respiratory disease, or translational research. Excellent organisational skills and attention to detail, and an ability to work both independently and as part of a collaborative team.

Open to UK nationals only.

You will need to meet the entry requirements for our PhD programme.

This is basic research with a strong molecular, cellular and bioinformatic focus project and undergraduates with a degree in a related discipline would be expected. Medical and veterinary graduates are encouraged to apply. A masters degree in related subject is desirable and previous experience in a laboratory environment with some statistical methodology is desirable.