Maria Teresa Esposito

Dr Maria Teresa Esposito

Senior Lecturer in Biochemistry

Academic and research departments

Department of Biochemical Sciences, School of Biosciences.


My qualifications

PgCert Teaching and Learning in Higher Education. Passed with distinction.

University of East London
PhD Molecular Medicine, European School of Molecular Medicine
University of Napoli Federico II, Napoli (Italy)
BSc +MSc Medical Biotechnologies. First Class.
University of of Napoli Federico II, Napoli (Italy)


Research interests




  • Di Mambro A, Arroyo-Berdugo Y, Fioretti T,  Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Calle Y, Patel B, Esposito MT “SET-PP2A complex as a new avenue for therapeutic targeting of KMT2A-driven leukemia” Oncogene 2023 doi: 10.1038/s41388-023-02840-1.
  • Krebs Kleingsendis E, de Almeida Parizotto L, Effer B, Monteiro G, Long PF, Arroyo-Bedrugo Y, Behrends V, Esposito MT, Calle Y, Pessoa A Jr " Downstream process and evaluation of the concomitant impact of a recombinant glycosylated L-asparaginase on leukemic cancer cells and thye bone marrow tumor microenvironment" Process Biochemistry 2023 Aug 131 41-51
  • Mauro CSI, Kadiri hassani M, Barone M, Esposito MT, Calle Y, Behrends V, Garcia B, Brigidi P, Turroni S, Costabile A "Cerrado and Pantanal fruit flours affect gut microbiota composition in healthy and post-COVID-19 individuals: an in vitro pilot fermentation study" Int J Food Sci Technol 2023 Jan 14:10.1111/ijfs.16274. doi: 10.1111/ijfs.16274
  • Di Mambro A, Esposito MT “Thirty years of SET/TAF1Beta/I2PP2A: from the identification of the biological functions to its implications in cancer and Alzheimer’s disease” Invited Review article for Bioscience reports 2022 42 (11): BSR20221280.
  • Esposito MT, Hagstrom-Andersson A, Stam RW, Bortoluzzi S“Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements”invited editorial Frontiers in Pharmacology 2022 DOI: 10.3389/fphar.2022.977741
  • Roy NK, Tewari D, Esposito MT “Chemosensitizing effect of natural products against cancers: application in enhancing chemotherapy and immunotherapy”invited editorial Frontiers in Pharmacology 2022 DOI: 10.3389/fphar.2022.988226
  • Nuuri, K., Y. Arroyo-Berugo, and M.T. Esposito, “Analysis of expression of MSH2 and MSH3 genes in Mixed Lineage Leukemia (MLL)-Acute Lymphoblastic Leukemia (ALL) human cell lines”. Journal of Young investigator, 2020.doi:10.22186/jyi.37.4.38-48
  • Esposito M.T. “Imatinib, the magic bullet for treatment of blood cancer” Frontiers for Young Minds, 2020 8:17. doi: 10.3389/frym.2020.00017
  • Esposito, M.T., The Impact of PI3-kinase/RAS Pathway Cooperating Mutations in the Evolution of KMT2A-rearranged Leukemia. HemaSphere, 2019. 3(3).DOI: 10.1097/HS9.0000000000000195
  • Esposito, M.T., Blood factory: which stem cells? BMC hematology, 2018. 18: p. 10.DOI: 10.1186/s12878-018-0105-4
  • Patel S, Hayes N, Esposito MT “Trastuzumab resistance: what are we offering to patients?” Journal of Clinical and Experimental Oncology 2017 6, 6 doi: 10.4172/2324-9110.1000203
  • Esposito MT Haematopoietic stem cells meet iPS technology. Haematologica 2016 Sept 101 (9) 999-1001 DOI: 10.3324/haematol.2016.150755
  • Esposito MT, Zhao L, Fung TK, Rane JK, Wilson A, Martine N, Gil J, Ashworth A, So CW. “Synthetic lethal targeting of oncogenic transcription factors in acute leukaemia using PARP inhibitors” Nature Medicine 2015 Dec 21 (12): 1481-90 DOI: 10.1038/nm.3993
  • Querques F, Cantilena B, Cozzolino C, Esposito MT, Passaro F, Parisi S, Lombardo B, Russo T, Pastore L. “Angiotensin receptor I stimulates osteoprogenitors proliferation through TGF-β mediated signalling” J Cell Physiology 2015 Jul 230(7):1466-74. DOI: 10.1002/jcp.24887
  • Esposito MT and Chi Wai Eric So “DNA damage accumulation and repair defects in the pathogenesis of Acute Myeloid Leukaemia: implications for pathogenesis, disease progression and chemotherapy resistance.” Chromosoma 2014 Dec 123(6):545-61 DOI: 10.1007/s00412-014-0482-9
  • Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L. “Thymidine kinase- mediated shut down of Bone Morphogenetic Protein-4 expression allows regulated bone production” Current Gene Therapy, 2013 Jan 7  10.2174/1566523211313030005
  • Yeung J, Esposito MT, Grandillet A., Ziesig, BB, Griessinger E Bonnet D, So CW “β catenin mediates the establishment and drug resistance of MLL leukemic cells.” Cancer Cell, 2010 Dec 14;18(6):606-18. DOI: 10.1016/j.ccr.2010.10.032
  • Caiazzo M, Colucci-D’Amato L, Esposito MT, Parisi S, Stifani S, Ramirez F, di Porzio U “Transcription factor KLF7 regulates differentiation of neuroectodermal and mesenchymal lineages” Exp. Cell Res. 2010 Aug15;316 (14):2365-76.
  • Tarallo V, Vesci L, Esposito MT, Riccioni T, Pastore L, Orlandi A, Pisano C De Falco S “A Placental growth factor variant unable to recognize VEGFR-1 inhibits VEGF- dependent tumor angiogenesis via heterodimerization” Cancer Res. 2010 Mar 1;70(5):1804-13. Epub 2010 Feb 9. DOI: 10.1158/0008-5472.CAN-09-2609
  • Esposito MT, Di Noto R, Mirabelli P, Del Vecchio L, Parisi S, Pastore L “Culture conditions select different mesenchymal progenitors from adult mouse bone marrow” Tissue Eng Part A. 2009 Sep;15(9):2525-36 Epub 2009 Mar 17. DOI: 10.1089/ten.tea.2008.0509
  • Savarino L, Baldini N, Greco M, Capitani O, Pinna S, Valentini S, Lombardo B, Esposito MT, Pastore L, Ambrosio L, Battista S, Causa F, Zeppetelli S, Guarino V, Netti PA“ The performance of poly-ecaprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4”. Biomaterials  2007 28(20)