William Lockley

Professor William Lockley


Visiting Professor
+44 (0)1483 686828
30 AZ 02

Academic and research departments

Department of Chemistry.

Biography

Research

Research interests

My publications

Publications

Isotope reviews

  • 30 Years with ortho-directed hydrogen isotope exchange labelling, Lockley WJS, J Label Compd Radiopharm, 50, 779-788 (2007).
  • Tritium chemistry: history, current status and future developments. Lockley WJS in Synth Appl Isotop Lab Comp, Proc 9th Int Symp, Edinburgh, 2006, Eds Willis CL, Lockley WJS, J Label Compd Radiopharm, 50, 256-259 (2007), ISSN 0362-4803
  • Radiochemistry: a vital role supporting drug development. Drug Discovery World, Fall 2004, 59-64 (2004).

Isotope labelling methodologies

  • Tritium labelling via an iridium-based solid-phase catalyst. Hickey MJ, Kingston LP, Mather AN, Lockley WJS, Wilkinson DJ. J Label Compd Radiopharm, 49, (4) 2006, 388-389.
  • One-step exchange-labelling of pyridines and other N-heteroaromatics using deuterium gas: catalysis by heterogeneous rhodium and ruthenium catalysts, E Alexakis E, Jones JR, Lockley WJS, Tetrahedron Letters, 47, 5025-5028 (2006).
  • Labelling of anilines, benzylamines and some N-heterocyclics using cycloocta-1,5-dienyliridium(I)-1,1,1,5,5,5-hexafluoro-pentan-2,4-dionate and isotopic hydrogen gas in DMF or DMA, Garman RN, Hickey MJ, Kingston LP, McAuley B, Jones JR, Lockley WJS, Mather AN, Wilkinson DJ. J Label Compd Radiopharm, 48 (1) 75-84 (2005)
  • One-step exchange-labelling of piperidines, piperazines and dialkylamines with deuterium oxide: catalysis by various ruthenium complexes. Alexakis E, Hickey MJ, Jones JR, Kingston LP, Lockley WJS, Mather AN, Smith T, Wilkinson DJ, Tetrahedron Letters, 46 , 4291-4293 (2005).
  • A solid-phase iridium-based ortho -exchange catalyst for the one-step labelling of aromatic substrates with deuterium, Hickey MJ, Kingston LP, Jones JR, Lockley WJS, Mather AN, Wilkinson DJ, Tetrahedron Letters, 45 8621-8623 (2004).
  • Iridium-catalysed labelling of anilines, benzylamines and nitrogen heterocycles using deuterium gas and cycloocta-1,5-dienyliridium(I) 1,1,1,5,5,5-hexafluoropentane-2,4-dionate. Hickey MJ, Kingston LP, McAuley B, Jones JR, Lockley WJS, Mather AN, Wilkinson DJ, Tetrahedron Letterss, 44 3959-3961 (2003).
  • Convenient and efficient deuteration of functionalised aromatics with deuterium oxide: catalysis by cycloocta-1,5-dienyliridium(I) 1,3-dionates. Hickey MJ, Kingston LP, McAuley BM, Jones JR, Lockley WJS, Mather AN, Spink E, Thompson SP, Wilkinson DJ, J Label Compd Radiopharm, 46, 1191-1204 (2003).