Dr Rachel Simmonds FRSB

Senior Lecturer in Immunopathogenesis
B.Sc. (Manchester), PhD (Imperial)

Academic and research departments

School of Biosciences and Medicine.


University roles and responsibilities

  • Director of Post-Graduate Research for the Department of Microbial Sciences

    Academic networks


      Research interests

      Research collaborations

      Indicators of esteem

      • Member of the Wellcome Trust Expert Review Group on Pathogen Biology

      • Editorial board of Tuberculosis

      • Member of the Biochemical Society's Awards Committee

      • Visiting Research Fellow at University of Southampton

      • Visiting Lecturer at the University of Ghana


      Postgraduate research supervision

      My teaching

      Courses I teach on


      Postgraduate taught

      Postgraduate research

      Biosciences and Medicine MD

      My publications


      McKenna M, Simmonds Rachel, High S (2017)Mycolactone reveals substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis, In: Journal of Cell Science130pp. 1307-1320 Company of Biologists
      Hall BS, Simmonds R, Benbow ME, Mosi L, Roberts S, Williamso Jordan H (2015)Mycobacterium ulcerans and Buruli Ulcer, In: Singh SK (eds.), Human Emerging and Re-emerging Infections: Viral and Parasitic Infections, Volume I1(44) John Wiley and Sons
      McKenna M, Simmonds RE, High S (2016)Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone., In: Journal of Cell Science129 The Company of Biologists
      Rezende SM, Lane DA, Zoller B, Mille-Baker B, Laffan M, Dahlback B, Simmonds RE (2002)Genetic and phenotypic variability between families with hereditary protein S deficiency, In: THROMBOSIS AND HAEMOSTASIS87(2)pp. 258-265 SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
      Ogbechi Joy, Hall Belinda, Sbarrato Thomas, Taunton Jack, Willis Anne E., Wek Ronald C., Simmonds Rachel (2018)Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4, In: Cell Death & Disease9397 Nature Publishing Group
      Simmonds RE, Ireland H, Kunz G, Lane DA, Bhavnani M, Castaman G, Hambley H, Laffan M, OConnor N, Sas G, Tew CJ, Walker ID (1996)Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis, In: BLOOD88(11)pp. 4195-4204 W B SAUNDERS CO
      Gandrille S, Borgel D, Ireland H, Lane DA, Simmonds R, Reitsma PH, Mannhalter C, Pabinger I, Saito H, Suzuki K, Formstone C, Cooper DN, Espinosa Y, Sala N, Bernardi F, Alach M (1997)Protein S deficiency: A database of mutations - For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis, In: THROMBOSIS AND HAEMOSTASIS77(6)pp. 1201-1214
      Simmonds RE, Hermida J, Rezende SM, Lane DA (2001)Haemostatic genetic risk factors in arterial thrombosis, In: THROMBOSIS AND HAEMOSTASIS86(1)pp. 374-385
      Rezende SM, Lane DA, Mille-Baker B, Samama MM, Conard J, Simmonds RE (2002)Protein S Gla-domain mutations causing impaired Ca2+-induced phospholipid binding and severe functional protein S deficiency, In: BLOOD100(8)pp. 2812-2819 AMER SOC HEMATOLOGY
      Simmonds RE, Lane DA (2001)The endothelial cell protein C receptor: A candidate genetic risk factor for thrombosis, In: THROMBOSIS AND HAEMOSTASIS86(4)pp. 939-941 F K SCHATTAUER VERLAG GMBH
      Rance JB, Follows GA, Cockerill PN, Bonifer C, Lane DA, Simmonds RE (2003)Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites, In: BLOOD101(11)pp. 4393-4401 AMER SOC HEMATOLOGY
      Gandrille S, Borgel D, Sala N, Espinosa-Parrilla Y, Simmonds R, Rezende S, Lind B, Mannhalter C, Pabinger I, Reitsma PH, Formstone C, Cooper DN, Saito H, Suzuki K, Bernardi F, Aiach M (2000)Protein S deficiency: A database of mutations - Summary of the first update, In: THROMBOSIS AND HAEMOSTASIS84(5)pp. 918-918 F K SCHATTAUER VERLAG GMBH
      Rezende SM, Simmonds RE, Zoller B, Dahlback B, Lane DA (1999)The molecular basis of type I/III protein S deficiency, In: THROMBOSIS AND HAEMOSTASISpp. 426-427 F K SCHATTAUER VERLAG GMBH
      Bodman-Smith K, Vogel M, Wu HL, Stainer A, Esmon CT, Ahnström J, Ogbechi J, Ruf MT, Hall BS, Pluschke G, Simmonds RE (2015)Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions., In: PLoS Pathog11(7) PLoS
      Simmonds RE, Ireland H, Lane DA, Zoller B, de Frutos PG, Dahlback B (1998)Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect, In: ANNALS OF INTERNAL MEDICINE128(1)pp. 8-+ AMER COLL PHYSICIANS
      Biguzzi E, Razzari C, Lane DA, Castaman G, Cappellari A, Bucciarelli P, Fontana G, Margaglione M, D'Andrea G, Simmonds RE, Rezende SM, Preston R, Prisco D, Faioni EM (2005)Molecular diversity and thrombotic risk in Protein S deficiency: The PROSIT study, In: HUMAN MUTATION25(3)pp. 259-269 WILEY-LISS
      Simmonds RE, Lali FV, Smallie T, Small PLC, Foxwell BM (2009)Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism, In: JOURNAL OF IMMUNOLOGY182(4)pp. 2194-2202 AMER ASSOC IMMUNOLOGISTS
      Mille-Baker B, Rezende SM, Simmonds RE, Mason PJ, Lane DA, Laffan MA (2003)Deletion or replacement of the second EGF-hke domain of protein S results in loss of APC cofactor activity, In: BLOOD101(4)pp. 1416-1418 AMER SOC HEMATOLOGY
      Zong Guanghui, Hu Zhijian, O’Keefe Sarah, Tranter Dale, Iannotti Michael J., Baron Ludivine, Hall Belinda, Corfield Katherine, Paatero Anja O., Henderson Mark J., Roboti Peristera, Zhou Jianhong, Sun Xianwei, Govindarajan Mugunthan, Rohde Jason M., Du Yuchun, Blanchard Nicolas, Simmonds Rachel, Inglese James, Demangel Caroline, High Stephen, Paavilainen Ville O., Shi Wei Q. (2019)Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation, In: Journal of the American Chemical Society141(21)pp. 8450-8461 American Chemical Society
      Moyo N, Westcott D, Simmonds R, Steinbach F (2012)Equine arteritis virus replication in monocytic cells suppresses differentiation and function of dendritic cells, In: IMMUNOLOGY137pp. 625-625

      Additional publications