Mohammed Asim

Mohammad Asim


Head of Oncology (Section Lead) & University Lecturer in Molecular Cancer Biology
BSc MSc PhD FHEA
Mon-Fri, By appointment only

Biography

Areas of specialism

Cancer Biology ; Transcription Biology; Prostate Cancer; Cancer Therapeutics; Nuclear hormone receptors

University roles and responsibilities

  • Personal Tutor
  • PTY Tutor
  • MD/PhD examiner

My qualifications

2014
Fellowship of the Higher Education Academy of the United Kingdom
Higher Education Academy of the United Kingdom
October 2003-October 2006
Doctor of Philosophy (PhD)
PhD thesis studying the role of signal transduction and transcriptional cofactors in the regulation of androgen receptor function in prostate cancer
Justus Liebig University Germany
August 1999-July 2001
MSc in Biotechnology
Hamdard University, New Delhi, India
August 1995- July 1998
BSc in Botany, Chemistry, Zoology
MJP Rohilkhand University, Bareilly, India

Affiliations and memberships

1. American Association for the Advancement of Science
2. American Association for Cancer Research
3. Higher Education Academy of the United Kingdom
4. The Royal Society of Biology of the United Kingdom

Research

Research interests

My teaching

Courses I teach on

Undergraduate

My publications

Highlights

Publications

Asim M (Corresponding author), Tarish F, Zecchini HI, Sanjiv K, Gelali E, Massie CE, Baridi A, Warren AY, Zhao W, Ogris C, McDuffus LA, Mascalchi P, Shaw G, Dev H, Wadhwa K, Wijnhoven P, Forment JV, Lyons SR, Lynch AG, O'Neill C, Zecchini VR, Rennie PS, Baniahmad A, Tavaré S, Mills IG, Galanty Y, Crosetto N, Schultz N, Neal D, Helleday T. (2017) Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nat Commun. 29;8(1):374. PMID: 28851861

Ross-Adams H, Ball S, Lawrenson K, Halim S, Russell R, Wells C, Strand SH, Ørntoft TF, Larson M, Armasu S, Massie CE, Asim M, Mortensen MM, Borre M, Woodfine K, Warren AY, Lamb AD, Kay J, Whitaker H, Ramos-Montoya A, Murrell A, Sørensen KD, Fridley BL, Goode EL, Gayther SA, Masters J, Neal DE, Mills IG. (2016) 'HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer.' Oncotarget. 2016 Oct 9. PMID: 27732966

Asim M (Corresponding author), Massie CE, Neal DE. (2016) 'Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer.' Mol Cell Oncol. 2016 Feb 24;3(3):e1140262. PMID: 27314091

Asim M (Corresponding author), Massie CE, Orafidiya F, Pértega-Gomes N, Warren AY, Selth LA, Zecchini HI, Qureshi A, Baridi A, Menon S, Madhu B, Escriu C, Lyons S, Zecchini V, Shaw G, Hessenkemper W, Russell R, Mohammed H, Stefanos N, Lynch AG, Grigorenko E, D'Santos C, Taylor C, Lamb A, Sriranjan R, Yang J, Stark R, Dehm SM, Rennie PS, Baniahmad A, Carroll JS, Griffiths JR, Tavaré S, McEwan IJ, Mills IG, Tilley WD, & Neal DE. (2016) 'Choline kinase alpha is an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target' J Natl Cancer Inst. 11;108(5). PMID: 26657335

Pertega-Gomes N, Felisbino S, Massie CE, Vizcaino JR, Coelho R, Sandi C, Sousa S, Jurmeister S, Ramos-Montoya A, Asim M, Tran M, Oliveira E, Lobo da Cunha A, Maximo V, Baltazar F, Neal DE, Fryer LG. (2015) 'A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: A role for Monocarboxylate Transporters as metabolic targets for therapy.' J Pathol. Aug;236(4):517-30. PMID: 25875424

Mahmood I, Ahmad I, Asim M, Lopes TT, Costa L (2014) 'Silica-coated iron oxide nano-particles in vitro genotoxicity assessment and its interference with mercury co-exposure in European eel Anguilla anguilla L.' Environmental Science and Pollution Research Mar;22(5):3687-96. PMID: 25256583

Zecchini V, Madhu B, Russell R, Pértega-Gomes N, Warren A, Gaude E, Borlido J, Stark R, Zecchini HI, Rao R, Scott H, Boren J, Massie C, Asim M, Brindle K, Griffiths J, Frezza C, Neal D, Mills IG. (2014) 'Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer.' EMBO Journal Jun 17;33(12):1365-82. PMID: 24837709

Eckey M, Kraft F, Kob R, Escher N, Asim M, Fischer H, Fritsche MK, Melle C, Baniahmad A. (2013) 'The corepressor activity of Alien is controlled by CBP/p300.' FEBS Journal Apr;280(8):1861-8. PMID: 23441852

Altay G, Asim M, Markowetz F, Neal DE. (2011) 'Differential C3NET reveals disease networks of direct physical interactions.' BMC Bioinformatics Jul 21;12:296. PMID: 21777411

Asim M, Hafeez BB, Siddiqui IA, Gerlach C, Patz M, Mukhtar H, Baniahmad A. (2011) 'Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.' Journal of Biological Chemistry Oct 28;286(43):37108-17. PMID: 21856747

Siddiqui IA, Asim M (Joint first), Hafeez BB, Adhami VM, Tarapore RS, Mukhtar H. (2011) 'Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer.' FASEB Journal Apr;25(4):1198-207. PMID: 21177307

Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H. (2009) 'Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.' Carcinogenesis May;30(5):808-17. PMID: 19233958

Eisold M, Asim M, Eskelinen H, Linke T, Baniahmad A. (2009) 'Inhibition of MAPK-signaling pathway promotes the interaction of the corepressor SMRT with the human androgen receptor and mediates repression of prostate cancer cell growth in the presence of antiandrogens.' J Mol Endocrinol. May;42(5):429-35. PMID: 19223455

Siddiqui IA, Adhami VM, Bharali DJ, Hafeez BB, Asim M, Khwaja SI, Ahmad N, Cui H, Mousa SA, Mukhtar H. (2009) 'Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate.' Cancer Research Mar 1;69(5):1712-6. PMID: 19223530

Hafeez BB, Adhami VM, Asim M, Siddiqui IA, Bhat KM, Zhong W, Saleem M, Din M, Setaluri V, Mukhtar H. (2009) 'Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator.' Clin Cancer Research Jan 15;15(2):452-9. PMID: 19147749

Khan N, Asim M (Joint first), Afaq F, Abu Zaid M, Mukhtar H. (2008) 'A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.' Cancer Research Oct 15;68(20):8555-63. PMID: 18922931

Asim M, Siddiqui IA, Hafeez BB, Baniahmad A, Mukhtar H. (2008) 'Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.' Oncogene Jun 5;27(25):3596-604. PMID: 18223692

Hafeez BB, Asim M, Siddiqui IA, Adhami VM, Murtaza I, Mukhtar H. (2008) 'Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth.' Cell Cycle 2008 Nov 1;7(21):3320-6. PMID: 1894874

Hafeez BB, Siddiqui IA, Asim M, Malik A, Afaq F, Adhami VM, Saleem M, Din M, Mukhtar H. (2008) 'A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.' Cancer Research 2008 Oct 15;68(20):8564-72. PMID: 18922932

Saleem M, Maddodi N, Abu Zaid M, Khan N, bin Hafeez B, Asim M, Suh Y, Yun JM, Setaluri V, Mukhtar H. (2008) 'Lupeol inhibits growth of highly aggressive human metastatic melanoma cells in vitro and in vivo by inducing apoptosis.' Clin Cancer Research Apr 1;14(7):2119-27. PMID: 18381953

Siddiqui IA, Shukla Y, Adhami VM, Sarfaraz S, Asim M, Hafeez BB, Mukhtar H. (2008) 'Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.' Pharm Res. Sep;25(9):2135-42. PMID: 18317887

Moehren U, Papaioannou M, Reeb CA, Grasselli A, Nanni S, Asim M, Roell D, Prade I, Farsetti A, Baniahmad A. (2008) 'Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development.' FASEB Journal Apr;22(4):1258-67.PMID: 17991730

Siddiqui IA, Malik A, Adhami VM, Asim M, Hafeez BB, Sarfaraz S, Mukhtar H. (2008) 'Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis.' Oncogene Mar 27;27(14):2055-63. PMID: 17998943

Siddiqui IA, Saleem M, Adhami VM, Asim M, Mukhtar H. (2007) 'Tea beverage in chemoprevention and chemotherapy of prostate cancer.' Acta Pharmacol Sin. Sep;28(9):1392-408. PMID: 17723173

Gessner G, Schönherr K, Soom M, Hansel A, Asim M, Baniahmad A, Derst C, Hoshi T, Heinemann SH. (2005) 'BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells.' J Membr Biol. Dec;208(3):229-40. PMID: 16604468

Papaioannou M, Reeb C, Asim M, Dotzlaw H, Baniahmad A. (2005) 'Co-activator and corepressor interplay on the human androgen receptor.' Andrologia. Dec;37(6):211-2.