Investigating quantum effects in olfaction: combining simulation and closed/open quantum system analytic theory

This project involves the investigation of olfaction as a quantum effect, therefore it will comprise of an analysis of olfaction as a closed and an open quantum system. We will explore these models and calculate the required parameters for the olfactory receptor protein environments with state of art accuracy in theoretical physics.
Start date
1 October 2019
Duration
3 years
Application deadline
Funding information

This studentship is fully funded through a grant from the Leverhulme Trust. 

All University fees are covered for the duration of the project with a stipend of approximately £15,000 per year for eligible UK/EU students.

About

Olfaction (smell) is a fascinating but challenging field in science. Theories for the signalling transduction mechanism are still disputed and hotly debated, and not yet established. One theory suggests that odorants are characterized by their quantum mechanical vibrations (phonons) [1]. Since this proposition a mathematical model for this phenomenon as a signalling mechanism was derived and shown to be robust given certain parameters [2]. This so-called 'phonon assisted electron tunneling' has been indicated to exist as a mechanism in other bio-systems however not necessarily in olfaction. More detailed and accurate calculations of the important parameters are required, and also more definitive experimental testing of the possibility that electron transfer actually initiates the olfactory signalling event. More recently investigations have indicated that the semi-classical approach of phonon-assisted tunneling in [2] is not sufficient to model olfaction, but that including dissipation effects in an open quantum system may be the way towards finally reaching a quantitative result for how smell works [3].

Fundamental to this project is the investigation of olfaction as a quantum effect, therefore it will comprise of an analysis of olfaction as a closed and an open quantum system. We will explore these models and calculate the required parameters for the olfactory receptor protein environments with state of art accuracy in theoretical physics. This will be performed in collaboration with experimental tests of the theory that olfaction uses non-classical mechanics.

Related links
Leverhulme Doctoral Training Centre for Quantum Biology
References

[1] Luca Turin. “A Spectroscopic Mechanism for Primary Olfactory Reception” (1997), Chemical senses. 21. 773-91. 10.1093/chemse/21.6.773.

[2] Jennifer C. Brookes, Filio Hartoutsiou, A. P. Horsfield, and A. M. Stoneham. “Could Humans Recognize Odor by Phonon Assisted Tunneling?” (2007), Phys. Rev. Lett. 98, 038101.

[3] Agata Chęcińska, Felix A. Pollock, Libby Heaney, and Ahsan Nazir “Dissipation enhanced vibrational sensing in an olfactory molecular switch”, J Chem. Phys. 142, 025102 (2015).

Eligibility criteria

Essential requirements:

  • First class honours degree (2:1 or above) or the international equivalent of a BSc or MPhys degree in physics, or biophysics or the equivalent in chemistry
  • An A-level in mathematics
  • A willingness to work across the disciplines.

Language requirements:

If English is not your first language, you will be required to have an IELTS Academic of 6.5 or above (or equivalent), with no sub-test score below 6.

How to apply

Applications can be made through our Biosciences and Medicine PhD applications portal.

Please state the project title and supervisor clearly on the “research proposal” part of the application. 

Biosciences and Medicine PhD


Application deadline

Contact details

Jim Al-Khalili
08 BB 03
Telephone: +44 (0)1483 686808
E-mail: J.Al-Khalili@surrey.ac.uk

Research group: Leverhulme Doctoral Training Centre for Quantum Biology.

This work is intended as a collaboration with Dr Jennifer Brookes at UCL who will be leading aspects of the research.

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