Prof. Chuan-Yu (Charley) Wu is a professor in Chemical Engineering at the Department of Chemical and Process Engineering and the coordinator of the Unilever-IPE-Surrey collaborative doctoral training programme in sustainable manufacture, multi-scale modelling, formulation and product engineering. He was also the coordinator of a EU FP7 Initial Training Network (ITN) consortium (€3.8M) on the development of in silico models for roll compaction, which consists of 10 full partners and 4 associate partners from 8 EU countries. He has expertise in discrete element analysis, multiscale modelling and simulations, pharmaceutical engineering, particle technology and granular dynamics. Prof. Wu has been working closely with global pharmaceutical companies over the last 10 years and has run industrial collaborative research projects with Pfizer, AstraZeneca, MSD and Sanofi in developing advanced numerical modelling techniques for pharmaceutical application and established a strong link with the global pharmaceutical industry.
Prof. Wu is currently an executive editor for Powder Technology. He co-authored a monograph on “Particle Technology and Engineering” published by Elsevier and edited two books entitled “Discrete Element Modelling of Particulate Media” and “Particulate Materials: Synthesis, Characterisation, Processing and Modelling” published by RSC publishing. He also edited five journal special issues and published over 100 scientific papers with an H-index of 18. He has given more than 30 invited presentations and seminars at international conferences, global pharmaceutical companies and universities worldwide. Prof. Wu is a member of the advisory and editorial board for “Particuology”, “Acta Pharmaceutica Sinica B (APSB) ” and “Journal of Engineering”.
Prof. Wu is also a grant assessor for ESPRC, Royal Society, European Research Council, French research council (ANR), Canada Research Council, China National Science Foundation and Romania Research Council. He also served as a PhD examiner for the universities of Cambridge, Edinburgh, Birmingham, Leicester, Leeds and Sheffield in the UK, the University of New South Wales and Monash University in Australia, and Abo Akademi University in Finland.
Prof. Wu organized five conferences as the chairman in the fields of particle technology and discrete element modelling (Die compaction and Roll Compaction, 2007; UK-China Particle Technology Forum III, 2009; International Symposium on Discrete Element Modelling, 2012, PARTEC, 2013, Particulate Processing in Pharmaceutical Industry IV, 2014) and is a member of the international advisory and scientific committees for three international conference series (ECI conference on Particulate Processing in Pharmaceutical Industry; UK-China Particle Technology Forum; Coupled Problems).
Areas of specialism
Powder compaction is a widely used manufacturing technique for producing high quality particulate products. Depending on the processing methods, there are two types of powder compaction: roll compaction and die compaction, which have been used either in combination or separately to produce certain particulate products. Powder compaction has distinctive advantages such as cost effectiveness, low waste, continuous process with high productivity and easy online controls. Whilst the same process could be used in manufacturing high value-added products with heat sensitive materials, such as organic materials and polymers, its implementation is significantly hindered by the accumulation of heat, which can significantly degrade heat sensitive materials during the manufacturing processes. THERMOPC is an EC FP7 project funded through the Marie Curie Intra-European Fellowship (IEF) scheme, and employs an inter-disciplinary approach to understand the fundamental mechanisms of powder compaction processes and to develop predictive computational tools for modelling the thermomechanical behaviour during powder compaction.
Indicators of esteem
Proposal Reviewer: European Research Council (ERC); National Science Foundation of China (NSFC); Natural Sciences and Engineering Research Council of Canada; The Executive Agency for Higher Education, Research, Development and Innovation, Romania; French National Research Agency (ANR); Qatar National Research Fund (QNRF).
Member of EPSRC College (2005-)
Guest Editor: Powder Technology, Particuology, Granular Matter, Materials.
Editorial Board Member: Particuology, Journal of Engineering.
PhD Examiner: The universities of Cambridge, Imperial College, Edinburgh, Southampton, Birmingham, Sheffield, Leicester, Leeds, Newcastle, Surrey and Glasgow Caledonian University in the UK; Abo Akademi University in Finland; University of New South Wales \& Monash University in Australia; University of Toulouse in France.
Opponent for PhD thesis public defence: Abo Akademi University, Finland; Ecole Des Mines, Albi, France
Peer Reviewer: Powder Technology, AICHE J, Chemical Engineering Science, Proceedings of the Royal Society London, International Journal of Pharmaceuticals, Journal of Pharmaceutical Science.
Expert Consultant: In the field of X-ray Computed Tomography for pharmaceutical solid oral dosage forms.
Chemical Reaction Engineering and Numerical Methods (Module Coordinator, 2013- 2016)
Equipment Design (2013-2016)
Multidisciplinary Design Project (MDDP, 2013-2015)
Transferable Skills (2013-2014)
Research Methods and Projects (2016)
Chemical Product Design (2017-)
Numerical Methods (2018-)
Multiphase Systems (2007-2012)
Mass Transfer (2009-2012)
Functional Products (2006-2007)
Powder Handling and Processing (Module Coordinator, 2006-2012).
The penetration of a plate into granular media was analyzed, and the effects of particle–plate and particle–particle frictions, penetration direction, and initial plate orientation were examined. Results showed that stress was directly proportional to immersion depth for frictionless particles but jumped at the bed surface and then increased linearly for frictional particles. Moreover, stress was mostly independent of the penetration direction when the plate was frictionless. However, initial orientation always had an effect regardless of whether the plate was frictional or frictionless. Furthermore, a theoretical model was developed for stress analysis. This model revealed that friction on the plate essentially affected stress via changing the push angle of the particles that were in contact with the plate.
Roller compaction followed by milling of the generated ribbons is a typical dry granulation route. It is desirable to be able to predict the size distribution of the granules exiting the mill based on the ribbon properties and mill operational conditions. Two DEM-PBM approaches for predicting this size distribution are compared; a direct approach where the size distribution is experimentally determined, and an indirect approach where the successive change in size distribution due to each stressing event is determined mathematically by the PBM. The experimental component of the direct approach assumes shear deformation to be the dominant breakage mechanism. This approach provides a reasonable agreement to experimental data, though the influence of mill parameters is not experimentally tested. When considering breakage to be driven by impact, the indirect approach predicts the correct magnitude of fines generation, though incorrectly predicts the fine fraction to increase with impeller speed. When abrasion is assumed to be the dominant breakage mechanism, the indirect approach suggests the same trend, though with a less pronounced effect of impeller speed and a closer agreement to experimental data. Prediction accuracy is expected to improve by considering distributions of stressing conditions and material strength, the latter being explicitly captured in the experimental component of the direct method. Furthermore, the direct method accounts for the variable loading conditions of the fragments in the mill.
•The equilibrium position is located below the centerline when both walls are hot.•The equilibrium positions are well characterised by the Richardson number and size ratio.•Bifurcation of the equilibrium position occurs when the temperature of two walls are different.•The critical Reynolds number at the transition point follows a power law of the size ratio. A numerical investigation of lateral migration of a neutrally buoyant particle in Couette flow with two different thermal boundary conditions is performed using a lattice Boltzmann method coupled with a discrete element method. The effects of the channel Reynolds number (Re), the Grashof number (Gr) as well as the particle size on the migration behaviour are explored in detail. It was found that when both the top and bottom walls are hot, the equilibrium positions are located below the centerline for all the particle sizes studied, which can be well characterised using a dimensionless force ratio determined by the Richardson number (Ri=Gr/Re2) and the confinement ratio. With the increase of the force ratio, the equilibrium position moves towards the bottom wall. On the other hand, when the top wall is cold and the bottom wall is hot, a transition of the equilibrium position is observed, which switches from below the centerline to above the centerline as the particle size is increased above a certain threshold. It is discovered that the critical Reynolds number at transition can be well described by a power law of the confinement ratio. Furthermore, it is also found that the variation of the equilibrium positions above the centerline is governed by a new dimensionless parameter Gr/Re for a fixed particle size, which is attributed to the finite size effect.
© 2015 Elsevier B.V. Contact electrification is generally referred to as the charge transfer process between particles during collisions. The transferred charge can be accumulated on the surface of the particles especially for insulating materials with irregular shapes, which can lead to a non-uniform charge distribution and eventually affects the charge accumulation process. In this study, in order to investigate the influence of the particle shape on contact electrification, a sphere-tree multi-sphere method and a contact electrification model are implemented into the discrete element method (DEM) to model the charging process of irregular particles in a rotating drum. Irregular particles with various Sauter mean diameters but the same maximum diameter and equivalent volume diameters are considered. The charge distribution and accumulation on the particles are investigated. It is found that the charge transfer originates from the contact between the particle and the drum due to the contact potential difference and initially takes place primarily at the region near the wall of the drum. The charge eventually propagates to the entire granular bed. The charge of the particles increases exponentially to an equilibrium value. For particles with the same maximum diameter, a larger charging coefficient is obtained for the particles with smaller Sauter mean diameters and sphericities, which leads to a faster charge accumulation, while for particles with the same equivalent volume diameter and fill ratio, similar charging coefficients are observed. A non-uniform intra-particle charge distribution is induced on each individual multi-sphere particle.
Ball indentation is a technique capable of assessing powder flowability down to very low consolidation stresses (≤1 kPa). With this method, powder flowability is determined by measuring the hardness of a powder bed, which allows the unconfined yield strength to be inferred via the constraint factor. The latter is well established for continuum materials, whereas for particulate systems its dependency on stress level and powder properties is not well defined. This work investigates these factors by simulating the ball indentation method using DEM. The constraint factor is shown to be independent of pre-consolidation stress. Constraint factor generally increases with interface energy for relatively cohesion-less powders, though not for cohesive powders. An increase in plastic yield stress leads to a decrease in the constraint factor. Increasing the coefficient of interparticle static friction reduces the constraint factor, while increasing the coefficient of inter-particle rolling friction significantly increases the constraint factor.
© 2015. Milling is a critical process for controlling the properties of the granules produced by roll compaction. In the current study, the positron emission particle tracking (PEPT) technique was used to examine the milling kinematics of roll-compacted ribbons at various milling speeds. Microcrystalline cellulose (MCC, Avicel PH-102) was used as the model feed material and a radioactive particle (tracer) was mixed with the MCC powder and roll-compacted to form sample ribbons. They were then milled using an oscillating mill at various speeds and the kinematics of the ribbons (trajectory, velocity, and occupancy) were quantitatively determined using PEPT. A close examination of the PEPT data reveals that, for milling MCC PH-102 ribbons using the oscillating mill considered in this study, the milling speed plays an important role: at low values, the milling process is dominated by cooperative motion of the ribbons with the blade (i.e. the speeds of the ribbons and the blade are similar, and the ribbons move along with the blade) and the ribbons are milled primarily by abrasion; as the speed increases the ribbons undergo more random motion involving collisions that results in an increase in ribbon breakage and hence an increase in the milling efficiency. It is shown that the PEPT technique is a useful technique for examining milling kinematics of roll-compacted ribbons.
Hoppers and silos are widely used in storing powders in various industries, such as agricultural, chemical, food and pharmaceutical industries. It is of practical importance to design hoppers and silos to ensure smooth discharge of bulk solids from these devices, and to minimise the occurrence of arching, blockage and build-up of materials around the walls. However, due to the complex nature of bulk solids, arching behaviour of bulk solids in silos and hoppers is still not well understood. In this study, a combined experimental and numerical study was performed to explore the transition from non-flow to flow of bulk solids from a flat bottom hopper. Glass beads of various sizes were considered and the minimal orifice size through which these materials can be discharged was determined experimentally using a FlodexTM
Aimed at addressing these challenges, this book contains a selection of papers discussing the state-of-the-art research in particulate materials science that were presented at the UK China Particle Technology Forum III held at Birmingham, ...
© 2014 Elsevier Ltd. The electrostatic charge can be transferred between particles during collisions. The particle shape plays an important role and, in the current study, the charge accumulation and distribution on elongated particles in a vibrating container are investigated using a discrete element method, in which a contact electrification model is implemented. The elongated particle geometry is modelled using a multi-sphere approach. Five different shapes are considered and characterized using a shape factor, δ, which is defined as the ratio of the difference of the radii between the distal sphere and central sphere to the mean radius of the particle. It is found that the net charge on the central sphere is greater than that on the distal sphere when δ0, greater net charge is accumulated on the larger distal sphere. The maximum surface charge difference between the distal and central sphere increases as the shape factor increases. The net charge of the granular system with different particle shapes achieves an equilibrium state during the vibrating process. This accumulating process follows an exponential trend.
The impact between particles or agglomerates and a device wall is considered as an important mechanism controlling the dispersion of active pharmaceutical ingredient (API) particles in dry powder inhalers (DPIs). In order to characterise the influencing factors and better understand the impact induced dispersion process for carrier-based DPIs, the impact behaviour between an agglomerate and a wall is systematically investigated using the discrete element method. In this study, a carrier-based agglomerate is initially formed and then allowed to impact with a target wall. The effects of impact velocity, impact angle and work of adhesion on the dispersion performance are analysed. It is shown that API particles in the near-wall regions are more likely to be dispersed due to the deceleration of the carrier particle resulted from the impact with the wall. It is also revealed that the dispersion ratio increases with increasing impact velocity and impact angle, indicating that the normal component of the impact velocity plays a dominant role on the dispersion. Furthermore, the impact induced dispersion performance for carrier-based DPI formulations can be well approximated using a cumulative Weibull distribution function that is governed by the ratio of overall impact energy and adhesion energy.
Air flow and particle-particle/wall impacts are considered as two primary dispersion mechanisms for dry powder inhalers (DPIs). Hence, an understanding of these mechanisms is critical for the development of DPIs. In this study, a coupled DEM-CFD (discrete element method-computational fluid dynamics) is employed to investigate the influence of air flow on the dispersion performance of the carrier-based DPI formulations. A carrier-based agglomerate is initially formed and then dispersed in a uniformed air flow. It is found that air flow can drag API particles away from the carrier and those in the downstream air flow regions are prone to be dispersed. Furthermore, the influence of the air velocity and work of adhesion are also examined. It is shown that the dispersion number (i.e., the number of API particles detached from the carrier) increases with increasing air velocity, and decreases with increasing the work of adhesion, indicating that the DPI performance is controlled by the balance of the removal and adhesive forces. It is also shown that the cumulative Weibull distribution function can be used to describe the DPI performance, which is governed by the ratio of the fluid drag force to the pull-off force.
Dry granulation through roll compaction followed by milling is a widely used pharmaceutical process. The material properties of powders and the roll compaction process conditions affect the strength of ribbons, and subsequently the granule size distribution (GSD). Accurate prediction of the granule size distribution from milling of ribbons with different properties is essential for ensuring tablet quality in the final compaction stage. In this study, MCC, PH-102 ribbons with precisely controlled porosities were produced and milled in a cutting mill and granule size distribution was analysed using QicPic. A population balance model with a new breakage function based on the Weibull function was developed to model the ribbon milling process. Eight model parameters were initially obtained for each ribbon porosity and very good agreement between the model and experimental results was obtained. Sensitivity analysis was then performed and thus reduced the number of model parameters that changed with ribbon porosity to two in the breakage function. The refined model was able to predict the granule size distribution both within and outside the experimental boundaries. It was shown that the model developed in this study has a great potential for predicting granule properties and therefore the optimisation of the dry granulation process.
Ribbon milling is a critical step in dry granulation using roll compaction as it determines the properties of granules, and subsequently the properties of final products. During ribbon milling, fragmentation of ribbons or flakes (i.e. compressed agglomerates from dry powders) are induced by either impact or abrasion. Understanding these fragmentation mechanisms is critical in optimising ribbon milling processes. In the current study, the discrete element method (DEM) was used to model fragmentation at the microscopic level, providing a detailed insight into the underlying breakage mechanism. In DEM modelling, virtual ribbons were created by introducing an appropriate interfacial energy using the cohesive particle model. A set of three-dimensional parallelepiped ribbons with solid fraction φ=0.7422 and surface energies ranging from γ=0.03 J⁄m^2 and γ=2 J⁄m^2 were created and then fractured during impacts with a plane at various impact velocities, in order to model impact dominated milling. The fragmentation rate, and the number and size of fragments (i.e. granules) resulting from the breakage of a ribbon during the impact were determined. The DEM simulations showed that the granules size distribution had a bimodal pattern and there was a strong correlation between the size of fines generated from fragmentation during impact and the size of the feed powder (i.e. the size of the primary particles in this study), which was consistent with the observation from physical experiments. Two quantities were calculated from the DEM simulations: the number of fragments p and the fraction of fines z for each breakage event which can be used as input parameters for population balance models (PBM) to develop a DEM-PBM modelling framework.
Roll compaction is a commonly used dry granulation process in pharmaceutical, fine chemical and agrochemical industries for materials sensitive to heat or moisture. The ribbon density distribution plays an important role in controlling properties of granules (e.g. granule size distribution, porosity and strength). Accurate characterisation of ribbon density distribution is critical in process control and quality assurance. The terahertz imaging system has a great application potential in achieving this as the terahertz radiation has the ability to penetrate most of the pharmaceutical excipients and the refractive index reflects variations in density and chemical compositions. The aim of this study is to explore whether terahertz pulse imaging is a feasible technique for quantifying ribbon density distribution. A series of ribbons were made of two grades of microcrystalline cellulose (MCC), Avicel PH102 and DG, using a roll compactor at various process conditions and the ribbon density variation was investigated using terahertz imaging and sectioning methods. The density variations obtained from both methods were compared to explore the reliability and accuracy of the terahertz imaging system. An average refractive index is calculated from the refractive index values in the frequency range between 0.5 and 1.5 THz. It is shown that the refractive index gradually decreases from the middle of the ribbon towards to the edges. Variations of density distribution across the width of ribbon are also obtained using both the sectioning method and the terahertz imaging system. It is found that the terahertz imaging results are an excellent agreement with that obtained using the section method, demonstrating that terahertz imaging is a feasible and rapid tool to characterize ribbon density distributions.
The inability of cohesive powders to flow consistently and reliably is a major cause of process downtime and reduced efficiency across a wide range of powder processing industries. Most methods to assess powder flowability fail at low consolidation pressures (
The reduction of raw materials into particulate form using grinding mills is an energy and cost intensive task. Optimization of grinding processes is not trivial as obtaining information on the dynamics of media in the mill via experimental means is extremely difficult due to the harsh environment inside, thus computational modeling is the most feasible option to obtain information on the dynamics of the media. However the computational cost of modeling each particle is high, resulting in the shape of the media being approximated by simple shapes and in most cases a reduction in the size of the mill. Even with these simplifications typical simulations take many weeks to months to complete making it unfeasible for quick design prototyping and process optimization. In the last decade the Graphical Processor Unit (GPU) has enabled large scale simulations of tens of millions of spheres in ball mills using the Blaze-DEM GPU code. Recently this code was expanded to provide detailed contact detection for polyhedra using the volume overlap method which is the most accurate approach amongst commercial and academic codes. In this study we firstly validate the code against experiment for polyhedral both as well as spherical particles. We then perform a number of simulations to study the effect of particle shape, in particular angularity and aspect ratio. We clearly demonstrate the importance of accurate particle shape representation in mill simulations by comparing charge profile, power draw and force network for various polyhedra approximations against spheres.
In this paper, die filling from a stationary shoe in vacuum and in air was analysed using a coupled discrete element method (DEM) and computational fluid dynamics (CFD) code in which the powder is modelled using DEM while the air is analysed using CFD, and the airparticle interaction is considered. The influence of particle size and size distribution on the flow behaviour was also explored. It has been demonstrated that the coupled DEM/CFD is capable of simulating the complex interaction between the air and the powder during die filling. The numerical simulations have revealed that the presence of air during die filling has a significant impact on the powder flow behaviour, especially for the system with smaller particle sizes.
Particle–fluid flows are ubiquitous in nature and industry. Understanding the dynamic behaviour of these complex flows becomes a rapidly developing interdisciplinary research focus. In this work, a numerical modelling approach for complex particle–fluid flows using the discrete element method coupled with the lattice Boltzmann method (DEM-LBM) is presented. The discrete element method and the lattice Boltzmann method, as well as the coupling techniques, are discussed in detail. The DEM-LBM is thoroughly validated for typical benchmark cases: the single-phase Poiseuille flow, the gravitational settling and the drag force on a fixed particle. In order to demonstrate the potential and applicability of DEM-LBM, three case studies are performed, which include the inertial migration of dense particle suspensions, the agglomeration of adhesive particle flows in channel flow and the sedimentation of particles in cavity flow. It is shown that DEM-LBM is a robust numerical approach for analysing complex particle–fluid flows.
Dry granulation using roll compaction (DGRC) becomes increasingly adopted in the pharmaceutical industry due to its unique advantage of not requiring liquid binder and a subsequent drying process. However the DGRC process presents also some challenges, in particular, high fine fraction generated during the milling stage significantly limits its application. Although the fines produced can be recycled in practice, it may lead to poor content uniformity of the final product. At present there is a lack of mechanistic understanding of milling of roll compacted ribbons. For instance, it is not clear how fines are generated, what are the dominant mechanisms and controlling attributes and if any measurement technique can be used to characterise ribbon milling behaviour. Therefore, the aim of this paper was to assess if ribbon milling behaviour can be assessed using some characterization methods. For this purpose, friability was evaluated for ribbons made of microcrystalline cellulose (MCC) powders using a friability tester that was originally developed for characterising the tendency of pharmaceutical tablets to generate small pieces while being abraded. Granules were also produced by milling of the ribbons and their size distributions were analysed. The correlation between the fine fraction of the granules with ribbon friability was then explored. It was found that there was a strong correlation between ribbon friability and the fine fraction of granules generated during milling. This implies that friability tests can be performed to characterise ribbon milling behaviour, and ribbon friability provides a good indication of the fraction of fines generated during ribbon milling.
The use of desktop X ray microtomography (XMT) to characterize randomly packed pharmacheutical particulate systems was discussed. The XMT work was performed using a 1072 Sky Scan desktop system. Glass spheres were used for the particle packing experiment with an average particle size of 200 μm transferred to borosilicate glass capillary tubes of 3 mm diameter. The 2D X-ray tomography images showed clearly defined spheres contained in capillary tube.
Pharmaceutical tablets are the most popular dosage form for drug delivery. The tablets are generally produced by compacting dry powders. During pharmaceutical powder compaction, the tablets produced need to sustain their integrity during the process and have to be strong enough to sustain any possible load experienced during the post-compaction processes, such as coating, packing and handling. Hence, any defects, such as chipping, capping and laminating, are not tolerable during pharmaceutical powder compaction. However, such defects are common problems during the tabletting process. Therefore, understanding the failure mechanisms of these defects has attracted considerable attention. In this paper, only the mechanisms of capping were considered. Previous studies on capping during pharmaceutical powder compaction have been reviewed. Capping mechanisms have been further explored by conducting a combined experimental and computational study on pharmaceutical powder compaction. An instrumented hydraulic press (also known as compaction simulator) has been used to investigate the powder behaviour during the compaction. In addition, an instrumented die has also been used, which enable the material properties to be extracted for some real pharmaceutical powders. Close attentions have been paid to the occurrence of capping during tabletting. An X-ray Computed Microtomography system has also used to examine the internal failure patterns of the tablets produced using the compactions simulator. Furthermore, pharmaceutical powder compaction has also been analysed using finite element (FE) methods, in which the powder was modelled as an elastic-plastic continuum medium following Drucker-Prager-Cap yield criteria and the material properties were determined from the uniaxial compaction with an instrumented die. In both experimental and numerical studies, cylindrical tablets with different surface curvatures, including Flat-face round tablets and convex tablets, were considered. From the experimental observation, it is clear that different capping patterns were obtained for different shaped tablets: cone-shaped capping for flat-faced tablets and normal capping with essentially horizontal failure surface for convex tablets. It was also observed in the experiments that capping takes place at the early stage of decompression (unloading), i.e., the top punch begins to withdraw. Close examination of FEA results reveals that the capping is associated with an intensive shear band developed at the early stage of unloading for all cases considered. Therefore, the combined experimental and numerical studies demonstrated that the intensive shear bands developed at the early stage of unloading are responsible for the occurrence of capping.
Roll compaction is a critical unit operation in the pharmaceutical manufacture. During roll compaction, a change in the internal energy of powder due to applying of external work from the rolls can generate heat and cause an increase in the temperature of the powder, which can subsequently affect the roll compaction behaviour and the quality of ribbons. Thus, it is crucial to understand the thermal response of pharmaceutical formulations during roll compaction. This study hence aims to examine the evolution of temperature and density in powders during roll compaction. For this purpose, a systematic experimental study is performed using the peripheral quantitative computed tomography (PQCT), for the first time, and the thermographic method to investigate the thermomechanical behaviour of pharmaceutical powders during roll compaction. A finite element model is also developed to describe the transformation of irreversible compression work to heat as well as the energy dissipation due to the wall friction, and to predict the thermomechanical behaviour. In particular, the effect of roll speeds on the thermomechanical behaviour of powders during roll compaction is examined. It was shown that at low roll speeds, the highest temperature is reached inside of the compacted powder. As the roll speed increases, more heat is generated on the ribbon surfaces due to the powder-wall friction, while the density of ribbon deceases. It was found that the density and the temperature at the ribbon centre, were generally higher than that near to the edge, for roll compaction with fixed cheek plates.
Positron Emission Particle Tracking (PEPT) is a non-invasive technique which enables quantitative information on the position and 3D motion of a tracer particle during processing to be determined at high frequencies. This technique has been successfully used to investigate powder behaviour during mixing, fluidization, granulation, etc. In this study, PEPT was employed to examine the flow behaviour of powders during die filling. Time histories of displacement and velocity of traced particles were determined. It has been found that the measured displacement and velocity in the moving direction of the feed shoe corresponds very well with the specified shoe motion, demonstrating that the motion of particles during die filling can be accurately determined using PEPT. This will provide useful information to fully understand the die filling process.
Contact electrification occurs in many powder handling processes and involves electrostatic charges that are transferred between contacting particles during collisions. In the current paper, a successive condenser model was developed and implemented into a discrete element method coupled with computational fluid dynamics (DEM-CFD) to analyse the charge transfer during powder processing. The numerical results for the contact electrification between a dielectric particle and a neutral conductive surface were in excellent agreement with experimental data reported in the literature. It was also shown that, during single collisions, the transferred charge is proportional to the maximum contact area but decreases linearly as the initial charge of the particle increases. In a successive impact process, charge accumulation on a particle increases exponentially with the number of collisions and eventually reaches an equilibrium state. During these processes, larger particles gain higher steady state charge but the charge-to-mass ratio is smaller. Nevertheless, particles of different sizes have identical surface charge density and charging coefficient when the impact velocity is identical. In the case of gas fluidization, the electrostatic charge gradually accumulates on particles and eventually reaches an equilibrium state. Non-uniform charge distribution is generally induced. A higher superficial gas velocity results in a faster charge accumulation due to increased collision frequency and impact velocity. © 2013 Elsevier B.V.
In this paper, the compaction of lactose powder, a typical pharmaceutical excipient, is modelled using finite element methods (FEM) in which the powder is represented by an elastic-plastic continuum medium following Drucker-Prager Cap yield criteria. In a recent numerical and experimental study by the present authors , it was found that cone-shaped capping failure occurs during compaction of flat-faced round tablets, and that cone capping is associated with intensive shear band formation during the decompression stage. It is hence instructive to explore possible approaches that might alleviate the propensity for capping. Two approaches to alleviate capping were therefore investigated through finite element analysis: (i) altering the surfaces of the punches, i.e. to make convex tablets using the same material properties, and (ii) altering the material properties, i.e. changing the elasticity of the materials. It was found that capping still takes place even if the surface curvatures of the punches are altered. These predictions have been confirmed by physical experiments using a compaction simulator. The experiments have also demonstrated convincingly that the capping occurs during decompression. The second approach has been investigated in such a way that only the Young's modulus of the powder is changed to values twice and one-half that of lactose. Numerical results reveal that intensive shear bands are still developed during decompression even when the material properties are changed in this way. This implies that similar capping patterns are still possible for those materials. It is anticipated that the reason that some pharmaceutical excipients, such as microcrystalline cellulose (Avicel PH-102), do not cap is because of the high bonding strength of such materials (which can be generally characterised by tensile strength) .
Die filling is a critical process step in pharmaceutical tablet manufacturing. Mass and content uniformity of the tablets as well as production throughput depend upon the die filling performance of the formulations. The efficiency of the die filling process is influenced by powder properties, such as flowability, cohesion, particle size and morphology, as well as the process conditions. It is hence important to understand the influence of powder properties on the die filling performance. The purpose of the present study is to identify the critical material attributes that determine the efficiency of die filling. For this purpose, a model rotary die filling system was developed to mimic the die filling process in a typical rotary tablet press. The system consists of a round die table of 500 mm diameter, equipped with a rectangular die. The die table can rotate at an equivalent translational velocity of up to 1.5 m/s. The filling occurs when the die passes through a stationary shoe positioned above the die table. Using this system, die filling behaviours of 7 commonly used pharmaceutical excipients with various material characteristics (e.g. particle size distribution, sphericity and morphology) and flow properties were examined. The efficiency of die filling is evaluated using the concept of critical filling velocity. It was found that the critical filling velocity is strongly dependent on such properties as cohesion, flowability, average particle size and air sensitivity index. In particular, the critical filling velocity increases proportionally as the mean particle size, flow function, air permeability and air sensitivity index increase, while it decreases with the increase of specific energy and cohesion.
Numerous practical applications of the Discrete Element Method (DEM) require a flexible description of particles that can account for irregular and non-convex particle shape features. Capturing the particle non-convexity is important since it allows to model the physical interlocking when the particles are in contact. To that end, the most flexible approach to capture the particle shape is via a polyhedron, which provides a faceted representation of any shape, albeit at a significant computational cost. In this study we present a decomposition approach to modeling non-convex polyhedral particles as an extension of an existing open source convex polyhedral discrete element code, BlazeDEM-GPU, which computes using general purpose graphical processing units (GPGPUs). Although the principle of decomposition of non-convex particles into convex particles is not new, its application by the discrete element modeling community has been rather limited. The non-convex extension of BlazeDEM-GPU was validated using a hopper flow experiment with identical convex and identical non-convex 3D printed particles. The experiment was designed around two sensitive flow points, with the convex particles following the intermittent flow and the nonconvex particles forming stable arches. It was demonstrated that the DEM simulations can be applied to reproduce both the convex and the non-convex flow behavior using the same parameter set. This study is a significant step towards general computing of non-convex particles for industrial-scale applications using the GPGPUs.
Dry granulation through roll compaction is a technology commonly used in the pharmaceutical industry for producing roll compacted ribbons. The significance of the feed screw speed and roll speed during ribbon production was highlighted in recent publications. However, previous studies focused primarily on the individual effects of either the feed screw speed or roll speed on ribbon porosity, and the synergetic effect of these parameters was rarely examined. The aim of this study therefore was to investigate the effects of the screw-to-roll speed ratio on the porosity of roll compacted ribbons, produced at different roll compaction conditions using the microcrystalline cellulose MCC, Avicel PH-102 feed material. It was observed that ribbon porosity decreased linearly with increasing screw-to-roll speed ratio. Furthermore, an increase in the speed ratio led to an increase in the roll gap and mass throughput while a decrease in the screw constant was observed. Thus, this study demonstrates that the screw-to-roll speed ratio can be treated as one of the critical process parameters for controlling ribbon porosity and can also be used to determine the optimum operating regimes during roll compaction.
In dry granulation, fine cohesive powders are compacted into large multi-particle entities, i.e., briquettes, flakes or ribbons. The powder compaction is generally followed by milling, a size reduction process, which is crucial to obtain the desired granule size or properties. Abrasion and impact are two primary mechanisms of comminution in ribbon milling, but they are not completely understood. The aim of this paper was hence to investigate numerically the fragmentation process induced by abrasion during ribbon milling. The discrete element method (DEM) was employed to simulate abrasion tests, for which three-dimensional parallelepiped ribbons were generated using auto-adhesive elastic spheres. The fragmentation rate, and the fragments size and number were determined for various surface energies and abrasive velocities. The DEM results showed that the mass-equivalent fragment size distributions were bi-modal, similar to the experimental observations and the numerical results for impact-dominated ribbon milling reported in the literature. In addition, two quantities were determined from the DEM analysis, i.e. the number of large fragments and the fraction of fines, which was then integrated into the population balance models (PBM) so that a DEM-PBM multiscale modelling framework was developed to predict the granule size distribution during ribbon milling. The DEM-PBM results were compared with the experimental results reported in the literature, and a broad agreement was obtained, implying the proposed DEM-PBM can be used to analyse the ribbon milling behaviour.
In blast furnaces, burden topography and packing density affect the stability of the burden, permeability of gas flow as well as the heat transfer efficiency. A fundamental understanding of the influence and interaction of coke and ore particles on the burden topography and packing density is therefore essential, in particular the influence of particle shape polydispersity and particle size polydispersity. In this paper we analyze the effect of particle shape and size polydispersity on the coke and ore charge distribution inside a bell-less blast furnace using the discrete element method (DEM). We first validate experimentally the polyhedral particle model with a simplified lab-scale charging experiment. A comparative study between spheres, with rolling friction to account for shape, and polyhedra is conducted for shape and size polydisperse particle systems. It was found that shape polydispersity mainly influenced the topography of the burden, whereas the size polydispersity mainly influenced the inter-layer percolation, i.e. localized particle diffusion, hence the local spatial packing density. The differences between the spherical particle models and polyhedral particle models on the burden topography are also quantitatively and qualitatively presented, especially on the role of particle shape on the push-up of coke in the centre. This study demonstrates that modelling particle shape effects using spheres with rolling friction is insufficient to fully describe the complex behaviour of shaped particles in a blast furnace, as the particle shape has a noteworthy influence on the burden characteristics.
Rotary tabletting presses are widely used to produce tablets in the pharmaceutical industry. In the tabletting process using a rotary press, rotary die filling is one of critical process steps, as powder behaviour during die filling dictates the quality of final products, such as dosage and weight variations. It is hence of importance to understand powder flow behaviour during rotary die filling. The purpose of this study is to identify the critical process parameters and material attributes that determine the die filling performance. For this purpose, a model rotary die filling system with a paddle feeder was constructed to mimic the powder feeding process in a typical rotary press. Using this model system, the effects of turret speed and paddle speed on die filling behaviour were investigated. Three grades of microcrystalline cellulose powders were considered. It was found that the turret speed has a more pivotal role in controlling the die filling performance than the paddle speed. In addition, it is demonstrated that powder flowability has a great impact on the fill weight variation, and a higher weight variation is induced for the powders with poorer flowability.
The flowability and dispersion behavior are two important physicochemical properties of pharmaceutical formulations for dry powder inhalers (DPIs). They are usually affected by the environmental conditions, such as temperature and relative humidity (RH). However, very few studies have been focused on the relationship between the two properties and their dependence on RH during storage. In this research, model pharmaceutical formulations were prepared using mixtures of coarse and fine lactose. The fractions of fines in the mixtures were 0%, 5%, 10% and 20%, respectively. These blends were stored at four different RH, 0%, 30%, 58% and 85%, for 48 hours. The FT4 Powder Rheometer was used to evaluate the powder flowability, and the Malvern Spraytec® laser diffraction system was employed to assess the powder dispersion performance. The results indicated that both the flow and dispersion properties of lactose blends deteriorate after being stored at 85% RH, but improved after being conditioned at 58% RH. The fine particle fractions (FPFs) of the blends with 5% and 10% fine fractions and the as-received coarse lactose decreased when they were conditioned at 30% RH. For the blend with 20 % fine fraction, a high RH during storage (i.e., 85%RH) affected the dispersion property, but had a limited influence on its flowability. While, for the coarse lactose powder, the different RH conditions only affected its flowability, but not the dispersion results. A strong correlation between the powder flowability and its dispersion performance was found.
Thermal properties of powders are critical material attributes that control temperature rise during tableting and roll compaction. In this study, various analytical methods were used to measure the thermal properties of widely used pharmaceutical excipients including microcrystalline cellulose (MCC) of three different grades (Avicel PH 101; Avicel PH 102 and Avicel DG), lactose and mannitol. The effect of relative density on the measured thermal properties was investigated by compressing the powders into specimen of different relative densities. Differential thermal analysis (DTA) was employed to explore endothermic or exothermic events in the temperature range endured during typical pharmaceutical manufacturing processes, such as tabletting and roll compaction. Thermogravimetric analysis (TGA) was performed to analyse the water/solvent content, either in the form as solvates or as loosely bound molecules on the particle surface. Thermal conductivity analysis (TCA) was conducted to measure thermal conductivity and volumetric heat capacity. It is shown that, for the MCC powders, almost no changes in morphology or structural changes were observed during heating to temperatures up to 200 °C. An increase in relative density or temperature leads to a high thermal conductivity and the volumetric heat capacity. Among all MCC powders considered, Avicel DG showed the highest increase in thermal conductivity and the volumetric heat capacity, but this heat capacity was not sensitive to the measurement temperature. For lactose and mannitol, some endothermic events occurred during heating. The thermal conductivity increased with the increase in temperature and relative density. A model was also developed to describe the variation of the thermal conductivity and the volumetric heat capacity with the relative density and the temperature. It was shown that the empirical model can well predict the dependency of the thermal conductivity and the volumetric heat capacity on the relative density and the temperature.
Large-scale gas-solid flow systems, e.g., fluidized beds, cyclone separators and pneumatic conveyors, are often encountered in chemical engineering. Numerical modeling technologies are widely applied for design and understanding of complex phenomena in these gas-solid flow systems, for which the coupled model of the discrete element method (DEM) and computational fluid dynamics is generally employed. However, application of the numerical simulations for these systems is still limited because the number of the particles that can be modeled (about several hundreds of thousand) is quite small comparing with the immeasurable number of particles used in the industrial processes, and not sufficient to fully understand the complex behavior in these processes. The coarse graining DEM is then developed to provide an alternative approach for modeling the real industrial processes. Accuracy of the coarse graining DEM has been proven for simple systems so far. In the present study, applicability of the coarse graining DEM for complex shaped domains is explored, for which typical industrial processes, such as fluidization with inserted tubes, and powder flow into a confined space, are considered. In these calculations, signed distance functions (SDF) and immersed boundary method (IBM) are used to model an arbitrary shape wall boundary in a gas-solid flow. Both numerical modeling using the coarse graining DEM and experimental investigation are performed with a thorough comparison between the experimental and numerical results. It is demonstrated that the coarse graining DEM is capable of accurately modeling of industrial gas-solid two-phase systems. Besides, this numerical approach is shown to provide valuable information such as pressure profile during powder injection and interaction between bubbles and structures in a fluidized bed.
In this work, a computational intelligence (CI) technique named flexible neural tree (FNT) was developed to predict die filling performance of pharmaceutical granules and to identify significant die filling process variables. FNT resembles feedforward neural network, which creates a tree-like structure by using genetic programming. To improve accuracy, FNT parameters were optimized by using differential evolution algorithm. The performance of the FNT-based CI model was evaluated and compared with other CI techniques: multilayer perceptron, Gaussian process regression, and reduced error pruning tree. The accuracy of the CI model was evaluated experimentally using die filling as a case study. The die filling experiments were performed using a model shoe system and three different grades of microcrystalline cellulose (MCC) powders (MCC PH 101, MCC PH 102, and MCC DG). The feed powders were roll-compacted and milled into granules. The granules were then sieved into samples of various size classes. The mass of granules deposited into the die at different shoe speeds was measured. From these experiments, a dataset consisting true density, mean diameter (d50), granule size, and shoe speed as the inputs and the deposited mass as the output was generated. Cross-validation (CV) methods such as 10FCV and 5x2FCV were applied to develop and to validate the predictive models. It was found that the FNT based CI model (in the cases of both CV methods) performed much better than other CI models. Additionally, it was observed that process variables such as the granule size and the shoe speed had a higher impact on the predictability than that of the powder property such as d50. Furthermore, validation of model prediction with experimental data showed that the die filling behavior of coarse granules could be better predicted than that of fine granules.
In this study a hybrid numerical framework for modelling solid-liquid multiphase flow is established with a single-relaxation-time lattice Boltzmann method and the discrete element method implemented with the Hertz contact theory. The numerical framework is then employed to systematically explore the effect of particle concentration on the inertial migration of neutrally buoyant particle suspensions in planar Poiseuille flow. The results show that the influence of particle concentration on the migration is primarily determined by the characteristic channel Reynolds number Re0. For relatively low Re0 (Re0˂20), the migration behaviour can only be observed at a very low particle concentration (≤5%). However, when Re0˃20 the migration behaviour can be observed at a high concentration (≥20%). Furthermore, a focusing number Fc is proposed to characterise the degree of inertial migration. It was found that the inertial migration can be classified into three regimes depending on two critical values of the focusing number, Fc+ and Fc-: i) when Fc˃Fc+, a full inertial migration occurs; ii) when Fc˂Fc-, particles are laterally unfocused; iii) when Fc-˂Fc˂Fc+, a partially inertial migration takes place.
Mixing of particulate systems is an important process to achieve uniformity, in particular pharmaceutical processes that requires the same amount of active ingredient per tablet. Several mixing processes exist, this study is concerned with mechanical mixing of crystalline particles using a four-blade mixer. Although numerical investigations of mixing using four-blades have been conducted, the simplification of particle shape to spherical or rounded superquadric particle systems is universal across these studies. Consequently. we quantify the effect of particle shape, that include round shapes and sharp edged polyhedral shapes, on the mixing kinematics (Lacey Mixing Index bounded by 0 and 1) that include radial and axial mixing as well as the inter-particle force chain network in a numerical study. We consider six 100 000 particles systems that include spheres, cubes, scaled hexagonal prism, bilunabirotunda, truncated tetrahedra, and a mixed particle system. This is in addition to two six million particle systems consisting of sphere and truncated tetrahedra particles that we can simulate within a realistic time frame due to GPU computing. We found that spherical particles mixed the fastest with Lacey mixing indices of up to 0.9, while polyhedral shaped particle systems mixing indexes varied between 0.65 and 0.87, for the same mixing times. In general, to obtain a similar mixing index (of 0.7), polyhedral shaped particle systems needed to be mixed for 50% longer than a spherical particle system which is concerning given the predominant use of spherical particles in mixing studies.
Dry granulation is commonly used in the pharmaceutical industry for compressing heat and moisture sensitive feed materials into compacts, subsequently followed by milling. Population balance models (PBMs) are often used to explore the effects of milling conditions on the granule size distribution (GSD) but limited studies have investigated the effects of the feed material and ribbon properties on the resulting GSD. In this work, a variety of feed materials and ribbons with different mechanical properties were used to validate a mass-based bi-modal breakage function developed in a previous study (Olaleye et al., 2019). Ribbon like tablets (referred to as ribblets) with a range of precisely controlled porosities were produced using an Instron machine and pharmaceutical excipients including the microcrystalline cellulose MCC 101, MCC DG and a DCPA/MCC mixture. Roll compacted ribbons were also produced using MCC 102 and MCC DG excipients. The ribblets and ribbons were milled in an impact-dominated cutting mill and PBM parameters were obtained from the ribblet milling data. Mechanistic models related to the feed ribbon property were then developed. It was found that the PBM with the mass-based bi-modal breakage function can accurately predict the GSDs of both the milled ribblets and roll compacted ribbons. The model developed was successfully linked to ribbon properties such as porosity for the first time and the model parameter a that reflects the fines mode in the bi-modal breakage function increased linearly with ribblet porosity. This work demonstrates the versatility of the developed PBM and provides a systematic approach for describing the ribbon milling process.
Contact electrification and electrostatic interactions often occur in the fluidization process, which can significantly influence the dynamic behaviour of particles and the fluidization performance. In this study, a discrete element method coupled with computational fluid dynamics (DEM-CFD) is developed by implementing contact electrification and electrostatic interaction models and the combined effects of contact electrification and electrostatic interaction on fluidization are analysed. It is found that the charge of the particle system increase with the superficial gas velocity. Particles of different material properties (especially work function) can be bi-charged and form agglomerates. At low superficial gas velocities, the particle bed cannot be fully fluidized and the pressure drop tends to be stable rather than fluctuating as the gas flows through the micro-channels of agglomerates. However, at high superficial gas velocities, the agglomerates can break, inducing strong fluctuation of pressure drop. Clearly, the electrostatic phenomena and fluidization behaviour can mutually influence each other during the process.
Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method, which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criterion is proposed to determine the lowest impact velocity at which two elastic autoadhesive spherical particles will rebound from each other during impact. Furthermore, the process of fine API particles adhering to a large carrier in a vibrating container is investigated. It was found that there are optimal amplitude and frequency for the vibration velocity that can maximise the number of particles contacting with the carrier (i.e. the contact number). The impact number and detachment number during the vibration process both increase with increasing vibration amplitude and frequency while the sticking efficiency decreases as the amplitude and frequency are increased. © 2013 Springer-Verlag Berlin Heidelberg.
The present study investigated particle size-induced segregation during die filling of binary pharmaceutical blends, consisting of fine and coarse particles in various fractions. Coarse fraction was made of milled and sieved acetylsalicylic acid, whereas the fine fraction was mannitol. The die filling process was carried out in gravity filling and suction filling. The segregation was assessed through determination of the coarse component concentration using UV–Visible spectrophotometry. The obtained values of concentration, determined for ten units of identical volume inside the die, were used to calculate the segregation index (SI), which was an indicator of uniformity of the powder blend deposited into the die. It was found that high segregation tendency was generally observed during gravity filling at a low velocity, due to the effect of air drag, and during gravity filling at a high velocity, as it was carried out through three consecutive filling steps. The lowest segregation tendency was generally observed during suction filling at a low velocity. The horizontal segregation was mostly observed in the top layers of the die, due to mainly two mechanisms: coarse particles cascading down the heap formed by the powder in the final steps of die filling, which produces higher coarse concentration at the near side of the die, observed at low coarse concentration; or coarse particle cascading down the top surface of the flowing powder stream into the die, which increases the coarse concentration at the far end of the die.
Understanding the dependence of the strength of agglomerates on material properties, interfacial properties and structure of the agglomerate is critical in many processes involving agglomerates. For example, in the manufacturing of pharmaceutical tablets and pellets with dry granulation, understanding the relationship between the ribbon properties and the properties of the granules is critical in controlling the granulation behaviour, and the ribbon properties (e.g. tensile strength and density distribution) is determined by the material properties of the feed powders, interfacial properties between particles and the process condition, which determine the structure of the ribbons. This study aims to investigate the effect of the surface energy and porosity on the bending strength of pharmaceutical ribbons, for which three-dimensional discrete element modelling with a cohesive particle model based upon the JKR theory was performed. Simulations were carried out using specimens of various porosities and surface energies. The dependence of the bending strength on the surface energy and the ribbon porosity was examined. It was found that there is a strong correlation between the bending strength with porosity and surface energy. In particular, the bending strength is proportional to the surface energy and is an exponential function of the porosity.
We study the size-density/topology relations} in random packings of dry adhesive polydisperse microspheres with Gaussian and lognormal size distributions through a geometric tessellation. We find that the dependence of the neighbour number on the centric particle size is always quasilinear, regardless of the size distribution, the size span or interparticle adhesion. The average local packing fraction as a function of normalized particle size for different size variances is well regressed on the same profile, which increases to larger values as the relative strength of adhesion decreases. The variations of the local coordination number with the particle size converge onto a single curve for all the adhesive particles, but gradually transfer to another branch for non-adhesive particles. Such adhesion induced size-density/topology relations} are interpreted theoretically with a modified geometrical "granocentric" model, where the model parameters are dependent on a single dimensionless adhesion number. Our findings, together with the modified theory, provide a more unified perspective on the substantial geometry of amorphous polydisperse systems, especially those with fairly loose structures.
As one of the commonly-used solid dosage forms, pharmaceutical tablets have been widely used to deliver active drugs into the human body, satisfying patient’s therapeutic requirements. To manufacture tablets of good quality, diluent powders are generally used in formulation development to increase the bulk of formulations and to bind other inactive ingredients with the active pharmaceutical ingredients (APIs). For formulations of a low API dose, the drug products generally consist of a large fraction of diluent powders. Hence, the attributes of diluents become extremely important and can significantly influence the final product property. Therefore, it is essential to accurately characterise the mechanical properties of the diluents and to thoroughly understand how their mechanical properties affect the manufacturing performance and properties of the final products, which will build a sound scientific basis for formulation design and product development. In this study, a comprehensive evaluation of the mechanical properties of the widely-used pharmaceutical diluent powders, including microcrystalline cellulose (MCC) powders with different grades (i.e., Avicel PH 101, Avicel PH 102, and DG), mannitol SD 100, lactose monohydrate, and dibasic calcium phosphate, were performed. The powder compressibility was assessed with Heckel and Kawakita analyses. The material elastic recovery during decompression and in storage was investigated through monitoring the change in the dimensions of the compressed tablets over time. The powder hygroscopicity was also evaluated to examine the water absorption ability of powders from the surroundings. It was shown that the MCC tablets exhibited continuous volume expansion after ejection, which is believed to be induced by (1) water absorption from the surrounding, and (2) elastic recovery. However, mannitol tablets showed volume expansion immediately after ejection, followed by the material shrinkage in storage. It is anticipated that the expansion was induced by elastic recovery to a limited extent, while the shrinkage was primarily due to the solidification during storage. It was also found that, for all powders considered, the powder compressibility and the elastic recovery depended significantly on the particle breakage tendency: a decrease in the particle breakage tendency led to a slight decrease in the powder compressibility and a significant drop in immediate elastic recovery. This implies that the particle breakage tendency is a critical material attribute in controlling the compression behaviour of pharmaceutical powders.
The oral drug delivery system using bilayer (or multilayer) tablets has become more commonly used in therapeutic strategies. However, one of the most common problems associated with bilayer tablets is the insufficient interfacial strength between layers, which leads to product failure during manufacturing. Therefore, it is important to better understand the interfacial strength of bilayer pharmaceutical tablets. For this purpose, in this study, the interfacial strength of bilayer tablets made of microcrystalline cellulose (MCC PH 102) at various manufacturing conditions was systematically examined. Three cases were considered: (1) the effect of interfacial curvature on the interfacial strength, for which the interfaces between two layers with different curvatures were produced using flat, convex and concave punches. (2) The effect of water content on the interfacial strength, for which the powder was conditioned at various relative humidity before being used to produce bilayer tablets. (3) The effect of the particle size of the powder used in first layer on the interfacial strength, for which the feed powder was sieved to obtain powders with specific particle sizes that were then used to produce the first layer of the bilayer tablets. For all cases considered, direct tensile tests were performed to measure the tablet interfacial strength. It is found that the interfacial curvature, the water content and the particle size in the first layer affected the interfacial strength significantly. It is also shown that the tablet interfacial strength was increased when larger particles were used in the first layer, or when curved punches (i.e. either convex or concave punches) were used to produce curved interfaces with increased interfacial areas. In addition, a higher interfacial strength can also be achieved by properly controlling water content in the powder.
Solid pharmaceutical tablets can be manufactured via three processing technologies: direct compression, dry granulation and wet granulation before the final compaction process. Dry granulation using roll compaction generally involves production of ribbons, followed by milling to produce granules and the production of tablets. The mechanical properties of ribbons produced during roll compaction can influence breakage behaviour in a mill and hence the performance of a drug formulation. Therefore it is important to explore critical factors that determine the quality of ribbons. In this study, MCC Avicel PH-102 was used as the model powder for roll compaction and the critical operating factors affecting ribbon quality were studied. MCC 102 ribbons were manufactured at a range of process conditions (roll speed, feed screw speed and compaction pressure) using the TF mini roll compactor with a serrated die & punch (DPS), grooved roll surface. The key ribbon properties measured are the powder feed ratio (defined as the ratio of feed screw speed to that of roll speed) and mass throughput ratio (defined as the mass of ribbons produced in a given time to that of fines). The porosity of ribbons was observed to depend significantly on powder feed ratio into the compaction zone. Porosity remained constant at a fixed feed ratio irrespective of the absolute roll speed and the feed screw speed conditions used. Mass throughput ratio is another factor that was introduced to describe process efficiency i.e. to draw comparison between the amount of ribbons and fines. The amount of ribbons and fines generated at a given process condition depends significantly on the feed screw speed and the compaction pressure. In addition, ribbon porosity decreased with increasing pressure but there was negligible effect on ribbon porosity when excessively high pressure (> 60 bar) was used. Ribbon porosity was also observed to decrease with increasing feed screw speed but the converse is true with increasing roll speed. In conclusion, the impact of various roll compaction process parameters were critically investigated and a detailed insight into the main factors (powder feed and mass throughput ratios) that govern the behaviour of roll compacted ribbons was provided. In future, the focus is to relate these process properties (and ribbon porosity) to granule size distribution from a milling process.
Flowability that quantifies the flow behaviour of powders is an important material attribute for such applications as packing, hopper flow and powder transport. It is also one of the critical material attributes of pharmaceutical formulations for solid dosage forms. It is anticipated that size enlargement via dry/wet granulation will improve the flowability of feed powders, but it is still unclear how significant the flowability can be enhanced. Therefore, in this study, an experimental investigation was performed to explore how dry granulation affects the flowability of pharmaceutical powders, such as microcrystalline cellulose (MCCs), mannitol and lactose. Both as-received powders and binary mixtures were considered. Granules of various sizes were produced using roll compaction followed by ribbon milling, and the flowability of as-received powders and produced granules was characterised using two methods: 1) the critical filling speed measured using a model die filling system and 2) the flow index measured using a Flodex tester. It was shown that the flowability increases as the size of the granules increases for all materials considered. Furthermore, it was found that there is a strong correlation between the critical filling speed and the flow index: the critical filling speed is proportional to the flow index to a power of − 5/2.
Die filling is an important process step in manufacturing of tablets. An important mechanism in the die filling process is suction that is developed with the downward motion of the bottom punch once the die is covered by powder. However, the contribution of suction to the die filling performance is still poorly understood. Hence, the present study aimed to experimentally investigate the flow behaviour of powders during suction filling. Four different types of pharmaceutical powders were used and a model suction filling system was developed. Effects of filling and suction velocities, as well as powder properties, on the efficiency of die filling were systematically investigated. Cohesive and free-flowing powders behaved differently at various filling-to-suction velocity ratios. The filling behaviour of cohesive powders was improved at high filling-to-suction ratios due to acceleration-induced densification. Free-flowing powders performed better at low filling-to suction ratios.
The presence of liquids in particulate materials can have a significant effect on their bulk behaviour during processing and handling. It is well recognised that the bulk behaviour of particulate materials is dominated by the interactions between particles. Therefore, a thorough understanding of particle-particle interaction with the presence of liquids is critical in unravelling complex mechanics and physics of wet particulate materials. In the current study, a discrete element method for wet particulate systems was developed, in which a contact model for interactions with pendular liquid bridges between particles of different sizes was implemented. In order to evaluate the accuracy and robustness of the developed DEM, normal elastic impacts of wet particles with a wall were systematically analysed. It was shown that the DEM simulations can accurately reproduce the experimental observations reported in the literature. In addition, the DEM analysis was also in good agreement with the elastohydrodynamic model. It was further demonstrated that the rebound behaviour of wet particles is dominated by the Stokes number. There was a critical Stokes number, below which the particle will stick with the wall. For impacts with a Stokes number higher than the critical Stokes number, the coefficient of restitution increases as the stokes number increases for elastic particles. It was also found that the contact angle and surface tension played an insignificant role in the normal impact of wet particles, while the viscosity of the liquid has a dominant effect on the rebound behaviour.