My research project
Control of avian pathogenic Escherichia coli by non-antibiotic compounds inducing trained immunity of chicken macrophages
Avian colibacillosis is a global health and welfare issue, resulting in significant economic losses to the poultry industry. Historically, the causative organism Avian Pathogenic Escherichia coli (APEC) was controlled with antibiotics. However, the increasing prevalence of resistance to antimicrobials has driven demand for alternative approaches. In this project, trained immunity, the non-specific immunological memory of innate immune cells resulting from epigenetic changes following organic or inorganic stimulation, was investigated as a novel control strategy for APEC.