Dr Lisiane Meira
Biography
Education and qualifications:
2009 – 2011
PGC, Academic Practice, University of Surrey, Guildford, Surrey, UK
1989 – 1994
PhD, Molecular Biology and Genetics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
1991 – 1993
Doctoral research, Institute Curie, Paris, France
1984 – 1988
BSc, Biological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Employment:
2009 –
Lecturer in DNA Damage and Ageing/Toxicology (University of Surrey)
2008 – 2009
Research fellow (St. George’s University of London)
2001 – 2008
Research scientist (Massachusetts Institute of Technology, Cambridge, USA)
1999 – 2000
Instructor (UT Southwestern Medical Center, Dallas, USA)
1995 – 1998
Post-doctoral fellow (UT Southwestern Medical Center, Dallas, USA)
Research
Research interests
Summary and Research Vision
The overarching theme of my research has been the study of cellular responses to stress and their importance in the pathogenesis and therapeutics of cancer and other chronic diseases. In particular, my work has focused on alkylating agents, a ubiquitous family of reactive chemicals that are cytotoxic and mutagenic and pose significant threats to human health but are also commonly used systemically in the clinic as cancer chemotherapeutic agents.
My research has uncovered novel relationships between stress pathways and cellular metabolism that are important in the response to alkylating agents. The long-term goal of my research is to use knowledge from our studies to define new mechanisms of stress response and to develop therapies to treat human disease.
Supervision
Postgraduate research supervision
Dr. Eirini Martinou - PhD student
Thomas "Tom" Cox - PhD student
Abbey Pearson - MSci in Biochemistry
Postgraduate research supervision
Primary Supervision
Amy Barber, PhD awarded
Anzhalika Talstaya, PhD awarded
Nikunj Shah, MD awarded
Clara Forrer Charlier, PhD awarded
Abdullah Aljohani, PhD awarded
Fahad Alhumaydhi, PhD awarded
Co-supervision
Styliani Totti, PhD student, awarded
Eleanor Healing, PhD awarded
Natalie Mayhead, PhD awarded
Larissa Milano, PhD awarded
Matshedisho Zachariah, PhD awarded
Balqees Issa Mohammed Al Yahyaei, PhD awarded
Ali Jbbar, PhD awarded
Rati Mohan, PhD awarded
Noura Alasmael, PhD awarded
My teaching
BMS1025 - Cell Biology
BMS3063 - Cancer: Pathogenesis and Therapeutics
BMS3099 - Mechanistic Toxicology and Pharmacokinetics
BMSM024 - Developing as a Scientist: Advanced Techniques in Biochemistry
Courses I teach on
Undergraduate
My publications
Publications
Additional publications
Healing, Eleanor, Charlier, Clara. F, Meira, Lisie and Elliott, Ruan (2019) A panel of colorimetric assays to measure enzymatic activity in the base excision DNA repair pathway Nucleic Acids Research, 47 (11), e61.
Leguisamo, NM, Gloria, HC, Kalil, AN, Martins, TV, Azambuja, DB, Meira, Lisiane and Saffi, J (2017) Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy Oncotarget. pp. 1-16.
Totti, Styliani, Vernardis, SI, Meira, Lisiane, Pérez-Mancera, PA, Costello, E, Greenhalf, W, Palmer, D, Neoptolemos, J, Mantalaris, A and Velliou, Eirini (2017) Designing a bio-inspired bio-mimetic in vitro system for the optimisation of ex vivo studies of pancreatic cancer Drug Discovery Today, 22 (4). pp. 690-701.
Alasmael, N, Mohan, R, Meira, LB, Swales, KE and Plant, NJ (2015) Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential Cancer Letters.
Meira, LB, Calvo, JA, Shah, D, Klapacz, J, Moroski-Erkul, CA, Bronson, RT and Samson, LD (2014) Repair of endogenous DNA base lesions modulate lifespan in mice DNA REPAIR, 21. pp. 78-86.
Brignull, LM, Czimmerer, Z, Saidi, H, Daniel, B, Villela, I, Bartlett, NW, Johnston, SL, Meira, LB, Nagy, L and Nohturfft, A (2013) Reprogramming of lysosomal gene expression by interleukin-4 and Stat6 BMC GENOMICS, 14, ARTN 8.
Bordin, DL, Lima, M, Lenz, G, Saffi, J, Meira, LB, Mesange, P, Soares, DG, Larsen, AK, Escargueil, AE and Henriques, JAP (2013) DNA alkylation damage and autophagy induction MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 753 (2). pp. 91-99.
Polycarpou, E, Meira, LB, Carrington, S, Tyrrell, E, Modjtahedi, H and Carew, MA (2013) Resveratrol 3-O-D-glucuronide and resveratrol 4 '-O-D-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest MOLECULAR NUTRITION & FOOD RESEARCH, 57 (10). pp. 1708-1717.
Calvo, JA, Moroski-Erkul, CA, Lake, A, Eichinger, LW, Shah, D, Jhun, I, Limsirichai, P, Bronson, RT, Christiani, DC, Meira, LB and Samson, LD (2013) Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1 PLOS GENETICS, 9 (4), ARTN e.
Barazzuol, L, Jena, R, Burnet, NG, Meira, LB, Jeynes, JC, Kirkby, KJ and Kirkby, NF (2013) Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. Radiat Oncol, 8.
Calvo, JA, Meira, LB, Lee, CY, Moroski-Erkul, CA, Abolhassani, N, Taghizadeh, K, Eichinger, LW, Muthupalani, S, Nordstrand, LM, Klungland, A and Samson, LD (2012) DNA repair is indispensable for survival after acute inflammation. The Journal of Clinical Investigation, 122 (7). pp. 2680-2689.
Villela, I, Heidenreich, B, Cheema, M, di Martino, T, Samson, LD and Meira, LB (2011) Dissecting the mechanism of DNA damage induced photoreceptor cell death TOXICOLOGY, 290 (2-3). p. 143.
Kisby, GE, Fry, RC, Lasarev, MR, Bammler, TK, Beyer, RP, Churchwell, M, Doerge, DR, Meira, LB, Palmer, VS, Ramos-Crawford, A-L, Ren, X, Sullivan, RC, Kavanagh, TJ, Samson, LD, Zarbl, H and Spencer, PS (2011) The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner PLOS ONE, 6 (6), ARTN e.
Unnikrishnan, A, Raffoul, JJ, Patel, HV, Prychitko, TM, Anyangwe, N, Meira, LB, Friedberg, EC, Cabelof, DC and Heydari, AR (2009) Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice FREE RADICAL BIOLOGY AND MEDICINE, 46 (11). pp. 1488-1499.
Bugni, JM, Meira, LB and Samson, LD (2009) Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins ONCOGENE, 28 (5). pp. 734-741.
Meira, LB, Moroski-Erkul, CA, Green, SL, Calvo, JA, Bronson, RT, Shah, D and Samson, LD (2009) Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci U S A, 106 (3). pp. 888-893.
Klapacz, J, Meira, LB, Luchetti, DG, Calvo, JA, Bronson, RT, Edelmann, W and Samson, LD (2009) O-6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106 (2). pp. 576-581.
Maor-Shoshani, A, Meira, LB, Yang, X and Samson, LD (2008) 3-methyladenine DNA glycosylase ill important for cellular resistance to psoralen interstrand cross-links DNA REPAIR, 7 (8). pp. 1399-1406.
Meira, LB, Bugni, JM, Green, SL, Lee, C-W, Pang, B, Borenshtein, D, Rickman, BH, Rogers, AB, Moroski-Erkul, CA, McFaline, JL, Schauer, DB, Dedon, PC, Fox, JG and Samson, LD (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice JOURNAL OF CLINICAL INVESTIGATION, 118 (7). pp. 2516-2525.
Ringvoll, J, Moen, MN, Nordstrand, LM, Meira, LB, Pang, B, Bekkelund, A, Dedon, PC, Bjelland, S, Samson, LD, Falnes, PO and Klungland, A (2008) AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA CANCER RESEARCH, 68 (11). pp. 4142-4149.
Lingaraju, GM, Kartalou, M, Meira, LB and Samson, LD (2008) Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag) DNA REPAIR, 7 (6). pp. 970-982.
Dong, L, Meira, LB, Hazra, TK, Samson, LD and Cao, W (2008) Oxanine DNA glycosylase activities in mammalian systems DNA REPAIR, 7 (1). pp. 128-134.
Longerich, S, Meira, L, Shah, D, Samson, LD and Storb, U (2007) Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination DNA REPAIR, 6 (12). pp. 1764-1773.
Beyer, RP, Fry, RC, Lasarev, MR, McConnachie, LA, Meira, LB, Palmer, VS, Powell, CL, Ross, PK, Bammler, TK, Bradford, BU, Cranson, AB, Cunningham, ML, Fannin, RD, Higgins, GM, Hurban, P, Kayton, RJ, Kerr, KF, Kosyk, O, Lobenhofer, EK, Sieber, SO, Vliet, PA, Weis, BK, Wolfinger, R, Woods, CG, Freedman, JH, Linney, E, Kaufmann, WK, Kavanagh, TJ, Paules, RS, Rusyn, I, Samson, LD, Spencer, PS, Suk, W, Tennant, RJ and Zarbl, H (2007) Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses TOXICOLOGICAL SCIENCES, 99 (1). pp. 326-337.
Lee, CW, Rickman, B, Meira, LB, Samson, L and Fox, JG (2007) Base excision repair genes alkyl adenine DNA glycosylase (Aag) and O6-methylguanine DNA methyltransferase (Mgmt) suppresses Helicobacter pylori-associated inflammation and progression to cancer GASTROENTEROLOGY, 132 (4). A319-A319.
Friedberg, EC and Meira, LB (2006) Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7 DNA REPAIR, 5 (2). pp. 189-209.
Meira, LB, Burgis, NE and Samson, LD (2005) Base excision repair pp. 125-173.
Friedberg, EC and Meira, LB (2004) Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage (Version 6) DNA REPAIR, 3 (12). pp. 1617-1638.
Hitchcock, TM, Dong, L, Connor, EE, Meira, LB, Samson, LD, Wyatt, MD and Cao, WG (2004) Oxanine DNA glycosylase activity from mammalian alkyladenine glycosylase JOURNAL OF BIOLOGICAL CHEMISTRY, 279 (37). pp. 38177-38183.
Raffoul, JJ, Cabelof, DC, Nakamura, J, Meira, LB, Friedberg, EC and Heydari, AR (2004) Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair JOURNAL OF BIOLOGICAL CHEMISTRY, 279 (18). pp. 18425-18433.
Ham, AJL, Engelward, BP, Koc, H, Sangaiah, R, Meira, LB, Samson, LD and Swenberg, JA (2004) New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N-6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo DNA REPAIR, 3 (3). pp. 257-265.
Friedberg, EC and Meira, LB (2003) Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 5 DNA REPAIR, 2 (5). pp. 501-530.
Meira, LB, Cheo, DL, Reis, AM, Chaij, N, Burns, DK, te Riele, H and Friedberg, EC (2002) Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer (vol 1, pg 929, 2002) DNA REPAIR, 1 (12), PII S1568-. p. 1063.
Meira, LB, Cheo, DL, Reis, AM, Claij, N, Burns, DK, Riele, HT and Friedberg, EC (2002) Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer DNA REPAIR, 1 (11), PII S1568-. pp. 929-934.
Meira, LB, Devaraj, S, Kisby, GE, Burns, DK, Daniel, RL, Hammer, RE, Grundy, S, Jialal, I and Friedberg, EC (2001) Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress CANCER RESEARCH, 61 (14). pp. 5552-5557.
Meira, LB, Reis, AMC, Cheo, DL, Nahari, D, Burns, DK and Friedberg, EC (2001) Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 477 (1-2). pp. 51-58.
Friedberg, EC and Meira, LB (2000) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4 MUTATION RESEARCH-DNA REPAIR, 459 (4). pp. 243-274.
Meira, LB, Graham, JM, Greenberg, CR, Busch, DB, Doughty, ATB, Ziffer, DW, Coleman, DM, Savre-Train, I and Friedberg, EC (2000) Manitoba aboriginal kindred with original cerebro-oculo-facio-skeletal syndrome has a mutation in the Cockayne syndrome group B (CSB) gene AMERICAN JOURNAL OF HUMAN GENETICS, 66 (4). pp. 1221-1228.
Graham, JM, Meira, LB, Greenberg, CR, Busch, DB, Doughty, ATB, Ziffer, DW, Coleman, DM, Savre-Train, I and Friedberg, EC (2000) Original COFS syndrome Manitoba Aboriginal kindred has a mutation in the Cockayne syndrome group B (CSB) gene PEDIATRIC RESEARCH, 47 (4). 81A-81A.
Friedberg, EC, Bond, JP, Burns, DK, Cheo, DL, Greenblatt, MS, Meira, LB, Nahari, D and Reis, AM (2000) Defective nucleotide excision repair in Xpc mutant mice and its association with cancer predisposition MUTATION RESEARCH-DNA REPAIR, 459 (2). pp. 99-108.
Reis, AM, Cheo, DL, Meira, LB, Greenblatt, MS, Bond, JP, Nahari, D and Friedberg, EC (2000) Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice CANCER RESEARCH, 60 (6). pp. 1571-1579.
Cheo, DL, Meira, LB, Burns, DK, Reis, AM, Issac, T and Friedberg, EC (2000) Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: Genotype-specific effects on cancer predisposition and pathology of tumors CANCER RESEARCH, 60 (6). pp. 1580-1584.
Graham, JM, Meira, LB, Greenberg, CR, Busch, D and Friedberg, EC (2000) Original COFS syndrome kindred from Manitoba has a mutation in the cockayne syndrome group B (CSB) gene. JOURNAL OF INVESTIGATIVE MEDICINE, 48 (1). 48A-48A.
Graham, JM, Meira, LB, Greenberg, CR, Jaspers, NGJ, Busch, D, Coleman, DM, Ziffer, DW and Friedberg, EC (1999) Original COFS syndrome Manitoba Aboriginal kindred has a mutation in the Cockayne syndrome group B (CSB) gene. AMERICAN JOURNAL OF HUMAN GENETICS, 65 (4). A299-A299.
Friedberg, EC and Meira, LB (1999) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3 MUTATION RESEARCH-DNA REPAIR, 433 (2). pp. 69-87.
Cheo, DL, Burns, DK, Meira, LB, Houle, JF and Friedberg, EC (1999) Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53(-/-) mice CANCER RESEARCH, 59 (4). pp. 771-775.
Friedberg, EC, Meira, LB and Cheo, DL (1998) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 2 MUTATION RESEARCH-DNA REPAIR, 407 (3). pp. 217-226.
Meira, LB, Cheo, DL, Hammer, RE, Burns, DK, Reis, A and Friedberg, EC (1997) Genetic interaction between HAP1/REF-1 and p53 NATURE GENETICS, 17 (2). p. 145.
Friedberg, EC, Meira, LB and Cheo, DL (1997) Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage MUTATION RESEARCH-DNA REPAIR, 383 (2). pp. 183-188.
Cheo, DL, Ruven, HJT, Meira, LB, Hammer, RE, Burns, DK, Tappe, NJ, vanZeeland, AA, Mullenders, LHF and Friedberg, EC (1997) Characterization of defective nucleotide excision repair in XPC mutant mice MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 374 (1). pp. 1-9.
Cheo, DL, Meira, LB, Hammer, RE, Burns, DK, Doughty, ATB and Friedberg, EC (1996) Synergistic interactions between XPC and p53 mutations in double-mutant mice: Neural tube abnormalities and accelerated UV radiation-induced skin cancer CURRENT BIOLOGY, 6 (12). pp. 1691-1694.