Dr Sarah Bailey


Teaching Fellow in Physiology
BSc(Hons) Molecular Biology, DPhil Biochemistry, Fellow of HEA
+44 (0)1483 684463
19 AY 04
08.30 - 16.30

Academic and research departments

School of Biosciences and Medicine.

Biography

I seem to have wandered around the last 15 years being at places beginning with the letter S! I started out my career in science right here at the University of Surrey, where I undertook a BSc in Molecular Biology which included a PTY in New York City at Cornell University.

My experience in the lab there sparked my interest in cell signalling and I followed this interest to Brighton, to the University of Sussex, where I undertook a PhD in the lab of Dr Alison Sinclair. My project was on the intracellular interactions of the Epstein-Barr Virus transcription factor Zta (BZLF1) and this quickly led me to the field of DNA Damage response in combination with cellular signalling.

One of the few places left in the south of England with a university and an S to their name was Southampton, so in preparation to leave Sussex, I sought out Dr Paul Townsend who was undertaking some research on STAT-1 and collaborating on a p53 project, which I had found in my PhD research.

While writing up my PhD thesis I co-authored grants (with Dr Townsend and Dr Cragg) to fund my research on p73 and STAT-1 in Lymphoma. The project started in January 2009, just as I handed in my completed PhD thesis. I remained at the University of Southampton while I undertook a further 2 projects which focused more on downstream cell signalling in hormone dependent cancers of the breast (with Mr Ramsey Cutress) and prostate (Dr Simon Crabb) and left the university in April 2014. In my time at the University of Southampton I pursued teaching CPDs, hoping one day that I would make it to be a lecturer.

Following this I had a career break and spent some time teaching swimming (which is how I funded writing my PhD thesis and grants in 2008 and building on my experience as a competitive swimmer when I was at school) and undertaking a part time visiting lecturer post at the University of Westminster, where I focused on small group teaching in Biochemistry, which made a welcome change and allowed me to stretch my brain while also looking after my new daughter.

Finally I returned to where my journey began (and yet another S), joining the University of Surrey teaching staff as a Teaching Fellow in Physiology in January 2017.

Research

Research interests

Indicators of esteem

  • Fellow of Higher Education Academy

My teaching

My publications

Publications

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

Regufe da Mota S, Bailey S, Strivens RA, Hayden AL, Douglas LR, Duriez PJ, Borrello MT, Benelkebir H, Ganesan A, Packham G, Crabb SJ.

Cancer Cell Int. 2018 May 9;18:71. doi: 10.1186/s12935-018-0568-1. eCollection 2018.

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells.

Papadakis E, Robson N, Yeomans A, Bailey S, Laversin S, Beers S, Sayan AE, Ashton-Key M, Schwaiger S, Stuppner H, Troppmair J, Packham G, Cutress R.

Oncotarget. 2016 Apr 5;7(14):18851-64. doi: 10.18632/oncotarget.7944.

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, Mattevi A.

ACS Chem Biol. 2013 Aug 16;8(8):1677-82. doi: 10.1021/cb4001926. Epub 2013 Jun 11.

Regulation of myocardial interleukin-6 expression by p53 and STAT1.

Carroll CJ, Sayan BS, Bailey SG, McCormick J, Stephanou A, Latchman DS, Townsend PA.

J Interferon Cytokine Res. 2013 Sep;33(9):542-8. doi: 10.1089/jir.2012.0165. Epub 2013 May 15.

Role of STAT1 in the breast.

Bailey SG, Cragg MS, Townsend PA.

JAKSTAT. 2012 Jul 1;1(3):197-9. doi: 10.4161/jkst.20967.

Family friction as ΔNp73 antagonises p73 and p53.

Bailey SG, Cragg MS, Townsend PA.

Int J Biochem Cell Biol. 2011 Apr;43(4):482-6. doi:10.1016/j.biocel.2010.12.022. Epub 2011 Jan 7. Review.

Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases.

Shuttleworth SJ, Bailey SG, Townsend PA.

Curr Drug Targets. 2010 Nov;11(11):1430-8. Review.

Regulating the genome surveillance system: miRNAs and the p53 super family.

Bailey SG, Sanchez-Elsner T, Stephanou A, Cragg MS, Townsend PA.

Apoptosis. 2010 May;15(5):541-52. doi: 10.1007/s10495-010-0456-1. Review.

Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

Bailey SG, Verrall E, Schelcher C, Rhie A, Doherty AJ, Sinclair AJ.

J Virol. 2009 Nov;83(21):11116-22. doi: 10.1128/JVI.00512-09. Epub 2009 Aug 5.

Mechanisms of action and clinical implications of cardiac urocortin: a journey from the heart to the systemic circulation, with a stopover in the mitochondria.

Kuizon E, Pearce EG, Bailey SG, Chen-Scarabelli C, Yuan Z, Abounit K, McCauley RB, Saravolatz L, Faggian G, Mazzucco A, Townsend PA, Scarabelli TM.

Int J Cardiol. 2009 Nov 12;137(3):189-94. doi: 10.1016/j.ijcard.2009.03.112. Epub 2009 Apr 29. Review.

DNA-damage response pathways triggered by viral replication.

Sinclair A, Yarranton S, Schelcher C.

Expert Rev Mol Med. 2006 Mar 3;8(5):1-11. Review.