The simple and effective approach of ?dipping and drying? cotton yarn in a dispersion of poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT:PSS) and multi-walled carbon nanotubes (MWCNT) resulted in the development of a highly conductive and flexible cotton fibres. Subsequent polyaniline (PANi) deposition yielded electrodes with significant biocompatible and antibacterial properties that could be fabricated (alongside quasi-reference electrodes) into solid-state wearable pH sensors, which achieve rapid, selective, and Nernstian responses (-61 ± 2 mV pH-1) over a wide pH range (2.0 ? 12.0), even in a pH-adjusted artificial sweat matrix. This development represents an important progression towards the realisation of real-time, on-body, wearable sensors.
Skin diseases are common in the UK, especially in children where 34% suffer from such diseases at some point. Wound care and management is also a significant burden to the UK healthcare system, estimated at an annual cost of £5.3 billion. Epidermal pH gives an indication of the physiological condition of the skin and the healing progress of wounds. An effective pH-sensing dermal patch would provide non-invasive skin and wound monitoring, aiding treatment. The aim of this work was to develop a fibre-based flexible electrode to measure skin/wound pH. This will facilitate point-of-care analysis and allow appropriate care to be administrated by medical professionals.
Highly conductive wet-spun poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) fibres, a prior concept developed by Reid et al., were adopted for pH analysis. With an optimised polyaniline (PANi) coating, these fibres displayed Nernstian responses (in a solid-state sensor containing a fabricated quasi-reference electrode) across a pH range of 3.0 to 9.0 when in contact with both pH-adjusted artificial sweat matrix and human plasma; the fibres had additional desirable antibacterial and biocompatible properties. To date, wet-spun PEDOT:PSS fibres have not been adopted in a chemical sensing capacity. This invention provides opportunities for future wearable, fibre-based sensors capable of real-time, on-body pH sensing (to monitor wound healing and skin disease). However, a primary limitation was poor tensile strength (32 ± 11 MPa), which could lead to fibre breakages in real-life wearable applications. To overcome this limitation, another substrate, modified electrically conductive cotton, was explored.
A simple and effective ?dipping and drying? approach involving cotton yarns in a dispersion of PEDOT:PSS and multi-walled carbon nanotubes (MWCNT) resulted in the development of a flexible, highly conductive cotton fibre. Subsequent PANi deposition yielded electrodes with significant biocompatible and antibacterial properties that could be fabricated (alongside quasi-reference electrodes) into a solid-state wearable pH sensor, which achieved rapid, selective, and Nernstian responses (-61 ± 2 mV pH-1) over a wide pH range (2.0 ? 12.0), even in pH-adjusted artificial sweat matrix and human plasma. To date, there is no prior published research that reports on this combination of conductive materials and cotton in such a sensing capacity. Furthermore, few previous reports have described conducting cotton threads with low enough electrical resistances to allow the electrodeposition of functional polymers, like PANi, whilst retaining the necessary flexibility for wearable applications. Thus, this development represents an important progression towards the realisation of real-time, on-body, wearable sensors.
There is a growing desire for wearable sensors in health applications. Fibers are inherently flexible and as such can be used as the electrodes of flexible sensors. Fiber-based electrodes are an ideal format to allow incorporation into fabrics and clothing and for use in wearable devices. Electrically conducting fibers were produced from a dispersion of poly (3,4-ethylenedioxythiophene)-poly (styrenesulfonate) (PEDOT: PSS). Fibers were wet spun from two PEDOT: PSS sources, in three fiber diameters. The effect of three different chemical treatments on the fibers were investigated and compared. Short 5 min treatment times with dimethyl sulfoxide (DMSO) on 20 ¼m fibers produced from Clevios PH1000 were found to produce the best overall treatment. Up to a six-fold increase in electrical conductivity was achieved, reaching 800 S cm?1, with no loss of mechanical strength (150 MPa). With a pH-sensitive polyaniline coating, these fibers displayed a Nernstian response across a pH range of 3.0 to 7.0, which covers the physiologically critical pH range for skin. These results provide opportunities for future wearable, fiber-based sensors including real-time, on-body pH sensing to monitor skin disease.