Radiation-inactivated virus for vaccine development

The project aims to investigate the feasibility of using radiation to inactivate virus for vaccine formulation.

Ionizing radiation could provide an alternative option with significant benefits compared to current vaccine formulations. The concept relies on inactivating the virus by damaging its RNA material without destroying the key epitopes or its structural integrity (retaining therefore the full breadth of antigens targets).

Start date

1 October 2022

Duration

3 years

Application deadline

Funding source

University of Surrey, EPSRC and NPL

Funding information

UK and EU fees covered. Annual stipend of £15,609 per annum.

About

The project aims to investigate the feasibility of using radiation to inactivate virus for vaccine formulation. The recent Covid-19 pandemic has highlighted the importance of vaccines and the needs for faster, economically affordable and safer vaccine development methods. Vaccines prevent an estimated 3 million deaths/year worldwide but a further 1.5 million lives/year could be saved with better vaccines and wider coverage (Wellcome). Ionizing radiation could provide an alternative option with significant benefits compared to current vaccine formulations. The concept relies on using ionizing radiation to inactivate the virus by damaging its RNA material without destroying the key epitopes or its structural integrity (retaining therefore the full breadth of antigens targets). Simulations have confirmed that this could be achieved with an optimum selection of radiation quality and dose. The inactivated virus would then be used in combination with an adjuvant to stimulate the immune system response. The project will assess the efficiency of different radiation modalities in virus inactivation, establish dose response curves, develop sample radiation-vaccines and compare their efficacy against chemical and other conventional vaccine modalities using a range of biological systems. Cost-effectiveness and ease of manufacturing, including access to radiation facilities and transport, will also be addressed.

The project is a collaboration between the University of Surrey (Radiation and Medical Physics Group and Section of Immunology, School of Biosciences and Medicine) and the National Physical Laboratory

Related links

Radiation and Medical Physics Group Section of Immunology

Eligibility criteria

Candidates must hold a First or 2:1 UK honours degree in a relevant subject area, or a 2:2 alongside a good masters degree (a distinction is usually required).

This studentships is available to UK or EU candidates.

IELTS requirements: An IELTS Academic of 6.5 or above with 6 in each individual category (or equivalent qualification from other agencies). For more details on English Language requirements see English Language requirements.

How to apply

Applications can be made through our Physics PhD course page. Please state the project title and supervisor clearly on all applications.


Application deadline

Contact details

Giuseppe Schettino
14 BC 04
Telephone: +44 (0)1483 689320
E-mail: giuseppe.schettino@surrey.ac.uk
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