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Dr Lisiane Meira


Lecturer in DNA Damage and Ageing
+44 (0)1483 686449
29 PGM 02

Academic and research departments

School of Biosciences and Medicine.

Biography

Research

Research interests

Supervision

Postgraduate research supervision

Postgraduate research supervision

My teaching

Courses I teach on

Undergraduate

My publications

Publications

Zachariah Matshediso, Maamoun Hatem, Milano Larissa , RAYMAN MARGARET PHILOMENA, MEIRA LISIANE BORGES, Agouni Abdelali (2020)Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium, In: Journal of Cellular Physiology
Alhumaydhi Fahad A., de O. Lopes Debora, Bordin Diana L., Aljohani Abdullah S. M., Lloyd Cameron B., McNicholas Michael D., Milano Larissa, Charlier Clara F., Plant Kathryn E., Elliott Ruan M., Meira Lisiane B., Villela Izabel, Henriques João Antonio P. (2020)Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition, In: Scientific Reports10(1) Nature Publishing Group
Leguisamo NM, Gloria HC, Kalil AN, Martins TV, Azambuja DB, Meira Lisiane, Saffi J (2017)Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy, In: Oncotargetpp. 1-16 Impact Journals
AVERBECK D, DARDALHON M, MAGANASCHWENCKE N, MEIRA LB, MENIEL V, BOITEUX S, SAGE E (1992)NEW ASPECTS OF THE REPAIR AND GENOTOXICITY OF PSORALEN PHOTOINDUCED LESIONS IN DNA, In: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY14(1-2)pp. 47-63 ELSEVIER SCIENCE SA LAUSANNE
MEIRA LB, FONSECA MB, AVERBECK D, SCHENBERG ACG, HENRIQUES JAP (1992)THE PSO4-1 MUTATION REDUCES SPONTANEOUS MITOTIC GENE CONVERSION AND RECIPROCAL RECOMBINATION IN SACCHAROMYCES-CEREVISIAE, In: MOLECULAR & GENERAL GENETICS235(2-3)pp. 311-316 SPRINGER VERLAG
Friedberg EC, Bond JP, Burns DK, Cheo DL, Greenblatt MS, Meira LB, Nahari D, Reis AM (2000)Defective nucleotide excision repair in Xpc mutant mice and its association with cancer predisposition, In: MUTATION RESEARCH-DNA REPAIR459(2)pp. 99-108 ELSEVIER SCIENCE BV
Meira LB, Cheo DL, Reis AM, Chaij N, Burns DK, te Riele H, Friedberg EC (2002)Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer (vol 1, pg 929, 2002), In: DNA REPAIR1(12)PII S1568-pp. 1063-1063 ELSEVIER SCIENCE BV
Cheo DL, Meira LB, Burns DK, Reis AM, Issac T, Friedberg EC (2000)Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: Genotype-specific effects on cancer predisposition and pathology of tumors, In: CANCER RESEARCH60(6)pp. 1580-1584 AMER ASSOC CANCER RESEARCH
Carrington S, Tyrrell E, Modjtahedi H, Carew MA, Polycarpou E, Meira LB (2013)Resveratrol 3-O-D-glucuronide and resveratrol 4 '-O-D-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest, In: MOLECULAR NUTRITION & FOOD RESEARCH57(10)pp. 1708-1717 WILEY-BLACKWELL
PAESITORESAN SO, MEIRA LB, BRENDEL M, HENRIQUES JAP, QUEROL CB (1994)ISOLATION AND CHARACTERIZATION OF 3 MUTANTS WITH INCREASED SENSITIVITY TO PHOTOACTIVATED 3-CARBETHOXYPSORALEN IN SACCHAROMYCES-CEREVISIAE, In: CURRENT GENETICS25(5)pp. 407-411 SPRINGER VERLAG
Graham JM, Meira LB, Greenberg CR, Jaspers NGJ, Busch D, Coleman DM, Ziffer DW, Friedberg EC (1999)Original COFS syndrome Manitoba Aboriginal kindred has a mutation in the Cockayne syndrome group B (CSB) gene., In: AMERICAN JOURNAL OF HUMAN GENETICS65(4)pp. A299-A299 UNIV CHICAGO PRESS
Reis AM, Cheo DL, Meira LB, Greenblatt MS, Bond JP, Nahari D, Friedberg EC (2000)Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice, In: CANCER RESEARCH60(6)pp. 1571-1579 AMER ASSOC CANCER RESEARCH
Graham JM, Meira LB, Greenberg CR, Busch DB, Doughty ATB, Ziffer DW, Coleman DM, Savre-Train I, Friedberg EC (2000)Original COFS syndrome Manitoba Aboriginal kindred has a mutation in the Cockayne syndrome group B (CSB) gene, In: PEDIATRIC RESEARCH47(4)pp. 81A-81A INT PEDIATRIC RESEARCH FOUNDATION, INC
Longerich S, Meira L, Shah D, Samson LD, Storb U (2007)Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination, In: DNA REPAIR6(12)pp. 1764-1773 ELSEVIER SCIENCE BV
Meira LB, Samson L (2003)Complex responses to damaging agents, In: DRUG METABOLISM REVIEWS35pp. 15-15
Meira LB, Cheo DL, Reis AM, Claij N, Burns DK, Riele HT, Friedberg EC (2002)Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer, In: DNA REPAIR1(11)PII S1568-pp. 929-934 ELSEVIER SCIENCE BV
Friedberg EC, Meira LB (2000)Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4, In: MUTATION RESEARCH-DNA REPAIR459(4)pp. 243-274 ELSEVIER SCIENCE BV
MEIRA LB, HENRIQUES JAP, MAGANASCHWENCKE N (1995)8-METHOXYPSORALEN PHOTOINDUCED PLASMID-CHROMOSOME RECOMBINATION IN SACCHAROMYCES-CEREVISIAE USING A CENTROMERIC VECTOR, In: NUCLEIC ACIDS RESEARCH23(9)pp. 1614-1620 OXFORD UNIV PRESS
Kobayashi K, Meira LB, Samson LD (2003)Transcriptional responses of Aag knockout mouse embryonic stem cells upon exposure to Me-Lex., In: TOXICOLOGICAL SCIENCES72pp. 256-256
Meira LB, Cheo DL, Hammer RE, Burns DK, Reis A, Friedberg EC (1997)Genetic interaction between HAP1/REF-1 and p53, In: NATURE GENETICS17(2)pp. 145-145 NATURE PUBLISHING CO
Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, Kayton RJ, Sieber SO, Kerr KF, Kosyk O, Lobenhofer EK, Vliet PA, Weis BK, Wolfinger R, Woods CG, Freedman JH, Linney E, Rusyn I, Kaufmann WK, Kavanagh TJ, Paules RS, Samson LD, Spencer PS, Suk W, Tennant RJ, Zarbl H (2007)Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses, In: TOXICOLOGICAL SCIENCES99(1)pp. 326-337 OXFORD UNIV PRESS
Villela I, Heidenreich B, Cheema M, di Martino T, Samson LD, Meira LB (2011)Dissecting the mechanism of DNA damage induced photoreceptor cell death, In: TOXICOLOGY290(2-3)pp. 143-143 ELSEVIER IRELAND LTD
Shah NR, Meira L, Elliott RM, Howlett PJ, Brown AJ, Williams M, West NE, Hoole S, Mahmoudi M (2015)DNA repair activity determines atherosclerotic plaque stability in patients with stable coronary artery disease, In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY66(15)pp. B124-B124
MEIRA LB, MAGANASCHWENCKE N, AVERBECK D, HENRIQUES JAP (1994)INVOLVEMENT OF THE PS03 GENE OF SACCHAROMYCES-CEREVISIAE IN INTRACHROMOSONAL MITOTIC RECOMBINATION AND GENE AMPLIFICATION, In: MOLECULAR & GENERAL GENETICS245(6)pp. 750-759 SPRINGER VERLAG
Kolm Paul, Mariathas Mark, Curzen Nick, Mahmoudi Michael, Shah Nikunj, Meira Lisiane B., Elliott Ruan M., Hoole Stephen P., West Nick E., Kuku Kayode O., Brown Adam J., Bennett Martin R., Garcia-Garcia Hector M., Dan Kazuhiro (2019)DNA damage and repair in patients with coronary artery disease: Correlation with plaque morphology using optical coherence tomography (DECODE study), In: Cardiovascular Revascularization Medicine20(9)pp. 812-818 Elsevier
Maor-Shoshani A, Meira LB, Yang X, Samson LD (2008)3-methyladenine DNA glycosylase ill important for cellular resistance to psoralen interstrand cross-links, In: DNA REPAIR7(8)pp. 1399-1406 ELSEVIER SCIENCE BV
Friedberg EC, Meira LB, Cheo DL (1997)Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage, In: MUTATION RESEARCH-DNA REPAIR383(2)pp. 183-188 ELSEVIER SCIENCE BV
Graham JM, Meira LB, Greenberg CR, Busch D, Friedberg EC (2000)Original COFS syndrome kindred from Manitoba has a mutation in the cockayne syndrome group B (CSB) gene., In: JOURNAL OF INVESTIGATIVE MEDICINE48(1)pp. 48A-48A LIPPINCOTT WILLIAMS & WILKINS
Meira LB, Devaraj S, Kisby GE, Burns DK, Daniel RL, Hammer RE, Grundy S, Jialal I, Friedberg EC (2001)Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress, In: CANCER RESEARCH61(14)pp. 5552-5557 AMER ASSOC CANCER RESEARCH
Unnikrishnan A, Raffoul JJ, Patel HV, Prychitko TM, Anyangwe N, Meira LB, Friedberg EC, Cabelof DC, Heydari AR (2009)Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice, In: FREE RADICAL BIOLOGY AND MEDICINE46(11)pp. 1488-1499 ELSEVIER SCIENCE INC
Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD (2013)Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1, In: PLOS GENETICS9(4)ARTN epp. ?-? PUBLIC LIBRARY SCIENCE
Hitchcock TM, Dong L, Connor EE, Meira LB, Samson LD, Wyatt MD, Cao WG (2004)Oxanine DNA glycosylase activity from mammalian alkyladenine glycosylase, In: JOURNAL OF BIOLOGICAL CHEMISTRY279(37)pp. 38177-38183 AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Meira LB, Calvo JA, Shah D, Klapacz J, Moroski-Erkul CA, Bronson RT, Samson LD (2014)Repair of endogenous DNA base lesions modulate lifespan in mice, In: DNA REPAIR21pp. 78-86 ELSEVIER SCIENCE BV
Klapacz J, Meira LB, Edelmann W, Samson LD (2004)Investigating the role of exonuclease I in the O-6-methylguanine-induced apoptosis, In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS44(3)pp. 210-210
Kirkby NF, Barazzuol L, Jena R, Burnet NG, Meira LB, Jeynes JC, Kirkby KJ (2013)Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma., In: Radiat Oncol8pp. 65-?
Meira LB, Pease K, Kerrison F, Dong M, Fry R, Dedon P, Samson LD (2004)Defective repair of alkylation DNA damage in mice, In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS44(3)pp. 215-215
Healing Eleanor, Meira Lisiane, Aston Philip, Tindall M.J., Elliott Ruan (2016)Measurement of DNA repair activity in hepatocytes exposed to fatty acids, In: Proceedings of the Nutrition Society Volume 75, Issue OCE3 (Summer Meeting, 11–14 July 2016, New technology in nutrition research and practice)75(OCE3)
Cheo DL, Meira LB, Hammer RE, Burns DK, Doughty ATB, Friedberg EC (1996)Synergistic interactions between XPC and p53 mutations in double-mutant mice: Neural tube abnormalities and accelerated UV radiation-induced skin cancer, In: CURRENT BIOLOGY6(12)pp. 1691-1694 CURRENT BIOLOGY LTD
Friedberg EC, Meira LB, Cheo DL (1998)Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2, In: MUTATION RESEARCH-DNA REPAIR407(3)pp. 217-226 ELSEVIER SCIENCE BV
Raffoul JJ, Cabelof DC, Nakamura J, Meira LB, Friedberg EC, Heydari AR (2004)Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair, In: JOURNAL OF BIOLOGICAL CHEMISTRY279(18)pp. 18425-18433 AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Mendes MM, Darling AL, Meira L, Lanham-New SA (2014)Vitamin D status and body composition in UK Caucasian and South Asian postmenopausal women: results from the DFINES II study, In: PROCEEDINGS OF THE NUTRITION SOCIETY73(OCE1)pp. E40-E40
Shah D, Marinov G, Meira L, Samson L (2006)Cellular responses to 3-methyladenine DNA lesions., In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS47(6)pp. 467-467
Cheo DL, Ruven HJT, Meira LB, Hammer RE, Burns DK, Tappe NJ, vanZeeland AA, Mullenders LHF, Friedberg EC (1997)Characterization of defective nucleotide excision repair in XPC mutant mice, In: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS374(1)pp. 1-9 ELSEVIER SCIENCE BV
Dong L, Meira LB, Hazra TK, Samson LD, Cao W (2006)Novel oxanine DNA glycosylase activities in mammalian systems., In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS47(6)pp. 449-449
Healing Eleanor, Charlier Clara. F, Meira Lisie, Elliott Ruan A panel of colorimetric assays to measure enzymatic activity in the base excision DNA repair pathway, In: Nucleic Acids Research47(11)e61 Oxford University Press
Brignull LM, Czimmerer Z, Saidi H, Daniel B, Villela I, Bartlett NW, Johnston SL, Meira LB, Nagy L, Nohturfft A (2013)Reprogramming of lysosomal gene expression by interleukin-4 and Stat6, In: BMC GENOMICS14ARTN 8 BIOMED CENTRAL LTD
Dong L, Meira LB, Hazra TK, Samson LD, Cao W (2008)Oxanine DNA glycosylase activities in mammalian systems, In: DNA REPAIR7(1)pp. 128-134 ELSEVIER SCIENCE BV
Calvo J, Meira L, Lee C-Y, Moroski-Erkul C, Abolhassani N, Taghizadeh K, Muthupalani S, Nordstrand L, Klungland A, Samson L (2012)DNA Repair Is Indispensable for Survival after Acute Inflammation in Mice, In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS53pp. S14-S14
Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, Samson LD (2009)Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice., In: Proc Natl Acad Sci U S A106(3)pp. 888-893
Bordin DL, Lima M, Lenz G, Saffi J, Meira LB, Mesange P, Soares DG, Larsen AK, Escargueil AE, Henriques JAP (2013)DNA alkylation damage and autophagy induction, In: MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH753(2)pp. 91-99 ELSEVIER SCIENCE BV
Meira LB, Palmer VS, Ramos-Crawford A-L, Ren X, Sullivan RC, Kavanagh TJ, Samson LD, Zarbl H, Spencer PS, Kisby GE, Fry RC, Lasarev MR, Bammler TK, Beyer RP, Churchwell M, Doerge DR (2011)The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner, In: PLOS ONE6(6)ARTN epp. ?-? PUBLIC LIBRARY SCIENCE
Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD (2012)DNA repair is indispensable for survival after acute inflammation., In: J Clin Invest.122(7)pp. 2680-2689 American Society for Clinical Investigation
Meira LB, Graham JM, Greenberg CR, Busch DB, Doughty ATB, Ziffer DW, Coleman DM, Savre-Train I, Friedberg EC (2000)Manitoba aboriginal kindred with original cerebro-oculo-facio-skeletal syndrome has a mutation in the Cockayne syndrome group B (CSB) gene, In: AMERICAN JOURNAL OF HUMAN GENETICS66(4)pp. 1221-1228 UNIV CHICAGO PRESS
Meira LB, Reis AMC, Cheo DL, Nahari D, Burns DK, Friedberg EC (2001)Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions, In: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS477(1-2)pp. 51-58 ELSEVIER SCIENCE BV
Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD (2009)O-6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA106(2)pp. 576-581 NATL ACAD SCIENCES
Bugni JM, Meira LB, Samson LD (2009)Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins, In: ONCOGENE28(5)pp. 734-741 NATURE PUBLISHING GROUP
Meira LB, Bugni JM, Green SL, Lee C-W, Rogers AB, Pang B, Borenshtein D, Rickman BH, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD (2008)DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice, In: JOURNAL OF CLINICAL INVESTIGATION118(7)pp. 2516-2525 AMER SOC CLINICAL INVESTIGATION INC
Dong L, Glass RA, Meira LB, Samson LD, Cao W (2007)Novel xanthine DNA glycosylase (XDG) activities in mammalian and yeast systems., In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS48(7)pp. 569-569
Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PO, Klungland A (2008)AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA, In: CANCER RESEARCH68(11)pp. 4142-4149 AMER ASSOC CANCER RESEARCH
Meira LB, Burgis NE, Samson LD (2005)Base excision repair, In: Back N, Cohen IR, Kritchevsky D, Lajtha A, Paoletti R, Nigg EA (eds.), Genome Instability in Cancer Development570pp. 125-173 SPRINGER
Totti Stella, Vernardis SI, Meira Lisiane, Pérez-Mancera PA, Costello E, Greenhalf W, Palmer D, Neoptolemos J, Mantalaris A, Velliou Eirini (2017)Designing a bio-inspired bio-mimetic in vitro system for the optimisation of ex vivo studies of pancreatic cancer, In: Drug Discovery Today22(4)pp. 690-701 Elsevier

Additional publications