The role of TGFβ on modulation of immune responses in Marek's disease

Regulatory T cells suppress many different immune cells and thus they are involved in immune modulation to inhibit inflammatory responses. Some pathogens activate expansion of regulatory T cells to escape immune control, however the mechanism involved in the induction and expansion of regulatory T cells by pathogens is not understood.

Start date
1 April 2021
Duration
3.5 years
Application deadline
Funding information

This is a fully-funded studentship only open to UK students and eligible EU students who qualify for home-rated fees, in line with Residential Guidelines for Research Council Studentships. Eligible students will receive a minimum annual stipend of £15,285 per annum, plus a cost of living top-up allowance of £2,200 per annum. University registration fees will be paid.

 

Funding source
50% The Pirbright Institute (3 years).  50% University of Surrey, from Matched Funding stream of the Doctoral College Studentship Awards (3 years).  100% The Pirbright Institute for the final 6 months.
Supervised by

About

Regulatory T cells suppress many different immune cells and thus they are involved in immune modulation to inhibit inflammatory responses. Some pathogens activate expansion of regulatory T cells to escape immune control, however the mechanism involved in the induction and expansion of regulatory T cells by pathogens is not understood.

Marek’s disease virus causes a lymphoproliferative disease in chickens and causes transformation of lymphocytes. Our group has shown that infection with Marek’s disease virus induces expansion of novel regulatory T cells in the infected chickens, and this may explain immunosuppression observed in these birds (Gurung et al. PLoS Pathogen 2017). We have also recently shown that Marek’s disease virus activates metabolic changes in the infected cells (Boodhoo et al. Journal of Virology 2019 and Boodhoo et al. Journal of Virology January 2020, Boodhoo et al. Journal of Virology September 2020). The studentship will investigate the mechanism involved in induction and activation of regulatory T cells by the virus and determine the role of metabolites produced by the infected cells in induction of regulatory T cells. 

The student will join a successful, motivated multidisciplinary team with expertise in cellular and molecular immunology, virology and metabolism. A combination of cellular and molecular immunology as well as classical virology techniques including flow cytometry, confocal microscopy, metabolic analysis, molecular biology and gene silencing will be utilised in this project.

 

Related links
Co-supervisor - Dr Nitin Kamble The Pirbright Institute

The student will be based primarily at The Pirbright Institute and registered with the University of Surrey. The student will visit the university to meet with their supervisors and undertake training or complete specific project tasks as required. A full range of research and transferrable skills training will be made available to the student as appropriate.

Eligibility criteria

This studentship is open to science graduates (with, or who anticipate obtaining, at least a 2:1 or equivalent, in a relevant biological subject in their undergraduate degree, or a Masters degree - subject to university regulations). Other first degrees, e.g. veterinary science, will be considered. You should be looking for a challenging, interdisciplinary research training environment and have an active interest in the control of infectious diseases.

This studentship is open to UK students and eligible EU students who qualify for home-rated fees, in line with Residential Guidelines for Research Council Studentships.

Students without English as a first language must provide evidence that they meet the English language requirement, e.g. an average IELTS score of 7.0, with no lower than 7.0 in listening/reading and no lower than 6.5 in speaking/writing.

How to apply

Applications for this studentship must be made via The Pirbright Institute, not to the University of Surrey.

To apply you must submit: 

  • The Pirbright Institute Application Form
  • CV T
  • Two references sent directly by your referees.

The application form and further details can be found here.

 


Application deadline

Contact details

Yvonne Walsh

email: studentship@pirbright.ac.uk

Telephone: 01483 868230

 

Avian Oncogenic Viruses

The Pirbright Institute

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