Dr Morro ML Touray


Research Fellow in Health Economics
MSc (GCU), MSc (LSE), PhD (USW)
+44 (0)1483 688614
02 PGM 00
Monday to Friday: 09:00 - 17:00

Biography

My qualifications

1999
MSc Development Management (Distinction)
Glasgow Caledonian University
2006
Postgraduate Diploma
London School of Hygiene and Tropical Medicine
2006
MSc Health Policy, Planning and Finance
London School of Economics and Political Science
2018
PhD in Health Economics
University of South Wales

Affiliations and memberships

1. The Association for the Study of Obesity - UK (ASO)
2. The International Association for the Study of Obesity (IASO)
3. Scottish Health Economics (SHE)

Research

Research interests

My publications

Publications

Touray MM (2013) Research on obesity ? time to think about the next agendas, Progress in Health Sciences 3 (2) pp. 40-52 Medical University of Bialystok
The purpose of this paper is to highlight a fundamental gap in the economic research on obesity -- the demand for unnecessary weight gain preventive goods. Such research is important as it will provide understanding of people's preventive behaviours and for that matter inform policies and practices with regards to influencing people's uptake of obesity preventive goods. Using MeSH and PICO approaches, a search strategy was developed to search for relevant articles in a number of academic and scientific journal repositories including PubMed Central, EconLit, Medline, Medscape and relevant (economic) journals' archives. A total of 1351 potentially relevant articles (titles and abstracts) were reviewed. No publications could be found that concerned people's preventive behaviours in terms of demand with respect to obesity preventive goods. Only one article which was not specific to obesity looked into people's preventive behaviours using an economic model. Despite the huge economic and health burden of obesity, participations in activities deemed supportive to weight gain prevention are dismal.
Touray MM, Hutubessy R, Acharya A (2011) The cost effectiveness of pneumococcal conjugate vaccine in the routine infant immunisation programme of The Gambia,Journal of Pharmaceutical Health Services Research 2 (3) pp. 175-184 Wiley
Abstract
Objectives? To evaluate the cost effectiveness of the use of nine-valent pneumococcal polysaccharide conjugate vaccine in a routine infant immunisation programme based on the Pneumococcal Vaccine Trial (PVT) study in The Gambia.
Methods? This was a clinical trial-based cost-effectiveness study conducted as part of the PVT study. The PVT was an intention-to-treat double-blind placebo-controlled trial of a nine-valent pneumococcal polysaccharide conjugate vaccine. The trial was conducted in the eastern parts of The Gambia, West Africa and recruited 17 437 children aged 40?364 days. A deterministic static cohort model was developed to evaluate direct benefits and costs of pneumococcal conjugate vaccine in The Gambia's routine immunisation programme. The incremental cost-effectiveness ratio (iCER) is defined as vaccinating infants against pneumococcal disease compared with no vaccination from a public provider's perspective using The Gambia's 2005 projected under-one-year population.
Key findings? The results show the use of the vaccine in The Gambia's routine infant vaccination programme to be cost effective using an assumed price of US$5.00 per vial in single-dose vials. Compared with offering no vaccination, the incremental cost per DALYs averted would be 30 DALYs from the public provider perspective. At least 1569 and 340 invasive childhood pneumococcal illnesses and deaths respectively among the cohort would be prevented. In the absence of the vaccine 16 871 DALYs would be lost while with the use of the vaccine 7804 DALYs would be lost. Given the average treatment cost of pneumococcal illnesses to be US$191 (95% confidence interval 180 to 203) the introduction of the vaccine programme would lead to an additional cost of US$274 279 (about US$8.43/child).
Conclusions? The availability of a cost-effective vaccine that can prevent thousands of pneumococcal illnesses and related deaths is a major development towards improving the disease burden in sub-Saharan African countries. This study supports the introduction of nine-valent pneumococcal vaccine into the infant immunisation programme of The Gambia as it is cost effective and will avert many preventable deaths and illnesses. Despite differences in distribution of serotypes between countries, the static model used in the analysis makes the results applicable to other developing countries, particularly those in sub-Saharan Africa.
Touray MM (2014) Development of a Theory Based Dynamic Model on Demand for Obesity Preventive Goods, Journal of Behavioural Economics, Finance, Entrepreneurship, Accounting and Transport 2 (3) pp. 70-76 Science and Education Publishing
Introduction: Obesity is one of the leading causes of preventable morbidity and mortality world-wide. The behavioural nature of the condition has been highlighted by the fact that it is largely the result of an energy imbalance between calories consumed and calories expended. In that respect, obesity related morbidity and mortality can be reduced through preventive behaviours. As behavioural scientists, economists have done little to date to explain and understand why the demand for obesity preventing activities is low. The aim of this paper is to develop an economic theory-based dynamic model to gain better understanding of people?s obesity preventive behaviours. Methods: A literature search using a PICO approach was developed to identify the relevant variables considered to influence the demand for obesity preventive goods. To inform the model, a framework was developed to group variables and help determine appropriate linkages between them. Results: Anchors, anxiety and anxiety driven variables are fundamental influences of people?s risk reduction actions. The anchors, which are environmental as well as personal in character, serve as references and stimulate anxieties. However, anxiety levels are driven by many other variables including stigma and perceived health outcomes. In response to one?s anxiety an individual will take actions which can be explained, at least in part, by conventional economic theories particularly in terms of costs and utilities. Conclusions: Conventional economic theories of consumer behaviour cannot fully explain the demand for obesity preventive goods. The model demonstrates that many factors have to be considered including health economic, psychological and behavioural economic theories. The model should be tested through a well designed questionnaire before using it in a general adult population.
Touray M (2018) Estimation of Quality-adjusted Life Years alongside clinical trials: the impact of ?time-effects? on trial results,Journal of Pharmaceutical Health Services Research 9 (2) pp. 109-114 Wiley

Objectives

The objectives were to investigate the impact of ?time-effect? on the estimation of quality-adjusted life years (QALYs) along prospective clinical trials? outcomes using an assumed fixed time duration versus the actual time durations for each case. The ?time? duration is the length of time in a health state.

Methods

Two methods were used in the estimation of QALYs based using EQ-5D 3L scores collected at specific time-point intervals. One method used the actual time durations for each case based on CRF records, and the other used an assumed time duration and globally applied it to all the cases. Using SPSS® software program, we used paired-sample t-tests to assess whether the ?time-effect? can potentially affect trial results using CONSTRUCT trial data as reported in the trial results publications. The trial compared use of Infliximab with Cyclosporine for patients with Ulcerative Colitis and it involved some 270 participants.

Key findings

The results largely indicate statistically significant differences between the two methods of QALY estimations. QALYs at the respective time-points indicate no statistical difference between the two approaches. However, the difference in terms of total QALYs between the two QALY estimation approaches is statistically significant with considerable impact on costs/QALY.

Conclusions

Considering the possible impact of the time-effect on QALY estimations, the result implies that it can have significant implications for resources allocations decisions. In this respect, researchers have to pay due considerations to the approach they use and where possible, actual time durations must be used in QALY estimations along prospective clinical trials.

Touray Morro, Antonini A, Gentile G, Giglio M, Marcante A, Gage Heather, Fotiadis D, Gatsios D, Konitsiotis S, Timotijevic Lada, Egan B, Hodgkins Charo, Biundo R, Pellicano C (2018) Acceptability to patients, carers and clinicians of a mHealth platform for the management of Parkinson's disease (PD_Manager): study protocol for a pilot randomised controlled trial,Trials 19 (492) BioMed Central
Background: Parkinson?s disease is a degenerative neurological condition causing multiple motor and non-motor
symptoms that have a serious adverse effect on quality of life. Management is problematic due to the variable and
fluctuating nature of symptoms, often hourly and daily. The PD_Manager mHealth platform aims to provide a
continuous feed of data on symptoms to improve clinical understanding of the status of any individual patient and
inform care planning. The objectives of this trial are to (1) assess patient (and family carer) perspectives of PD_
Manager regarding comfort, acceptability and ease of use; (2) assess clinician views about the utility of the data
generated by PD_Manager for clinical decision making and the acceptability of the system in clinical practice.
Methods/design: This trial is an unblinded, parallel, two-group, randomised controlled pilot study. A total of 200
persons with Parkinson?s disease (Hoehn and Yahr stage 3, experiencing motor fluctuations at least 2 h per day),
with primary family carers, in three countries (110 Rome, 50 Venice, Italy; 20 each in Ioannina, Greece and Surrey,
England) will be recruited. Following informed consent, baseline information will be gathered, including the
following: age, gender, education, attitudes to technology (patient and carer); time since Parkinson?s diagnosis,
symptom status and comorbidities (patient only). Randomisation will assign participants (1:1 in each country), to
PD_Manager vs control, stratifying by age (1 d 70 : 1 > 70) and gender (60% M: 40% F). The PD_Manager system
captures continuous data on motor symptoms, sleep, activity, speech quality and emotional state using wearable
devices (wristband, insoles) and a smartphone (with apps) for storing and transmitting the information. Control
group participants will be asked to keep a symptom diary covering the same elements as PD_Manager records.
After a minimum of two weeks, each participant will attend a consultation with a specialist doctor for review of the
data gathered (by either means), and changes to management will be initiated as indicated. Patients, carers and
clinicians will be asked for feedback on the acceptability and utility of the data collection methods. The PD_
Manager intervention, compared to a symptom diary, will be evaluated in a cost-consequences framework Discussion: Information gathered will inform further development of the PD_Manager system and a larger
effectiveness trial.
Trial registration: ISRCTN Registry, ISRCTN17396879. Registered on 15 March 2017.
Waight Michael, Elawady Abdula, Gage Heather, Touray Morro, Adhya Shaumik (2019) Day case complex devices: the state of the UK,Open Heart 6 e001023 pp. 1-7 BMJ Publishing Group

Objective: Complex cardiac devices including implantable cardioverter defibrillator (ICD) and cardiac resynchronisation therapy (CRT) devices can safely be implanted as a day case procedure as opposed to overnight stay. We assess how common day case complex device therapy is and the cost implications of more widespread adoption across the UK.

Methods: A freedom of information request was sent to all centres performing complex cardiac devices across the UK to assess the adoption of this technique. Cost implications were assessed using Department of Health National Schedule of Reference Costs 2016?2017.

Results: 100 UK centres were surveyed, 80% replied. Eighty per cent of UK centres already implant complex cardiac devices as a day case to some extent. 64.06% of centres have a protocol for this. 12.82% of centres do Â25% of complex devices as a day case. 15.38% do 25%?50% as day case. 17.95% do 50%?75% as day case and 33.33% do Ã75% as day case. There was no relationship between centre volume and the proportion of devices done as a day case as opposed to overnight stay. The cost saving of performing a complex device as a day case as opposed to overnight stay was £412 per ICD, £525 per CRT-pacemaker and £2169 per CRT-defibrillator.

Conclusions: Day case complex devices are already widespread across the UK, however, there is scope for increase. An increase in proportion of day case devices could translate to £5 583 265 in savings annually for the National Health Service if all centres performed 75% of devices as a day case.

Macken Lucia, Mason Louise, Bremner Stephen, Gage Heather, Touray Morro, Evans Catherine, Cooper Max, Timeyin Jean, Steer Shani, Lambert Debbie, Crook David, Austin Mark, Parnell Nick, Thomson Sam, Sheridan David, Wright Mark, Isaacs Peter, Hashim Ahmed, Verma Sumita (2019) SAT-076-Long term palliative abdominal drains versus large volume paracentesis in refractory ascites due to cirrhosis: a multi-centre feasibility randomised controlled trial (the REDUCe Study),Journal of Hepatology - supplement: The International Liver Congress 2019 Abstract Book 70, 1 (1) pp. e660-e661 Elsevier

Background and aims: Ascites develops in about 90% with advanced
cirrhosis; when refractory to medical therapy, standard of care is
repeated large volume paracentesis (LVP) with albumin support.
Refractory ascites (RA) confers a median life expectancy of six months
without liver transplantation (LT). LVP is not an optimal palliative
strategy. One alternative is long-term abdominal drains (LTAD), used
in advanced malignant ascites, also enabling community management. Our ultimate aim is to improve end of life care (EoLC) in
advanced cirrhosis and RA. This feasibility randomised controlled
trial (RCT) aimed to resolve uncertainties in designing a definitive
RCT.

Method: Multicentre feasibility RCT with 1:1 randomisation between
standard of care (LVP) vs. LTAD (Rocket Medical) in adults with RA,
ineligible for LT. Both arms received prophylactic antibiotics. LTAD
were inserted under ultrasound guidance. Community nurses
undertook home visits to drain ascites dependent on symptoms;
(maximum 6L/week), without albumin support. Follow-up was 12
weeks with home visits every two weeks for the following
assessments: clinical, questionnaire based to include quality of life,
palliative care needs, carer burden and health economics (HE). Here
we report clinical and HE outcomes.

Results: Thirty six patients were randomised; 19 LVP (two withdrew,
wanting LTAD) and 17 LTAD (one withdrew-insufficient ascites). Mean
age (years) LTAD vs. LVP 66 + 10.4 vs. 68 ± 12; predominately male
(76% vs. 74%). Participants were well matched at baseline in liver tests
and prognostic scores: LTAD vs. LVP (serum bilirubin (¼mol/L) 26 ±
15.8 vs. 16 ±10, serum albumin (g/L) 33 ± 4.2 vs. 31 ± 3.3, serum
creatinine (mmol/L) 113 ± 46.7 vs.118 ± 53.1; MELD 14 ± 4.6 vs. 16 ±
7.2). One LTAD participant required hospitalisation for repeated LVP.
Serum albumin (g/L) in the LTAD arm declined to 29 ± 3.3 at week
two, subsequently remaining stable LTAD vs. LVP (29 ± 5.6 vs. 31 ±
5.5). Serum creatinine remained stable in both arms. There were no
LTAD related serious adverse reactions. LTAD related adverse reactions
included mild cellulitis (n = 4) and small volume leakage around LTAD
insertion site (n = 3), all resolving rapidly. Peritonitis was rare, LTAD
(possible) n = 1 and LVP n = 2. Overall mortality was 36% (12/33).
Mortality and median survival (days in those who died) were 7/16
(44%) vs. 5/17 (29%), 53 days (IQR 43) vs. 61 days (IQR 35) in LTAD vs.
LVP respectively. All but one death was liver related. Those in LTAD
arm spent H20% less time in hospital. All nine alive in the LTAD arm at
end of study elected to keep LTAD in. Detailed clinical and HE analysis
is underway.

Conclusion: Preliminary data from the REDUCe study supports the
safety and efficacy of palliative LTAD in RA due to advanced cirrhosis.
LTAD allows successful management in the community with
reduction in health resource utilisation. Proceeding to a definitive
RCT is justified.

Timotijevic Lada, Banks Carys, Rusconi Patrice, Egan Bernadette, Peacock Matthew, Seiss Ellen, Touray Morro, Gage Heather, Pellicano C., Spalletta G., Assogna F., Giglio M., Marcante A., Gentile G., Cikajilo I., Gatsios D., Konitsiotis S., Fotiadis D. (2020) Designing a mHealth Clinical Decision Support System for Parkinson?s Disease: A Theoretically Grounded User Needs Approach,BMC Medical Informatics and Decision Making 20 (34) BMC (Springer Nature)
Background: Despite the established evidence and theoretical advances explaining human judgments under uncertainty, developments of mobile health (mHealth) Clinical Decision Support Systems (CDSS) have not explicitly applied the psychology of decision making to the study of user needs. We report on a user needs approach to develop a prototype of a mHealth CDSS for Parkinson?s Disease (PD), which is theoretically grounded in the psychological literature about expert decision making and judgement under uncertainty.
Methods: A suite of user needs studies was conducted in 4 European countries (Greece, Italy, Slovenia, the UK) prior to the development of PD_Manager, a mHealth-based CDSS designed for Parkinson?s Disease, using wireless technology. Study 1 undertook Hierarchical Task Analysis (HTA) including elicitation of user needs, cognitive demands and perceived risks/benefits (ethical considerations) associated with the proposed CDSS, through structured interviews of prescribing clinicians (N=47). Study 2 carried out computational modelling of prescribing clinicians? (N=12) decision strategies based on social judgment theory. Study 3 was a vignette study of prescribing clinicians? (N=18) willingness to change treatment based on either self-reported symptoms data, devices-generated symptoms data or combinations of both.
Results: Study 1 indicated that system development should move away from the traditional silos of ?motor? and ?non-motor? symptom evaluations and suggest that presenting data on symptoms according to goal-based domains would be the most beneficial approach, the most important being patients? overall Quality of Life (QoL). The computational modelling in Study 2 extrapolated different factor combinations when making judgements about different questions. Study 3 indicated that the clinicians were equally likely to change the care plan based on information about the change in the patient?s condition from the patient?s self-report and the wearable devices.
3
Conclusions: Based on our approach, we could formulate the following principles of mHealth design: 1) enabling shared decision making between the clinician, patient and the carer; 2) flexibility that accounts for diagnostic and treatment variation among clinicians; 3) monitoring of information integration from multiple sources. Our approach highlighted the central importance of the patient-clinician relationship in clinical decision making and the relevance of theoretical as opposed to algorithm (technology)-based modelling of human judgment.
Gatsios D., Antonini A., Gentile G., Marcante A., Pellicano C., Macchiusi L., Assogna F., Spalletta G., Gage H., Touray M., Timotijevic L., Hodgkins C., Chondrogiorgi M., Rigas G., Fotiadis D.I., Konitsiotis S. (2020) Mhealth for remote monitoring and management of Parkinson?s disease: determinants of compliance and validation of a tremor evaluation method,JMIR mHealth and uHealth JMIR Publications

Background: mhealth, predominantly wearable technology and mobile apps, have been considered in Parkinson?s Disease to provide valuable ecological data between face to face visits and improve monitoring of motor symptoms remotely.

Objective: In this study we explore the feasibility of using a technology based mhealth platform comprising a smartphone in combination with a smartwatch and a pair of smart insoles, described in the present study as the PD_manager system, to collect clinically meaningful data. We also explore outcomes and disease related factors which are important determinants to establish feasibility. Finally, we further validate a tremor evaluation method with data collected while patients perform their daily activities.

Methods: PD_manager trial was an open label parallel group randomized study. The mheath platform consists of a wristband, a pair of sensor insoles, a smartphone (with dedicated mobile Android apps and a knowledge platform) serving as the cloud backend. The compliance was assessed with statistical analysis and the factors affecting it using appropriate regression analysis. The correlation of the scores of our previous algorithm for tremor evaluation and the respective UPDRS estimations by clinicians were explored.

Results: There were 65 of the 75 study participants (87%) who completed the protocol. They used the PD_manager system for a median 11.57 days (Std. dev. 3.15). The regression analysis suggests that the main factor associated with high usage was caregivers? burden. Motor Aspects of Experiences of Daily Living and patients? self-rated health status also influence the system?s usage. Our algorithm provided clinically meaningful data for the detection and evaluation of tremor.

Conclusions: We found that PD patients, regardless of their demographics and disease characteristics, used the system for 11-14 days. The study further supports that mhealth can be an effective tool for the ecologically valid, passive, unobtrusive monitoring and evaluation of symptoms. Future studies will be required to demonstrate that an mhealth platform can improve disease management and care.