Nia co-funding scheme: Nox enzymes in aging bladder dysfunction

Biography

Biography

1995-2000: Lecturer, Department of Medicine and Institute of Urology, University College London.

2001-2008 (Feb): Senior Lecturer, Department of Medicine and Institute of Urology, University College London.

2008-2016: Senior Lecturer, Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey

2017-2021: Reader, Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey

2021 - to date: Professor, Department of Biochemistry and Physiology, Faculty of Health and Medical Sciences, University of Surrey

Research interests

Cellular physiology and pathophysiology; ageing and health; oxidative stress, physiological rhythms; inflammation and immunology; environmental medicine and toxicology

1. Excitable tissue: smooth muscle and cardiac muscle

2. Non-excitable tissue: epithelial/endothelial cells, fibroblasts/myofibroblasts/interstitial cells, hepatocytes.

Research strength: Ca2+ imaging, electrophysiology, cell signaling, purinergic function, cell to cell interaction and sensory mechanisms, oxidative stress, ageing, inflammatory mediators, circadian rhythms. 

Recent grants as PI:

2003-2004 An investigation of the cellular physiology of suburothelium myofibroblasts. St Peter's Trust for Kidney, Bladder & Prostate Research. £48,409. C Wu, G Sui, C Fry

2004-2008 The cellular basis of spontaneous activity in the unstable urinary bladder. The WellcomeTrust, £224,816. C Wu, C Fry, G Sui.

2009-2012 Mode of action of sensory transmitters in bladder urothelium and the effect of ageing. BBSRC. £491,735. C Wu, C Fry, G Sui

2012-2016 Surrey and Shanghai Jiao Tong partnership on visceral organ sensory research during ageing. BBSRC £26,144.

2012-2016 Urothelial TRPV4 receptors in pathologically overactive human bladders – a potential novel target for treatment. Age UK  £74250.

2016-2018    Hypoxia-inducible factor 1a in the pathogenesis of systemic lupus erythematosus. The Royal Society, £12,000.

2016-2021    Nox enzymes in ageing bladder dysfunction. BBSRC and NIH, £1,014,035

2020-2021 Nox enzymes in ageing bladder dysfunction - extension, supplement grant. The BBSRC, £252,277

2020-2023 A novel in-vitro 3-D cell culture model to study physiological mechanism of ageing in urothelial cells. Dunhill Medical Trust, £63,000

Research collaborations

University of Sheffield, sensory mechanisms

University College London, system biology; urinary incontinence and infection

Royal Veterinary College, epithelial cell physiology

Anhui Medical University, Environmental Medicine and Dermatotoxicology; Public Health and Epidemiology

Shanghai Jiaotong University, visceral organ cell physiology and sensory mechanism

Capital Medical University Beijing, Urology and Rehabilitation Research

Teaching

Pathology and Medicine - Module BMS2046 (module organiser)

Physiology - Module BMS1032

Clinical Immunology and Immunohaematology - BMS3054

Microbial Sciences, Immunology & Haematology - HCSM006 MSc Health & Clin. Sci. (module organiser)

Biomedical Science Final Year research project - BMS3048

Affiliations

The Physiological Society, full member

International Continence Society, full member

Visiting Professor in Occupational Medicine and Environmental Health, Anhui Medical University, China

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