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Dr Changhao Wu

Reader in Cell Physiology
+44 (0)1483 682960

Academic and research departments

School of Biosciences and Medicine.



Research interests

My publications


  • Wu, C, Sui, G, Archer, SN, Sassone-Corsi, P, Aitken, K, Bagli, D, Chen, Y. (2014) Local receptors as novel regulators for peripheral clock expression. FASEB J. 28:4610-6
  • Zhou CF, Zhou DC, Zhang JX, Wang F, Cha WS, Wu CH et al. Bleomycin-induced epithelial-mesenchymal transition in sclerotic skin of mice: Possible role of oxidative stress in the pathogenesis. Toxicol.Appl.Pharmacol. 2014; 277: 250-258.
  • Sui G, Fry CH, Montgomery B, Roberts M, Wu R, Wu C. Purinergic and muscarinic modulation of ATP release from the urothelium and its paracrine actions (2014). Am.J.Physiol Renal Physiol 306, F286-298.9.
  • Wang F, Zha WS, Zhang JX, Li SL, Wang H, Ye LP, Shen,T, Wu, CH and Zhu,QX (2014). Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice. Toxicol.Lett. 229:229-39.
  • Zhang, J, Tu, K, Xu, Y, Pan, L, Wu, C, Chen, X, Wu, M et al (2013). Sphingomyelin in erythrocyte membranes increases the total cholesterol content of erythrocyte membranes in patients with acute coronary syndrome. Coron Artery Dis 24, 361-367.
  • Ma, T., Li, Y. Y., Zhu, J., Fan, L. L., Sun, G. P., Li, J. B., Du, W. D. & Wu, C. H. (2013) Enhanced autophagic flux by endoplasmic reticulum stress in human hepatocellular carcinoma cells contributes to the maintenance of cell viability. Oncology Reports 30, 433-440.
  • Zhang J, Zha W, Wang F, Jiang T, Xu S, Yu J, Zhou, C, Shen, T, Wu, C and Zhu,Q (2013). Complement activation and liver impairment in trichloroethylene-sensitized BALB/c mice. 32:431-41.
  • Liu, C. C., Huang, Y., Zhang, J. H., Xu, Y. & Wu, C. H. (2013) Effect of carvedilol on cardiac dysfunction 4 days after myocardial infarction in rats: role of toll-like receptor 4 and β-arrestin 2. Eur Rev Med Pharmacol Sci 17, 2103-2110.
  • Liu Q, Zhang J, Xu Y, Huang Y, Wu C (2013). Effect of carvedilol on cardiomyocyte apoptosis in a rat model of myocardial infarction: A role for toll-like receptor 4. 45:458-63.
  • Wu C, Guiping Sui G, Archer S and Chen Y (2012). Expression of circadian clock gene Period2 in the mammalian bladder identified by real-time imaging with luciferase reporter gene. AUA News 2012 September: 13-15.
  • Wu C, Sui G and Fry CH (2011). Intracellular Ca2+ regulation and electrophysiolgical properties of bladder urothelium subjected to stretch and exogenous agonists. Cell Calcium 49:395-9.
  • Zhang J, Pan L, Xu Y, Wu C, Wang C, Cheng Z, Zhao R (2011). Total cholesterol content of erythrocyte membranes in acute coronary syndrome: correlation with apolipoprotein A-I nd lipoprotein (a). Coron Artery Dis 2011; 22: 145-152.
  • Sui G, Fry CH, Malone-Lee J and Wu C (2009). Aberrant Ca2+ oscillations in smooth muscle cells from overactive human bladders. Cell Calcium 45: 456-464
  • Roosen, A, Sui GP, Fry CH and Wu, C. (2009). Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and independent mechanisms. Cell Calcium 45: 11-17.
  • Roosen A, Wu C, Sui G, Chowdhury RA, Patel PM, Fry CH (2009). Characteristics of Spontaneous Activity in the Bladder Trigone. Eur Urol 56: 237-406
  • Fry CH, Roosen A, Wu C, Sui GP, AJ Kanai AJ. The pathophysiology of the overactive bladder (OAB): recent developments in the understanding of aetiology and mechanisms. A book chapter in Key Advances in Medicine (in press).
  • Sui G, Wu C, Roosen A, Ikeda Y, Kanai KJ, Fry CH (2008). Modulation of bladder myofibroblast activity: implications for bladder function. Am J Physiol (Renal Physiol) 295: F688-97.
  • Shen T, Zhu QX, Yang S, Wu CH, Zhang HF, Zhou CF, Zhang XJ (2008). Trichloroethylene induced cutaneous irritation in BALB/c hairless mice: histopathological changes and oxidative damage. Toxicology. 248:113-20.
  • Roosen, A, Wu, C, Sui GP, and Fry CH. (2008). Synergistic effects in neuromuscular activation and calcium sensitization in the bladder trigone. BJU International 101(5):610-4.
  • Fry CH, Sui G.-P , Kanai AJ, Wu C. (2007). The function of suburothelial myofibroblasts in the bladder. Neurourol and Urodyn 26 (S6): 914-919.
  • Wu, C, Thiruchelvam, N, Sui, G., Woolf, AS, et al (2007). Ca2+ regulation in detrusor smooth muscle from ovine fetal bladder after in utero bladder outflow obstruction. J Urol 177(2): 776-780.
  • Sui, G, Wu, C., Severs, N, Newgreen D., and Fry, CH. (2007). The association between T-type Ca2+ current and outward current in isolated human detru sor cells from stable and overactive bladders. BJU International. 99(2), 436-441.
  • Wu, C, Sui, G, Thiruchelvam, N, Cuckow, P, Fry, CH. (2006). Ca2+ regulation in detrusor smooth muscle from developing fetal sheep bladders. Cell Calcium 39(4), 367-374.
  • Sui GP, Wu C, Fry CH. (2006). Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts. BJU International 97(6), 1327-1331.
  • Fry CH, Sui G, Wu C. (2006). T-type Ca2+ channels in non-vascular smooth muscles. Cell Calcium 40(2), 231-239.
  • Besarani, D, Wu, C, Fry, CH. (2006). The influence of changes in extracellular and intracellular sodium concentration on detrusor contractility. BJU International 97(5), 1083-1086.
  • Wu, C, Fry, PM, Sui, G, Fry, CH. (2005). Intracellular Ca2+ regulation in a human prostate stromal cell culture. Neurourol Urodyn 24(1), 81-88.
  • Sui, GP, Wu, C, Fry, CH. (2004). Ca2+ currents in smooth muscle cells isolated from human prostate. Prostate 59: 275-281.
  • Wu, C, Sui, GP, Fry, CH. (2004). Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol 559, 231-243.
  • Sui, GP, Wu, C, Fry, CH. (2004). Electrical characteristics of suburothelial cells isolated from the human bladder. J Urol 171: 938-943.
  • Fry, CH, Hussain, M, McCarthy, C, Ikeda, Y, Sui, GP, Wu, C. (2004). Recent advances in detrusor muscle function. Scand J Urol and Nephrol. Suppl 215, 20-25.
  • Fry, CH, Ikeda, Y, Harvey, R, Wu, C, Sui, GP. (2004). Control of bladder function by peripheral nerves: avenues for novel drug targets. Urology 63(3 Suppl 1), 24-31.
  • Fry, CH, Sui, GP, Severs, NJ, Wu, C. (2004). Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity? Urology 63: 3-10.
  • Sui G, Wu C and Fry CH (2003). A description Ca2+ channels in human detrusor smooth muscle. BJU Int 92: 476-482.
  • Fry, CH, Wu, C, Sui, GP. (2003). Cellular properties of human sub-urothelial myofibroblasts - their role in bladder sensation. Neurourology and Urodynamics 22, 374-375.
  • Chow K-Y, Wu C, Sui GP, Fry CH (2003). The role of the T-type Ca2+ current on the contractile performance of guinea-pig detrusor smooth muscle. Neurourol Urodyn 22: 77-82.
  • Thiruchelvam N, Wu C, David A, Woolf AS, Cuckow PM and Fry CH (2003). Neurotransmission and visco-elasticity in the ovine fetal bladder after in utero bladder outflow obstruction. Am J Physiol 284:R1296-1305.
  • Fry CH, Skennerton D, Wood DN and Wu C (2002). The cellular basis of contraction in human detrusor smooth muscle from patients with stable and unstable bladders. Urology 59, Supplement 5A: 3-12.
  • Wu C, Sui G, Mundy AR and Fry CH (2002). The role of the L-type Ca2+ channel in refilling functional intracellular Ca2+ stores in detrusor smooth muscle cells. J Physiol, 538: 357-369.
  • Wu C and Fry CH (2001). Evidence for Na+/Ca2+ exchange and its role in intracellular Ca2+ regulation in guinea-pig detrusor smooth muscle cells. Am J Physiol (Cell Physiology), 280: C1090-1096.
  • Sui G, Wu C and Fry CH (2001). The electrophysiological properties of cultured and freshly isolated detrusor smooth muscle cells. J Urol, 165: 627-632.
  • Sui G, Wu C and Fry CH (2001). Inward Ca2+ currents in cultured and freshly isolated detrusor muscle cells - evidence of a T-type Ca2+ current. J Urol, 165: 621-626.