Exploration of ion selectivity in the Epithelial Sodium Channel

This exciting project aims to investigate the quantum mechanisms behind how channels select and transport certain ions, whilst at the same time simulating the effects of transport of different ions through the epithelial sodium channel.

Start date
1 October 2020
Duration
3 years
Application deadline
Funding information

The studentship fully covers all academic fees with a stipend of £15,285 per annum for UK/EU students.

Funding for future years will be subjected to the UKRI increase

Funding source
Leverhulme Trust and University of Surrey
Supervised by

About

Ion channels in living cells are examples of where quantum effects can play a role in biology. These proteins provide a selective conduction of ions across cellular membranes, which is crucial for cell survival. The quantum mechanisms behind how channels select and transport certain ions, whilst rejecting others, are still poorly understood. This exciting project aims to investigate these experimentally, whilst at the same time simulating the effects of transport of different ions through the epithelial sodium channel. We will iteratively test and refine a simulation of ion selectivity through the channel pore, whilst experimentally measuring the channel kinetics. 

Related links
Leverhulme Quantum Biology Doctoral Training Centre

Eligibility criteria

Applicants should have a BSc/master’s in chemistry, biological or physical Sciences, ideally with computer modelling/simulation experience. Cell culture techniques would be an advantage.

Only UK and EU students will be funded, overseas students will need to source their own funding.

English language requirements: IELTS overall score of 6.5 or above with a minimum of 6.0 in each component (or equivalent).

 

How to apply

To apply for this studentship:

  1. Firstly apply for the Quantum Biology PhD.  
  2. During your application, please mention your desire to apply to this studentship in order to be considered.  
  3. When the system asks you to add your ‘Research Project’ please copy and paste the project description of the project you wish to apply for.

Application deadline

Contact details

Rebecca Lewis
01 VSM 02
Telephone: +44 (0)1483 682396
E-mail: rebecca.lewis@surrey.ac.uk

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