How children become obese: A genetics study of individual-level BMI curves

This is an exciting opportunity to join a multidisciplinary team to develop dynamic Bayesian networks of BMI trajectories leading to childhood obesity. The project builds on cutting edge research developed by the University of Surrey modelling BMI dynamics in childhood and Bayesian semi-mechanistic modelling of dynamic processes.

Start date
1 April 2022
Duration
3 years
Application deadline
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Funding source
The University of Surrey, Doctoral College
Funding information

The funding package for this studentship award is as follows:

  • Full tuition fee covered (UK/international)
  • Stipend at £15,609 p.a.
  • Conference and training stipend of £1,000 p.a.
  • Project desktop or laptop computer

About

Childhood obesity, a risk factor for adult cardio-metabolic disease, is defined as a body mass index (BMI) above the 95th percentile. Currently, over 20% of children are obese, and the prevalence is rising.  Despite the relatively large heritability (40-86%), the genes controlling the increase and decrease of BMI at different periods of infancy and childhood remain largely unknown.

Recently, we showed that distinct genetic factors control infant and child BMI [1]. This finding led us to speculate that genetic effects are dynamic, varying throughout life. We, therefore, aim to investigate whether BMI trajectories associated with normal, overweight and obese children are controlled by different genes and whether these genes have varying genetic effects.

Despite the significant progress of growth modelling, BMI remains a challenging phenotype because the BMI trajectory is highly nonlinear and controlled by multiple environmental and genetic factors. Current approaches have focused on data-driven models, while semi-mechanistic models [2] and the incorporation of domain-specific knowledge have been left unexplored.

The focus of this project is to evaluate and develop probabilistic models of BMI trajectories, and apply them to real data to identify genes controlling BMI trajectories. We intend to develop statistical software for the application of these models in the Comprehensive R Archive Network (CRAN) and make it publicly available.

The candidate will join a supervisory team composed of:

In collaboration with:

  • Prof. John Wright, Epidemiologist and Director of the Born in Bradford (BiB) Study[7];
  • Ms Gillian Santorelli, Principal Statistician at BiB and expert modelling longitudinal data at BiB[5].
Related links
Daily Mail obesity article Applied and Computational Measurable Dynamics book

References

  1. Couto Alves, A. et al (2019) GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Sci. Adv. 5, eaaw3095. 
  2. Santitissadeekorn, N. et al (2020) Approximate filtering of conditional intensity process for Poisson count data Comput. Stat. Data Anal. 144, 106850
  3. Bolt & Santitissadeekorn (2013)  Applied and Computational Measurable Dynamics, SIAM
  4. Arshad, S., Hodgekiss, C., Holloway, J.W., et. al. (2018)  Lung Function Trajectories From Childhood To Young Adulthood. JACI
  5. Fairley, L., (…), Wright, J. (2013) Describing differences in weight and length growth trajectories between white and Pakistani infants in the UK. Arch Dis Child.
  6. Arshad, S. et. al. (2020) Cohort Profile: The Isle of Wight Whole Population Birth Cohort. Int J Epidemiol.
  7. Wrigth, J. et. al. (2013) Cohort Profile: The Born in Bradford multi-ethnic family cohort study. Int J Epidemiol.

Eligibility criteria

Applicants should have completed an MSc degree by the time the PhD starts. We will consider applicants with an MSc. or BSc degree in statistics, physics, mathematics, data science, machine learning, bioinformatics, computer science, or related degrees. Candidates that do not hold any of the above degrees but have strong research potential may also be considered.

A solid background in any of the programming languages R, Python or C is required.

Experience with Bayesian statistics, longitudinal models, or genetics data analysis is highly desired.

English Language requirements

IELTS Academic: 6.5 or above (or equivalent) with 6 in each individual category.

How to apply

Applications must be submitted via the Biosciences and Medicine PhD programme page on the ‘Apply’ tab. State clearly the project and supervisor.

Please prepare to submit your CV; degree certificates and transcripts; names of two referees (ideally uploading two references at time of application also); and research proposal (including examples of previous project work).


Application deadline

Contact details

Alexessander Couto Alves
Telephone: +44 (0)1483 684658
E-mail: a.coutoalves@surrey.ac.uk

Bioinformatics and Statistical Genomics Group

Our research focuses on the genetic determinants of adult health and disease. We collaborate in large international consortia running large scale genetic studies of human disease and phenotypes. We apply and develop computational and statistical methods for understanding the aetiology of adult health and disease. We are part of the Centre for Mathematical and Computational Biology where our research on semi-mechanistic models of dynamic processes is based.

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