Professor Charley Wu


Professor of Chemical Engineering
+44 (0)1483 683506
15 BC 02

Biography

Areas of specialism

Computational formulation engineering; Pharmaceutical engineering; Discrete Element Modelling; Particle Engineering and Technology

My qualifications

PhD
Aston University

Research projects

Indicators of esteem

  • Proposal Reviewer: European Research Council (ERC); National Science Foundation of China (NSFC); Natural Sciences and Engineering Research Council of Canada; The Executive Agency for Higher Education, Research, Development and Innovation, Romania; French National Research Agency (ANR); Qatar National Research Fund (QNRF).

    Member of EPSRC College (2005-)

    Guest Editor: Powder Technology, Particuology, Granular Matter, Materials.

    Editorial Board Member: Particuology, Journal of Engineering.

    PhD Examiner: The universities of Cambridge, Imperial College, Edinburgh, Southampton, Birmingham, Sheffield, Leicester, Leeds, Newcastle, Surrey and Glasgow Caledonian University in the UK; Abo Akademi University in Finland; University of New South Wales \& Monash University in Australia; University of Toulouse in France.

    Opponent for PhD thesis public defence: Abo Akademi University, Finland; Ecole Des Mines, Albi, France

    Peer Reviewer: Powder Technology, AICHE J, Chemical Engineering Science, Proceedings of the Royal Society London, International Journal of Pharmaceuticals, Journal of Pharmaceutical Science.

    Expert Consultant: In the field of X-ray Computed Tomography for pharmaceutical solid oral dosage forms.

     

    My teaching

    My publications

    Publications

    Yu S, Gururajan B, Reynolds G, Roberts R, Wu C-Y, Adams M (2010)Exploring roll compaction of two commonly used pharmaceutical powders, In: JOURNAL OF PHARMACY AND PHARMACOLOGY62(10)pp. 1434-1435 WILEY-BLACKWELL
    Yu S, Gururajan B, Reynolds G, Roberts R, Adams MJ, Wu C-Y (2012)A comparative study of roll compaction of free-flowing and cohesive pharmaceutical powders, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS428(1-2)pp. 39-47 ELSEVIER SCIENCE BV
    Yu S, Wu CY, Adams MJ, Reynolds G, Gururajan B, Gargiuli J, Leadbeater T, Roberts R, Parker DJ (2015)The use of positron emission particle tracking (PEPT) to study milling of roll-compacted microcystalline cellulose ribbons, In: Powder Technology285pp. 74-79
    Andrews J, Yu S, Gururajan B, Reynolds G, Roberts R, Wu C-Y, Adams M (2010)Analytical solutions for roll compaction of pharmaceutical powders, In: JOURNAL OF PHARMACY AND PHARMACOLOGY62(10)pp. 1403-1404 WILEY-BLACKWELL
    Yu S, Adams M, Gururajan B, Reynolds G, Roberts R, Wu C-Y (2013)The effects of lubrication on rollcompaction, ribbon milling and tabletting, In: CHEMICAL ENGINEERING SCIENCE86pp. 9-18 PERGAMON-ELSEVIER SCIENCE LTD
    Wu C (2000)Impact behaviour of elastoplastic spheres with a rigid wall, In: Proc. I. Mech. E. Part C- Journal of Mechanical Engineering Science214(8)pp. 1107-1114
    Xue Jun, Schiano Serena, Zhong Wenzhen, Chen Lan, Wu Chuan Yu Determination of the flow/no-flow transition from a flat bottom hopper, In: Powder Technology Elsevier
    Wu C-Y, Ge W, Britain RSOCG (2011)Particulate Materials Synthesis, Characterisation, Processing and Modelling Royal Society of Chemistry
    Wu C, Pei C, Byard S (2013)A DEM model for contact electrification of irregular shaped particles, In: AIP Conference Proceedings1542pp. 101-104
    Pei C, Pei C, Wu CY, Adams M, England D, Byard S, Berchtold H (2015)Contact electrification and charge distribution on elongated particles in a vibrating container, In: Chemical Engineering Science125pp. 238-247
    Yang J, Wu C-Y, Adams M (2015)DEM analysis of the effect of particle-wall impact on the dispersion performance in carrier-based dry powder inhalers, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS487(1-2)pp. 32-38 ELSEVIER SCIENCE BV
    Wu Chuan-Yu, Liu Lian X., Olaleye Busayo, Pozza Filippo Population balance modelling of ribbon milling with a new mass-based breakage function, In: International Journal of Pharmaceutics118765 Elsevier
    Loreti Simone, Wu Chuan-Yu, Reynolds G, Mirtič A, Seville Jonathan (2017)DEM-PBM Modelling Of Impact Dominated Ribbon Milling, In: AIChE Journal63(9)pp. 3692-3705 Wiley
    Guo Y, Wu C-Y, Kafui KD, Thornton C (2010)Numerical analysis of density-induced segregation during die filling, In: POWDER TECHNOLOGY197(1-2)pp. 111-119 ELSEVIER SCIENCE SA
    Yang J, Wu C-Y, Adams M (2013)DEM Analysis of Effects of Particle Properties and Mixing Conditions on Particle Attachment Processes, In: Yu A, Dong K, Yang R, Luding S, (eds.), POWDERS AND GRAINS 20131542pp. 967-970
    Radjai F., Stavrou Alexandros Georgios, Hare Colin, Hassanpour Ali, Wu Chuan-Yu, Nezamabadi S., Luding S., Delenne J.Y. (2017)Flowability assessment of weakly consolidated powders, In: EPJ Web of Conferences140pp. 03085-1 EDP Sciences: EPJ Open Access
    Nwose EN, Pei C, Wu C-Y (2012)Modelling die filling with charged particles using DEM/CFD, In: PARTICUOLOGY10(2)pp. 229-235 ELSEVIER SCIENCE INC
    Wu CY, Dihoru L, Cocks ACF (2003)The flow of powder into simple and stepped dies, In: POWDER TECHNOLOGY134(1-2)pp. 24-39 ELSEVIER SCIENCE SA
    Govender Nicolin, Rajamani Raj, Wilke Daniel N, Wu Chuan-Yu, Khinast Johannes, Glasser Benjamin J (2018)Effect of particle shape in grinding mills using a GPU based DEM code., In: Minerals Engineering129pp. 71-84 Elsevier
    Coube O, Cocks ACF, Wu CY (2005)Experimental and numerical study of die filling, powder transfer and die compaction, In: POWDER METALLURGY48(1)pp. 68-76 MANEY PUBLISHING
    Wu C-Y (2008)DEM simulations of die filling during pharmaceutical tabletting, In: PARTICUOLOGY6(6)pp. 412-418 ELSEVIER SCIENCE INC
    Guo Y, Kafui KD, Thornton C, Wu CY (2007)A numerical study of die filling using a coupled discrete element method and computational fluid dynamics, In: Proceedings of the Euro Powder Metallurgy Congress and Exhibition, Euro PM 20073pp. 317-322
    Schiano S, Wu CY, Mirtic A, Reynolds G (2016)A Novel Use of Friability Testing for Characterising Ribbon Milling Behaviour., In: Eur J Pharm Biopharm104pp. 82-88 Elsevier
    Milroy GE, Dutt M, Wu CY, Bentham AC, Hancock BC, Elliott JA, Cameron RE (2004)The use of desktop x-ray microtomography to characterise randomly packed and compacted pharmaceutical participate systems, In: Transactions - 7th World Biomaterials Congresspp. 1647-?
    Wu CY (2006)Capping mechanisms during pharmaceutical powder compaction, In: AIChE Annual Meeting, Conference Proceedings
    Wu CY, Cocks ACF (2006)Numerical and experimental investigations of the flow of powder into a confined space, In: MECHANICS OF MATERIALS38(4)pp. 304-324 ELSEVIER SCIENCE BV
    Wu CY, Li LY, Thornton C (2003)Rebound behaviour of spheres for plastic impacts, In: INTERNATIONAL JOURNAL OF IMPACT ENGINEERING28(9)pp. 929-946 PERGAMON-ELSEVIER SCIENCE LTD
    Krok Alexander, Wu Chuan-Yu Evolutions of temperature and density during roll compaction of a pharmaceutical excipient, In: International Journal of Pharmaceutics572118822 Elsevier
    Wu C-Y, Guo Y (2012)Numerical modelling of suction filling using DEM/CFD, In: CHEMICAL ENGINEERING SCIENCE73pp. 231-238 PERGAMON-ELSEVIER SCIENCE LTD
    Yang J, Wu C-Y, Adams M (2015)Numerical Modelling of Agglomeration and Deagglomeration in Dry Powder Inhalers: A Review, In: CURRENT PHARMACEUTICAL DESIGN21(40)pp. 5915-5922 BENTHAM SCIENCE PUBL LTD
    Wu CY, Best SM, Bentham AC, Hancock BC, Bonfield W (2005)A simple predictive model for the tensile strength of binary tablets, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES25(2-3)pp. 331-336 ELSEVIER SCIENCE BV
    Wu CY, Fan XF, Motazedian F, Seville JPK, Parker DJ, Cocks ACF (2007)An experimental study of die filling using positron emission particle tracking, In: Proceedings of the Euro Powder Metallurgy Congress and Exhibition, Euro PM 20073pp. 335-340
    Wu C-Y, Bentham AC, Mills A (2007)Analysis of failure mechanisms during powder compaction, In: Kim YS, Yoon DY, Kang SJL, Eun KY, (eds.), Progress in Powder Metallurgy, Pts 1 and 2534-53pp. 237-240
    Goey CH, Wu C-Y (2013)Cooperative Dynamics of a Group of Intruders Subsiding in Granular Media: a DEM Study, In: Yu A, Dong K, Yang R, Luding S, (eds.), POWDERS AND GRAINS 20131542pp. 437-440
    Wu C-Y, Ge W (2012)Special Issue on Emerging Particle Technology, In: POWDER TECHNOLOGY227pp. 1-2 ELSEVIER SCIENCE SA
    Wu CY, Cocks ACF (2004)Flow behaviour of powders during die filling, In: POWDER METALLURGY47(2)pp. 127-136 MANEY PUBLISHING
    Wu C-Y, Hancock BC, Mills A, Bentham AC, Best SM, Elliott JA (2008)Numerical and experimental investigation of capping mechanisms during pharmaceutical tablet compaction, In: POWDER TECHNOLOGY181(2)pp. 121-129
    Adams M, Pei C, Wu CY, England D, Byard S, Berchtold H (2013)Numerical analysis of contact electrification using DEM-CFD, In: Powder Technology248pp. 34-43
    Wu CY, Ruddy OM, Bentham AC, Hancock BC, Best SM, Elliott JA (2005)Modelling the mechanical behaviour of pharmaceutical powders during compaction, In: POWDER TECHNOLOGY152(1-3)pp. 107-117 ELSEVIER SCIENCE SA
    Murray FJ, Hicks M, Colón J, Wu CY, Natoli D, Kirsch D, Salvemini D (2012)Optimizing manufacturing processes: conditions, challenges and opportunities, In: American Pharmaceutical Review15(3)
    Wu CY, Hancock BC, Elliott JA, Best SM, Bentham AC, Bonfield W (2005)Finite element analysis of capping mechanisms during pharmaceutical powder compaction, In: Advances in Powder Metallurgy and Particulate Materials - 2005, Proceedings of the 2005 International Conference on Powder Metallurgy and Particulate Materials, PowderMet 2005pp. 62-73
    Yu S, Guo Y, Wu C-Y (2009)DEM/CFD modelling of the deposition of dilute granular systems in a vertical container, In: CHINESE SCIENCE BULLETIN54(23)pp. 4318-4326 SCIENCE PRESS
    Wu C-Y, Thornton C, Li L-Y (2009)Predicting Rebound Kinematics of Elastic and Rigid Particles Resulting from Oblique Impacts, In: Nakagawa M, Luding S, (eds.), POWDERS AND GRAINS 20091145pp. 755-758
    Zakhvatayeva A., Zhong W., Makroo H.A., Hare C., Wu C. (2018)An experimental study of die filling of pharmaceutical powders using a rotary die filling system, In: International Journal of Pharmaceutics553(1-2)pp. 84-96 Elsevier
    Govender Nicolin, Wilke D, Wu Charley, Khinast J, Pizette P, Xu W (2018)Hopper flow of irregularly shaped particles (non-convex polyhedra): GPU-based DEM simulation and experimental validation, In: Chemical Engineering Science188pp. 34-51 Elsevier
    Olaleye Busayo, Wu Chuan-Yu, Liu Lian The effects of screw-to-roll speed ratio on ribbon porosity during roll compaction, In: International Journal of Pharmaceutics Elsevier
    Loreti Simone, Wu Chuan-Yu, Reynolds G, Seville Jonathan (2017)DEM-PBM modelling of abrasion dominated ribbon breakage, In: AIChE Journal64(4)pp. 1191-1204 JOHN WILEY & SONS INC
    Miguelez-Moran AM, Wu C-Y, Seville JPK (2008)The effect of lubrication on density distributions of roller compacted ribbons, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS362(1-2)pp. 52-59 ELSEVIER SCIENCE BV
    Govender Nicolin, Wilke Daniel N., Wu Chuan-Yu, Tuzun Ugur, Kureck Hermann (2019)A numerical investigation on the effect of angular particle shapes on blast furnace burden formation using a GPU enhanced discrete element method, In: Chemical Engineering Science204pp. 9-26 Elsevier
    Wu C-Y, Hung W-L, Miguelez-Moran AM, Gururajan B, Seville JPK (2010)Roller compaction of moist pharmaceutical powders, In: INTERNATIONAL JOURNAL OF PHARMACEUTICS391(1-2)pp. 90-97 ELSEVIER SCIENCE BV
    Tang Xue, Zakhvatayeva Anastasiya, Zhang Ling, Wu Zhen-Feng, Sun Ping, Wu Chuan-Yu Flow behaviour of pharmaceutical powders during rotary die filling with a paddle feeder, In: International Journal of Pharmaceutics585119547 Elsevier
    Wu C-Y, Seville JPK (2009)A comparative study of compaction properties of binary and bilayer tablets, In: POWDER TECHNOLOGY189(2)pp. 285-294 ELSEVIER SCIENCE SA
    Pei C, Wu C-Y, Byard S, England D (2010)Numerical analysis of electrostatic effects during powder deposition using DEM/CFD, In: JOURNAL OF PHARMACY AND PHARMACOLOGY62(10)pp. 1454-1455 WILEY-BLACKWELL
    Miguelez-Moran AM, Wu C-Y, Dong H, Seville JPK (2009)Characterisation of density distributions in roller-compacted ribbons using micro-indentation and X-ray micro-computed tomography, In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS72(1)pp. 173-182 ELSEVIER SCIENCE BV
    Wu C-Y, Armstrong B, Vlachos N (2012)Characterization of Powder Flowability for Die Filling, In: PARTICULATE SCIENCE AND TECHNOLOGY30(4)pp. 378-389 TAYLOR & FRANCIS INC
    Lu X-Y, Chen L, Wu Chuan-Yu, Chan H-K, Freeman T (2017)Effects of relative humidity on flowability and dispersion performance of lactose mixtures, In: Materials10(6)592 MDPI
    Wu C-Y (2013)Special issue on discrete element modelling, In: POWDER TECHNOLOGY248pp. 1-2 ELSEVIER SCIENCE BV
    Wu C-Y, Michrafy A, Mendyk A, Watano S (2015)Pharmaceutical Particle Technology, In: POWDER TECHNOLOGY285pp. 1-1 ELSEVIER SCIENCE BV
    Qiu L-C, Wu C-Y (2014)A hybrid DEM/CFD approach for solid-liquid flows, In: JOURNAL OF HYDRODYNAMICS26(1)pp. 19-25 ELSEVIER SCIENCE INC
    Krok A, Vitorino N, Zhang Jianyi, Ribeiro Frade J, Wu Chuan-Yu (2017)Thermal properties of compacted pharmaceutical excipients, In: International Journal of Pharmaceutics534(1-2)pp. 119-127 Elsevier
    Mori Yuki, Wu Chuan-Yu, Sakai Mikio (2019)Validation study on a scaling law model of the DEM in industrial gas-solid flows, In: Powder Technology343pp. 101-112 Elsevier
    Xing M, Wu C, Adams MJ (2011)The saltations of different sized particles in aeolian sand transport, In: GEOMORPHOLOGY134(3-4)pp. 217-223 ELSEVIER SCIENCE BV
    Thornton C, Ning Z, Wu CY, Nasrullah M, Li LY (2001)Contact mechanics and coefficients of restitution, In: Poschel T, Luding S, (eds.), GRANULAR GASES564pp. 184-194
    Wu C-Y, Thornton C, Li L-Y (2009)A semi-analytical model for oblique impacts of elastoplastic spheres, In: PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES465(2103)pp. 937-960 ROYAL SOC
    Guo Y, Wu C-Y, Thornton C (2011)The effects of air and particle density difference on segregation of powder mixtures during die filling, In: CHEMICAL ENGINEERING SCIENCE66(4)pp. 661-673 PERGAMON-ELSEVIER SCIENCE LTD
    Ojha VK, Schiano Serena, Wu Chuan-Yu, Snasel V, Abraham A (2016)Predictive Modelling of Die Filling of the Pharmaceutical Granules Using the Flexible Neural Tree, In: Neural Computing and Applications29(7)pp. 467-481 Springer Verlag
    Guo Y, Wu C-Y, Kafui KD, Thornton C (2011)3D DEM/CFD analysis of size-induced segregation during die filling, In: POWDER TECHNOLOGY206(1-2)pp. 177-188 ELSEVIER SCIENCE SA
    Wu C-Y, Fan XF, Motazedian F, Seville JPK, Parker DJ, Cocks ACF (2010)Quantitative investigation of powder flow during die filling using positron emission particle tracking, In: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART E-JOURNAL OF PROCESS MECHANICAL ENGINEERING224(E3)pp. 169-175 SAGE PUBLICATIONS LTD
    Wu CY, Cocks ACF, Gillia OT (2003)Die filling and powder transfer, In: INTERNATIONAL JOURNAL OF POWDER METALLURGY39(4)pp. 51-64 AMER POWDER METALLURGY INST
    Patel BA, Adams MJ, Turnbull N, Bentham AC, Wu C-Y (2010)Predicting the pressure distribution during roll compaction from uniaxial compaction measurements, In: CHEMICAL ENGINEERING JOURNAL164(2-3)pp. 410-417
    Wu CY, Li LY, Thornton C (2005)Energy dissipation during normal impact of elastic and elastic-plastic spheres, In: INTERNATIONAL JOURNAL OF IMPACT ENGINEERING32(1-4)pp. 593-604
    Wu CY, Thornton C, Li LY (2003)Coefficients of restitution for elastoplastic oblique impacts, In: ADVANCED POWDER TECHNOLOGY14(4)pp. 435-448
    Wu C-Y, Guo Y, Nikoosaleh S, Thornton C (2009)Competing Flow of Dissimilar Granular Materials in Air, In: Nakagawa M, Luding S, (eds.), POWDERS AND GRAINS 20091145pp. 985-988
    Wu C-Y, Guo Y (2010)Modelling of the flow of cohesive powders during pharmaceutical tabletting, In: JOURNAL OF PHARMACY AND PHARMACOLOGY62(10)pp. 1450-1451 WILEY-BLACKWELL
    Wu C-Y, Poeschel T (2013)Micro-mechanics and dynamics of cohesive particle systems, In: GRANULAR MATTER15(4)pp. 389-390 SPRINGER
    Stavrou Alexandros Georgios, Hare Colin, Hassanpour Ali, Wu Chuan-Yu (2020)Investigation of powder flowability at low stresses by DEM modelling, In: Chemical Engineering Science211115307 Elsevier
    Wu C-Y, Thornton C, Li L-Y (2008)Rebound behaviour of spheres during elastic-plastic oblique impacts, In: INTERNATIONAL JOURNAL OF MODERN PHYSICS B22(9-11)pp. 1095-1102
    Govender Nicolin, Wilke Daniel, Wu Chuan-Yu, Rajamani Raj, Khinast Johannes, Glasser Benjamin J. (2018)Large-scale GPU based DEM modeling of mixing using irregularly shaped particles, In: Advanced Powder Technology29(10)pp. 2476-2490 Elsevier
    Li LY, Wu CY, Thornton C (2002)A theoretical model for the contact of elastoplastic bodies, In: PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE216(4)UNSP C0640pp. 421-431 PROFESSIONAL ENGINEERING PUBLISHING LTD
    Olaleye Busayo, Wu Chuan-Yu, Liu Lian X (2020)Impact of feed material properties on the milling of pharmaceutical ribbons: A PBM analysis, In: International journal of pharmaceutics590pp. 119954-119954 Elsevier B.V
    Wu C-Y (2013)An Energy-based Splash Function for the Impact of Particles with Granular Beds, In: Yu A, Dong K, Yang R, Luding S, (eds.), POWDERS AND GRAINS 20131542pp. 630-633
    Guo Y, Kafui KD, Wu C-Y, Thornton C, Seville JPK (2009)A Coupled DEM/CFD Analysis of the Effect of Air on Powder Flow During Die Filling, In: AICHE JOURNAL55(1)pp. 49-62 JOHN WILEY & SONS INC
    Wu C-Y, Best SM, Bentham AC, Hancock BC, Bonfield W (2006)Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders, In: PHARMACEUTICAL RESEARCH23(8)pp. 1898-1905 SPRINGER/PLENUM PUBLISHERS
    Adams M, England D, Byard S, Berchtold H, Pei C, Wu C-Y (2013)A DEM Model for Contact Electrification of Irregular Shaped Particles, In: Yu A, Dong K, Yang R, Luding S, (eds.), POWDERS AND GRAINS 20131542pp. 101-104
    Zakhvatayeva A., Hare C., Wu C.Y. (2019)Size-induced segregation during die filling, In: International Journal of Pharmaceutics: X1100032 Elsevier B V
    Liu Wenwei, Chen Sheng, Wu Chuan-Yu, Li Shuiqing Unified size-density and size-topology relations in random packings of dry adhesive polydisperse spheres, In: Physical Review E American Physical Society
    Wu CY, Cocks ACF, Gillia OT, Thompson DA (2003)Experimental and numerical investigations of powder transfer, In: POWDER TECHNOLOGY138(2-3)pp. 216-228 ELSEVIER SCIENCE SA
    Zhang Jianyi, Wu Chuan-Yu, Storey David, Byrne Gerard (2017)The interfacial strength of bilayer pharmaceutical TABLETs, In: Powder Technology Elsevier
    Onasile B, Wu C-Y, Liu Lian (2017)Evaluation of critical factors affecting the quality of roll compacted ribbons, In: 8th International Granulation Workshop Proceedings181
    Schiano Serena, Chen L, Wu Chuan-Yu (2017)The effect of dry granulation on flow behaviour of pharmaceutical powders during die filling, In: Powder Technology337pp. 78-83 Elsevier
    Zakhvatayeva Anastasiya, Hare Colin, Wu Chuan-Yu (2019)Suction filling of pharmaceutical powders, In: Powder Technology Elsevier
    Zhang Ling, Wu Chuan-Yu (2020)Discrete element analysis of normal elastic impact of wet particles, In: Powder Technology362pp. 628-634 Elsevier