Dr Giovanna Nalesso


Lecturer in Musculoskeletal Biology, Director of Research, School of Veterinary Medicine
PhD
10-6 by appointment only

Academic and research departments

School of Veterinary Medicine.

Biography

University roles and responsibilities

  • Research Director of the School of Veterinary Medicine

    Previous roles

    01 July 2019 - 30 March 2021
    PGR director of the School of Veterinary Medicine
    University of Surrey

    Research

    Research interests

    Research collaborations

    Indicators of esteem

    • 2019: University of Surrey Researcher of the Year, runner up

      2014: New Investigator Award, Osteoarthritis Research Society International

      2011-present: reviewer for: Frontiers Bioengineering and Biotechnology, Stem Cells Reports, Scientific reports, Annals of Rheumatic diseases, Arthritis and Rheumatology, Arthritis Research and Therapy, Osteoarthritis and Cartilage, ECM, Tissue Engineering, Cartilage, PLOS one, Journal of Physiology, Journal of British Pharmacology

       

      Supervision

      Postgraduate research supervision

      My teaching

      Courses I teach on

      Undergraduate

      My publications

      Highlights

      ● Scucuglia Heluany C, Barbim Donate P, Henriques Schneider A, Fabris AL, Gomes RA, Villas-Boas IM, Vilarinho Tambourgi D, Aparecida Silva T, Goulart Trossini GH, Nalesso G, Lani Volpe Silveira E, Queiroz Cunha F, Poliselli 4 Farsky SH, Hydroquinone exposure worsens rheumatoid arthritis through the activation of the aryl hydrocarbon receptor and interleukin-17 pathways. Antioxidants 2021, Accepted, in press

      ● Thomas BL, Nosrati B, Alvarez M, Thorup AS, Nalesso G, Caxaria S, Eldridge SE, Barawi A, Nicholson JG, Perretti M, Gaston-Muassett C, Maloney A, Moore A, Jupp R, Dell’Accio F WNT3A-loaded exosomes enable cartilage repair. J Extracell Vesicles. 2021 May;10(7):e12088. doi: 10.1002/jev2.12088. Epub 2021 May 19. ● Nalesso G# , Thorup AS, Eldridge SE, de Palma A, Kaur A, Peddireddi K, Blighe K, Rana S, Stott B, Vincent TL, Balu S, Thomas BL, Bertrand J, Sherwood, J, Fioravanti A, Achan P, Pitzalis C, Dell’Accio F, Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. Sci rep, 2021 Mar 11;11(1):5682. doi: 10.1038/s41598-021-82067-w.

      ● Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford J, Pitzalis C, Aigner T , Corder R, Bertrand J and Dell’Accio F. ROR2 blockade as a therapy for osteoarthritis. Sci Transl Med 2020 Sep 16;12(561):eaax3063.doi: 10.1126/scitranslmed.aax3063. ● Budd E, Nalesso G, Mobasheri A. Extracellular genomic biomarkers of osteoarthritis. Expert Rev Mol Diagn. 2018 Jan;18(1):55-74. doi: 10.1080/14737159.2018.1415757. Epub 2017 Dec 15.

      ● Rahmati M, Nalesso G, Mobasheri A, Mozafari M. Aging and Osteoarthritis: Central Role of the Extracellular Matrix. Ageing Res Rev. 2017 Jul 31. pii: S1568-1637(16)30284-7. doi: 10.1016/j.arr.2017.07.004. [Epub ahead of print] Review.

      ● Nalesso G*, Thomas BL, Yu Y, Sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup AS, Dale L, Schett G, Zwerina J, El Tawil N, Pitzalis C, Dell’Accio F. Wnt16 antagonizes excessive canonical WNT activation and protects cartilage in osteoarthritis. Ann Rheum Dis. 2017 Jan;76(1):218-226. doi: 10.1136/annrheumdis-2015-208577.

      ● Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M, Dell’Accio F. Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Ann Rheum Dis. 2015 Aug

      ● Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell'Accio F. A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis. 2014 Aug 18

      ● Greco KV*, Nalesso G*, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F, Perretti M. Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol. 2014 Aug 9

      ● Heywood HK, Nalesso G, Lee DA, Dell'accio F. Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access. 2014 Feb 1

      ● Slack RJ, Russell L, Barton NP, Weston C, Nalesso G, Thompson S-A, Allen M, Chen YH, Barnes A, Hodgson ST, Hall DA. Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.Pharma Pharmacology research and Perspectives 30 DEC 2013 ● Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'accio F, Raschke MJ, Pap T, Dreier R. Bone fracture repair, but not fetal skeletal development is supported by syndecan-4. Arthritis Rheum. 2012 Dec 11

      ● Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W, Rutsch F, Dell'accio F, Pap T Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.. Ann Rheum Dis. 2012

      ● Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell’Accio F, Perretti M. High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol. 2011 Dec 15

      ● Nalesso G; Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell’Accio F. “WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways”., J Cell Biol.,2011 May; 193: 551-564. This paper attracted a comment from Kestler and Kuhl in the same issue (J Cell Biol., 2011 May; 193: 431-3) and has been selected as editor’s choice in a comment by Gough in Science Signalling (Sci Signal., 2011 May; 172:ec134).

      ● Brunati AM, Tibaldi E, Carraro A, Gringeri E, D'Amico F Jr, Toninello A, Massimino ML, Pagano MA, Nalesso G, Cillo U. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. Biochim Biophys Acta. 2008 Mar; 1783(3):347-5.5 *co-first authorship; # corresponding author

      Publications

      • Nalesso G*, Thomas BL*, Yu Y, Sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup AS, Dale L, Schett G, Zwerina J, El Tawil N, Pitzalis C, Dell'Accio F. Wnt16 antagonizes excessive canonical WNT activation and protects cartilage in osteoarthritis. Ann Rheum Dis. 2016 May 4. pii: annrheumdis-2015-208577. doi: 10.1136/annrheumdis-2015-208577. [Epub ahead of print]

      • Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M, Dell'Accio F. Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Ann Rheum Dis. 2015 Aug

      • Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C, Luyten FP, Pitzalis C, Pap T, Dell'Accio F. A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis. 2014 Aug 18

      • Greco KV*, Nalesso G*, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F, Perretti M. Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol. 2014 Aug 9

      • Heywood HK, Nalesso G, Lee DA, Dell'accio F. Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access. 2014 Feb 1

      • Slack RJ, Russell L, Barton NP, Weston C, Nalesso G, Thompson S-A, Allen M, Chen YH, Barnes A, Hodgson ST, Hall DA. Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor.Pharma Pharmacology research and Perspectives 30 DEC 2013

      • Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P, Dell'accio F, Raschke MJ, Pap T, Dreier R. Bone fracture repair, but not fetal skeletal development is supported by syndecan-4. Arthritis Rheum. 2012 Dec 11

      • Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W, Rutsch F, Dell'accio F, Pap T Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.. Ann Rheum Dis. 2012 Apr 17

      • Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell'Accio F, Perretti M. High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol. 2011 Dec 15

      • Nalesso G; Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F. “WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways”., J Cell Biol.,2011 May; 193: 551-564. This paper attracted a comment from Kestler and Kuhl in the same issue (J Cell Biol., 2011 May; 193: 431-3) and has been selected as editor's choice in a comment by Gough in Science Signalling (Sci Signal., 2011 May; 172:ec134).

      • Brunati AM, Tibaldi E, Carraro A, Gringeri E, D'Amico F Jr, Toninello A, Massimino ML, Pagano MA, Nalesso G, Cillo U. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. Biochim Biophys Acta. 2008 Mar; 1783(3):347-5.