2pm - 3pm
Thursday 15 April 2021
The unexpected role(s) of Cryptochrome based magnetoreception
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This seminar will take place online via Zoom.
To register for this seminar email Dr Youngchan Kim.
The flavoprotein Cryptochrome (CRY) is now generally believed to be a magnetosensor, providing geomagnetic information via a quantum effect on a light-initiated radical pair reaction between the tryptophan residues of CRY and its cofactor FAD. Despite being non-migratory the fruit-fly Drosophila melanogaster has proven to be an ideal living test-tube for the study of CRY based magnetoreception. Previous behavioural studies have shown that in stark contrast to the canonical ‘tryptophan-FAD’ radical pair mechanism, the C-terminus of CRY alone is capable of imparting magnetosensivity to the fly. Here, I will present my current work using electrophysiological recordings of Drosophila neurons to investigate the roles of both the CRY C-terminus and cellular flavins as a non-canonical radical pair based magnetoreception pathway.
Adam Bradlaugh is a post-doc in Richard Baines' lab at the Univerisity of Manchester. He first became interested in the neurogenetics and molecular mechanims underpinning sensory systems during his undergraduagte work with Bambos Kyriacou in Leicester. He then went on to do his PhD with Ralf Stanewsky at UCL on light input to the Drosophila circadian clock. In Manchester and in collaboration with Alex Jones at NPL Adam uses electrophysiology to record the activity Drosophila neurons in the study of Cryptochrome as a magnetoreceptor.