Giuseppe Schettino

Professor Giuseppe Schettino


Professor of Medical Physics
+44 (0)1483 689320
14 BC 04

Biography

Research

Research interests

My publications

Publications

Mohajer Jonathan Kim, Nisbet Andrew, Velliou Eirini, Ajaz Mazhar, Schettino Giuseppe (2018) Biological effects of static magnetic field exposure in the context of MR-guided radiotherapy, British Journal of Radiation 92 (1094) British Institute of Radiology

The clinical introduction of magnetic resonance imaging guided radiotherapy has
prompted consideration of the potential impact of the static magnetic field on biological
responses to radiation. This review provides an introduction to the mechanisms of
biological interaction of radiation and magnetic fields individually, in addition to a
description of the magnetic field effects on megavoltage photon beams at the
macroscale, microscale and nanoscale arising from the Lorentz force on secondary
charged particles.

A relatively small number of scientific studies have measured the impact of combined
static magnetic fields and ionising radiation on biological endpoints of relevance to
radiotherapy. Approximately half of these investigations found that static magnetic
fields in combination with ionising radiation produced a significantly different outcome
compared with ionising radiation alone. MRI strength static magnetic fields appear to
modestly influence the radiation response via a mechanism distinct from modification
to the dose distribution. This review intends to serve as a reference for future biological
studies, such that understanding of static magnetic field plus ionising radiation
synergism may be improved, and if necessary, accounted for in magnetic resonance
imaging guided radiotherapy treatment planning.

Kokurewicz K., Brunetti E., Welsh G. H., Wiggins S. M., Boyd M., Sorensen A., Chalmers A. J., Schettino G., Subiel A., DesRosiers C., Jaroszynski D. A. (2019) Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements, Scientific Reports 9 10837 pp. 1-10 Nature Research
The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.

Additional publications