Dr Alexessander da Silva Couto Alves


Lecturer in Bioinformatics
PhD, MSc, MEng

University roles and responsibilities

  • Head of Bioinformatics Core Facility

Affiliations and memberships

American Society of Human Genetics
Member

Research

Research interests

Indicators of esteem

  • Personal research awards and fellowships

    2018 Research Fellow, School of Public Health, Imperial College London

    2015 Research Fellow, Dept of Twin Research and Genetic Epidemiology, King’s College London

    2007 PhD Fellowship of the Portuguese National Science and Technology Foundation

  • Keynote and plenary addresses at conferences

    2014 Systems biology and functional analysis of disease genes. European academy of allergy and clinical immunology congress.

  • Editorial roles

    Reviewer for:

    • Journal of the Royal Statistical Society
    • Genome Medicine
    • Nature scientific reports
    • Annals of Human Genetics
    • Bioscience reports
    • Conference organisation

      2007 Co-chair Workshop on Computational Methods in Bioinformatics and Systems Biology. As part of the Portuguese Conference on Artificial

      2005 Co-chair Workshop on Computational Methods in Bioinformatics. As part of the Portuguese Conference on Artificial Intelligence.

    My teaching

    Supervision

    Completed postgraduate research projects I have supervised

    My publications

    Highlights

    Couto Alves, A., De Silva, N. M. G.,  Karhunen, V. , Sovio, U., Das, S., et al. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances (2019).

    Couto Alves, A.; Glastonbury, CA; Moustafa, JSES; Small, KS Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue. BMC genomics (2018)

    Demenais, F., Margaritte-Jeannin, P., Barnes, K. C., Cookson, W. O., Altmüller, J., Ang, W., Barr, R. G., Beaty, T. H., Becker, A. B., Beilby, J., et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nature genetics 50, 1 (2018), 42.

    Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Couto Alves, A., et al. Exome-wide association study of plasma lipids in> 300,000 individuals. Nature genetics 49, 12 (2017), 1758.

    Ried, J. S., Chu, A. Y., Bragg-Gresham, J. L., Van Dongen, J.,Huffman, J. E., Ahluwalia, T. S., Cadby, G., Eklund, N., Eriksson, J., Esko, T., et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature communications 7 (2016), 13357.

    Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., et al. Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature genetics 47, 12 (2015), 1449

    Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Leach, I. M., et al. Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for dna methylation. Nature genetics 47, 11 (2015), 1282–1293

    Loth, D. W., Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., Smith, A. V., Duan, Q., Oldmeadow, C., et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature genetics 46, 7 (2014), 669–677.

    Bønnelykke, K., Matheson, M. C., Pers, T. H., Granell, R., Strachan, D. P., Couto Alves, A., Linneberg, A., Curtin, J. A., Warrington, N. M., Standl, M., et al. Meta-analysis of genomewide association studies identifies ten loci influencing allergic sensitization. Nature genetics 45, 8 (2013), 902–906.

    Paternoster, L., Standl, M., Chen, C.-M., Ramasamy, A., Bønnelykke, K., Duijts, L., Ferreira, M. A., Couto Alves, A., Thyssen, J. P., Albrecht, E., et al. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature genetics 44, 2 (2012), 187–192.

    Additional publications